LOCUS       NM_022228               2554 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus UDP glucuronosyltransferase family 2 member A1
            (Ugt2a1), mRNA.
ACCESSION   NM_022228
VERSION     NM_022228.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2554)
  AUTHORS   Neiers,F., Jarriault,D., Menetrier,F., Faure,P., Briand,L. and
            Heydel,J.M.
  TITLE     The odorant metabolizing enzyme UGT2A1: Immunolocalization and
            impact of the modulation of its activity on the olfactory response
  JOURNAL   PLoS One 16 (3), e0249029 (2021)
   PUBMED   33765098
  REMARK    GeneRIF: The odorant metabolizing enzyme UGT2A1: Immunolocalization
            and impact of the modulation of its activity on the olfactory
            response.
            Erratum:[PLoS One. 2024 Feb 23;19(2):e0299662. doi:
            10.1371/journal.pone.0299662.. PMID: 38394150]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2554)
  AUTHORS   Sneitz,N., Court,M.H., Zhang,X., Laajanen,K., Yee,K.K., Dalton,P.,
            Ding,X. and Finel,M.
  TITLE     Human UDP-glucuronosyltransferase UGT2A2: cDNA construction,
            expression, and functional characterization in comparison with
            UGT2A1 and UGT2A3
  JOURNAL   Pharmacogenet Genomics 19 (12), 923-934 (2009)
   PUBMED   19858781
REFERENCE   3  (bases 1 to 2554)
  AUTHORS   Lazard,D., Zupko,K., Poria,Y., Nef,P., Lazarovits,J., Horn,S.,
            Khen,M. and Lancet,D.
  TITLE     Odorant signal termination by olfactory UDP glucuronosyl
            transferase
  JOURNAL   Nature 349 (6312), 790-793 (1991)
   PUBMED   1900353
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jun 1, 2021 this sequence version replaced NM_022228.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.495930.1,
                                           SRR22582416.50205.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760476 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-811               JAXUCZ010000014.1  20800263-20801073
            812-960             JAXUCZ010000014.1  20817869-20818017
            961-1092            JAXUCZ010000014.1  20819267-20819398
            1093-1180           JAXUCZ010000014.1  20821270-20821357
            1181-1400           JAXUCZ010000014.1  20821841-20822060
            1401-2554           JAXUCZ010000014.1  20823958-20825111
FEATURES             Location/Qualifiers
     source          1..2554
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..2554
                     /gene="Ugt2a1"
                     /gene_synonym="Ugt2a1p"
                     /note="UDP glucuronosyltransferase family 2 member A1"
                     /db_xref="GeneID:63867"
                     /db_xref="RGD:69432"
     exon            1..811
                     /gene="Ugt2a1"
                     /gene_synonym="Ugt2a1p"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1680
                     /gene="Ugt2a1"
                     /gene_synonym="Ugt2a1p"
                     /EC_number="2.4.1.17"
                     /note="UGT-OLF; UDPGT 2A1; UDP-glucuronosyltransferase
                     2A1; UDP glycosyltransferase 2 family, polypeptide A1; UDP
                     glucuronosyltransferase 2 family, polypeptide A1"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 2A1 precursor"
                     /protein_id="NP_071564.2"
                     /db_xref="GeneID:63867"
                     /db_xref="RGD:69432"
                     /translation="MLKNILLWSLQLSLLGMSLGGNVLIWPMEGSHWLNVKIIIDELL
                     RKEHNVTVLVASGALFITPSVSPSLTFEIYPVPFGKEKIESVIKDFVLTWLENRPSPS
                     TIWTFYKEMAKVIEEFHLVSRGICDGVLKNEKLMTKLQRGKFEVLLSDPVFPCGDIVA
                     LKLGIPFIYSLRFSPASTVEKHCGKVPFPPSYVPAILSELTDQMSFADRVRNFISYRM
                     QDYMFETLWKQWDSYYSKALGRPTTLCETMGKAEIWLMRTYWDFEFPRPYLPNFEFVG
                     GLHCKPAKPLPKEMEEFVQTSGEHGVVVFSLGSMVKNLTEEKANLIASALAQIPQKVL
                     WRYKGKIPATLGSNTRLFDWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPMVGVP
                     MFADQPDNIAHMKAKGAAVEVNMNTMTSADLLSAVRAVINEPFYKENAMRLSRIHHDQ
                     PVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLACMASAILLVIK
                     CCLFVFQKIGKTGKKNKRD"
     exon            812..960
                     /gene="Ugt2a1"
                     /gene_synonym="Ugt2a1p"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1092
                     /gene="Ugt2a1"
                     /gene_synonym="Ugt2a1p"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1180
                     /gene="Ugt2a1"
                     /gene_synonym="Ugt2a1p"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1400
                     /gene="Ugt2a1"
                     /gene_synonym="Ugt2a1p"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..2554
                     /gene="Ugt2a1"
                     /gene_synonym="Ugt2a1p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttaaagaag agtcctattt ttgtgttttt tttttcttca ggaaagtaga gaaatttgtt
       61 tgttccacat tttcagaagt ttacatcaaa ccagtcatgt tgaagaacat tctactgtgg
      121 tctcttcagc taagtctcct aggaatgagt cttggcggga atgttctcat ctggccaatg
      181 gaaggcagtc actggctaaa tgttaagatc ataatagacg aactcctaag gaaagagcat
      241 aacgtgactg tccttgttgc atccggggcc cttttcatca caccgtcggt cagcccatct
      301 ctgacattcg aaatatatcc agtgcccttc ggcaaggaaa aaatcgaaag cgtgatcaag
      361 gactttgttt tgacgtggct ggaaaacagg ccgtctcctt caactatctg gactttctat
      421 aaggaaatgg ccaaagtcat cgaggagttc cacttggtgt ccagagggat ctgtgatggc
      481 gttcttaaga atgaaaagct gatgaccaag ctgcagagag gaaagtttga agtactgttg
      541 tcagacccag tatttccgtg tggcgatatc gtagctttaa aactggggat tccatttatc
      601 tattccttgc ggttttctcc tgcctccaca gtggaaaagc actgtggaaa agtcccgttt
      661 cctccttcct atgttcctgc aatcttgtca gaactcacag accagatgtc cttcgctgac
      721 cgagtaagga actttatctc ctaccgaatg caggactaca tgtttgaaac tctttggaag
      781 caatgggatt cctattacag taaagcctta ggaagaccca ccacactgtg cgagactatg
      841 gggaaagctg agatttggct aatgcgaaca tattgggatt ttgaatttcc tcgtccatat
      901 ttgcctaatt ttgagtttgt gggaggactg cactgcaaac ctgccaagcc tttgcctaag
      961 gaaatggaag agtttgtcca gacctcaggg gaacatggtg ttgtggtgtt ttctttgggg
     1021 tcaatggtca aaaacctgac agaagaaaag gccaatctca ttgcctcagc ccttgcccag
     1081 attcctcaga aggttttgtg gcgatacaaa ggaaagatac cagccacatt aggatccaat
     1141 acgagattgt ttgactggat tcctcagaat gatcttcttg gacatcccaa aaccagagct
     1201 tttatcaccc atggtggaac aaatggaatc tatgaggcca tttaccacgg gatcccgatg
     1261 gtgggagttc ccatgttcgc tgatcagcct gacaacatag ctcacatgaa ggctaaagga
     1321 gcagctgtgg aggtgaacat gaacacgatg acgagtgcag atctgctcag tgctgtgaga
     1381 gcagtcatca atgagccatt ttataaagag aatgccatga gactatcaag aattcaccac
     1441 gatcagccag tgaagcccct ggacagagcc gtcttctgga ttgagtttgt catgcgtcac
     1501 aaaggagcca agcaccttcg tgtggcagcg catgacctca gctggtttca gtaccactct
     1561 ctagatgtga ttgggttcct gctggcttgt atggcatctg ccatattatt ggttataaaa
     1621 tgttgtttat ttgtatttca aaaaattggt aagacaggaa agaagaataa aagggactag
     1681 atgaaggaaa gacatctcag gtctctgggt ttggtcaagc accaactgga gtagcaatag
     1741 tacttagaaa cccagggagt tgccagtcac ctatcctcat cccattttca atcattccat
     1801 tcctgtctta gcttgaggta aattggagga tgcaacatac tttctttgct atttcaatga
     1861 cggtcctatc gtttccttat attcctggca caggggcact attaatttaa atatgttctt
     1921 tcagaatgtc atttaactat aaacaagata ataacaatga taacaagtct gaatcatttg
     1981 aaaaggcaca cagggtatac tgaattttct ttaaggatca tgcaagggtc atgtatacag
     2041 gtcctcatgg agcacacaaa ttgggctctg accataggga ttagcgtatt atgagaagaa
     2101 tcattatttt ctttttaaat aaattctagc tattgtgttt ctctggtgtc acaggcatta
     2161 gaggatcagt tcagaactgg gacaccatat tatagtagga aaaatacata aattgttagt
     2221 acatttaaat tatgctggtc tatatttttt gcttttccct aaaatataca tctgcatgct
     2281 tactctccag tcaaaggttt tagatagttt ttccaagaaa tgaaggcatg aatggatcca
     2341 ccattttttt gcaaataata atatttgaaa gttatttcta gaaaaagtaa atgttaaaat
     2401 attgtaataa tttcttaaat tttaactgac tgctctttgg atctgtgtta atccattata
     2461 cttaaaaatt gtgtagttca tactctataa tcactattta taatgaagtg cttaattttc
     2521 tgccaaaata aaaaacttat attgagatca ctgt
//
