LOCUS       NM_057105               2313 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Rattus norvegicus UDP glucuronosyltransferase family 1 member A6
            (Ugt1a6), transcript variant 2, mRNA.
ACCESSION   NM_057105 XM_346856 XM_347378
VERSION     NM_057105.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2313)
  AUTHORS   Yang,H., You,L., Wang,Z., Yang,L., Wang,X., Wu,W., Zhi,H., Rong,G.,
            Sheng,Y., Liu,X. and Liu,L.
  TITLE     Bile duct ligation elevates 5-HT levels in cerebral cortex of rats
            partly due to impairment of brain UGT1A6 expression and activity
            via ammonia accumulation
  JOURNAL   Redox Biol 69, 103019 (2024)
   PUBMED   38163420
  REMARK    GeneRIF: Bile duct ligation elevates 5-HT levels in cerebral cortex
            of rats partly due to impairment of brain UGT1A6 expression and
            activity via ammonia accumulation.
REFERENCE   2  (bases 1 to 2313)
  AUTHORS   Zhang,C., He,Y., Shan,K.R., Tan,K., Zhang,T., Wang,C.J. and
            Guan,Z.Z.
  TITLE     Correlations between polymorphisms in the uridine
            diphosphate-glucuronosyltransferase 1A and C-C motif chemokine
            receptor 5 genes and infection with the hepatitis B virus in three
            ethnic groups in China
  JOURNAL   J Int Med Res 46 (2), 739-751 (2018)
   PUBMED   29239247
REFERENCE   3  (bases 1 to 2313)
  AUTHORS   Asai,Y., Tanaka,H., Nadai,M. and Katoh,M.
  TITLE     Effect of status epilepticus on expression of brain
            UDP-glucuronosyltransferase 1a in rats
  JOURNAL   Biopharm Drug Dispos 39 (2), 75-82 (2018)
   PUBMED   29131354
  REMARK    GeneRIF: study indicated that Status Epilepticus altered the
            expression of brain Ugt1a1 and Ugt1a7, which could alter
            glucuronidation in the brain.
REFERENCE   4  (bases 1 to 2313)
  AUTHORS   Sakakibara,Y., Katoh,M., Kondo,Y. and Nadai,M.
  TITLE     Effects of beta-Naphthoflavone on Ugt1a6 and Ugt1a7 Expression in
            Rat Brain
  JOURNAL   Biol Pharm Bull 39 (1), 78-83 (2016)
   PUBMED   26725430
  REMARK    GeneRIF: This study clarified that Ugt1a6 and Ugt1a7 mRNA
            expression and their enzyme activities were altered by
            beta-naphthoflavone, suggesting that these changes may lead to
            alteration in the pharmacokinetics of UGT substrate in rat brain.
REFERENCE   5  (bases 1 to 2313)
  AUTHORS   Sakakibara,Y., Katoh,M., Suzuki,M., Kawabe,R., Iwase,K. and
            Nadai,M.
  TITLE     Effect of adrenalectomy on expression and induction of
            UDP-glucuronosyltransferase 1A6 and 1A7 in rats
  JOURNAL   Biol Pharm Bull 37 (4), 618-624 (2014)
   PUBMED   24694608
  REMARK    GeneRIF: results indicate that adrenal-dependent factors such as
            glucocorticoids are partially involved in the basal regulation of
            UGT1A6 and UGT1A7 transcription.
REFERENCE   6  (bases 1 to 2313)
  AUTHORS   Emi,Y., Ikushiro,S. and Iyanagi,T.
  TITLE     Drug-responsive and tissue-specific alternative expression of
            multiple first exons in rat UDP-glucuronosyltransferase family 1
            (UGT1) gene complex
  JOURNAL   J Biochem 117 (2), 392-399 (1995)
   PUBMED   7608130
REFERENCE   7  (bases 1 to 2313)
  AUTHORS   Iyanagi,T.
  TITLE     Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme
            deficiencies in the hyperbilirubinemic rat (Gunn rat)
  JOURNAL   J Biol Chem 266 (35), 24048-24052 (1991)
   PUBMED   1748678
REFERENCE   8  (bases 1 to 2313)
  AUTHORS   Iyanagi,T., Watanabe,T. and Uchiyama,Y.
  TITLE     The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase
            deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a
            -1 frameshift mutation
  JOURNAL   J Biol Chem 264 (35), 21302-21307 (1989)
   PUBMED   2512292
REFERENCE   9  (bases 1 to 2313)
  AUTHORS   Harding,D., Fournel-Gigleux,S., Jackson,M.R. and Burchell,B.
  TITLE     Cloning and substrate specificity of a human phenol
            UDP-glucuronosyltransferase expressed in COS-7 cells
  JOURNAL   Proc Natl Acad Sci U S A 85 (22), 8381-8385 (1988)
   PUBMED   3141926
REFERENCE   10 (bases 1 to 2313)
  AUTHORS   Iyanagi,T., Haniu,M., Sogawa,K., Fujii-Kuriyama,Y., Watanabe,S.,
            Shively,J.E. and Anan,K.F.
  TITLE     Cloning and characterization of cDNA encoding 3-methylcholanthrene
            inducible rat mRNA for UDP-glucuronosyltransferase
  JOURNAL   J Biol Chem 261 (33), 15607-15614 (1986)
   PUBMED   3096993
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC107931.1 and AC120922.4.
            
            On Mar 9, 2006 this sequence version replaced NM_057105.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF461737.1, BC107931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2302              BC107931.1         12-2313
            2303-2313           AC120922.4         161016-161026       c
FEATURES             Location/Qualifiers
     source          1..2313
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..2313
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
                     /note="UDP glucuronosyltransferase family 1 member A6"
                     /db_xref="GeneID:113992"
                     /db_xref="RGD:620949"
     exon            1..940
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1678
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
                     /EC_number="2.4.1.17"
                     /note="UDP-glucuronosyltransferase 1-6; UDP
                     glucuronosyltransferase 1A6; A1; UGT1*6; UGT1.6; UGT1-06;
                     P-nitrophenol specific; P-nitrophenol-specific UDPGT; UDP
                     glycosyltransferase 1 family, polypeptide A6; UDP
                     glucuronosyltransferase 1 family, polypeptide A6"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 1A6 precursor"
                     /protein_id="NP_476446.2"
                     /db_xref="GeneID:113992"
                     /db_xref="RGD:620949"
                     /translation="MACLLPAARLPAGFLFLVLWGSVLGDKLLVVPQDGSHWLSMKEI
                     VEHLSERGHDIVVLVPEVNLLLGESKYYRRKSFPVPYNLEELRTRYRSFGNNHFAASS
                     PLMAPLREYRNNMIVIDMCFFSCQSLLKDSATLSFLRENQFDALFTDPAMPCGVILAE
                     YLKLPSVYLFRGFPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIANILEN
                     YLYHCLYSKYEILASDLLKRDVSLPALHQNSLWLLRYDFVFEYPRPVMPNMIFIGGTN
                     CKKKGNLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRY
                     TGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFG
                     DQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIE
                     PLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCA
                     YGCRKCFGGKGRVKKSHKSKTH"
     exon            941..1072
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1160
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1380
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..2313
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2282..2287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
     polyA_site      2302
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
     polyA_site      2313
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
ORIGIN      
        1 ctgaagtcac tgggtgtgtg agagggagta gctcagagcc ctgcagcttc aggagtgctc
       61 actgttgcct tccctcccca ctaggatggc ttgccttctt cctgctgctc gacttcctgc
      121 aggctttctc ttcttagtgc tctggggctc agttctaggt gacaagctgc tggtggtccc
      181 ccaggatggc agccactggc ttagcatgaa ggagatagtg gagcacctca gtgaacgcgg
      241 acacgacatt gtggtgctag tgccagaagt caatttgctt ttgggagaat ccaaatacta
      301 caggaggaaa agcttcccgg tcccctacaa cctagaagag ttgcggaccc gctatcgctc
      361 ctttgggaac aaccactttg ctgccagttc ccccctgatg gctcctctaa gagagtacag
      421 gaacaacatg attgtcattg acatgtgctt tttcagctgc cagagcctcc tgaaggactc
      481 ggccaccctc agcttcctca gggagaacca gtttgatgct ctgttcacag acccggccat
      541 gccctgtggt gtgatcctgg ctgagtatct caagctgcct tccgtctacc tcttcagagg
      601 tttcccatgc tctctggagc acatgcttgg tcaaagccca agccccgtat cctatgttcc
      661 cagattctac accaaattct cagaccacat gacatttccc caacggctgg ccaacttcat
      721 tgctaacatc ttggagaact acctttatca ttgtctgtac tcaaagtatg agatccttgc
      781 ctcagacctc ctcaagagag atgtgtccct acctgcctta caccagaact ctctgtggct
      841 gttacggtat gattttgtgt tcgaataccc ccggccagtc atgcccaaca tgatcttcat
      901 tggagggacc aactgcaaga agaaggggaa cctgtctcag gaatttgaag cctatgtcaa
      961 cgcctccgga gaacatggca tcgtggtttt ctctttggga tccatggtct cagagattcc
     1021 agagaagaaa gcgatggaaa ttgctgaggc tttgggcaga attcctcaga cggtcctgtg
     1081 gcgctacacc ggaactagac catcgaacct tgcaaagaac actattcttg tcaaatggct
     1141 accccaaaac gatctgcttg gtcatccaaa ggctcgggcg ttcatcacac actccggttc
     1201 ccatggtatt tatgaaggaa tatgcaatgg ggttccaatg gtgatgatgc ccttgtttgg
     1261 tgatcagatg gacaacgcca agcgcatgga aactcgggga gctggggtga ccctgaatgt
     1321 cctggaaatg actgccgatg atttggaaaa cgcccttaaa actgtcatca ataacaagag
     1381 ttacaaggag aacatcatgc gcctctccag ccttcacaag gaccgtccta tcgagcctct
     1441 ggacctggct gtgttctggg tggagtacgt gatgaggcac aagggggcgc cacacctgcg
     1501 ccccgccgcc cacgacctca cctggtacca gtaccactcc ttggacgtga ttggctttct
     1561 cctggccatc gtgttgacgg tggtcttcat tgtctataaa agttgtgcct atggctgccg
     1621 gaaatgcttt gggggaaagg gtcgagtgaa gaaatcacac aaatccaaga cccactgaga
     1681 agtggcagga agtgaaggag aagtattagt cccttatcca atcagttgaa acttggaaac
     1741 aagtgttaaa tccatgttgc ttttattagg gaaataattc accatacact atacacccag
     1801 aacaattttt tttctttttc tttttttcgg agctggggac cgaacccaga acattttttt
     1861 ttttaaataa aaacaatcta attgctggcc acacccatca gggaagatac tggaatatgt
     1921 gatctgtttc tccagtatct tcagtctgga caatgactgc catctgttgg taacttacag
     1981 aaagtttagt gttctgcctt cagtgacagc accacagttt cccttactcc tgtcagctaa
     2041 tggcttcctc ccctggattc tcagaccagt gtggccttcc cagtgttagt cattcctcac
     2101 tgtgctcatg ttttgtgggt ggcacggcct ttgagctttg ggagaaaaga agatgaggct
     2161 gtgacactgg tggccctgtg tttgagataa taattattgc ttgtctctga atttgatgaa
     2221 aactgaagta cattctaaag aaagtatgtc ttctattgtg ttcccaaacc aagaacttgt
     2281 caataaattc atataaattg tattattact ttt
//
