LOCUS       NM_001013884            2518 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ubiquitin interaction motif containing 1 (Uimc1),
            mRNA.
ACCESSION   NM_001013884 XM_214427
VERSION     NM_001013884.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2518)
  AUTHORS   Panier,S., Ichijima,Y., Fradet-Turcotte,A., Leung,C.C., Kaustov,L.,
            Arrowsmith,C.H. and Durocher,D.
  TITLE     Tandem protein interaction modules organize the ubiquitin-dependent
            response to DNA double-strand breaks
  JOURNAL   Mol Cell 47 (3), 383-395 (2012)
   PUBMED   22742833
REFERENCE   2  (bases 1 to 2518)
  AUTHORS   Wang,B., Hurov,K., Hofmann,K. and Elledge,S.J.
  TITLE     NBA1, a new player in the Brca1 A complex, is required for DNA
            damage resistance and checkpoint control
  JOURNAL   Genes Dev 23 (6), 729-739 (2009)
   PUBMED   19261749
REFERENCE   3  (bases 1 to 2518)
  AUTHORS   Feng,L., Huang,J. and Chen,J.
  TITLE     MERIT40 facilitates BRCA1 localization and DNA damage repair
  JOURNAL   Genes Dev 23 (6), 719-728 (2009)
   PUBMED   19261748
REFERENCE   4  (bases 1 to 2518)
  AUTHORS   Shao,G., Patterson-Fortin,J., Messick,T.E., Feng,D., Shanbhag,N.,
            Wang,Y. and Greenberg,R.A.
  TITLE     MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to
            DNA double-strand breaks
  JOURNAL   Genes Dev 23 (6), 740-754 (2009)
   PUBMED   19261746
REFERENCE   5  (bases 1 to 2518)
  AUTHORS   Shao,G., Lilli,D.R., Patterson-Fortin,J., Coleman,K.A.,
            Morrissey,D.E. and Greenberg,R.A.
  TITLE     The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes
            RNF8-Ubc13-dependent ubiquitination events at DNA double strand
            breaks
  JOURNAL   Proc Natl Acad Sci U S A 106 (9), 3166-3171 (2009)
   PUBMED   19202061
REFERENCE   6  (bases 1 to 2518)
  AUTHORS   Kim,H., Chen,J. and Yu,X.
  TITLE     Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage
            response
  JOURNAL   Science 316 (5828), 1202-1205 (2007)
   PUBMED   17525342
REFERENCE   7  (bases 1 to 2518)
  AUTHORS   Sobhian,B., Shao,G., Lilli,D.R., Culhane,A.C., Moreau,L.A., Xia,B.,
            Livingston,D.M. and Greenberg,R.A.
  TITLE     RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage
            sites
  JOURNAL   Science 316 (5828), 1198-1202 (2007)
   PUBMED   17525341
REFERENCE   8  (bases 1 to 2518)
  AUTHORS   Wang,B., Matsuoka,S., Ballif,B.A., Zhang,D., Smogorzewska,A.,
            Gygi,S.P. and Elledge,S.J.
  TITLE     Abraxas and RAP80 form a BRCA1 protein complex required for the DNA
            damage response
  JOURNAL   Science 316 (5828), 1194-1198 (2007)
   PUBMED   17525340
REFERENCE   9  (bases 1 to 2518)
  AUTHORS   Yan,Z., Kim,Y.S. and Jetten,A.M.
  TITLE     RAP80, a novel nuclear protein that interacts with the
            retinoid-related testis-associated receptor
  JOURNAL   J Biol Chem 277 (35), 32379-32388 (2002)
   PUBMED   12080054
REFERENCE   10 (bases 1 to 2518)
  AUTHORS   Seol,W., Choi,H.S. and Moore,D.D.
  TITLE     Isolation of proteins that interact specifically with the retinoid
            X receptor: two novel orphan receptors
  JOURNAL   Mol Endocrinol 9 (1), 72-85 (1995)
   PUBMED   7760852
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087149.1.
            
            On Apr 20, 2005 this sequence version replaced XM_214427.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2518
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2518
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /note="ubiquitin interaction motif containing 1"
                     /db_xref="GeneID:290997"
                     /db_xref="RGD:1307009"
     exon            1..55
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /inference="alignment:Splign:2.1.0"
     exon            56..210
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2244
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /note="receptor-associated protein 80; ubiquitin
                     interaction motif-containing protein 1"
                     /codon_start=1
                     /product="BRCA1-A complex subunit RAP80"
                     /protein_id="NP_001013906.1"
                     /db_xref="GeneID:290997"
                     /db_xref="RGD:1307009"
                     /translation="MPRRKKKIKEASEGQNLEKKDLETTSSVSIKKKRRLEDLFIVIS
                     DSDGEETKEENGLQKMKTKQSNRSKCLAKRKIAQMSEEEQFALALKMSEQEAKEVNNQ
                     EEKEEELLRKAIAESLNSRWSSDASAARPRPLSTGPSSHPHQDSTKDSGTTEGIWQLA
                     PPSLCKGSQISQGNEAEEGKEPWDHSENPEEEPLSGSSGSQDQSSRPVFENEKVKCFD
                     RCTGHLAEHTQCGKPQESTGSGCAFPKAVQGRGDTSRQCLPTPADTKGLQDIGGTVHY
                     YWGVPFCPAGVDPDQYTSVILCQLEVYQKSLKMAQRQLVKKRGFGEPVLPRPPFLIQN
                     ECGQEEQTSEKHEGLSEDVRAGAREERQGSGASVWHSETKDSQKSPITSLKQRLLLEE
                     EPTTGRGQSSQGLFVEETSEEVLKSSEGDDAVPASQSIAVLTSKRDLVLMPEASTEEV
                     TVCPETQLSSFEPLDLNGEDSVDGREIPTELGMTVSNRQVDNREAGKDSRPPAVSASA
                     RVSCPLCNQDFPPTKIEQHAMYCTGLMEPETVLTRRRREAKKKSDGRTAAQPALDISR
                     KEKCYLCKSLVPLGEYQCHVETCLQLANVDRENGTEGMRRPRVCAPVEGKPKQRLRKS
                     KEKGHSQGRLLSLLEQSEHRTTGVERTPKCSEAGAFRMPSPDVEEAGCSRERQSSLSK
                     LNLNESPIKSFVPVSEATNCLVDFKGQFAFRSQTKSGRGRRRKS"
     exon            211..295
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /inference="alignment:Splign:2.1.0"
     exon            296..420
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /inference="alignment:Splign:2.1.0"
     exon            421..526
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /inference="alignment:Splign:2.1.0"
     exon            527..1263
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1349
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1426
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1530
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1681
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1760
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1938
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2002
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2045
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2491
                     /gene="Uimc1"
                     /gene_synonym="RGD1307009"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgctcgcg acccccagtg ttcgggaggc gctgggcgga gcggccagct tggcggtaaa
       61 aggatgccac gaagaaagaa aaaaattaaa gaagcctccg aaggtcagaa cctcgagaag
      121 aaggatctgg aaaccaccag ttctgtcagt ataaaaaaga agcgtcgact ggaggactta
      181 ttcatagtga tatctgatag tgatggagag gaaacaaaag aggaaaatgg attacagaaa
      241 atgaagacaa aacagtcaaa cagatcaaag tgtttggcta aaagaaaaat tgcacagatg
      301 tcagaagaag aacaatttgc tttggctctc aaaatgagtg agcaggaagc taaggaggtg
      361 aacaaccagg aggagaaaga agaagagctc ttgaggaaag ccattgctga aagcctgaat
      421 agtcgctggt cttctgacgc ttctgctgcc agaccccgac ctctgtctac tgggccgtcc
      481 tcacatcccc atcaagacag caccaaagat tctggaacca ctgaaggcat atggcagctg
      541 gcacctccat cactgtgcaa aggctcacag atcagtcagg gaaacgaggc tgaggaagga
      601 aaggagccct gggaccacag tgaaaaccct gaagaggagc cgctctctgg cagctcagga
      661 agccaggacc agtcaagccg gccagtgttt gagaatgaga aggttaaatg ttttgacaga
      721 tgtactggcc acttggctga gcacacacag tgtgggaagc cacaggaaag tactgggagt
      781 ggttgtgctt ttcccaaagc tgttcagggt aggggggaca cgtctaggca atgccttcct
      841 accccagcag acaccaaagg cctccaggac attgggggca cagtgcacta ctactggggt
      901 gttccattct gccctgctgg agtagaccct gatcaataca ccagtgtcat tctgtgccag
      961 ttggaggtgt atcagaagag cttgaaaatg gctcagagac agcttgttaa aaaaagaggg
     1021 tttggggaac cagtgttacc tagacctcct tttctgatcc agaatgaatg tggccaagaa
     1081 gagcagacta gtgaaaagca tgaaggcctc tcagaagatg tgagagctgg agccagggag
     1141 gaaaggcagg gctctggggc atctgtctgg cactcagaaa ccaaggattc tcaaaaaagt
     1201 cccattacaa gcttgaagca gagacttttg ttggaggaag aaccaacaac cggtcgtggt
     1261 cagtcttccc aaggtctgtt tgttgaagaa acttctgaag aagttctgaa gagttctgaa
     1321 ggagacgacg ctgtgcctgc ctcacaaagc attgcagttt tgaccagtaa gagagattta
     1381 gttcttatgc cggaagcttc tacagaagaa gtcactgttt gtcctgagac acagttaagt
     1441 tcctttgagc cccttgacct gaatggagaa gactctgtag atggcagaga gatccccact
     1501 gaactaggaa tgacagtgag taataggcag gttgataata gggaagctgg taaggacagt
     1561 cgtcctcctg cagtctcggc tagtgccagg gtgtcctgcc cactgtgtaa ccaagacttc
     1621 cctcccacaa agattgagca gcatgccatg tactgcactg gcctgatgga gccggaaaca
     1681 gtattgactc ggagacgaag agaggccaag aaaaaaagtg atggtaggac agctgcgcag
     1741 cctgccctgg acatcagcag gaaggagaag tgttatctgt gtaagtccct ggttccactt
     1801 ggggagtatc agtgtcatgt agagacctgt ctccagcttg caaatgttga cagagaaaat
     1861 gggactgaag ggatgaggag accaagagtg tgtgcacctg tggaggggaa accgaagcag
     1921 cgactgagga agtcaaagga aaaaggtcat agtcaaggcc gacttctcag tctcttggag
     1981 cagtctgagc acaggaccac aggtgtagag agaaccccca agtgttccga agcaggagcc
     2041 ttcaggatgc cctcaccaga tgtggaagag gctggctgca gcagagagag gcagagttcg
     2101 ctctcaaagc tcaacttaaa tgagtctccc atcaagtctt ttgttcctgt ttcagaagct
     2161 acaaattgct tagtggactt taaaggccaa tttgctttcc ggtcacaaac caaatcaggc
     2221 agaggaagga ggagaaaatc ttgaatttct tgagactgga ggatgaccag aatgattgtt
     2281 gttggattgg tcatgttcat taattattgt ggtctccagt ttgctgtgag agttctgacc
     2341 ctgttgtttt caccaccagc gtctgttcag caccctgatt tttatgtttt ataagatctc
     2401 ttcagacaac tgtgaatagt attctgtttt acaacagtct gtttgaattt gcttatagtt
     2461 aaaatttaaa tatatttatc tttgtatgaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
