LOCUS       NM_019276               3481 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus UDP glycosyltransferase 8 (Ugt8), mRNA.
ACCESSION   NM_019276 XM_579428
VERSION     NM_019276.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3481)
  AUTHORS   Thamizhoviya,G. and Vanisree,A.J.
  TITLE     Enriched Environment Enhances the Myelin Regulatory Factor by mTOR
            Signaling and Protects the Myelin Membrane Against Oxidative Damage
            in Rats Exposed to Chronic Immobilization Stress
  JOURNAL   Neurochem Res 46 (12), 3314-3324 (2021)
   PUBMED   34449011
REFERENCE   2  (bases 1 to 3481)
  AUTHORS   Garcia-Fresco,G.P., Sousa,A.D., Pillai,A.M., Moy,S.S.,
            Crawley,J.N., Tessarollo,L., Dupree,J.L. and Bhat,M.A.
  TITLE     Disruption of axo-glial junctions causes cytoskeletal
            disorganization and degeneration of Purkinje neuron axons
  JOURNAL   Proc Natl Acad Sci U S A 103 (13), 5137-5142 (2006)
   PUBMED   16551741
REFERENCE   3  (bases 1 to 3481)
  AUTHORS   Xiao,H.S., Huang,Q.H., Zhang,F.X., Bao,L., Lu,Y.J., Guo,C.,
            Yang,L., Huang,W.J., Fu,G., Xu,S.H., Cheng,X.P., Yan,Q., Zhu,Z.D.,
            Zhang,X., Chen,Z., Han,Z.G. and Zhang,X.
  TITLE     Identification of gene expression profile of dorsal root ganglion
            in the rat peripheral axotomy model of neuropathic pain
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 8360-8365 (2002)
   PUBMED   12060780
REFERENCE   4  (bases 1 to 3481)
  AUTHORS   Dupree,J.L., Coetzee,T., Blight,A., Suzuki,K. and Popko,B.
  TITLE     Myelin galactolipids are essential for proper node of Ranvier
            formation in the CNS
  JOURNAL   J Neurosci 18 (5), 1642-1649 (1998)
   PUBMED   9464989
REFERENCE   5  (bases 1 to 3481)
  AUTHORS   Coetzee,T., Fujita,N., Dupree,J., Shi,R., Blight,A., Suzuki,K.,
            Suzuki,K. and Popko,B.
  TITLE     Myelination in the absence of galactocerebroside and sulfatide:
            normal structure with abnormal function and regional instability
  JOURNAL   Cell 86 (2), 209-219 (1996)
   PUBMED   8706126
REFERENCE   6  (bases 1 to 3481)
  AUTHORS   van der Bijl,P., Strous,G.J., Lopes-Cardozo,M., Thomas-Oates,J. and
            van Meer,G.
  TITLE     Synthesis of non-hydroxy-galactosylceramides and
            galactosyldiglycerides by hydroxy-ceramide galactosyltransferase
  JOURNAL   Biochem J 317 (Pt 2) (Pt 2), 589-597 (1996)
   PUBMED   8713090
REFERENCE   7  (bases 1 to 3481)
  AUTHORS   Stahl,N., Jurevics,H., Morell,P., Suzuki,K. and Popko,B.
  TITLE     Isolation, characterization, and expression of cDNA clones that
            encode rat UDP-galactose: ceramide galactosyltransferase
  JOURNAL   J Neurosci Res 38 (2), 234-242 (1994)
   PUBMED   7521399
REFERENCE   8  (bases 1 to 3481)
  AUTHORS   Schulte,S. and Stoffel,W.
  TITLE     Ceramide UDPgalactosyltransferase from myelinating rat brain:
            purification, cloning, and expression
  JOURNAL   Proc Natl Acad Sci U S A 90 (21), 10265-10269 (1993)
   PUBMED   7694285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U07683.1, BF551096.1 and BG671666.1.
            
            On Apr 5, 2007 this sequence version replaced NM_019276.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L21698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984033 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1729              U07683.1           1-1729
            1730-1921           BF551096.1         26-217
            1922-2648           U07683.1           1922-2648
            2649-2972           BG671666.1         33-356
            2973-3366           U07683.1           2975-3368
            3367-3370           BG671666.1         744-747
            3371-3481           U07683.1           3372-3482
FEATURES             Location/Qualifiers
     source          1..3481
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..3481
                     /gene="Ugt8"
                     /gene_synonym="CGalT; Ugt8a"
                     /note="UDP glycosyltransferase 8"
                     /db_xref="GeneID:50555"
                     /db_xref="RGD:3938"
     exon            1..68
                     /gene="Ugt8"
                     /gene_synonym="CGalT; Ugt8a"
                     /inference="alignment:Splign:2.1.0"
     exon            69..892
                     /gene="Ugt8"
                     /gene_synonym="CGalT; Ugt8a"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1696
                     /gene="Ugt8"
                     /gene_synonym="CGalT; Ugt8a"
                     /EC_number="2.4.1.47"
                     /note="UDP-glucuronosyltransferase 8;
                     UDP-galactose-ceramide galactosyltransferase 8;
                     2-hydroxyacylsphingosine 1-beta-galactosyltransferase;
                     cerebroside synthase; ceramide UDP-galactosyltransferase;
                     UDP galactosyltransferase 8; UDP galactosyltransferase 8A"
                     /codon_start=1
                     /product="2-hydroxyacylsphingosine
                     1-beta-galactosyltransferase precursor"
                     /protein_id="NP_062149.1"
                     /db_xref="GeneID:50555"
                     /db_xref="RGD:3938"
                     /translation="MKSYTPYFMLLWSAVGIARAAKIIIVPPIMFESHLYIFKTLASA
                     LHERGHHTVFLLSEGRDIDPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVE
                     LVDILDHYTKNCDMMVGNQALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFST
                     GLWYPAEVGAPAPLAYVPEFNSLLTDRMNFLERMKNTGVYLISRMGVSFLVLPKYERI
                     MQKYNLLPAKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDL
                     QRWVDGAQEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVIWRFSGTKPKNLGNN
                     TKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQA
                     KGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDY
                     ILRHDGAHHLRSAVHQISFCQYFLLDIAFVLLLGAVALYFIVSYVTKFIYRKVKSLCS
                     RSTHSTVNGHYQNGILNGRYKGNGHIKHEKKVK"
     exon            893..1035
                     /gene="Ugt8"
                     /gene_synonym="CGalT; Ugt8a"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1112
                     /gene="Ugt8"
                     /gene_synonym="CGalT; Ugt8a"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1332
                     /gene="Ugt8"
                     /gene_synonym="CGalT; Ugt8a"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..3481
                     /gene="Ugt8"
                     /gene_synonym="CGalT; Ugt8a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgctccac agacaccgtc ccgcggcaga ggcgctttcc aactcccgcg cagcagccga
       61 aggacgcgct atgaagtctt atactccata tttcatgctc ctgtggagtg ctgttggaat
      121 agcaagggct gctaaaatca tcattgtgcc gccaattatg tttgaaagcc atttgtacat
      181 tttcaagaca ctagcatcag ccttgcacga gagaggccat cacactgtgt tcctcctctc
      241 agaaggcaga gacattgacc catctaatca ctacagcctc cagcgatacc cagggatctt
      301 caacagtacc acctcagatg ctttcctgca gtctaaaatg cggaatattt tctctggaag
      361 attgacagca gttgaactgg ttgacatact ggatcactat actaagaatt gtgacatgat
      421 ggttggcaac caagccctaa tccagggttt gaaaaaagaa aagtttgacc tgctactggt
      481 tgaccccaat gatatgtgtg gatttgtgat cgctcatctt ttaggcgtta agtatgctgt
      541 gttttctact ggcctttggt atcctgctga agttggagcg cctgctcctt tagcttatgt
      601 cccagagttt aactcactcc tcacagaccg catgaacttc ctggaaagga tgaaaaatac
      661 aggcgtttac ctcatatcca gaatgggggt tagctttctg gttcttccga aatatgaaag
      721 gataatgcag aagtacaacc tgctccctgc aaagtccatg tatgatttgg ttcatgggtc
      781 cagcttgtgg atgttatgta ctgacgtagc actggagttt ccaaggccca ccctgcctaa
      841 cgttgtatat gttggaggaa tcctaacaaa gccggccagc ccactgccag aagatctgca
      901 gaggtgggta gatggtgctc aggagcatgg ctttgtcctg gtatcttttg gagctggtgt
      961 caagtatctg tcagaagaca ttgctaacaa actggcagga gctctgggga gattgcctca
     1021 gaaagtgatt tggaggtttt ctggaaccaa accaaagaac ctaggaaaca acactaagct
     1081 catagaatgg ttacctcaaa atgacctgct tggccattca aacatcagag ccttcctaag
     1141 ccatggtggt ttgaacagta tatttgaaac tatgtatcat ggtgtccctg tagtaggaat
     1201 cccactcttt ggagaccatt atgatactat gactagagta caggcgaaag gcatggggat
     1261 cttgttagaa tggaatacag ttactgaagg ggagctgtat gatgcactgg tgaaagttat
     1321 caacaatccc agttatcggc agagggctca gaagttatcg gaaattcata aggatcaacc
     1381 cggccaccct gtcaatcgga ctacctattg gatagactac attcttcgcc acgacggagc
     1441 ccatcacctc cgttcggctg tccatcagat ctccttctgt cagtattttc tactggatat
     1501 tgcctttgtg cttctgcttg gtgctgtcgc gctctacttc atagtgtcct atgtgacaaa
     1561 atttatctat agaaaagtca aaagtctgtg ttctaggagt acgcacagca cagttaatgg
     1621 acactaccaa aatggaatcc tcaatggcag atacaaagga aatggtcata ttaaacatga
     1681 aaaaaaggta aaatgagcca acagcccagg cgacgggagc agatatgtct ggtcattgag
     1741 tttgtagtgc tactctttag tctaacagct accaaaacta aatgtcagca aacaatccta
     1801 acaccctcat cagaccctgt taatgaaatc catggataaa atgtctgtac agagcacaac
     1861 cccaagtgca aaaatgtatt ttattctaac actgatgcag aaagttggca gtgaaccatt
     1921 tagaagcctt aattatttaa atcaattaag tgattgtgtc ggacctgagt tttaagtgtt
     1981 atgtatgtat tacaggtgag ggatggtgtt tttctcttga taagatgcgt gtatgtttcc
     2041 cgtgtcgttg agttttagct tccatttgta tttagcttgt aacagtattt caaagactgt
     2101 ttcctaaact cagtgtaacg aggcaagtga aagatgggtg gcacagtttt tgtatttttg
     2161 tttattatag acatttttat ttttttcttt tgtatatgct tttttcttac caactatgga
     2221 tacttgcgaa ggaaactcgt aatgaagtaa ctgagtaaaa aggttttcac atttttttct
     2281 aatattttcc tcctaccaat aatttttctc cagaagaatt ttctaattag gacaaagcaa
     2341 caaagctctt acttttgttc aaagtactga agagtacggc tcaaacagca cttggaagca
     2401 gagccatgtg caaatgcttg tgtgacttgg atatcccatc atttgagttt gaatattcag
     2461 gtatcaactt ctaaaatttt agctttaaaa taatcacctc tcattccttt tattatctgg
     2521 gtcacgatat agtacatagg tgccaacata taattcctct taagcagaac atttgcgttt
     2581 ctcctccttg gtacctggtt tgactgcagg agtttgaagt ttgtcagcaa acaagacttc
     2641 ccatgcgaac agaagtgaca gaaattgtgc cacccatttg tgcaatgagt tcccgttccc
     2701 tcctcactcc atcagcccaa ctcggtagcc tttttggtca ttgtgcttga cacgggacag
     2761 taagagtatc tatttggaac agggagacga gtcacaacgt tcataaattc aggacctccc
     2821 tgttgaacca cttactaaac ggcaactgta agcttattct acgtcactgt gtttactgag
     2881 catttgcact gcacatgcgg agtgtgtgct ttatttattt gtggttggaa atcccaccct
     2941 tgacacttga gagtagagaa atgaaatatt tacttaacgt cactcaccaa cctggcagag
     3001 ttgtgaaaaa tctagaatgc tgtaaatcct tgtcatacac tgtgacatac aactttgtga
     3061 cactcccacc aggagccagt ctcatgtact tagatatcac cagtttttta atgcacagtg
     3121 catacagcct actgctttct gaatacttga aatggtatct gtacacacca gttagctact
     3181 ccttttcaca atcttatcac aatgttgccg ttcaaagagg aaaaaagatc aggcaatgaa
     3241 tggtggggca gcagagcata gagtgtatga acgagctgag tttacttttg gcatttgata
     3301 aagttggtaa taggcactaa ctggatgatt aaacataagt taatttccac tgtgatttaa
     3361 aaaaaaactt aaaacaataa acaaagttga aaatagaaaa atgttgttgg aataaaattt
     3421 ttattcggat tttattttac agtattatat ataggtatat ttacattata aacatgtttc
     3481 t
//
