LOCUS       NM_001191645            6379 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus unc-51 like autophagy activating kinase 2 (Ulk2),
            mRNA.
ACCESSION   NM_001191645 XM_006246498 XM_220541
VERSION     NM_001191645.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6379)
  AUTHORS   Hansen,M.D., Johnsen,I.B., Stiberg,K.A., Sherstova,T., Wakita,T.,
            Richard,G.M., Kandasamy,R.K., Meurs,E.F. and Anthonsen,M.W.
  TITLE     Hepatitis C virus triggers Golgi fragmentation and autophagy
            through the immunity-related GTPase M
  JOURNAL   Proc Natl Acad Sci U S A 114 (17), E3462-E3471 (2017)
   PUBMED   28389568
REFERENCE   2  (bases 1 to 6379)
  AUTHORS   Yang,Z. and Klionsky,D.J.
  TITLE     Mammalian autophagy: core molecular machinery and signaling
            regulation
  JOURNAL   Curr Opin Cell Biol 22 (2), 124-131 (2010)
   PUBMED   20034776
  REMARK    Review article
REFERENCE   3  (bases 1 to 6379)
  AUTHORS   Chan,E.Y., Longatti,A., McKnight,N.C. and Tooze,S.A.
  TITLE     Kinase-inactivated ULK proteins inhibit autophagy via their
            conserved C-terminal domains using an Atg13-independent mechanism
  JOURNAL   Mol Cell Biol 29 (1), 157-171 (2009)
   PUBMED   18936157
REFERENCE   4  (bases 1 to 6379)
  AUTHORS   Hara,T., Takamura,A., Kishi,C., Iemura,S., Natsume,T., Guan,J.L.
            and Mizushima,N.
  TITLE     FIP200, a ULK-interacting protein, is required for autophagosome
            formation in mammalian cells
  JOURNAL   J Cell Biol 181 (3), 497-510 (2008)
   PUBMED   18443221
REFERENCE   5  (bases 1 to 6379)
  AUTHORS   Zhou,X., Babu,J.R., da Silva,S., Shu,Q., Graef,I.A., Oliver,T.,
            Tomoda,T., Tani,T., Wooten,M.W. and Wang,F.
  TITLE     Unc-51-like kinase 1/2-mediated endocytic processes regulate
            filopodia extension and branching of sensory axons
  JOURNAL   Proc Natl Acad Sci U S A 104 (14), 5842-5847 (2007)
   PUBMED   17389358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Jun 3, 2021 this sequence version replaced
            XM_006246498.4, NM_001191645.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.38407.1,
                                           SRR26643289.28005.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-591               JAXUCZ010000010.1  47029254-47029844   c
            592-684             JAXUCZ010000010.1  47028097-47028189   c
            685-726             JAXUCZ010000010.1  47025579-47025620   c
            727-759             JAXUCZ010000010.1  47014953-47014985   c
            760-796             JAXUCZ010000010.1  47013960-47013996   c
            797-970             JAXUCZ010000010.1  47011537-47011710   c
            971-1044            JAXUCZ010000010.1  47010360-47010433   c
            1045-1146           JAXUCZ010000010.1  47006639-47006740   c
            1147-1205           JAXUCZ010000010.1  47005608-47005666   c
            1206-1288           JAXUCZ010000010.1  47003720-47003802   c
            1289-1336           JAXUCZ010000010.1  47002090-47002137   c
            1337-1425           JAXUCZ010000010.1  47000634-47000722   c
            1426-1597           JAXUCZ010000010.1  46994998-46995169   c
            1598-1658           JAXUCZ010000010.1  46985814-46985874   c
            1659-1796           JAXUCZ010000010.1  46982734-46982871   c
            1797-1942           JAXUCZ010000010.1  46978600-46978745   c
            1943-2023           JAXUCZ010000010.1  46976415-46976495   c
            2024-2310           JAXUCZ010000010.1  46974593-46974879   c
            2311-2498           JAXUCZ010000010.1  46974154-46974341   c
            2499-2605           JAXUCZ010000010.1  46973741-46973847   c
            2606-2755           JAXUCZ010000010.1  46965021-46965170   c
            2756-2964           JAXUCZ010000010.1  46962172-46962380   c
            2965-3143           JAXUCZ010000010.1  46958572-46958750   c
            3144-3262           JAXUCZ010000010.1  46957791-46957909   c
            3263-3420           JAXUCZ010000010.1  46957355-46957512   c
            3421-3556           JAXUCZ010000010.1  46956110-46956245   c
            3557-6379           JAXUCZ010000010.1  46951038-46953860   c
FEATURES             Location/Qualifiers
     source          1..6379
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..6379
                     /gene="Ulk2"
                     /note="unc-51 like autophagy activating kinase 2"
                     /db_xref="GeneID:303206"
                     /db_xref="RGD:1310181"
     exon            1..591
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             502..3615
                     /gene="Ulk2"
                     /EC_number="2.7.11.1"
                     /note="Unc-51 like kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase ULK2"
                     /protein_id="NP_001178574.1"
                     /db_xref="GeneID:303206"
                     /db_xref="RGD:1310181"
                     /translation="MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKK
                     NLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGT
                     LSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYASRRKSNVSGIRIKIADFG
                     FARYLHSNTMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANS
                     PQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQVPV
                     RKSCPVPVPVYSGPGPGSSCSSSPPCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQV
                     SKDSASNSSKNSSCDTDDFVLVPHNISSDHSYDMPMGTAGRRASNEFFVCGGQCQPTV
                     SPHSETAPIPVPTQVRNYQRIEQNLISTASSGTNPHSSPRSAVVRRSNTSPMGFLRVG
                     SCSPVPADTVQTGGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHEARSRHSSG
                     SPVPQTQSPQSLLLGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSLAGAGYSYSPQPS
                     RPGSLGTSPTKHMGSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVT
                     RHGPAESQSKDGNDPRQCSHCLLVQGSERHRSEQQSKAVFGRSVSTGKLSEQQHVKAP
                     LGGHQGSTDSLNTERPMDVAPAGACGVVLALPAGTAASARAVLFTVGSPPHSATAPTC
                     THMVLRTRTTSVGSNSSGGSLCSASGRVCVGSPPAPGFGSSPPGAEAAPSLRYVPYGA
                     SPPSLEGLITFEAPELPEETLMEREHTDTLRHLNMMLMFTECVLDLTAVRGGNPELCT
                     SAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSP
                     STAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVTAEKLIYNCAVE
                     MVQSAALDEMFQQTEDIVQRYHKAALLLEGLSKILQDPADAESVHKYKCSIERRLSAL
                     CCSTAAV"
     exon            592..684
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..726
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..759
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            760..796
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            797..970
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1044
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1146
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1205
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1288
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1336
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1425
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1597
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1658
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1796
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1942
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2023
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2310
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2498
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2605
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2755
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2964
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3143
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3262
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3420
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3421..3556
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..6379
                     /gene="Ulk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccggcg cgcgcgcgtg cgttgggtgc tcccgcgaag caggcaggag tcgccgcccc
       61 ggctgtgcgg gttccagggc ggcggcccct acacagcagc gccgtgggcg caacaagccg
      121 aggcagccgc acctgcgggg atggcgcggc cccggctctg caccgctgtc gggcgcgcgg
      181 gtagctccgg gtacgccctg tgacggtggc ggtgccttcg gccgggcagc gcccaagtcg
      241 cttggccaga gccccgcggc cgacggcggc ccgggccatg aggagcggcc gggcccaggc
      301 ctcgctgacc ccggctccgc gcggcgaccc gtcccgtttc cgctccggcc tctcggcatg
      361 agtgtccgtc cgggcccggg gccgtggctg cccccatccc gccgcccgcg ggcgcgcttg
      421 gggccctcgg gccggcggtg ctgatctccg ctctccgcca cgcctgccca cccgagcgct
      481 ctatgtcccg ggggcgcggc catggaggtg gtgggcgact tcgagtacag caagcgggac
      541 ctcgtgggac acggggcctt cgctgtggtc ttccgggggc ggcaccgcca gaaaactgat
      601 tgggaggtgg ctattaaaag tattaataaa aagaacttgt caaagtcaca aattctgctt
      661 ggaaaggaaa taaaaatctt aaaggaactt cagcatgaaa atatcgtagc actctatgat
      721 gttcaggaat tacccaactc tgtctttctg gtgatggagt attgcaatgg tggagatctg
      781 gcagattatt tgcaagctaa aggaactctg agtgaagata ctatcagagt gtttcttcat
      841 cagattgcag cagccatgcg aatcctgcac agcaaaggga taatccacag ggatctcaaa
      901 ccacagaaca tcttgttgtc ttacgccagt cgaaggaagt cgaatgtcag tggtattcgc
      961 atcaaaatag ctgactttgg ttttgcccgt tacctacata gtaacacaat ggcagcgaca
     1021 ctgtgtggat ccccaatgta catggctcct gaggttatca tgtctcaaca ttatgatgct
     1081 aaggcagatt tatggagcat aggaacggtg atctatcaat gcctagttgg aaaaccacct
     1141 tttcaggcta acagtcctca agacctaagg atgttttatg aaaaaaacag gagcttaatg
     1201 cctagtattc ccagagaaac atcaccttat ttggctaatc tccttttggg cttgcttcaa
     1261 agaaatcaga aggacagaat ggactttgaa gcgtttttca gtcatccttt ccttgagcaa
     1321 gttccagtta gaaaatcttg cccagtccca gtgcctgtgt actccggccc tggccctgga
     1381 agctcctgca gcagctcgcc accttgtcgc tttgcttctc caccatccct tccagatatg
     1441 cagcatattc aggaagaaaa cttatcctcc ccaccattgg gtcctcccaa ctatctacag
     1501 gtgtccaaag attctgccag taatagtagc aagaactctt cttgtgacac ggatgacttt
     1561 gttttggttc cacacaacat ctcgtcagac cactcatatg atatgccaat ggggactgct
     1621 ggcagacggg cttcaaatga gttctttgtg tgtggagggc agtgtcaacc tactgtgtca
     1681 cctcacagcg aaacagcccc aattccagtt cctactcaag taaggaatta tcagcgcata
     1741 gaacagaatc ttatatccac tgccagctct ggtacaaatc cacatagttc tccaagatct
     1801 gcagtggtac gaaggtctaa taccagcccc atgggcttcc tccgggttgg gtcctgctcc
     1861 cctgtaccag cagacacagt gcagacggga ggacgaagac tctcgaccgg ctcttccagg
     1921 ccttactcac catccccttt ggttggtact attcctgaac agtttagtca gtgctgctgt
     1981 ggacatcctc agggccatga agccaggagt agacactcct caggttctcc agtgccacag
     2041 acccagtcac cacagtcact cttactgggt gctagactgc agagtgcacc caccctcacc
     2101 gatatctatc agaacaagca gaagctcaga aagcagcact ctgaccctgt gtgtccatcc
     2161 cttgccgggg ctggatatag ttactcacct cagccgagtc ggcctggcag ccttggaacc
     2221 tctcccacca agcatatggg gtcctctcca cggagttctg actggttctt taaaactcct
     2281 ttaccaacaa tcattggctc tcctactaag actacagctc ctttcaaaat ccctaaaaca
     2341 caagcatctt ctaacctgtt agccttggtt actcgtcatg gacctgctga aagccagtcc
     2401 aaagatggaa atgaccctcg tcagtgttca cattgcctct tagtacaagg aagtgagagg
     2461 catcgatctg agcagcagag caaggcggta tttggcagat ctgtcagtac cgggaagttg
     2521 tcagaacaac agcacgtaaa ggcaccttta ggtggacacc agggcagcac agatagttta
     2581 aacacagaac gaccaatgga tgtagctcca gcaggagcct gtggtgttgt gttggcattg
     2641 ccagcaggaa cagcagcaag cgccagagct gtcctcttca ccgtggggtc tcctccacac
     2701 agtgccacag cccctacttg tactcacatg gtccttcgaa caagaaccac ctcagtgggg
     2761 tccaacagct caggaggctc cttgtgttct gcgagtggcc gagtgtgtgt gggctcccct
     2821 cctgcgccag ggttcggctc ctccccacca ggagcagagg cagctcccag cctaagatac
     2881 gtgccttacg gtgcttcacc acccagccta gagggtctca tcacctttga agcccctgaa
     2941 ctaccagagg agacactgat ggagcgagaa cacacagaca ccttacgtca tctgaacatg
     3001 atgctgatgt ttactgagtg tgtgctggac ctgacagcag tgaggggtgg gaaccctgag
     3061 ctgtgcacat ctgctgtgtc cctgtatcag attcaggaga gtgtagttgt ggaccagata
     3121 agccagctaa gcaaagattg ggggcgggta gagcagctgg tgttgtacat gaaggcggca
     3181 cagctgctgg cggcttccct gcatctcgcc aaagctcaga tcaagtccgg gaagctgagc
     3241 ccatccacgg ctgtgaaaca agttgttaaa aatctgaatg aaagatataa attctgcatc
     3301 accatgtgca agaaacttac agaaaagctg aatcgcttct tctctgataa acagagattt
     3361 attgatgaaa tcaacagtgt gactgcagag aaactcatct ataattgtgc tgtggaaatg
     3421 gttcagtctg cagccctgga tgagatgttc cagcagactg aagacatcgt tcagcgatac
     3481 cacaaggcag cccttctttt ggaaggctta agtaagatcc tgcaggaccc tgcagatgct
     3541 gagagtgtgc ataagtataa atgtagtatt gaaagaagat tgtcagcgct ctgctgtagc
     3601 actgcagctg tgtgaggagc aggcttgtct gtggaccagc atagaacagg aggtgcctga
     3661 ctgtggacca gcgtgaaaca ggaggtgata catttgatta catcttggtt ctgtcaccca
     3721 tcccaggaca ctgtggtgac taccaaagaa caaacagcaa cttaagaagg aaaacaatac
     3781 aaaactacta catattgtag gaaacctgcc ttattggaga agtcactccc tctttccttt
     3841 ctcttttaga agcagaagca aaagagttgt ccacatggct cgagttatta gaacctggca
     3901 aataaatgta ccttagaact agtatcataa gtacagttat tcttgtggat aattaaacag
     3961 gaaacaaagt gagtgacctc actcagctct ctgagctata tgtgaaagtc catgtttgct
     4021 aaagcataca caagcaaaag agtatacagc tcatccagac aacttgagat ttggggtaag
     4081 tttgcctgaa tctgagcgtg catctttaaa cagctcagga gaaggaattt taagaagaaa
     4141 caaggtgact cttggatgaa ctgtgaaatc ttcaacttga tctaatgtgg acatgacgtt
     4201 aatcttccaa aaatctttca tattgcacta atttattaaa taactatgta ttggattttg
     4261 caatttaaaa ctaactgagg cacaatggac ttgtttaaaa tattttactt gattacatac
     4321 atatgtcctt ttcagagttc atgtgtactc tccactgaac ttgtaaatgg tcagaacttg
     4381 cgttcatgtg agcctttgca tttttctcac ctgcgatata tcttcaccca cagatcttct
     4441 cagtggaagt ttgagttgct gattgtttgc attttttgtt gtgcatgcag aatgttcatc
     4501 gattcttgtg accttagttt tattaaaggc tgttgatttg ggcagtatta gaaagctatc
     4561 atgaatcaag aaatactctt gagaatttta tagggccaaa tcaaagtgat gaataatggc
     4621 ttgttagtga tgtggagttt ctacataaaa ttagtaagaa atgaggtttg ttttccctta
     4681 gaaaaatggg cagctctctc cagactaatg tgtacttctc agtgttaacc ctgagttcac
     4741 aaatagctgg tcatggcaga tcaacatctc cccaagaatg gtttctatgt tgtatattat
     4801 ttggtttctt ttacttacct gctttaatac ttgaataaac cattcaccgg ttttaatctt
     4861 tttacttcaa aactttgaca taatgacctg cgctctgata gctgcacaga agctctttgg
     4921 caccacactt actttagtgt gctgattaaa gttaacagag aaaatggttt tcatttactt
     4981 ggtgaacaaa gtaatgtaat ttttacatta tttatctgta tgaaattcta gcagttaatt
     5041 tgaacgttta tgtataggat gtttgtattt ttaggtcttt actacggtgt ttctacctct
     5101 catttgtaac tgcattatct tcaaaccagg taaaacccac tgagtcattg tggaatagtc
     5161 tttttaaatt gcttgtacaa atgtatatca aggttaaata aagctgacag tgtttttagg
     5221 gtacagttgg ggtgatatga agtggcttgt caagccagat gctttttgag agtgggtcgg
     5281 aaacttggtc gtcaatattc tttgccctgc tccaggattt aaaacccttg gtgactgtca
     5341 taccggctcc tgcagacaga ctgtacccct ccttatacta gtgataaaat gtcttctgta
     5401 atttttacac taaattcttt catgttctct taatcaccct gtttatctca gttggttttc
     5461 caagtaagca gatgtagttg gcctcctctt ctacactttt taaaaatata atatcaacaa
     5521 ttttggagag gatgaggttg gtgtaaagtc aggaataggt gagtgttgaa actgcactgt
     5581 tactctcaag ctcttcctgt gtgaccaagg tcttgtgggt ggtgtgagaa gcagcgacat
     5641 ctcagcagtg gagagcaact gcaaactctt gaataatggt tctgatatcc taccattatc
     5701 aaggccaatt gtttaaagaa atttttgcct tgattatagc aataataaat aaatgcttta
     5761 tgtttctgta tttttatttc atatcatgta tttcataaaa tggaattaga caagttcaca
     5821 cactcatggg tcagcacctg tattcacatc ctaacctgga aaataattga ccatgaaaat
     5881 gtaagtagag gaattatgag tgaattggtt ttcttgctat gtggattttc tttaactgtc
     5941 acatgttgga gatctgttgt tgacataatt acttcctaca gccctcacgt gcccttttct
     6001 ctactaggaa gaatagcagc ctcacaggaa ccagttatag gagctggtgt agctctcgtt
     6061 agtttattta taacggtaga aggaagttga gttgaatgca gaagagatgc ggacacagag
     6121 taggtcctgg atgcatctat cgcccgggtt cctatacatc ccttctgcat ggagctagta
     6181 cttggtgtca gtttcctgca gcacttcagg tagaaagaat ggcatccctc tttccaactc
     6241 atccgttttc tactcccttc tctacccagc tggccctgtg aagtagcatt tctcctgctt
     6301 gggaatactg tgcttaaaac tgctgataca caactttaat tattttgaga acattcaata
     6361 aatgaatgaa tgatttatt
//
