LOCUS       NM_031533               1975 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus UDP glycosyltransferase 2 family, polypeptide B
            (Ugt2b), mRNA.
ACCESSION   NM_031533 XM_001061549
VERSION     NM_031533.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1975)
  AUTHORS   Wen,H., Yang,H.J., An,Y.J., Kim,J.M., Lee,D.H., Jin,X., Park,S.W.,
            Min,K.J. and Park,S.
  TITLE     Enhanced phase II detoxification contributes to beneficial effects
            of dietary restriction as revealed by multi-platform metabolomics
            studies
  JOURNAL   Mol Cell Proteomics 12 (3), 575-586 (2013)
   PUBMED   23230277
  REMARK    GeneRIF: Data indicate that the up-regulation of phase II
            detoxification in the DR group was confirmed by mRNA and protein
            expression levels of uridinediphospho-glucuronosyltransferase and
            glycine-N-acyltransferase in actual liver tissues.
REFERENCE   2  (bases 1 to 1975)
  AUTHORS   Dumas,M.E., Wilder,S.P., Bihoreau,M.T., Barton,R.H.,
            Fearnside,J.F., Argoud,K., D'Amato,L., Wallis,R.H., Blancher,C.,
            Keun,H.C., Baunsgaard,D., Scott,J., Sidelmann,U.G., Nicholson,J.K.
            and Gauguier,D.
  TITLE     Direct quantitative trait locus mapping of mammalian metabolic
            phenotypes in diabetic and normoglycemic rat models
  JOURNAL   Nat Genet 39 (5), 666-672 (2007)
   PUBMED   17435758
REFERENCE   3  (bases 1 to 1975)
  AUTHORS   Yamashita,A., Watanabe,M., Tonegawa,T., Sugiura,T. and Waku,K.
  TITLE     Acyl-CoA binding and acylation of UDP-glucuronosyltransferase
            isoforms of rat liver: their effect on enzyme activity
  JOURNAL   Biochem J 312 (Pt 1) (Pt 1), 301-308 (1995)
   PUBMED   7492328
REFERENCE   4  (bases 1 to 1975)
  AUTHORS   Haque,S.J., Petersen,D.D., Nebert,D.W. and Mackenzie,P.I.
  TITLE     Isolation, sequence, and developmental expression of rat UGT2B2:
            the gene encoding a constitutive UDP glucuronosyltransferase that
            metabolizes etiocholanolone and androsterone
  JOURNAL   DNA Cell Biol 10 (7), 515-524 (1991)
   PUBMED   1909872
REFERENCE   5  (bases 1 to 1975)
  AUTHORS   Mackenzie,P.I.
  TITLE     Rat liver UDP-glucuronosyltransferase. cDNA sequence and expression
            of a form glucuronidating 3-hydroxyandrogens
  JOURNAL   J Biol Chem 261 (30), 14112-14117 (1986)
   PUBMED   2429951
REFERENCE   6  (bases 1 to 1975)
  AUTHORS   Jackson,M.R. and Burchell,B.
  TITLE     The full length coding sequence of rat liver androsterone
            UDP-glucuronyltransferase cDNA and comparison with other members of
            this gene family
  JOURNAL   Nucleic Acids Res 14 (2), 779-795 (1986)
   PUBMED   3003696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Feb 11, 2021 this sequence version replaced NM_031533.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089792.1, X03478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-758               JAXUCZ010000014.1  20985449-20986206
            759-907             JAXUCZ010000014.1  20989665-20989813
            908-1039            JAXUCZ010000014.1  20990844-20990975
            1040-1127           JAXUCZ010000014.1  21001691-21001778
            1128-1347           JAXUCZ010000014.1  21004370-21004589
            1348-1975           JAXUCZ010000014.1  21005640-21006267
FEATURES             Location/Qualifiers
     source          1..1975
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..1975
                     /gene="Ugt2b"
                     /gene_synonym="Ugt2b2"
                     /note="UDP glycosyltransferase 2 family, polypeptide B"
                     /db_xref="GeneID:24862"
                     /db_xref="RGD:3936"
     exon            1..758
                     /gene="Ugt2b"
                     /gene_synonym="Ugt2b2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1627
                     /gene="Ugt2b"
                     /gene_synonym="Ugt2b2"
                     /EC_number="2.4.1.17"
                     /note="UDP-glucuronosyltransferase 2B2; UDP
                     glucuronosyltransferase; RLUG23; UDPGTr-4; UDPGT 2B2;
                     3-hydroxyandrogen specific; 3-hydroxyandrogen-specific
                     UDPGT; Androsterone UDP-glucuronosyltransferase"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 2B2 precursor"
                     /protein_id="NP_113721.5"
                     /db_xref="GeneID:24862"
                     /db_xref="RGD:3936"
                     /translation="MPRKWISALFLLQISYCFKSGHCGKVLVWPMDFSHWMNIKIILD
                     ELVQRGHEVTVLKPSAYFFLDPKKSSDLKFEIFSTSISKDELQNHFIKLLDVWTYELP
                     RDTCLSYSPILQNLVYEFSYFYLSICKDAVSNKQLMTKLQESKFDVLFADPVASCGDL
                     IAELLHIPFLYSLSFSPGHKLEKSIGKFILPPSYVPVILSGLAGKMTFIDRVKNMICM
                     LYFDFWFEILRHKEWDTFYSEILGRPTTVDETMSKVEIWLIRSYWDLKFPHPTLPNVD
                     YIGGLHCKPAKPLPKDMEEFVQSSGEHGVVVFSLGSMVSNMTEEKANAIAWALAQIPQ
                     KVLWKFDGKTPATLGPNTRVYKWLPQNDILGHPKTKAFVTHGGANGLYEAIYHGIPMI
                     GIPLFGDQPDNIAHMVAKGAAVSLNIRTMSKLDFLSALEEVIDNPFYKKNVMLLSTIH
                     HDQPMKPLDRAVFWIEFIMRHKGAKHLRPLGHNLPWYQYHSLDVIGFLLTCFAVIAAL
                     TVKCLLFMYRFFVKKEKKMKNE"
     exon            759..907
                     /gene="Ugt2b"
                     /gene_synonym="Ugt2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1039
                     /gene="Ugt2b"
                     /gene_synonym="Ugt2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1127
                     /gene="Ugt2b"
                     /gene_synonym="Ugt2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1347
                     /gene="Ugt2b"
                     /gene_synonym="Ugt2b2"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1975
                     /gene="Ugt2b"
                     /gene_synonym="Ugt2b2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacactgtg accagaagga ctttgatgtt caaaatgccc agaaagtgga tttctgctct
       61 gttcctgcta cagataagtt actgtttcaa atctgggcac tgtgggaagg tgttggtgtg
      121 gccgatggac tttagtcact ggatgaatat aaaaataatc cttgatgaac ttgtacagag
      181 gggccatgag gtcactgttc tgaaaccttc ggcttacttt tttcttgatc cgaaaaaatc
      241 gtctgacctt aagtttgaaa ttttttctac atctatcagt aaagatgagc tgcaaaatca
      301 tttcataaaa cttttggatg tgtggactta tgagttgcca agagatacat gtttgtcata
      361 ttctcctatc cttcaaaatc tagtttatga attttcttat ttttatctaa gtatttgtaa
      421 agacgctgtt tcaaacaagc agctcatgac aaaactacag gaatccaagt ttgatgttct
      481 tttcgcagat cctgtggctt cctgtgggga tctgatagct gaactgctcc acattccttt
      541 tctgtacagt cttagcttct ctccaggcca caaacttgaa aagtccattg gaaaatttat
      601 actccctcca tcttatgtgc ctgtaatttt gtcgggactg gctggcaaaa tgacattcat
      661 agacagggta aaaaatatga tatgtatgct ttatttcgac ttttggttcg agatacttag
      721 acacaaggaa tgggacacgt tttacagtga gattttggga aggcccacca ccgtagatga
      781 gacaatgagc aaagtagaaa tatggcttat tagatcctat tgggatttga aatttcccca
      841 cccaacatta ccaaatgttg actatattgg aggactccat tgcaaacctg ctaaaccctt
      901 gcctaaggat atggaagaat ttgtccagag ctctggagag cacggtgtgg tggtgttttc
      961 tctggggtca atggtcagca acatgacaga agaaaaggcc aacgcaattg catgggccct
     1021 tgcccagatt ccacaaaagg ttctttggaa atttgatggc aaaaccccag caacattagg
     1081 acccaatacc agagtctaca agtggctccc gcagaatgac atcctgggtc acccaaaaac
     1141 caaagccttt gtaactcatg gtggagccaa tggcctctat gaggcaatct atcatggaat
     1201 ccctatgatt ggcattcctc tgtttggaga tcaacctgat aatattgccc acatggtggc
     1261 caaaggagca gctgtttcat tgaatatcag gacaatgtca aagttagatt ttctcagtgc
     1321 actggaggaa gtcatagaca atccgttcta taaaaaaaat gttatgttgt tgtcaaccat
     1381 tcaccatgac cagcctatga agcccctgga cagagctgtc ttctggattg agtttatcat
     1441 gcgccacaaa ggggccaagc acctgagacc acttggacat aaccttccct ggtaccagta
     1501 ccactctctg gatgtgattg gattcctgct cacctgtttt gcagtcattg cagctcttac
     1561 tgtaaaatgt ctcttgttca tgtaccgatt ctttgtaaag aaggaaaaga aaatgaagaa
     1621 tgagtagagc tcattgacaa tgcactacag aaatgaaatt tcagcgtcat tctaatttat
     1681 gaaccacctt ctaaaaatta ctaatttttt atcaaggtag ataacctttg taggaagaca
     1741 tataactccg tgaatactga tatgtactca aaaatccatc atttttaaat tttaaaacca
     1801 cttaatgtaa aagttacatt gtagaaaaat gtgcagaata aaattattct tgatagagtc
     1861 caaataatca aagtattaac cttaaaatat ttgaatagtg tccattagct tctttgtcta
     1921 atactgaatc tgtagctttc atacaataaa atgtagataa cttgtacacg ataaa
//
