LOCUS       NM_173295               1959 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus UDP glucuronosyltransferase 2 family, polypeptide
            B1 (Ugt2b1), mRNA.
ACCESSION   NM_173295
VERSION     NM_173295.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1959)
  AUTHORS   Mroz,A., Ryska,I., Sominko,H., Bejrowska,A. and Mazerska,Z.
  TITLE     Drug-drug interaction potential of antitumor acridine agent C-1748:
            The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the
            inhibitor of 1A9 and 2B7
  JOURNAL   Pharmacol Rep 70 (5), 972-980 (2018)
   PUBMED   30107347
REFERENCE   2  (bases 1 to 1959)
  AUTHORS   Gagez,A.L., Rouguieg-Malki,K., Sauvage,F.L., Marquet,P. and
            Picard,N.
  TITLE     Simultaneous evaluation of six human glucuronidation activities in
            liver microsomes using liquid chromatography-tandem mass
            spectrometry
  JOURNAL   Anal Biochem 427 (1), 52-59 (2012)
   PUBMED   22579593
REFERENCE   3  (bases 1 to 1959)
  AUTHORS   Rowbotham,S.E., Illingworth,N.A., Daly,A.K., Veal,G.J. and
            Boddy,A.V.
  TITLE     Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic
            acid metabolism in humans
  JOURNAL   Drug Metab Dispos 38 (7), 1211-1217 (2010)
   PUBMED   20308471
REFERENCE   4  (bases 1 to 1959)
  AUTHORS   Hasegawa,Y., Kishimoto,S., Shibatani,N., Nomura,H., Ishii,Y.,
            Onishi,M., Inotsume,N., Takeuchi,Y. and Fukushima,S.
  TITLE     The pharmacokinetics of morphine and its glucuronide conjugate in a
            rat model of streptozotocin-induced diabetes and the expression of
            MRP2, MRP3 and UGT2B1 in the liver
  JOURNAL   J Pharm Pharmacol 62 (3), 310-314 (2010)
   PUBMED   20487213
REFERENCE   5  (bases 1 to 1959)
  AUTHORS   Alkharfy,K.M., Poloyac,S.M., Congiu,M., Desmond,P.V. and Frye,R.F.
  TITLE     Effect of the acute phase response induced by endotoxin
            administration on the expression and activity of UGT isoforms in
            rats
  JOURNAL   Drug Metab Lett 2 (4), 248-255 (2008)
   PUBMED   19356101
REFERENCE   6  (bases 1 to 1959)
  AUTHORS   Li,Y., Wang,K., Yu,T., Zhao,B., Li,J., Zhang,S. and Zhao,X.
  TITLE     [The expression of uridine diphosphate glucuronosyltransferase mRNA
            regulated by alcohol]
  JOURNAL   Zhonghua Gan Zang Bing Za Zhi 9 (3), 172-174 (2001)
   PUBMED   11412396
REFERENCE   7  (bases 1 to 1959)
  AUTHORS   Ren,Q., Murphy,S.E., Dannenberg,A.J., Park,J.Y., Tephly,T.R. and
            Lazarus,P.
  TITLE     Glucuronidation of the lung carcinogen
            4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by rat
            UDP-glucuronosyltransferase 2B1
  JOURNAL   Drug Metab Dispos 27 (9), 1010-1016 (1999)
   PUBMED   10460800
REFERENCE   8  (bases 1 to 1959)
  AUTHORS   Li,Y.Q., Prentice,D.A., Howard,M.L., Mashford,M.L. and Desmond,P.V.
  TITLE     The effect of hormones on the expression of five isoforms of
            UDP-glucuronosyltransferase in primary cultures of rat hepatocytes
  JOURNAL   Pharm Res 16 (2), 191-197 (1999)
   PUBMED   10100302
REFERENCE   9  (bases 1 to 1959)
  AUTHORS   Mackenzie,P.I. and Rodbourn,L.
  TITLE     Organization of the rat UDP-glucuronosyltransferase, UDPGTr-2, gene
            and characterization of its promoter
  JOURNAL   J Biol Chem 265 (19), 11328-11332 (1990)
   PUBMED   2113533
REFERENCE   10 (bases 1 to 1959)
  AUTHORS   Mackenzie,P.I.
  TITLE     Rat liver UDP-glucuronosyltransferase. Sequence and expression of a
            cDNA encoding a phenobarbital-inducible form
  JOURNAL   J Biol Chem 261 (13), 6119-6125 (1986)
   PUBMED   3084479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 27, 2020 this sequence version replaced NM_173295.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M13506.1, SRR26643286.38458.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-746               JAXUCZ010000014.1  21378882-21379627
            747-895             JAXUCZ010000014.1  21380735-21380883
            896-1027            JAXUCZ010000014.1  21386895-21387026
            1028-1115           JAXUCZ010000014.1  21388121-21388208
            1116-1335           JAXUCZ010000014.1  21388343-21388562
            1336-1959           JAXUCZ010000014.1  21390008-21390631
FEATURES             Location/Qualifiers
     source          1..1959
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..1959
                     /gene="Ugt2b1"
                     /gene_synonym="2B1; Udpgtr2; Ugt2b17"
                     /note="UDP glucuronosyltransferase 2 family, polypeptide
                     B1"
                     /db_xref="GeneID:286954"
                     /db_xref="RGD:708541"
     exon            1..746
                     /gene="Ugt2b1"
                     /gene_synonym="2B1; Udpgtr2; Ugt2b17"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1612
                     /gene="Ugt2b1"
                     /gene_synonym="2B1; Udpgtr2; Ugt2b17"
                     /EC_number="2.4.1.17"
                     /note="UDP-glucuronosyltransferase 2B1; UDPGTr-2; UDPGT
                     2B1; UDP glucuronosyltransferase 2 family, polypeptide
                     B17; UDP-glucuronosyltransferase 2B4; liver
                     UDP-glucuronosyltransferase, phenobarbital-inducible form;
                     UDP glucuronosyltransferase family 2 member B17"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 2B1 precursor"
                     /protein_id="NP_775417.1"
                     /db_xref="GeneID:286954"
                     /db_xref="RGD:708541"
                     /translation="MSMKQTSVFLLIQLICYFRPGACGKVLVWPTEYSHWINIKIILN
                     ELAQRGHEVTVLVSSASILIEPTKESSINFEIYSVPLSKSDLEYSFAKWIDEWTRDFE
                     TLSIWTYYSKMQKVFNEYSDVVENLCKALIWNKSLMKKLQGSQFDVILADAVGPCGEL
                     LAELLKTPLVYSLRFCPGYRCEKFSGGLPLPPSYVPVVLSELSDRMTFVERVKNMLQM
                     LYFDFWFQPFKEKSWSQFYSDVLGRPTTLTEMMGKADIWLIRTFWDLEFPHPFLPNFD
                     FVGGLHCKPAKPLPREMEEFVQSSGEHGVVVFSLGSMVKNLTEEKANVVASALAQIPQ
                     KVVWRFDGKKPDTLGSNTRLYKWIPQNDLLGHPKTKAFVAHGGTNGIYEAIYHGIPIV
                     GIPLFADQPDNINHMVAKGAAVRVDFSILSTTGLLTALKIVMNDPSYKENAMRLSRIH
                     HDQPVKPLDRAVFWIEYVMRHKGAKHLRSTLHDLSWFQYHSLDVIGFLLLCVVGVVFI
                     ITKFCLFCCRKTANMGKKKKE"
     exon            747..895
                     /gene="Ugt2b1"
                     /gene_synonym="2B1; Udpgtr2; Ugt2b17"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1027
                     /gene="Ugt2b1"
                     /gene_synonym="2B1; Udpgtr2; Ugt2b17"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1115
                     /gene="Ugt2b1"
                     /gene_synonym="2B1; Udpgtr2; Ugt2b17"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1335
                     /gene="Ugt2b1"
                     /gene_synonym="2B1; Udpgtr2; Ugt2b17"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1959
                     /gene="Ugt2b1"
                     /gene_synonym="2B1; Udpgtr2; Ugt2b17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaagcattc catttctgca agatgtctat gaaacagact tcagtgtttc tgttgataca
       61 gctcatatgc tactttagac ctggagcctg tggaaaagtg ctagtgtggc ccacagaata
      121 cagccactgg attaatataa agataattct gaatgaactt gcccagagag gtcatgaagt
      181 cacggttctt gtatcttcgg cttccattct cattgagcct accaaggaat cttctattaa
      241 ttttgagatt tactctgtac ctttgagtaa aagtgatctt gaatatagtt ttgcaaaatg
      301 gatagatgaa tggacacgtg attttgaaac actctcgatt tggacatatt attcaaaaat
      361 gcaaaaagtc ttcaatgaat attctgatgt cgttgaaaat ttatgcaaag cactcatttg
      421 gaacaagagt cttatgaaaa aactccaagg atctcaattt gatgtcattc tcgcagatgc
      481 tgtgggtccc tgtggtgagc tgctagcaga actgcttaag acacctttag tgtacagtct
      541 ccgcttctgt cctggataca gatgtgaaaa gttcagtggg ggacttccac tgcctccttc
      601 ctatgtgcct gttgttcttt cagaattaag tgaccgcatg acatttgtgg aaagagtgaa
      661 gaatatgttg cagatgctgt attttgactt ttggtttcaa ccatttaaag agaagtcctg
      721 gagtcagttt tacagtgatg ttctaggtag acccacaaca ttaactgaga tgatggggaa
      781 ggcagatata tggctcattc gaaccttctg ggacttggaa tttccacacc cattcttacc
      841 taattttgac tttgttggag gactccattg caaaccagcc aaaccactgc ctagggaaat
      901 ggaagaattt gttcagagct ctggagaaca tggtgtagtg gtgttttctc tgggatcaat
      961 ggttaaaaac ctgactgaag aaaaagccaa tgtagttgct tctgctcttg cccaaattcc
     1021 acagaaggtt gtatggagat ttgatggtaa gaaaccagat accttaggat ctaacactcg
     1081 gctgtacaag tggatccccc agaatgacct tcttggtcat ccaaaaacca aagcttttgt
     1141 agctcatggt ggaacaaatg gcatctatga ggcaatctac catggcattc ctattgttgg
     1201 tattcccttg tttgcagatc aaccggataa cattaatcac atggtagcca aaggagctgc
     1261 tgttagagtt gacttcagca tactgtcaac tacaggcctt ctcactgcct tgaagattgt
     1321 catgaatgac ccttcctata aggagaatgc catgagatta tccagaatcc accatgatca
     1381 gccagtgaag cccctggacc gagccgtctt ctggatcgag tatgtcatgc gtcacaaagg
     1441 agccaagcac ctccgctcaa ctctgcatga ccttagctgg ttccagtacc actctctgga
     1501 tgtcattggg ttcctattgc tctgtgtggt aggtgtggta ttcatcatca caaaattctg
     1561 cctcttttgt tgccgtaaga ctgctaacat gggaaagaag aagaaagagt agcatcataa
     1621 aggctgaagc agagccctga gagatgagcc tctgccagct gcttccagca ggaacctgtt
     1681 gtcatgccag tgccttccct ctaaaagaag acagcgttgg gacctcattg aacatggctc
     1741 caatgaattc actatgttct gaagacatgc aagatttcat gccaaatata tattcagtgc
     1801 taaaaaaaca aaatcctgtg ttcagtttag aatgttttga tgtagctgag aagctttgcc
     1861 caacaacaat aactgaagct actgtagttc ataaagttca catggcttta tagcctttgc
     1921 aaaacatatc tataaatcaa ttactttttg aaaataccc
//
