LOCUS       NM_001004271            1896 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus UDP glucuronosyltransferase 2 family, polypeptide
            B35 (Ugt2b35), mRNA.
ACCESSION   NM_001004271 NM_031980 XM_346459
VERSION     NM_001004271.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1896)
  AUTHORS   Dam,P.T.M., Jang,Y.J., Park,J.I., Choi,B.C., Song,S.J. and
            Chun,S.Y.
  TITLE     Regulation of uridine diphosphate-glucuronosyltransferase 2B15
            expression during ovulation in the rat
  JOURNAL   Endocr J 64 (6), 605-612 (2017)
   PUBMED   28442641
  REMARK    GeneRIF: Data suggest that gonadotropins transiently stimulate
            Ugt2b15 expression and activity in granulosa cells of pre-ovulatory
            follicles as they undergo ovulation; Ugt2b15 mRNA levels appear to
            be regulated by signal transduction involving progesterone
            receptors and vitamin D receptors.
REFERENCE   2  (bases 1 to 1896)
  AUTHORS   Xu,L., Krenitsky,D.M., Seacat,A.M., Butenhoff,J.L., Tephly,T.R. and
            Anders,M.W.
  TITLE     N-glucuronidation of perfluorooctanesulfonamide by human, rat, dog,
            and monkey liver microsomes and by expressed rat and human
            UDP-glucuronosyltransferases
  JOURNAL   Drug Metab Dispos 34 (8), 1406-1410 (2006)
   PUBMED   16720684
REFERENCE   3  (bases 1 to 1896)
  AUTHORS   Green,M.D., Clarke,D.J., Oturu,E.M., Styczynski,P.B., Jackson,M.R.,
            Burchell,B. and Tephly,T.R.
  TITLE     Cloning and expression of a rat liver phenobarbital-inducible
            UDP-glucuronosyltransferase (2B12) with specificity for
            monoterpenoid alcohols
  JOURNAL   Arch Biochem Biophys 322 (2), 460-468 (1995)
   PUBMED   7574722
REFERENCE   4  (bases 1 to 1896)
  AUTHORS   Styczynski,P., Green,M., Puig,J., Coffman,B. and Tephly,T.
  TITLE     Purification and properties of a rat liver phenobarbital-inducible
            4-hydroxybiphenyl UDP-glucuronosyltransferase
  JOURNAL   Mol Pharmacol 40 (1), 80-84 (1991)
   PUBMED   1906977
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078782.1.
            
            On or before Oct 20, 2005 this sequence version replaced
            NM_031980.1, XM_346459.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078782.1, U06273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1896
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..1896
                     /gene="Ugt2b35"
                     /gene_synonym="Ugt2b12; Ugt2b15; Ugt2b36; Ugt2b4"
                     /note="UDP glucuronosyltransferase 2 family, polypeptide
                     B35"
                     /db_xref="GeneID:83808"
                     /db_xref="RGD:620895"
     exon            1..745
                     /gene="Ugt2b35"
                     /gene_synonym="Ugt2b12; Ugt2b15; Ugt2b36; Ugt2b4"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1614
                     /gene="Ugt2b35"
                     /gene_synonym="Ugt2b12; Ugt2b15; Ugt2b36; Ugt2b4"
                     /EC_number="2.4.1.17"
                     /note="UDP-glucuronosyltransferase 2B4;
                     UDP-glucuronosyltransferase 2B15; UDPGT 2B4;
                     UDP-glucuronosyltransferase 2B12; UDPGT 2B12; UDPGT 2B15;
                     UDPGT 2B36; UDP glucuronosyltransferase 2 family,
                     polypeptide B36; UDP-glucuronosyltransferase 2B36; UDP
                     glycosyltransferase 2 family, polypeptide B4; UDP
                     glucuronosyltransferase 2 family, polypeptide B15"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 2B15 precursor"
                     /protein_id="NP_001004271.1"
                     /db_xref="GeneID:83808"
                     /db_xref="RGD:620895"
                     /translation="MPGKWISALLLLQISFCFKSGNCGKVLVWPMEYSHWMNIKIILE
                     ELVQKGHEVTVLRPSASVFLDPKETSDLKFVTFPTSFSSHDLENFFTRFVNVWTYELP
                     RDTCLSYFLYLQDTIDEYSDYCLTVCKEAVSNKQFMTKLQESKFDVVFSDAIGPCGEL
                     IAELLQIPFLYSLRFSPGYTIEKYIGGVLFPPSYVPMIFSGLAGQMTFIERVHNMICM
                     LYFDFWFQTFREKKWDPFYSKTLGRPTTLAEIMGKAEMWLIRSYWDLEFPHPISPNVD
                     YIGGLHCKPAKPLPKDIEDFVQSSGEHGVVVFSLGSMVRNMTEEKANIIAWALAQIPQ
                     KVLWRFDGKKPPTLGPNTRLYKWLPQNDLLGHPKTKAFVTHGGANGIYEAIHHGIPMI
                     GIPLFGEQHDNIAHMVAKGAAVEVNFRTMSKSDMLNALEEVINNPFYKKNAMWLSTIH
                     HDQPTKPLDRAVFWIEFVMRHKGAKHLRSLGHNLPWYQYHSLDVIGFLLTCVAVTVVL
                     ALKCFLFVYRFFVKKEKKTKNE"
     exon            746..894
                     /gene="Ugt2b35"
                     /gene_synonym="Ugt2b12; Ugt2b15; Ugt2b36; Ugt2b4"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1026
                     /gene="Ugt2b35"
                     /gene_synonym="Ugt2b12; Ugt2b15; Ugt2b36; Ugt2b4"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1114
                     /gene="Ugt2b35"
                     /gene_synonym="Ugt2b12; Ugt2b15; Ugt2b36; Ugt2b4"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1334
                     /gene="Ugt2b35"
                     /gene_synonym="Ugt2b12; Ugt2b15; Ugt2b36; Ugt2b4"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1869
                     /gene="Ugt2b35"
                     /gene_synonym="Ugt2b12; Ugt2b15; Ugt2b36; Ugt2b4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaaggactt tgattttcag gatgcctggg aagtggattt ctgctctgct cctgctgcaa
       61 ataagtttct gctttaaatc tgggaactgc ggaaaggtgt tggtatggcc gatggaatat
      121 agtcactgga tgaatataaa gataatacta gaggaacttg tacagaaggg ccatgaagtc
      181 actgttctga gaccttcagc ttctgtcttt cttgatccca aggaaacttc tgaccttaaa
      241 tttgtaactt ttcctacatc tttcagtagt catgacctgg aaaatttttt tacaaggttt
      301 gtgaatgtat ggacttatga gttgccaaga gacacatgtt tgtcatattt tctttatcta
      361 caagatacga ttgatgaata ttctgactac tgtctgactg tttgtaaaga agcagtttca
      421 aacaaacagt tcatgacaaa actacaggaa tccaaatttg atgtcgtttt ctcagatgcc
      481 attggtccct gtggagagct gatagctgaa ctgctccaga ttccttttct gtacagtctt
      541 cgcttctctc ctggctacac aattgaaaag tacattggag gagttctatt ccctccctct
      601 tatgtaccta tgattttttc aggattagct ggccaaatga cattcataga gagggtacac
      661 aatatgatat gtatgcttta ttttgacttt tggttccaaa catttagaga gaagaaatgg
      721 gatccatttt acagcaaaac tttaggaagg cccaccacat tagctgagat aatgggcaaa
      781 gcagaaatgt ggctcattag atcctactgg gatttggagt ttccccaccc aatatcgcca
      841 aatgttgact acattggagg actccactgc aaacctgcta aacccttgcc caaggatatt
      901 gaagacttcg tccagagctc tggagagcat ggtgtggtgg tgttttctct ggggtcaatg
      961 gtcaggaaca tgacagaaga aaaggccaac atcattgcat gggcccttgc ccagattcca
     1021 caaaaggttc tttggagatt tgacggcaaa aaaccaccca ccttaggacc caataccaga
     1081 ctctacaagt ggcttcccca aaatgatctt cttggtcatc caaaaaccaa agcctttgta
     1141 acgcatggtg gagccaatgg catctatgag gcgatccatc atggaatccc tatgattggc
     1201 attcccctat ttggagagca acatgataac attgcccaca tggtggccaa aggagcagct
     1261 gtggaagtaa atttcaggac aatgtcaaag tcagatatgc tcaatgcact ggaggaagtc
     1321 ataaacaatc ctttttataa aaagaatgct atgtggttgt caaccattca ccatgaccag
     1381 cctacgaagc cactggacag agctgtcttc tggattgagt ttgtcatgcg ccacaaaggg
     1441 gccaagcacc tgagatcact tggacataac cttccctggt accagtacca ctctctggat
     1501 gtgattggat tcctgctcac ctgtgtggca gtcactgtag tccttgctct aaagtgcttt
     1561 ttatttgttt atcgattctt tgtaaagaag gaaaagaaaa caaagaatga gtagagctca
     1621 atgataatgc atcacatgaa tgaaatttgt tcatcatttt aagttatgaa ccaccttcta
     1681 aaaactcatt aataacttta cagaagcata gcttctttgt aattttgtac catgtaaaaa
     1741 gacatataat tctgaggctt ctgatatgtg accaaagaat cccatcattt attttaattt
     1801 tcaaactatt caatgtaaaa caatttgcct gtgtagaaaa atatataaat aaagatttaa
     1861 ttgaaagaga aaaaaaaaaa aaaaaaaaaa aaaaaa
//
