LOCUS       NM_001393844            3694 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus ubiquitin-like with PHD and ring finger domains 1
            (Uhrf1), transcript variant 1, mRNA.
ACCESSION   NM_001393844 XM_017596402
VERSION     NM_001393844.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3694)
  AUTHORS   Lu,R. and Wang,G.G.
  TITLE     Tudor: a versatile family of histone methylation 'readers'
  JOURNAL   Trends Biochem Sci 38 (11), 546-555 (2013)
   PUBMED   24035451
  REMARK    Review article
REFERENCE   2  (bases 1 to 3694)
  AUTHORS   Guan,D., Factor,D., Liu,Y., Wang,Z. and Kao,H.Y.
  TITLE     The epigenetic regulator UHRF1 promotes ubiquitination-mediated
            degradation of the tumor-suppressor protein promyelocytic leukemia
            protein
  JOURNAL   Oncogene 32 (33), 3819-3828 (2013)
   PUBMED   22945642
  REMARK    Erratum:[Oncogene. 2015 Oct 1;34(40):5206. PMID: 26424573]
REFERENCE   3  (bases 1 to 3694)
  AUTHORS   Buck-Koehntop,B.A. and Defossez,P.A.
  TITLE     On how mammalian transcription factors recognize methylated DNA
  JOURNAL   Epigenetics 8 (2), 131-137 (2013)
   PUBMED   23324617
  REMARK    Review article
REFERENCE   4  (bases 1 to 3694)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   5  (bases 1 to 3694)
  AUTHORS   Rajakumara,E., Wang,Z., Ma,H., Hu,L., Chen,H., Lin,Y., Guo,R.,
            Wu,F., Li,H., Lan,F., Shi,Y.G., Xu,Y., Patel,D.J. and Shi,Y.
  TITLE     PHD finger recognition of unmodified histone H3R2 links UHRF1 to
            regulation of euchromatic gene expression
  JOURNAL   Mol Cell 43 (2), 275-284 (2011)
   PUBMED   21777816
REFERENCE   6  (bases 1 to 3694)
  AUTHORS   Bostick,M., Kim,J.K., Esteve,P.O., Clark,A., Pradhan,S. and
            Jacobsen,S.E.
  TITLE     UHRF1 plays a role in maintaining DNA methylation in mammalian
            cells
  JOURNAL   Science 317 (5845), 1760-1764 (2007)
   PUBMED   17673620
REFERENCE   7  (bases 1 to 3694)
  AUTHORS   Dugas,J.C., Tai,Y.C., Speed,T.P., Ngai,J. and Barres,B.A.
  TITLE     Functional genomic analysis of oligodendrocyte differentiation
  JOURNAL   J Neurosci 26 (43), 10967-10983 (2006)
   PUBMED   17065439
  REMARK    GeneRIF: UHRF1 inhibits the late phase of oligodendrocyte
            differentiation.
REFERENCE   8  (bases 1 to 3694)
  AUTHORS   Unoki,M., Nishidate,T. and Nakamura,Y.
  TITLE     ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG
            through its SRA domain
  JOURNAL   Oncogene 23 (46), 7601-7610 (2004)
   PUBMED   15361834
REFERENCE   9  (bases 1 to 3694)
  AUTHORS   Citterio,E., Papait,R., Nicassio,F., Vecchi,M., Gomiero,P.,
            Mantovani,R., Di Fiore,P.P. and Bonapace,I.M.
  TITLE     Np95 is a histone-binding protein endowed with ubiquitin ligase
            activity
  JOURNAL   Mol Cell Biol 24 (6), 2526-2535 (2004)
   PUBMED   14993289
REFERENCE   10 (bases 1 to 3694)
  AUTHORS   Hopfner,R., Mousli,M., Jeltsch,J.M., Voulgaris,A., Lutz,Y.,
            Marin,C., Bellocq,J.P., Oudet,P. and Bronner,C.
  TITLE     ICBP90, a novel human CCAAT binding protein, involved in the
            regulation of topoisomerase IIalpha expression
  JOURNAL   Cancer Res 60 (1), 121-128 (2000)
   PUBMED   10646863
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000204.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001393844.2.
            
            On Mar 18, 2021 this sequence version replaced XM_017596402.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               JACYVU010000204.1  882835-883060
            227-402             JACYVU010000204.1  884531-884706
            403-645             JACYVU010000204.1  889289-889531
            646-806             JACYVU010000204.1  890273-890433
            807-1022            JACYVU010000204.1  891409-891624
            1023-1126           JACYVU010000204.1  892139-892242
            1127-1337           JACYVU010000204.1  892316-892526
            1338-1461           JACYVU010000204.1  894414-894537
            1462-1569           JACYVU010000204.1  894617-894724
            1570-1674           JACYVU010000204.1  894999-895103
            1675-1781           JACYVU010000204.1  896064-896170
            1782-1941           JACYVU010000204.1  897262-897421
            1942-2079           JACYVU010000204.1  897504-897641
            2080-2200           JACYVU010000204.1  899130-899250
            2201-2346           JACYVU010000204.1  899368-899513
            2347-2451           JACYVU010000204.1  900758-900862
            2452-3694           JACYVU010000204.1  901086-902328
FEATURES             Location/Qualifiers
     source          1..3694
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..3694
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /note="ubiquitin-like with PHD and ring finger domains 1"
                     /db_xref="GeneID:316129"
                     /db_xref="RGD:1595855"
     exon            1..226
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
     exon            227..402
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..2598
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase UHRF1; liver regeneration-related
                     protein LRRG126; ubiquitin-like PHD and RING finger
                     domain-containing protein 1; ubiquitin-like-containing PHD
                     and RING finger domains protein 1; ubiquitin-like,
                     containing PHD and RING finger domains, 1; nuclear protein
                     95; RING-type E3 ubiquitin transferase UHRF1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UHRF1 isoform 1"
                     /protein_id="NP_001380773.1"
                     /db_xref="GeneID:316129"
                     /db_xref="RGD:1595855"
                     /translation="MWIQVRTMDGKETHTVNSLSRLTKVQELRKKIEELFHVEPQLQR
                     LFYRGKQMEDGHTLFDYDVRLNDTIQLLVRQSLALPLSTKERDSELSDSDSGYGVGHS
                     ESDKSSTHGEGTADGDDKTVWEDTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKKAL
                     SEEEPCSSSAIMAPEDDIMYHIKYDDYPEHGVDIVKAKNVRARARTVIPWEDLEVGQV
                     VMANYNVDYPRKRGFWYDVEICRKRQTRTARELYGNVMLLNDSQLNNCRIIFVDEVLK
                     IELPNERSPLIGSPSRPPPALRNTGKSGPSCQYCKDDENKPCRKCACHICGGREAPEK
                     QVLCDECDMAFHLYCLQPPLTCVPPEPEWYCPSCRTDSSEVVQAGEKLKKSKKKAKMA
                     SATSSSRRDWGKGMACVGRTTECTIVPANHFGPIPGVPVGTMWRFRVQVSESGVHRPH
                     VAGIHGRSNDGAYSLVLAGGYEDDVDNGNFFTYTGSGGRDLSGNKRTAGQSSDQKLTN
                     NNRALALNCHSPINEKGAEAEDWRQGKPVRVVRNMKGGKHSKYAPAEGNRYDGIYKVV
                     KYWPEKGKSGFIVWRYLLRRDDTEPEPWTREGKDRTRQLGLTMQYPEGYLEALANKEK
                     NRKRPAKALEQGPSSSKIGKSKRKSTGPATTSPRVSKKSKLEPYTLPLQQANLIKEDK
                     GNAKLWDDVLSSLQDGPYQIFLSKVKEAFQCICCQELVFRPVTTVCQHNVCKDCLDRS
                     FRAQVFSCPACRYDLDHSSPTRVNQPLQTILNQLFPGYGSGR"
     exon            403..645
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
     exon            646..806
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1022
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1126
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1337
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1461
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1569
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1674
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1781
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1941
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2079
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2200
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2346
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2451
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..3694
                     /gene="Uhrf1"
                     /gene_synonym="Ac2-121; Np95"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggggtggca gtctcccgca gcaggctgtg ccacttctaa aaaacgccca gagttttcgc
       61 ggggaaaaaa ctcctagcag ctggaaggaa cccgcgcttt agtgctcact tgggtcttct
      121 gccatttacg cggttggttc ccttctgggt cactcagccg cagagtccta acctagagcc
      181 aggcgctcca ggggaaagga gagtgcggat cgtcgccgcg agagagtatt ccttcagcac
      241 atcggcatca tgtggatcca ggttcgaact atggatggga aggagaccca caccgtgaac
      301 tctctatccc ggttgaccaa ggtgcaggag ctgaggaaaa agattgagga gctgtttcac
      361 gtggaacccc aattgcagag actcttttac aggggcaaac agatggagga tggtcacaca
      421 ctcttcgatt atgacgtgcg cctcaatgac acaatccagc tgctggtgcg ccagagtctg
      481 gccctacctc tcagtacgaa agaacgggac tcggagctct cagactctga ctctggctat
      541 ggtgtgggtc acagtgaatc agacaagtcg tccacgcatg gtgaagggac agctgatggg
      601 gatgacaaga ctgtgtggga ggacactgac ctaggactgt acaaggttaa tgagtacgtg
      661 gacgtgcgtg acaatatctt tggtgcatgg tttgaggccc aggtggtcca ggtacagaag
      721 aaagccctat ctgaggaaga gccctgtagc tccagtgcca ttatggcccc agaggatgac
      781 atcatgtacc acatcaagta tgatgactat ccagagcatg gagtggacat tgtcaaagcc
      841 aagaatgtcc gtgctcgcgc tcgcactgtg atcccctggg aggacctgga ggtgggtcag
      901 gtggtcatgg ccaactacaa cgtggactat cccagaaaac gtggcttctg gtatgatgtt
      961 gagatttgta ggaagcgcca aaccaggacg gcacgtgaac tgtatggcaa cgtcatgctt
     1021 ttgaatgatt ctcagctcaa caactgtcgg atcatatttg tggatgaagt cttgaagatt
     1081 gagctcccta atgagaggag ccccttgatt ggtagcccct cgagaccccc tcctgccctc
     1141 cggaatacag ggaagagcgg cccatcctgc cagtactgca aggatgacga gaacaaaccg
     1201 tgtcgcaagt gtgcctgcca tatttgtggt gggcgtgagg ctcccgagaa acaagtgttg
     1261 tgtgatgagt gtgacatggc cttccacctg tactgcctgc agccaccgct cacctgtgtc
     1321 ccccctgagc cagagtggta ctgccccagc tgccgaactg actccagtga ggtggtacaa
     1381 gcaggggaga aactgaagaa aagcaagaag aaggcaaaga tggcgtcagc cacttcctcc
     1441 tcccgacggg actggggcaa gggcatggca tgtgtgggcc gcaccacaga gtgtactatt
     1501 gtaccggcca accacttcgg gcccatccct ggtgtccccg tgggcaccat gtggcgcttc
     1561 agagtccagg tcagtgagtc cggtgtgcat cggccacatg tggcgggtat tcatggtcgg
     1621 agcaacgacg gtgcctactc actggtgctg gctggtggct atgaggatga tgtggataat
     1681 ggcaatttct tcacctacac gggcagtggt ggccgagacc tctctggcaa caagcgtaca
     1741 gcgggacagt cctctgacca gaaactcact aataacaaca gggctctggc gctcaattgc
     1801 cactccccaa tcaatgagaa aggtgcggag gctgaagact ggcgccaggg taagccggtg
     1861 cgtgtggtcc ggaacatgaa gggaggcaaa catagcaagt acgcacctgc agaggggaac
     1921 cgctatgatg gcatctacaa ggtggtcaag tactggccgg agaaggggaa atctggcttc
     1981 attgtgtggc gctatctcct tcgacgggat gacactgaac ctgagccgtg gactcgggag
     2041 ggcaaggacc gcactcggca gctgggcctc actatgcagt atcctgaagg ctacttggag
     2101 gccttggcta acaaggagaa gaacaggaag cgcccggcca aggccttgga gcagggacca
     2161 tcatcttcca agataggcaa aagcaagcgg aagtccacag gcccggccac cacaagcccc
     2221 cgtgtctcca agaagagcaa gctggagccc tacacacttc cattgcagca ggccaacctc
     2281 atcaaggagg acaagggcaa cgccaagctg tgggatgacg tgctgagctc ccttcaggat
     2341 gggccgtacc agatcttcct gagcaaggtg aaggaggctt tccagtgcat ctgttgccag
     2401 gagttggtgt tccggccagt caccaccgtg tgtcagcaca acgtttgtaa ggactgcctg
     2461 gacaggtcct tccgtgccca ggtgttcagc tgcccagcat gtcgctatga cctggaccac
     2521 agctccccaa cccgagtgaa tcagcccttg cagaccattc tcaaccagct cttccctggc
     2581 tatggcagcg gccggtgatg ccaagaccca ggcagacggc ccaagttcat agtggatgta
     2641 gcttgaaggt gttgtcctat catgtctgtc cctggcaact cttctgctgt ggttgccagt
     2701 taaccaggaa cctataggaa ccccatgttc tggctaccag ttggactaat gtttttcatt
     2761 cctctttctt ttctttttaa ataacaaagc ctgcaattta ttctcccaaa agaaggggaa
     2821 aaaaactttt ctttttttct ttttcttttt tttggggggg gggggtggag atgggcttag
     2881 aaactgttga gccccatgag gtctgcctca tcatcatgtt ggaaggagtt ctctccccat
     2941 gccagctgct caggcacctc ttcctggcag ccatctatgt acttcattca agggataacc
     3001 cctgcagcca tccctcaggc cttcatagga gacctggaca gtgccatggg ccagcctcag
     3061 ccctggcctc catctgctga cacaacagta gaggaacttg gctgtcacct cagctcaggg
     3121 gaccagctga gttgaaactg catgtgcctt gggcttgaca tttcattgtg ttcaccagtg
     3181 agccattgga cgcccgccca cctgtgaagc ctggctttca gagtgcgccg ctgggtgggt
     3241 gtcattgagg gctgagatgg gcattagttc catcttgttt ttaactcagc aactgagaat
     3301 tccaagggtg tctgtattac atttttgttt ttgtttttgt tttttttttt aattataatt
     3361 tttatttttt tttaagcggg ataaatggtt tccttcatga atttattttg tagttacagc
     3421 ctgtaccaag gaagatgttt tctttggttg gtttttgttt tcttttgtga cttgtaactt
     3481 taccaaagtg tgcaggtgta tctcgtagaa actgaacatt tactgcaggc agagaggaca
     3541 gcacagtttt atagactgtt ttgttttctg gggttttttt ttgttagatt aacattgcaa
     3601 gaagataaaa ttccatgtgg atgttttcta aagttcccta tttcttgtta agattttaga
     3661 tctcaataaa tttttttctg caggtatatt tgaa
//
