LOCUS       NM_153314               1818 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus UDP glucuronosyltransferase family 2 member B15
            (Ugt2b15), mRNA.
ACCESSION   NM_153314
VERSION     NM_153314.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1818)
  AUTHORS   Alkharfy,K.M., Poloyac,S.M., Congiu,M., Desmond,P.V. and Frye,R.F.
  TITLE     Effect of the acute phase response induced by endotoxin
            administration on the expression and activity of UGT isoforms in
            rats
  JOURNAL   Drug Metab Lett 2 (4), 248-255 (2008)
   PUBMED   19356101
REFERENCE   2  (bases 1 to 1818)
  AUTHORS   Li,Y., Wang,K., Yu,T., Zhao,B., Li,J., Zhang,S. and Zhao,X.
  TITLE     [The expression of uridine diphosphate glucuronosyltransferase mRNA
            regulated by alcohol]
  JOURNAL   Zhonghua Gan Zang Bing Za Zhi 9 (3), 172-174 (2001)
   PUBMED   11412396
REFERENCE   3  (bases 1 to 1818)
  AUTHORS   Li,Y.Q., Prentice,D.A., Howard,M.L., Mashford,M.L. and Desmond,P.V.
  TITLE     The effect of hormones on the expression of five isoforms of
            UDP-glucuronosyltransferase in primary cultures of rat hepatocytes
  JOURNAL   Pharm Res 16 (2), 191-197 (1999)
   PUBMED   10100302
REFERENCE   4  (bases 1 to 1818)
  AUTHORS   Mackenzie,P.I.
  TITLE     Rat liver UDP-glucuronosyltransferase. Identification of cDNAs
            encoding two enzymes which glucuronidate testosterone,
            dihydrotestosterone, and beta-estradiol
  JOURNAL   J Biol Chem 262 (20), 9744-9749 (1987)
   PUBMED   3110162
REFERENCE   5  (bases 1 to 1818)
  AUTHORS   Harding,D., Wilson,S.M., Jackson,M.R., Burchell,B., Green,M.D. and
            Tephly,T.R.
  TITLE     Nucleotide and deduced amino acid sequence of rat liver 17
            beta-hydroxysteroid UDP-glucuronosyltransferase
  JOURNAL   Nucleic Acids Res 15 (9), 3936 (1987)
   PUBMED   3108864
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 27, 2020 this sequence version replaced NM_153314.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M31109.1, Y00156.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-754               JAXUCZ010000014.1  21122866-21123619
            755-903             JAXUCZ010000014.1  21125093-21125241
            904-1035            JAXUCZ010000014.1  21126645-21126776
            1036-1123           JAXUCZ010000014.1  21134214-21134301
            1124-1343           JAXUCZ010000014.1  21136700-21136919
            1344-1818           JAXUCZ010000014.1  21137976-21138450
FEATURES             Location/Qualifiers
     source          1..1818
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..1818
                     /gene="Ugt2b15"
                     /gene_synonym="Rlug38; Udpgt; UDPGT 2B5; Udpgtr-3;
                     Ugt2b17; Ugt2b3; Ugt2b5"
                     /note="UDP glucuronosyltransferase family 2 member B15"
                     /db_xref="GeneID:266685"
                     /db_xref="RGD:628623"
     exon            1..754
                     /gene="Ugt2b15"
                     /gene_synonym="Rlug38; Udpgt; UDPGT 2B5; Udpgtr-3;
                     Ugt2b17; Ugt2b3; Ugt2b5"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1623
                     /gene="Ugt2b15"
                     /gene_synonym="Rlug38; Udpgt; UDPGT 2B5; Udpgtr-3;
                     Ugt2b17; Ugt2b3; Ugt2b5"
                     /EC_number="2.4.1.17"
                     /note="UDP-glucuronosyltransferase 2B17; UDPGT 2B3;
                     17-beta-hydroxysteroid specific; testosterone,
                     dihydrotestosterone, and beta-estradiol specific;
                     17-beta-hydroxysteroid-specific UDPGT; testosterone,
                     dihydrotestosterone, and beta-estradiol-specific UDPGT;
                     UDPGT 2B17; UDP-glucuronosyltransferase 2B5; liver 17
                     beta-hydroxysteroid UDP-glucuronosyltransferase; UDP
                     glucuronosyltransferase 2 family, polypeptide B5; UDP
                     glucuronosyltransferase 2 family, polypeptide B17;
                     UDP-glucuronosyltransferase 2B3 precursor, microsomal; UDP
                     glycosyltransferase 2 family, member 3; UDP
                     glucuronosyltransferase 2 family, polypeptide B15;
                     UDP-glucuronosyltransferase 2A3-like;
                     UDP-glucuronosyltransferase 2B17-like"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 2B17 precursor"
                     /protein_id="NP_695226.3"
                     /db_xref="GeneID:266685"
                     /db_xref="RGD:628623"
                     /translation="MPGKWISALLLLQISCCFQSGNCGKVLVWPMEFSHWMNIKTILD
                     ELVQRGHEVTVLKPSAYYVLDPKKSPDLKFETFPTSVSKDELENYFIKLVDVWTYELQ
                     RDTCLSYSPLLQNMIDGFSDYYLSLCKDTVSNKQLMAKLQESKFDVLLSDPVAACGEL
                     IAEVLHIPFLYSLRFSPGYKIEKSSGRFILPPSYVPVILSGMGGPMTFIDRVKNMICT
                     LYFDFWFHMFNAKKWDPFYSEILGRPTTLAETMGKAEMWLIRSYWDLEFPHPTLPNVD
                     YIGGLQCRPPKPLPKDMEDFVQSSGEHGVVVFSLGSMVSSMTEEKANAIAWALAQIPQ
                     KVLWKFDGKTPATLGPNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMV
                     GIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEIINNPFYKKNAVWLSTIH
                     HDQPMKPLDKAVFWIEFVMRHKGAKHLRPLGHNLPWYQYHSLDVIGFLLTCSAVIAVL
                     TVKSFLFIYRLFVKKEKKMKNE"
     exon            755..903
                     /gene="Ugt2b15"
                     /gene_synonym="Rlug38; Udpgt; UDPGT 2B5; Udpgtr-3;
                     Ugt2b17; Ugt2b3; Ugt2b5"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1035
                     /gene="Ugt2b15"
                     /gene_synonym="Rlug38; Udpgt; UDPGT 2B5; Udpgtr-3;
                     Ugt2b17; Ugt2b3; Ugt2b5"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1123
                     /gene="Ugt2b15"
                     /gene_synonym="Rlug38; Udpgt; UDPGT 2B5; Udpgtr-3;
                     Ugt2b17; Ugt2b3; Ugt2b5"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1343
                     /gene="Ugt2b15"
                     /gene_synonym="Rlug38; Udpgt; UDPGT 2B5; Udpgtr-3;
                     Ugt2b17; Ugt2b3; Ugt2b5"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1818
                     /gene="Ugt2b15"
                     /gene_synonym="Rlug38; Udpgt; UDPGT 2B5; Udpgtr-3;
                     Ugt2b17; Ugt2b3; Ugt2b5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtgaaca gaaggatttt gatttttaag atgcctggga agtggatttc tgctcttctc
       61 ctgctacaga taagttgctg tttccaatct gggaactgtg ggaaggtgtt ggtgtggccg
      121 atggaattca gccactggat gaatataaaa acaatactgg atgaacttgt acagaggggc
      181 catgaagtca ctgttctgaa accttcggct tactatgttc ttgatccgaa aaaatcgcca
      241 gatcttaagt ttgaaacttt ccctacatct gtcagtaaag atgaactgga aaattatttc
      301 ataaagcttg tggatgtgtg gacttatgag ttgcaaagag atacatgttt gtcttattct
      361 cctttactac aaaatatgat agatggattt tctgattact atctaagtct ttgtaaagac
      421 accgtttcaa acaagcagct catggcaaaa ctacaggaat ccaagtttga tgttcttttg
      481 tcagatcctg tggctgcctg tggggagctg atagccgaag tgctccacat tccttttctg
      541 tacagtcttc gcttctctcc aggctacaaa attgaaaagt ccagtggaag atttatatta
      601 cctccatctt atgtaccagt aattttgtca ggaatgggtg gcccaatgac attcatagac
      661 agggtaaaaa atatgatatg tacgctttat tttgactttt ggttccatat gtttaatgcc
      721 aagaaatggg atccatttta cagtgagatt ttgggaaggc ccaccacctt agctgagaca
      781 atgggcaaag cagaaatgtg gctcattaga tcctactggg atttggaatt tccccaccca
      841 acattaccaa atgttgacta tattggagga ctccaatgca gacctcctaa acccttgccc
      901 aaggatatgg aagattttgt ccagagctct ggagagcatg gcgtggtggt gttttctctg
      961 gggtcaatgg tcagcagcat gacagaagaa aaggccaatg caattgcatg ggcccttgcc
     1021 cagattccac aaaaggttct ttggaaattt gatggcaaaa ccccagcaac cttaggaccc
     1081 aataccagag tctacaagtg gcttccccag aatgacctcc ttggtcatcc aaaaaccaaa
     1141 gcctttgtaa ctcatggtgg agccaatggt gtctatgagg ccatctatca tggaatccct
     1201 atggttggca ttcctatgtt tggagaacaa catgataaca ttgcccacat ggtggccaaa
     1261 ggagcagctg ttacactgaa tatcaggaca atgtcaaagt cagatttgtt caatgcacta
     1321 aaggaaataa taaacaatcc attctataaa aaaaatgctg tgtggttgtc aaccattcac
     1381 catgaccaac ctatgaagcc cctggacaag gctgtcttct ggattgagtt tgtcatgcgc
     1441 cacaaagggg ccaagcacct gagaccactt ggacataacc ttccctggta ccagtaccac
     1501 tctctggatg tgattggatt cctgctcacc tgttcggcag tcattgcagt ccttactgta
     1561 aaatccttct tgtttattta ccgactcttt gtgaagaagg aaaagaaaat gaagaatgag
     1621 tagagctcat tgacaatgca ctacaggaat gaaatttcag cctcattcta atttatgaat
     1681 caccttctta acacttcctg attatttttt tgtcaaggca gatcatcttt gtaagaagac
     1741 atataactcc ataaatactg atatgttatc aaaaattcca tcattcataa attttaatag
     1801 cacttaatat aaaaatat
//
