LOCUS       NM_201424               2231 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus UDP glycosyltransferase 1 family, polypeptide A3
            (Ugt1a3), mRNA.
ACCESSION   NM_201424
VERSION     NM_201424.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2231)
  AUTHORS   Tian,H., Ou,J., Strom,S.C. and Venkataramanan,R.
  TITLE     Activity and expression of various isoforms of uridine diphosphate
            glucuronosyltransferase are differentially regulated during hepatic
            regeneration in rats
  JOURNAL   Pharm Res 22 (12), 2007-2015 (2005)
   PUBMED   16222444
REFERENCE   2  (bases 1 to 2231)
  AUTHORS   Mackenzie,P.I., Bock,K.W., Burchell,B., Guillemette,C.,
            Ikushiro,S., Iyanagi,T., Miners,J.O., Owens,I.S. and Nebert,D.W.
  TITLE     Nomenclature update for the mammalian UDP glycosyltransferase (UGT)
            gene superfamily
  JOURNAL   Pharmacogenet Genomics 15 (10), 677-685 (2005)
   PUBMED   16141793
  REMARK    Review article
REFERENCE   3  (bases 1 to 2231)
  AUTHORS   Zhang,T., Haws,P. and Wu,Q.
  TITLE     Multiple variable first exons: a mechanism for cell- and
            tissue-specific gene regulation
  JOURNAL   Genome Res 14 (1), 79-89 (2004)
   PUBMED   14672974
REFERENCE   4  (bases 1 to 2231)
  AUTHORS   Emi,Y., Ikushiro,S. and Iyanagi,T.
  TITLE     Drug-responsive and tissue-specific alternative expression of
            multiple first exons in rat UDP-glucuronosyltransferase family 1
            (UGT1) gene complex
  JOURNAL   J Biochem 117 (2), 392-399 (1995)
   PUBMED   7608130
REFERENCE   5  (bases 1 to 2231)
  AUTHORS   Sato,H., Koiwai,O., Tanabe,K. and Kashiwamata,S.
  TITLE     Isolation and sequencing of rat liver bilirubin
            UDP-glucuronosyltransferase cDNA: possible alternate splicing of a
            common primary transcript
  JOURNAL   Biochem Biophys Res Commun 169 (1), 260-264 (1990)
   PUBMED   2112380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY435131.1 and AC120922.4.
            
            On Mar 9, 2006 this sequence version replaced NM_201424.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY435131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2219              AY435131.1         1-2219
            2220-2231           AC120922.4         161016-161027       c
FEATURES             Location/Qualifiers
     source          1..2231
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..2231
                     /gene="Ugt1a3"
                     /gene_synonym="UDPGT 1-3; Ugt1; Ugt1a4"
                     /note="UDP glycosyltransferase 1 family, polypeptide A3"
                     /db_xref="GeneID:396551"
                     /db_xref="RGD:1549728"
     CDS             1..1596
                     /gene="Ugt1a3"
                     /gene_synonym="UDPGT 1-3; Ugt1; Ugt1a4"
                     /EC_number="2.4.1.17"
                     /note="UDP-glucuronosyltransferase 1-3; B3; UDPGT; UGT1*3;
                     UGT1.3; UGT1-03; UDP glycosyltransferase 1 family
                     polypeptide A4; UDP-glucuronosyltransferase 1A3"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 1A3 precursor"
                     /protein_id="NP_958827.1"
                     /db_xref="GeneID:396551"
                     /db_xref="RGD:1549728"
                     /translation="MGIQGFLQKLSGLLLLLCALPWAEGGKVLVFPMEGSHWLSMRDV
                     VRELHARGHQAVVLAPEVTVHIKEEDFFTLQTYPVPYTKEEYRHHLLGHLQNFFETEF
                     SLKLVLQRMAAVNNVSTFYVRSCRGLLHNTALIQSLNSSSFDVVLTDPFFPCGAVLAM
                     YLRVPAVFFLQSMLCELEFEATNSPNPSSYIPRLLTLNSDHMSFLDRVKNMLYPVPWM
                     YLCHVNYGSLARLASDLLQREVSVVEILRHASVWLLRKDFVFYYPRPFMPNMVFIGGI
                     NCANRKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVLWR
                     YTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLF
                     GDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPI
                     EPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSC
                     AYGCRKCFGGKGRVKKSHKSKTH"
     exon            1..858
                     /gene="Ugt1a3"
                     /gene_synonym="UDPGT 1-3; Ugt1; Ugt1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            859..990
                     /gene="Ugt1a3"
                     /gene_synonym="UDPGT 1-3; Ugt1; Ugt1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1078
                     /gene="Ugt1a3"
                     /gene_synonym="UDPGT 1-3; Ugt1; Ugt1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1298
                     /gene="Ugt1a3"
                     /gene_synonym="UDPGT 1-3; Ugt1; Ugt1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..2231
                     /gene="Ugt1a3"
                     /gene_synonym="UDPGT 1-3; Ugt1; Ugt1a4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2200..2205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugt1a3"
                     /gene_synonym="UDPGT 1-3; Ugt1; Ugt1a4"
     polyA_site      2220
                     /gene="Ugt1a3"
                     /gene_synonym="UDPGT 1-3; Ugt1; Ugt1a4"
     polyA_site      2231
                     /gene="Ugt1a3"
                     /gene_synonym="UDPGT 1-3; Ugt1; Ugt1a4"
ORIGIN      
        1 atgggaatcc aagggttcct gcagaaactc tcaggactgc tgctcctgct gtgtgccctg
       61 ccctgggctg aaggtggaaa ggtgctggtg tttcccatgg agggcagcca ctggctgagc
      121 atgagggatg tcgtgaggga gctccacgcc cgaggtcacc aggctgtggt cctggctcca
      181 gaggtgactg tgcacatcaa agaagaggac ttcttcaccc tccaaaccta ccctgttcca
      241 tacaccaagg aagagtacag gcaccacttg ctgggccacc ttcaaaattt tttcgaaact
      301 gaattttctc tgaagttagt tctacagaga atggcagctg taaataacgt atcaacattc
      361 tatgtgagat cttgcagggg tctgctgcat aacacagctc tgatccagag cctgaactcc
      421 agctccttcg atgtggtttt aacagatccc tttttcccct gtggggcagt gctggccatg
      481 tacctgcgtg ttcctgctgt gttttttctg caatccatgc tctgtgaact ggaatttgaa
      541 gcaacaaaca gtccaaaccc ttcttcttat attcccaggt tactaacatt gaattctgac
      601 cacatgagct tcctagacag agtgaagaat atgctttatc ctgtgccatg gatgtattta
      661 tgccatgtta attatggctc tctggcgaga cttgcgtcag accttttgca gagggaggta
      721 tccgtggtag agatcctcag acatgcctct gtatggctgt tgagaaagga ctttgtgttc
      781 tactacccca ggcccttcat gcccaacatg gtcttcattg ggggcataaa ctgtgccaac
      841 aggaagccac tgtctcagga atttgaagcc tatgtcaacg cctccggaga acatggcatc
      901 gtggttttct ctttgggatc catggtctca gagattccag agaagaaagc gatggaaatt
      961 gctgaggctt tgggcagaat tcctcagacg gtcctgtggc gctacaccgg aactagacca
     1021 tcgaaccttg caaagaacac tattcttgtc aaatggctac cccaaaacga tctgcttggt
     1081 catccaaagg ctcgggcgtt catcacacac tccggttccc atggtattta tgaaggaata
     1141 tgcaatgggg ttccaatggt gatgatgccc ttgtttggtg atcagatgga caacgccaag
     1201 cgcatggaaa ctcggggagc tggggtgacc ctgaatgtcc tggaaatgac tgccgatgat
     1261 ttggaaaacg cccttaaaac tgtcatcaat aacaagagtt acaaggagaa catcatgcgc
     1321 ctctccagcc ttcacaagga ccgtcctatc gagcctctgg acctggctgt gttctgggtg
     1381 gagtacgtga tgaggcacaa gggggcgcca cacctgcgcc ccgccgccca cgacctcacc
     1441 tggtaccagt accactcctt ggacgtgatt ggctttctcc tggccatcgt gttgacggtg
     1501 gtcttcattg tctataaaag ttgtgcctat ggctgccgga aatgctttgg gggaaagggt
     1561 cgagtgaaga aatcacacaa atccaagacc cactgagaag tggcaggaag tgaaggagaa
     1621 gtattagtcc cttatccaat cagttgaaac ttggaaacaa gtgttaaatc catgttgctt
     1681 ttattaggga aataattcac catacactat acacccagaa caattttttt tctttttctt
     1741 tttttcggag ctggggaccg aacccagaac attttttttt ttaaataaaa acaatctaat
     1801 tgctggccac acccatcagg gaagatactg gaatatgtga tctgtttctc cagtatcttc
     1861 agtctggaca atgactgcca tctgttggta acttacagaa agtttagtgt tctgccttca
     1921 gtgacagcac cacagtttcc cttactcctg tcagctaatg gcttcctccc ctggattctc
     1981 agaccagtgt ggccttccca gtgttagtca ttcctcactg tgctcatgtt ttgtgggtgg
     2041 cacggccttt gagctttggg agaaaagaag atgaggctgt gacactggtg gccctgtgtt
     2101 tgagataata attattgctt gtctctgaat ttgatgaaaa ctgaagtaca ttctaaagaa
     2161 agtatgtctt ctattgtgtt cccaaaccaa gaacttgtca ataaattcat ataaattgta
     2221 ttattacttt t
//
