LOCUS       NM_001271135            1729 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus unc-51 like kinase 3 (Ulk3), mRNA.
ACCESSION   NM_001271135 XM_001077085
VERSION     NM_001271135.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1729)
  AUTHORS   Goruppi,S., Procopio,M.G., Jo,S., Clocchiatti,A., Neel,V. and
            Dotto,G.P.
  TITLE     The ULK3 Kinase Is Critical for Convergent Control of
            Cancer-Associated Fibroblast Activation by CSL and GLI
  JOURNAL   Cell Rep 20 (10), 2468-2479 (2017)
   PUBMED   28877478
REFERENCE   2  (bases 1 to 1729)
  AUTHORS   Maloverjan,A., Piirsoo,M., Kasak,L., Peil,L., Osterlund,T. and
            Kogerman,P.
  TITLE     Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog
            signaling pathway
  JOURNAL   J Biol Chem 285 (39), 30079-30090 (2010)
   PUBMED   20643644
  REMARK    GeneRIF: Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic
            hedgehog signaling pathway.
REFERENCE   3  (bases 1 to 1729)
  AUTHORS   Maloverjan,A., Piirsoo,M., Michelson,P., Kogerman,P. and
            Osterlund,T.
  TITLE     Identification of a novel serine/threonine kinase ULK3 as a
            positive regulator of Hedgehog pathway
  JOURNAL   Exp Cell Res 316 (4), 627-637 (2010)
   PUBMED   19878745
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Sep 1, 2012 this sequence version replaced XM_001077085.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.33931.1,
                                           SRR26643298.44500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000008.1  66888934-66889088
            156-296             JAXUCZ010000008.1  66889718-66889858
            297-417             JAXUCZ010000008.1  66889942-66890062
            418-522             JAXUCZ010000008.1  66890479-66890583
            523-666             JAXUCZ010000008.1  66891223-66891366
            667-749             JAXUCZ010000008.1  66891559-66891641
            750-905             JAXUCZ010000008.1  66892057-66892212
            906-1011            JAXUCZ010000008.1  66892396-66892501
            1012-1052           JAXUCZ010000008.1  66892691-66892731
            1053-1155           JAXUCZ010000008.1  66892949-66893051
            1156-1220           JAXUCZ010000008.1  66893180-66893244
            1221-1299           JAXUCZ010000008.1  66893328-66893406
            1300-1340           JAXUCZ010000008.1  66893477-66893517
            1341-1388           JAXUCZ010000008.1  66893826-66893873
            1389-1455           JAXUCZ010000008.1  66894000-66894066
            1456-1729           JAXUCZ010000008.1  66894167-66894440
FEATURES             Location/Qualifiers
     source          1..1729
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1729
                     /gene="Ulk3"
                     /note="unc-51 like kinase 3"
                     /db_xref="GeneID:691171"
                     /db_xref="RGD:1587417"
     exon            1..155
                     /gene="Ulk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1472
                     /gene="Ulk3"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase ULK3"
                     /protein_id="NP_001258064.1"
                     /db_xref="GeneID:691171"
                     /db_xref="RGD:1587417"
                     /translation="MAGSGWGLPRLDGFILTERLGSGTYATVYKAYAKKATREVVAIK
                     CVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDNDNIYLIMEFCAGGDLSRF
                     IHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGF
                     AQHMSPWDEKHVLRGSPLYMAPEMVCRRQYDARVDLWSVGVILYEALFGQPPFASRSF
                     SELEEKIRSNRVIELPLRPQLSLDCRDLLQRLLERDPSHRISFQDFFAHPWVDLEHMP
                     SGESLAQATALVVEAVKKDQEGDAAAALSLYCKALDFFVPALHYEVDAQRKEAIKAKV
                     GQYVSRAEELKAIVSSSNQALLRQGTTGQELLREMARDKPRLLAALEVASAAMAKEEE
                     AGKEQDALDLYQHSLGELLLLLAAEAPGRRRELLHTEVQNLMARAEYLKEQIKIRESH
                     WEAESLDKEGLSESVRSSCTLQ"
     exon            156..296
                     /gene="Ulk3"
                     /inference="alignment:Splign:2.1.0"
     exon            297..417
                     /gene="Ulk3"
                     /inference="alignment:Splign:2.1.0"
     exon            418..522
                     /gene="Ulk3"
                     /inference="alignment:Splign:2.1.0"
     exon            523..666
                     /gene="Ulk3"
                     /inference="alignment:Splign:2.1.0"
     exon            667..749
                     /gene="Ulk3"
                     /inference="alignment:Splign:2.1.0"
     exon            750..905
                     /gene="Ulk3"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1011
                     /gene="Ulk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1052
                     /gene="Ulk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1155
                     /gene="Ulk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1220
                     /gene="Ulk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1299
                     /gene="Ulk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1340
                     /gene="Ulk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1388
                     /gene="Ulk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1455
                     /gene="Ulk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1729
                     /gene="Ulk3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctggccgg aacctgcacc ccaaaccagg aaacacctgg cggcgggcgc gggatggctg
       61 ggtccggctg gggtctccct cggctggacg gtttcatcct taccgagcgc ctgggcagtg
      121 gcacgtacgc cacggtgtac aaggcctacg ccaagaaggc tactcgggaa gtggtagcca
      181 taaaatgcgt ggccaagaaa agtctcaaca aggcgtcagt ggaaaacctc ctgactgaga
      241 ttgagatcct caagggcatt cggcaccccc atatcgtgca gctgaaagac ttccagtggg
      301 acaatgacaa tatctacctc atcatggagt tctgtgcagg gggtgacctg tctcgcttca
      361 tccatacccg caggattctg cctgagaagg tggcccgtgt tttcatgcag cagttggcta
      421 gtgccctgca gttcctgcat gaacgaaaca tctctcactt ggatctgaag ccgcagaaca
      481 tcctcctgag ttctttggag aagccccacc tgaaactggc agactttggc tttgcccagc
      541 atatgtcccc gtgggatgag aaacatgtgc ttcgtggctc cccgctctac atggctcctg
      601 agatggtgtg tcggcggcag tatgacgcgc gtgtggacct ctggtctgtg ggggtcatcc
      661 tgtacgaagc tctctttggg cagcctccct ttgcctccag atcgttctca gagctagaag
      721 agaagattcg tagcaatcgg gttattgagc tccctcttcg gccccaactc tccctagact
      781 gccgggacct gttgcagcga cttctagagc gggaccccag ccatcgaatc tcctttcagg
      841 acttctttgc ccacccctgg gtggacctgg agcacatgcc tagtggggag agcctggcac
      901 aagcaacagc ccttgtggtg gaggccgtga agaaggacca ggagggggac gctgctgctg
      961 ccctgtcact ctactgcaag gccctggact tctttgtacc tgcactacac tacgaagtgg
     1021 atgcccagag gaaagaggcg attaaggcga aggtggggca gtatgtgtcc agggcagagg
     1081 agctcaaagc cattgtctcc tcctccaatc aggccctgct aaggcagggc acaactggcc
     1141 aagagctgct gcgagagatg gcccgtgaca agccacgcct cctagctgcc ctggaagtgg
     1201 cctcagctgc catggccaag gaggaggaag ctggcaaaga gcaggatgcc ctggacctgt
     1261 accagcacag cctcggggag ctgctactgc tgttggcagc agaagcccca ggccgaaggc
     1321 gggagctcct tcacactgag gttcagaacc tcatggctcg agctgaatac ctgaaggagc
     1381 agatcaagat cagggaatct cactgggaag cagagagtct ggacaaagag gggctgtcgg
     1441 agtctgttcg aagttcttgc acactgcagt gactccagaa gaacctgtgc atggaacatg
     1501 aacctagaga gaagcttcgt accaagccag gttgatgcct gtgcacctgg gacctctgga
     1561 tgagctcctc ccacctccta gttcccagca ttcctcagtg ttctccaccc ttggggcatc
     1621 tggtggcagg tgtactaaac tctgggagaa ttactttaat atgactttgt cattaggtga
     1681 tggctgacct aagcctgtta gctttaggac accatcaccc tgttgtttt
//
