LOCUS       NM_001107585            3583 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus ubiquitin like with PHD and ring finger domains 2
            (Uhrf2), mRNA.
ACCESSION   NM_001107585 XM_001080356 XM_219801
VERSION     NM_001107585.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3583)
  AUTHORS   Buck-Koehntop BA and Defossez PA.
  TITLE     On how mammalian transcription factors recognize methylated DNA
  JOURNAL   Epigenetics 8 (2), 131-137 (2013)
   PUBMED   23324617
  REMARK    Review article
REFERENCE   2  (bases 1 to 3583)
  AUTHORS   Pichler G, Wolf P, Schmidt CS, Meilinger D, Schneider K, Frauer C,
            Fellinger K, Rottach A and Leonhardt H.
  TITLE     Cooperative DNA and histone binding by Uhrf2 links the two major
            repressive epigenetic pathways
  JOURNAL   J Cell Biochem 112 (9), 2585-2593 (2011)
   PUBMED   21598301
REFERENCE   3  (bases 1 to 3583)
  AUTHORS   Li Y, Mori T, Hata H, Homma Y and Kochi H.
  TITLE     NIRF induces G1 arrest and associates with Cdk2
  JOURNAL   Biochem Biophys Res Commun 319 (2), 464-468 (2004)
   PUBMED   15178429
REFERENCE   4  (bases 1 to 3583)
  AUTHORS   Mori T, Li Y, Hata H and Kochi H.
  TITLE     NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP,
            a PEST-containing nuclear protein
  JOURNAL   FEBS Lett 557 (1-3), 209-214 (2004)
   PUBMED   14741369
REFERENCE   5  (bases 1 to 3583)
  AUTHORS   Mori T, Li Y, Hata H, Ono K and Kochi H.
  TITLE     NIRF, a novel RING finger protein, is involved in cell-cycle
            regulation
  JOURNAL   Biochem Biophys Res Commun 296 (3), 530-536 (2002)
   PUBMED   12176013
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_219801.4, XM_001080356.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3583
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..3583
                     /gene="Uhrf2"
                     /note="ubiquitin like with PHD and ring finger domains 2"
                     /db_xref="GeneID:309331"
                     /db_xref="RGD:1309990"
     exon            1..467
                     /gene="Uhrf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..2726
                     /gene="Uhrf2"
                     /EC_number="2.3.2.27"
                     /note="ubiquitin-like, containing PHD and RING finger
                     domains 2; ubiquitin-like with PHD and ring finger domains
                     2, E3 ubiquitin protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UHRF2"
                     /protein_id="NP_001101055.1"
                     /db_xref="GeneID:309331"
                     /db_xref="RGD:1309990"
                     /translation="MWIQVRTIDGSQTRTIEDVSRKATIEELRERVWALFDVRPECQR
                     LFYRGKQLENGYTLFDYDVGLNDIIQLLVRPDSSLPSTSKQNDVQVKPSSNNTPKVKK
                     TARGGSSSQPSTSARTCLIDPGFGLYKVNELVDARDAGLGAWFEAHIHSVTRASDGHS
                     RGKTPLKNGNSYKRTNGNVNHNSKENTNKLDNVPSTSNSDSVAADEDVIYHIEYDEYP
                     ESGTLEMNAKELRPRARTILKWNELNVGDVVMVNYNVENPGKRGFWYDAEITTLKTIS
                     RTKKEVRVKVFLGGSEGTLNDCRVMFVDEIFKIEKPGAHPLSFADGKFLRKNDPECDL
                     CGGDPDKTCHMCSCHKCGEKRDPNMQLLCDECNMAYHIYCLSPPLDKVPEEEYWYCPS
                     CKTDSSEVVKAGEKLKLSKKKAKMPSASTESRRDWGRGMACVGRTKECTIVPSNHYGP
                     IPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFEDEVDRGDEFTY
                     TGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRVI
                     RSFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGFLVWRYLLRRDDVEPAPWTSE
                     GIERSRRLCLRLQYPAGYPSDKEGKKTKGQSKKQTSEGTKRPASDDECPSDSKVQKTS
                     DSTEAVEAFQLTPQQQRLIKEDCQNQKLWDEVLASLVEGPNFLKKLEQSFMCVCCQEL
                     VYQPVTTECFHNVCKDCLQRSFKAQVFSCPACRHDLGQNYIMTLNETLQTVLDLFFPG
                     YSKGR"
     exon            468..701
                     /gene="Uhrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            702..961
                     /gene="Uhrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1180
                     /gene="Uhrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1290
                     /gene="Uhrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1477
                     /gene="Uhrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1601
                     /gene="Uhrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1709
                     /gene="Uhrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1814
                     /gene="Uhrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1921
                     /gene="Uhrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2084
                     /gene="Uhrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2225
                     /gene="Uhrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2322
                     /gene="Uhrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2480
                     /gene="Uhrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2579
                     /gene="Uhrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..3583
                     /gene="Uhrf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgagatccg ggttggcgcc gtgacctcca tgtgggagct gcatctctat aagtaaacac
       61 tccgcgccgc cgagacatgg cttcttccta tttgtgaggc gcaggctgcg ctagcaactc
      121 gggcgggttc cggtttcctt ccacctcgga gagagtgggc ggtcgaacgg tctagagcgt
      181 cagtcttcgc ccgcgttcgc cgagccgccg cagagaaccg gatccttcag aggaggcggc
      241 aggggccggg cggggcgcgg cggcccgagc gcaggggtag acaaaggggg tcggtcccct
      301 atcccggtgc cgcgatgtgg atccaggtcc gcaccatcga cggctcccag acgcgcacca
      361 tcgaggacgt ttctcgcaaa gccaccatcg aggagctgcg cgagagggtg tgggcgctgt
      421 tcgacgtaag gcccgagtgc cagcgcctgt tctaccgggg caagcagttg gaaaatggat
      481 atacgttatt tgactacgac gttggactga acgatataat tcagctgcta gttcgtcctg
      541 actccagtct tcctagcaca tctaagcaga atgatgttca ggttaaaccc tcttctaata
      601 atacgcctaa agtaaagaaa acagcaagag ggggatcttc cagtcaacca tctacatcag
      661 ctcgcacttg tcttattgac cctggctttg gactatataa ggtaaatgaa ttggtggatg
      721 ccagagatgc cggccttggt gcttggtttg aagcacatat acatagtgtt actagagctt
      781 ctgatggaca ttcacgtggc aaaactccac tgaagaatgg caattcttat aaaaggacta
      841 atggaaatgt aaatcataat tccaaagaga acacaaataa attggacaat gtgccctcta
      901 cgtctaattc agactcagtt gctgctgatg aagacgttat ttatcatatc gagtatgatg
      961 aatatccaga gagtggtaca ctagaaatga atgctaagga acttcgacca cgagcacgga
     1021 ccattttaaa atggaacgaa ctaaatgtcg gtgatgtggt aatggttaat tacaatgtag
     1081 aaaatccagg caaaagagga ttttggtatg atgccgaaat taccacattg aagacaatat
     1141 ccaggaccaa aaaggaagtt cgtgtgaaag ttttcctggg gggttctgaa ggaacattaa
     1201 atgactgccg agtaatgttc gtagacgaaa tcttcaagat tgagaagcct ggagcccatc
     1261 ctctttcctt tgcagatgga aagtttttaa ggaaaaatga ccctgaatgt gacctgtgtg
     1321 gtggagaccc agataagaca tgccacatgt gttcttgtca taagtgtgga gagaagcggg
     1381 atcccaacat gcagcttctg tgtgacgagt gcaatatggc ctatcacatt tactgcctga
     1441 gcccgccttt ggataaggtc ccggaagagg agtactggta ttgtccttcc tgtaaaactg
     1501 actccagcga ggtggtaaag gctggggaga aactcaagct gagtaagaag aaggcgaaga
     1561 tgccctcagc cagtacggag agccggagag actggggcag gggcatggct tgtgttggtc
     1621 gtacaaaaga atgtactatt gtcccatcca atcactatgg acctatccct ggtattcctg
     1681 tggggtcaac ttggagattc agagttcagg tgagtgaagc cggggttcat aggcctcatg
     1741 ttggtggaat ccatggtcgc agcaatgacg gggcttattc tcttgtgctg gctggaggat
     1801 tcgaagacga agttgaccga ggtgatgagt tcacatatac tggaagcggt ggtaaaaatc
     1861 ttgctggtaa taaaagaatt ggtgcaccgt cggctgacca gacactgaca aacatgaaca
     1921 gggcattggc cctaaactgc gatgctccat tggatgataa aattggagca gagtctcgga
     1981 attggagagc tggtaagcca gtcagagtga tacgcagttt taaagggagg aagatcagca
     2041 aatatgcacc agaagaaggc aacagatatg atggcattta taaggtagtg aaatattggc
     2101 cagagatttc atccagccat ggcttcttgg tttggcgtta tcttttaaga agagatgatg
     2161 tcgaacctgc tccttggacc tcagaaggaa tcgaacgatc aaggagactg tgtctgcgat
     2221 tgcagtatcc agcaggctac ccctcagata aggaagggaa gaaaaccaag gggcagtcaa
     2281 agaagcagac gagcgaaggc accaaaaggc cagcttccga tgatgagtgt ccaagtgatt
     2341 ccaaagtgca gaagacatca gattccacag aagccgtaga ggctttccag ctcacgcctc
     2401 agcagcaacg gctgatcaag gaagactgtc agaaccagaa gctgtgggat gaagtgctgg
     2461 cgtctcttgt agaaggaccg aattttctga agaaattgga acagtctttt atgtgtgtgt
     2521 gctgccaaga actagtgtac cagcctgtca caacagaatg ctttcacaac gtctgtaagg
     2581 attgcttaca gcgctccttt aaggcccagg ttttctcctg ccctgcttgc cggcatgacc
     2641 ttgggcagaa ttacatcatg actctaaatg agaccctcca aaccgtcctt gaccttttct
     2701 tccccggcta cagcaaaggc cggtgatctg cgtgcttctg tgtcgttcct ggtggatttt
     2761 tggacaataa caagtctaaa aatgagtggg gagggttaaa gcaatgctgg accgtgtctc
     2821 tcgtcgggaa gcagcagcat ctctttccct gtgcaccctc ctgtgtgtgt agtaagaggc
     2881 ccattctcaa ctgtctttta gatagcaaaa ggtagttctt ctcagtaaca actaattttc
     2941 atgaatgaag agttgcagcc tccactgtag ttgattaccc agtttatgat ttattttgca
     3001 actacctcag gacagaaaag atttacgggg attttaaaaa tcattgactt attagttaaa
     3061 tgagatttta gctacacact gcctcccaag tattagttgt gcctgttcct tgtacttcgc
     3121 ttttccagga aagaaggcag aggggcttgt tgggacgcgt gcagctcctg taatgtgcac
     3181 actcctttcc atgtctatcc catcacagtg cgtgctttgc aagaacaggt ccatttctaa
     3241 ctcacttgtg atctccatgg tgattgtttt ctggtgtttt atgcaaattg actactaatg
     3301 actaatgaga acaatatgaa tgcattgttg ctgcgttagt gtaatgtggt gtggtcttgc
     3361 aatgacagag gtgtccgaag ctccagtagt aaccgttcct gaaaagccgc tctgtcctcc
     3421 tcctctggcc cgcagtaatt cctcctagtg gtctccatct gcagcttagg agggctgtgc
     3481 tggcttttga gcagattcaa attgcttcac attgtgatcc tacattttat attcactata
     3541 ttccttaaga gtatacctta ataaatattt tatgatcaga aaa
//
