LOCUS       NM_130407               2264 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus UDP glucuronosyltransferase 1 family, polypeptide
            A7C (Ugt1a7c), mRNA.
ACCESSION   NM_130407 XM_346855 XM_347377
VERSION     NM_130407.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2264)
  AUTHORS   Sakakibara,Y., Katoh,M., Suzuki,M., Kawabe,R., Iwase,K. and
            Nadai,M.
  TITLE     Effect of adrenalectomy on expression and induction of
            UDP-glucuronosyltransferase 1A6 and 1A7 in rats
  JOURNAL   Biol Pharm Bull 37 (4), 618-624 (2014)
   PUBMED   24694608
  REMARK    GeneRIF: results indicate that adrenal-dependent factors such as
            glucocorticoids are partially involved in the basal regulation of
            UGT1A6 and UGT1A7 transcription.
REFERENCE   2  (bases 1 to 2264)
  AUTHORS   Xie,H., Sun,S., Cheng,X., Yan,T., Zheng,X., Li,F., Qi,Q., Wang,G.
            and Hao,H.
  TITLE     Dysregulations of intestinal and colonic
            UDP-glucuronosyltransferases in rats with type 2 diabetes
  JOURNAL   Drug Metab Pharmacokinet 28 (5), 427-434 (2013)
   PUBMED   23545594
REFERENCE   3  (bases 1 to 2264)
  AUTHORS   Gradinaru,D., Minn,A.L., Artur,Y., Minn,A. and Heydel,J.M.
  TITLE     Effect of oxidative stress on UDP-glucuronosyltransferases in rat
            astrocytes
  JOURNAL   Toxicol Lett 213 (3), 316-324 (2012)
   PUBMED   22846377
  REMARK    GeneRIF: Catalytic properties/expression of UGT1A6/7 are influenced
            by the pro-oxidant environment in astrocytes.
REFERENCE   4  (bases 1 to 2264)
  AUTHORS   Kishi,M., Emi,Y., Sakaguchi,M., Ikushiro,S. and Iyanagi,T.
  TITLE     Ontogenic isoform switching of UDP-glucuronosyltransferase family 1
            in rat liver
  JOURNAL   Biochem Biophys Res Commun 377 (3), 815-819 (2008)
   PUBMED   18938141
REFERENCE   5  (bases 1 to 2264)
  AUTHORS   Piepoli,A., Gentile,A., Valvano,M.R., Barana,D., Oliani,C.,
            Cotugno,R., Quitadamo,M., Andriulli,A. and Perri,F.
  TITLE     Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR
            gene polymorphisms and pancreatic cancer in Italian patients
  JOURNAL   World J Gastroenterol 12 (39), 6343-6348 (2006)
   PUBMED   17072959
REFERENCE   6  (bases 1 to 2264)
  AUTHORS   Bock,K.W., Raschko,F.T., Gschaidmeier,H., Seidel,A., Oesch,F.,
            Grove,A.D. and Ritter,J.K.
  TITLE     Mono- and Diglucuronide formation from benzo[a]pyrene and chrysene
            diphenols by AHH-1 cell-expressed UDP-glucuronosyltransferase
            UGT1A7
  JOURNAL   Biochem Pharmacol 57 (6), 653-656 (1999)
   PUBMED   10037450
REFERENCE   7  (bases 1 to 2264)
  AUTHORS   Metz,R.P. and Ritter,J.K.
  TITLE     Transcriptional activation of the UDP-glucuronosyltransferase 1A7
            gene in rat liver by aryl hydrocarbon receptor ligands and oltipraz
  JOURNAL   J Biol Chem 273 (10), 5607-5614 (1998)
   PUBMED   9488689
REFERENCE   8  (bases 1 to 2264)
  AUTHORS   Grove,A.D., Kessler,F.K., Metz,R.P. and Ritter,J.K.
  TITLE     Identification of a rat oltipraz-inducible
            UDP-glucuronosyltransferase (UGT1A7) with activity towards
            benzo(a)pyrene-7,8-dihydrodiol
  JOURNAL   J Biol Chem 272 (3), 1621-1627 (1997)
   PUBMED   8999837
REFERENCE   9  (bases 1 to 2264)
  AUTHORS   Emi,Y., Ikushiro,S. and Iyanagi,T.
  TITLE     Drug-responsive and tissue-specific alternative expression of
            multiple first exons in rat UDP-glucuronosyltransferase family 1
            (UGT1) gene complex
  JOURNAL   J Biochem 117 (2), 392-399 (1995)
   PUBMED   7608130
REFERENCE   10 (bases 1 to 2264)
  AUTHORS   Sato,H., Koiwai,O., Tanabe,K. and Kashiwamata,S.
  TITLE     Isolation and sequencing of rat liver bilirubin
            UDP-glucuronosyltransferase cDNA: possible alternate splicing of a
            common primary transcript
  JOURNAL   Biochem Biophys Res Commun 169 (1), 260-264 (1990)
   PUBMED   2112380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC078732.1 and AC120922.4.
            
            On Mar 9, 2006 this sequence version replaced NM_130407.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF461738.1, BC078732.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2253              BC078732.1         4-2256
            2254-2264           AC120922.4         161016-161026       c
FEATURES             Location/Qualifiers
     source          1..2264
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..2264
                     /gene="Ugt1a7c"
                     /gene_synonym="UDPGT 1-7; Ugt1; Ugt1a7; Ugt1a8"
                     /note="UDP glucuronosyltransferase 1 family, polypeptide
                     A7C"
                     /db_xref="GeneID:154516"
                     /db_xref="RGD:620950"
     exon            1..891
                     /gene="Ugt1a7c"
                     /gene_synonym="UDPGT 1-7; Ugt1; Ugt1a7; Ugt1a8"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1629
                     /gene="Ugt1a7c"
                     /gene_synonym="UDPGT 1-7; Ugt1; Ugt1a7; Ugt1a8"
                     /EC_number="2.4.1.17"
                     /note="UDP-glucuronosyltransferase 1-7; UDP
                     glucuronosyltransferase 1A7; A2; UDPGT; UGT1*7; UGT1.7;
                     UGT1-07; UDP glycosyltransferase 1 family, polypeptide A7;
                     UDP-glucuronosyltransferase 1A7C"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 1A7 precursor"
                     /protein_id="NP_569091.2"
                     /db_xref="GeneID:154516"
                     /db_xref="RGD:620950"
                     /translation="MAPADIPASLPLGLCLLLASGFGHAGKLLVVPMDGSHWFTMQMV
                     VEKLLPKGHEVVVVVPEVSWQLGKPLNFTVKTYSVSHTQEDLNREFKFFIDSQWKTQQ
                     EGGVLPLLTSPAQGFFELLFSHCRSLFKDKKLVEYLKQSSFDAVFLDPFDVCGLTVAK
                     YFSLPSVVFSRGIFCHYLEEGSQCPSPPSYVPRGILKLTDTMTFKERVWNLLSYMGEH
                     AFCPSFFKTATDIASEVLQTPVTMTDLFSPVSVWLLRTDFTLELPRPVMPNVIHIGGI
                     NCHQRKPLSKEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWR
                     YTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLF
                     GDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPI
                     EPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSC
                     AYGCRKCFGGKGRVKKSHKSKTH"
     exon            892..1023
                     /gene="Ugt1a7c"
                     /gene_synonym="UDPGT 1-7; Ugt1; Ugt1a7; Ugt1a8"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1111
                     /gene="Ugt1a7c"
                     /gene_synonym="UDPGT 1-7; Ugt1; Ugt1a7; Ugt1a8"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1331
                     /gene="Ugt1a7c"
                     /gene_synonym="UDPGT 1-7; Ugt1; Ugt1a7; Ugt1a8"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..2264
                     /gene="Ugt1a7c"
                     /gene_synonym="UDPGT 1-7; Ugt1; Ugt1a7; Ugt1a8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2233..2238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugt1a7c"
                     /gene_synonym="UDPGT 1-7; Ugt1; Ugt1a7; Ugt1a8"
     polyA_site      2253
                     /gene="Ugt1a7c"
                     /gene_synonym="UDPGT 1-7; Ugt1; Ugt1a7; Ugt1a8"
     polyA_site      2264
                     /gene="Ugt1a7c"
                     /gene_synonym="UDPGT 1-7; Ugt1; Ugt1a7; Ugt1a8"
ORIGIN      
        1 agcagctgtc ttgccttggt ctgcacttct cccatggctc ctgcagacat tccagcctct
       61 cttcctctcg gtctgtgcct gctgctggcc tctggctttg ggcatgcagg caagctgctg
      121 gtggtgccca tggatggcag ccactggttc accatgcaga tggttgtgga gaagctcctt
      181 cccaaaggcc atgaggtggt ggtggttgtt ccagaggtca gttggcagct gggaaaacca
      241 ctgaatttta cggtgaaaac gtattcagtt tctcacactc aggaggattt aaatcgggag
      301 ttcaagtttt ttattgactc tcagtggaaa actcaacaag agggcggagt tcttcctcta
      361 ctgactagcc ctgcccaggg tttcttcgaa ttactgtttt cacactgtag gagtttgttt
      421 aaggacaaga agttagtgga gtacttgaag cagagttcgt ttgatgctgt gtttctggat
      481 ccttttgatg tgtgtggctt aactgttgcc aagtactttt ctctcccgtc agtggtcttc
      541 agcaggggga tattttgtca ctatcttgaa gaaggctccc agtgccccag tcctccttca
      601 tatgtcccca gaggtatctt gaaactcaca gataccatga ctttcaagga aagagtgtgg
      661 aaccttcttt cctacatggg ggagcatgca ttctgtccca gttttttcaa aactgctacc
      721 gacattgcct ctgaagttct ccagaccccg gtgactatga cagacctctt cagcccagtg
      781 tccgtttggt tgttacgcac agacttcacg ttggaattac ccagacctgt gatgcccaat
      841 gtgatccaca ttggagggat caactgccac caaaggaagc cactttccaa ggaatttgaa
      901 gcctatgtca acgcctccgg agaacatggc atcgtggttt tctctttggg atccatggtc
      961 tcagagattc cagagaagaa agcgatggaa attgctgagg ctttgggcag aattcctcag
     1021 acggtcctgt ggcgctacac cggaactaga ccatcgaacc ttgcaaagaa cactattctt
     1081 gtcaaatggc taccccaaaa cgatctgctt ggtcatccaa aggctcgggc gttcatcaca
     1141 cactccggtt cccatggtat ttatgaagga atatgcaatg gggttccaat ggtgatgatg
     1201 cccttgtttg gtgatcagat ggacaacgcc aagcgcatgg aaactcgggg agctggggtg
     1261 accctgaatg tcctggaaat gactgccgat gatttggaaa acgcccttaa aactgtcatc
     1321 aataacaaga gttacaagga gaacatcatg cgcctctcca gccttcacaa ggaccgtcct
     1381 atcgagcctc tggacctggc tgtgttctgg gtggagtacg tgatgaggca caagggggcg
     1441 ccacacctgc gccccgccgc ccacgacctc acctggtacc agtaccactc cttggacgtg
     1501 attggctttc tcctggccat cgtgttgacg gtggtcttca ttgtctataa aagttgtgcc
     1561 tatggctgcc ggaaatgctt tgggggaaag ggtcgagtga agaaatcaca caaatccaag
     1621 acccactgag aagtggcagg aagtgaagga gaagtattag tcccttatcc aatcagttga
     1681 aacttggaaa caagtgttaa atccatgttg cttttattag ggaaataatt caccatacac
     1741 tatacaccca gaacaatttt ttttcttttt ctttttttcg gagctgggga ccgaacccag
     1801 aacatttttt tttttaaata aaaacaatct aattgctggc cacacccatc agggaagata
     1861 ctggaatatg tgatctgttt ctccagtatc ttcagtctgg acaatgactg ccatctgttg
     1921 gtaacttaca gaaagtttag tgttctgcct tcagtgacag caccacagtt tcccttactc
     1981 ctgtcagcta atggcttcct cccctggatt ctcagaccag tgtggccttc ccagtgttag
     2041 tcattcctca ctgtgctcat gttttgtggg tggcacggcc tttgagcttt gggagaaaag
     2101 aagatgaggc tgtgacactg gtggccctgt gtttgagata ataattattg cttgtctctg
     2161 aatttgatga aaactgaagt acattctaaa gaaagtatgt cttctattgt gttcccaaac
     2221 caagaacttg tcaataaatt catataaatt gtattattac tttt
//
