LOCUS       NM_001039691            2367 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Rattus norvegicus UDP glucuronosyltransferase family 1 member A6
            (Ugt1a6), transcript variant 1, mRNA.
ACCESSION   NM_001039691
VERSION     NM_001039691.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2367)
  AUTHORS   Yang,H., You,L., Wang,Z., Yang,L., Wang,X., Wu,W., Zhi,H., Rong,G.,
            Sheng,Y., Liu,X. and Liu,L.
  TITLE     Bile duct ligation elevates 5-HT levels in cerebral cortex of rats
            partly due to impairment of brain UGT1A6 expression and activity
            via ammonia accumulation
  JOURNAL   Redox Biol 69, 103019 (2024)
   PUBMED   38163420
  REMARK    GeneRIF: Bile duct ligation elevates 5-HT levels in cerebral cortex
            of rats partly due to impairment of brain UGT1A6 expression and
            activity via ammonia accumulation.
REFERENCE   2  (bases 1 to 2367)
  AUTHORS   Zhang,C., He,Y., Shan,K.R., Tan,K., Zhang,T., Wang,C.J. and
            Guan,Z.Z.
  TITLE     Correlations between polymorphisms in the uridine
            diphosphate-glucuronosyltransferase 1A and C-C motif chemokine
            receptor 5 genes and infection with the hepatitis B virus in three
            ethnic groups in China
  JOURNAL   J Int Med Res 46 (2), 739-751 (2018)
   PUBMED   29239247
REFERENCE   3  (bases 1 to 2367)
  AUTHORS   Asai,Y., Tanaka,H., Nadai,M. and Katoh,M.
  TITLE     Effect of status epilepticus on expression of brain
            UDP-glucuronosyltransferase 1a in rats
  JOURNAL   Biopharm Drug Dispos 39 (2), 75-82 (2018)
   PUBMED   29131354
  REMARK    GeneRIF: study indicated that Status Epilepticus altered the
            expression of brain Ugt1a1 and Ugt1a7, which could alter
            glucuronidation in the brain.
REFERENCE   4  (bases 1 to 2367)
  AUTHORS   Sakakibara,Y., Katoh,M., Kondo,Y. and Nadai,M.
  TITLE     Effects of beta-Naphthoflavone on Ugt1a6 and Ugt1a7 Expression in
            Rat Brain
  JOURNAL   Biol Pharm Bull 39 (1), 78-83 (2016)
   PUBMED   26725430
  REMARK    GeneRIF: This study clarified that Ugt1a6 and Ugt1a7 mRNA
            expression and their enzyme activities were altered by
            beta-naphthoflavone, suggesting that these changes may lead to
            alteration in the pharmacokinetics of UGT substrate in rat brain.
REFERENCE   5  (bases 1 to 2367)
  AUTHORS   Sakakibara,Y., Katoh,M., Suzuki,M., Kawabe,R., Iwase,K. and
            Nadai,M.
  TITLE     Effect of adrenalectomy on expression and induction of
            UDP-glucuronosyltransferase 1A6 and 1A7 in rats
  JOURNAL   Biol Pharm Bull 37 (4), 618-624 (2014)
   PUBMED   24694608
  REMARK    GeneRIF: results indicate that adrenal-dependent factors such as
            glucocorticoids are partially involved in the basal regulation of
            UGT1A6 and UGT1A7 transcription.
REFERENCE   6  (bases 1 to 2367)
  AUTHORS   Emi,Y., Ikushiro,S. and Iyanagi,T.
  TITLE     Drug-responsive and tissue-specific alternative expression of
            multiple first exons in rat UDP-glucuronosyltransferase family 1
            (UGT1) gene complex
  JOURNAL   J Biochem 117 (2), 392-399 (1995)
   PUBMED   7608130
REFERENCE   7  (bases 1 to 2367)
  AUTHORS   Iyanagi,T.
  TITLE     Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme
            deficiencies in the hyperbilirubinemic rat (Gunn rat)
  JOURNAL   J Biol Chem 266 (35), 24048-24052 (1991)
   PUBMED   1748678
REFERENCE   8  (bases 1 to 2367)
  AUTHORS   Iyanagi,T., Watanabe,T. and Uchiyama,Y.
  TITLE     The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase
            deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a
            -1 frameshift mutation
  JOURNAL   J Biol Chem 264 (35), 21302-21307 (1989)
   PUBMED   2512292
REFERENCE   9  (bases 1 to 2367)
  AUTHORS   Harding,D., Fournel-Gigleux,S., Jackson,M.R. and Burchell,B.
  TITLE     Cloning and substrate specificity of a human phenol
            UDP-glucuronosyltransferase expressed in COS-7 cells
  JOURNAL   Proc Natl Acad Sci U S A 85 (22), 8381-8385 (1988)
   PUBMED   3141926
REFERENCE   10 (bases 1 to 2367)
  AUTHORS   Iyanagi,T., Haniu,M., Sogawa,K., Fujii-Kuriyama,Y., Watanabe,S.,
            Shively,J.E. and Anan,K.F.
  TITLE     Cloning and characterization of cDNA encoding 3-methylcholanthrene
            inducible rat mRNA for UDP-glucuronosyltransferase
  JOURNAL   J Biol Chem 261 (33), 15607-15614 (1986)
   PUBMED   3096993
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Apr 13, 2021 this sequence version replaced NM_001039691.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05132.1, J02612.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               JAXUCZ010000009.1  96195018-96195155
            139-994             JAXUCZ010000009.1  96198827-96199682
            995-1126            JAXUCZ010000009.1  96252164-96252295
            1127-1214           JAXUCZ010000009.1  96252942-96253029
            1215-1434           JAXUCZ010000009.1  96253295-96253514
            1435-2367           JAXUCZ010000009.1  96255332-96256264
FEATURES             Location/Qualifiers
     source          1..2367
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..2367
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
                     /note="UDP glucuronosyltransferase family 1 member A6"
                     /db_xref="GeneID:113992"
                     /db_xref="RGD:620949"
     exon            1..138
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            139..994
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1732
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
                     /EC_number="2.4.1.17"
                     /note="UDP-glucuronosyltransferase 1-6; UDP
                     glucuronosyltransferase 1A6; A1; UGT1*6; UGT1.6; UGT1-06;
                     P-nitrophenol specific; P-nitrophenol-specific UDPGT; UDP
                     glycosyltransferase 1 family, polypeptide A6; UDP
                     glucuronosyltransferase 1 family, polypeptide A6"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 1A6 precursor"
                     /protein_id="NP_001034780.1"
                     /db_xref="GeneID:113992"
                     /db_xref="RGD:620949"
                     /translation="MACLLPAARLPAGFLFLVLWGSVLGDKLLVVPQDGSHWLSMKEI
                     VEHLSERGHDIVVLVPEVNLLLGESKYYRRKSFPVPYNLEELRTRYRSFGNNHFAASS
                     PLMAPLREYRNNMIVIDMCFFSCQSLLKDSATLSFLRENQFDALFTDPAMPCGVILAE
                     YLKLPSVYLFRGFPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIANILEN
                     YLYHCLYSKYEILASDLLKRDVSLPALHQNSLWLLRYDFVFEYPRPVMPNMIFIGGTN
                     CKKKGNLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWRY
                     TGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFG
                     DQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIE
                     PLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCA
                     YGCRKCFGGKGRVKKSHKSKTH"
     exon            995..1126
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1214
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1434
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..2367
                     /gene="Ugt1a6"
                     /gene_synonym="Udpgt; UDPGT 1-6; Ugt1; Ugt1a7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctttggtg gtggttagga aacccggaat tcagatggtg gctgagggtg gctgactgaa
       61 aaacggactt ccagatttct tactcttcca caagggccct catcacgtgc gcaggtctct
      121 aaccttactc tctgaaagga tggcttgcct tcttcctgct gctcgacttc ctgcaggctt
      181 tctcttctta gtgctctggg gctcagttct aggtgacaag ctgctggtgg tcccccagga
      241 tggcagccac tggcttagca tgaaggagat agtggagcac ctcagtgaac gcggacacga
      301 cattgtggtg ctagtgccag aagtcaattt gcttttggga gaatccaaat actacaggag
      361 gaaaagcttc ccggtcccct acaacctaga agagttgcgg acccgctatc gctcctttgg
      421 gaacaaccac tttgctgcca gttcccccct gatggctcct ctaagagagt acaggaacaa
      481 catgattgtc attgacatgt gctttttcag ctgccagagc ctcctgaagg actcggccac
      541 cctcagcttc ctcagggaga accagtttga tgctctgttc acagacccgg ccatgccctg
      601 tggtgtgatc ctggctgagt atctcaagct gccttccgtc tacctcttca gaggtttccc
      661 atgctctctg gagcacatgc ttggtcaaag cccaagcccc gtatcctatg ttcccagatt
      721 ctacaccaaa ttctcagacc acatgacatt tccccaacgg ctggccaact tcattgctaa
      781 catcttggag aactaccttt atcattgtct gtactcaaag tatgagatcc ttgcctcaga
      841 cctcctcaag agagatgtgt ccctacctgc cttacaccag aactctctgt ggctgttacg
      901 gtatgatttt gtgttcgaat acccccggcc agtcatgccc aacatgatct tcattggagg
      961 gaccaactgc aagaagaagg ggaacctgtc tcaggaattt gaagcctatg tcaacgcctc
     1021 cggagaacat ggcatcgtgg ttttctcttt gggatccatg gtctcagaga ttccagagaa
     1081 gaaagcgatg gaaattgctg aggctttggg cagaattcct cagacggtcc tgtggcgcta
     1141 caccggaact agaccatcga accttgcaaa gaacactatt cttgtcaaat ggctacccca
     1201 aaacgatctg cttggtcatc caaaggctcg ggcgttcatc acacactccg gttcccatgg
     1261 tatttatgaa ggaatatgca atggggttcc aatggtgatg atgcccttgt ttggtgatca
     1321 gatggacaac gccaagcgca tggaaactcg gggagctggg gtgaccctga atgtcctgga
     1381 aatgactgcc gatgatttgg aaaacgccct taaaactgtc atcaataaca agagttacaa
     1441 ggagaacatc atgcgcctct ccagccttca caaggaccgt cctatcgagc ctctggacct
     1501 ggctgtgttc tgggtggagt acgtgatgag gcacaagggg gcgccacacc tgcgccccgc
     1561 cgcccacgac ctcacctggt accagtacca ctccttggac gtgattggct ttctcctggc
     1621 catcgtgttg acggtggtct tcattgtcta taaaagttgt gcctatggct gccggaaatg
     1681 ctttggggga aagggtcgag tgaagaaatc acacaaatcc aagacccact gagaagtggc
     1741 aggaagtgaa ggagaagtat tagtccctta tccaatcagt tgaaacttgg aaacaagtgt
     1801 taaatccatg ttgcttttat tagggaaata attcaccata cactatacac ccagaacaat
     1861 tttttttctt tttctttttt tcggagctgg ggaccgaacc cagaacattt ttttttttaa
     1921 ataaaaacaa tctaattgct ggccacaccc atcagggaag atactggaat atgtgatctg
     1981 tttctccagt atcttcagtc tggacaatga ctgccatctg ttggtaactt acagaaagtt
     2041 tagtgttctg ccttcagtga cagcaccaca gtttccctta ctcctgtcag ctaatggctt
     2101 cctcccctgg attctcagac cagtgtggcc ttcccagtgt tagtcattcc tcactgtgct
     2161 catgttttgt gggtggcacg gcctttgagc tttgggagaa aagaagatga ggctgtgaca
     2221 ctggtggccc tgtgtttgag ataataatta ttgcttgtct ctgaatttga tgaaaactga
     2281 agtacattct aaagaaagta tgtcttctat tgtgttccca aaccaagaac ttgtcaataa
     2341 attcatataa attgtattat tactttt
//
