LOCUS       NM_201423               2237 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus UDP glucuronosyltransferase 1 family, polypeptide
            A2 (Ugt1a2), mRNA.
ACCESSION   NM_201423
VERSION     NM_201423.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2237)
  AUTHORS   Gagez,A.L., Rouguieg-Malki,K., Sauvage,F.L., Marquet,P. and
            Picard,N.
  TITLE     Simultaneous evaluation of six human glucuronidation activities in
            liver microsomes using liquid chromatography-tandem mass
            spectrometry
  JOURNAL   Anal Biochem 427 (1), 52-59 (2012)
   PUBMED   22579593
REFERENCE   2  (bases 1 to 2237)
  AUTHORS   Bellemare,J., Rouleau,M., Girard,H., Harvey,M. and Guillemette,C.
  TITLE     Alternatively spliced products of the UGT1A gene interact with the
            enzymatically active proteins to inhibit glucuronosyltransferase
            activity in vitro
  JOURNAL   Drug Metab Dispos 38 (10), 1785-1789 (2010)
   PUBMED   20610558
REFERENCE   3  (bases 1 to 2237)
  AUTHORS   Rowbotham,S.E., Illingworth,N.A., Daly,A.K., Veal,G.J. and
            Boddy,A.V.
  TITLE     Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic
            acid metabolism in humans
  JOURNAL   Drug Metab Dispos 38 (7), 1211-1217 (2010)
   PUBMED   20308471
REFERENCE   4  (bases 1 to 2237)
  AUTHORS   Brand,W., Boersma,M.G., Bik,H., Hoek-van den Hil,E.F., Vervoort,J.,
            Barron,D., Meinl,W., Glatt,H., Williamson,G., van Bladeren,P.J. and
            Rietjens,I.M.
  TITLE     Phase II metabolism of hesperetin by individual
            UDP-glucuronosyltransferases and sulfotransferases and rat and
            human tissue samples
  JOURNAL   Drug Metab Dispos 38 (4), 617-625 (2010)
   PUBMED   20056724
REFERENCE   5  (bases 1 to 2237)
  AUTHORS   Kishi,M., Emi,Y., Sakaguchi,M., Ikushiro,S. and Iyanagi,T.
  TITLE     Ontogenic isoform switching of UDP-glucuronosyltransferase family 1
            in rat liver
  JOURNAL   Biochem Biophys Res Commun 377 (3), 815-819 (2008)
   PUBMED   18938141
REFERENCE   6  (bases 1 to 2237)
  AUTHORS   Mackenzie,P.I., Bock,K.W., Burchell,B., Guillemette,C.,
            Ikushiro,S., Iyanagi,T., Miners,J.O., Owens,I.S. and Nebert,D.W.
  TITLE     Nomenclature update for the mammalian UDP glycosyltransferase (UGT)
            gene superfamily
  JOURNAL   Pharmacogenet Genomics 15 (10), 677-685 (2005)
   PUBMED   16141793
  REMARK    Review article
REFERENCE   7  (bases 1 to 2237)
  AUTHORS   Zhang,T., Haws,P. and Wu,Q.
  TITLE     Multiple variable first exons: a mechanism for cell- and
            tissue-specific gene regulation
  JOURNAL   Genome Res 14 (1), 79-89 (2004)
   PUBMED   14672974
REFERENCE   8  (bases 1 to 2237)
  AUTHORS   Vansell,N.R. and Klaassen,C.D.
  TITLE     Increase in rat liver UDP-glucuronosyltransferase mRNA by
            microsomal enzyme inducers that enhance thyroid hormone
            glucuronidation
  JOURNAL   Drug Metab Dispos 30 (3), 240-246 (2002)
   PUBMED   11854140
REFERENCE   9  (bases 1 to 2237)
  AUTHORS   Emi,Y., Ikushiro,S. and Iyanagi,T.
  TITLE     Drug-responsive and tissue-specific alternative expression of
            multiple first exons in rat UDP-glucuronosyltransferase family 1
            (UGT1) gene complex
  JOURNAL   J Biochem 117 (2), 392-399 (1995)
   PUBMED   7608130
REFERENCE   10 (bases 1 to 2237)
  AUTHORS   Sato,H., Koiwai,O., Tanabe,K. and Kashiwamata,S.
  TITLE     Isolation and sequencing of rat liver bilirubin
            UDP-glucuronosyltransferase cDNA: possible alternate splicing of a
            common primary transcript
  JOURNAL   Biochem Biophys Res Commun 169 (1), 260-264 (1990)
   PUBMED   2112380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY435130.1 and AC120922.4.
            
            On Mar 9, 2006 this sequence version replaced NM_201423.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY435130.1, M34007.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2225              AY435130.1         1-2225
            2226-2237           AC120922.4         161016-161027       c
FEATURES             Location/Qualifiers
     source          1..2237
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..2237
                     /gene="Ugt1a2"
                     /gene_synonym="Udpgt; UDPGT 1-2; Ugt1"
                     /note="UDP glucuronosyltransferase 1 family, polypeptide
                     A2"
                     /db_xref="GeneID:396527"
                     /db_xref="RGD:1549741"
     CDS             1..1602
                     /gene="Ugt1a2"
                     /gene_synonym="Udpgt; UDPGT 1-2; Ugt1"
                     /EC_number="2.4.1.17"
                     /note="UDP glucuronosyltransferase 1A2;
                     UDP-glucuronosyltransferase 1-2; B2; UGT1*0; UGT1.2;
                     UGT1-02; bilirubin specific; bilirubin-specific UDPGT; UDP
                     glycosyltransferase 1 family polypeptide A2"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase 1-2 precursor"
                     /protein_id="NP_958826.1"
                     /db_xref="GeneID:396527"
                     /db_xref="RGD:1549741"
                     /translation="MDTGLCAPLRGLSGLLLLLCALPWAEGGKVLVFPMEGSHWLSMR
                     DVVRELHARGHQAVVLAPEVTVHMKGEDFFTLQTYAFPYTKEEYQREILGNAKKGFEP
                     QHFVKTFFETMASIKKFFDLYANSCAALLHNKTLIQQLNSSSFDVVLTDPVFPCGALL
                     AKYLQIPAVFFLRSVPCGIDYEATQCPKPSSYIPNLLTMLSDHMTFLQRVKNMLYPLT
                     LKYICHLSITPYESLASELLQREMSLVEVLSHASVWLFRGDFVFDYPRPIMPNMVFIG
                     GINCVIKKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTVL
                     WRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMP
                     LFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDR
                     PIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYK
                     SCAYGCRKCFGGKGRVKKSHKSKTH"
     exon            1..864
                     /gene="Ugt1a2"
                     /gene_synonym="Udpgt; UDPGT 1-2; Ugt1"
                     /inference="alignment:Splign:2.1.0"
     exon            865..996
                     /gene="Ugt1a2"
                     /gene_synonym="Udpgt; UDPGT 1-2; Ugt1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1084
                     /gene="Ugt1a2"
                     /gene_synonym="Udpgt; UDPGT 1-2; Ugt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1304
                     /gene="Ugt1a2"
                     /gene_synonym="Udpgt; UDPGT 1-2; Ugt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..2237
                     /gene="Ugt1a2"
                     /gene_synonym="Udpgt; UDPGT 1-2; Ugt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2206..2211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ugt1a2"
                     /gene_synonym="Udpgt; UDPGT 1-2; Ugt1"
     polyA_site      2226
                     /gene="Ugt1a2"
                     /gene_synonym="Udpgt; UDPGT 1-2; Ugt1"
     polyA_site      2237
                     /gene="Ugt1a2"
                     /gene_synonym="Udpgt; UDPGT 1-2; Ugt1"
ORIGIN      
        1 atggacacag gattgtgtgc accccttcga ggactctcag gactgctgct cctgctgtgt
       61 gccctgccct gggctgaagg tggaaaggtg ctggtgtttc ccatggaggg cagccactgg
      121 ctgagcatga gggatgtcgt gagggagctc cacgcccgag gtcaccaggc tgtggtcctg
      181 gctccagagg tgactgtgca catgaaagga gaggacttct tcaccctcca aacctatgcc
      241 tttccatata ccaaggaaga atatcagcgg gaaatactgg gcaacgctaa gaagggcttc
      301 gaaccacaac attttgtgaa gactttcttt gaaactatgg catctataaa aaagtttttc
      361 gatctctacg caaattcttg tgcagctcta ttgcacaata agaccctgat ccagcaactg
      421 aattccagtt ccttcgatgt ggtcttaaca gaccctgttt tcccctgtgg agcattactg
      481 gccaagtatc tacagattcc tgctgtgttt tttctgcgct ctgttccctg tggcatagac
      541 tatgaggcta cacaatgtcc gaaaccttcc tcttatattc cgaacctact cacaatgctt
      601 tctgaccaca tgaccttcct gcaaagggtc aagaacatgc tgtaccctct gaccttgaag
      661 tacatttgcc atttatcaat cactccctat gaaagcctgg cctctgagct tttgcagaga
      721 gaaatgtctt tagtggaggt tctcagtcat gcatctgtgt ggctgttccg aggggacttt
      781 gtgtttgact acccgaggcc catcatgcct aatatggtct tcattggagg cataaactgt
      841 gtcatcaaga agcccctctc tcaggaattt gaagcctatg tcaacgcctc cggagaacat
      901 ggcatcgtgg ttttctcttt gggatccatg gtctcagaga ttccagagaa gaaagcgatg
      961 gaaattgctg aggctttggg cagaattcct cagacggtcc tgtggcgcta caccggaact
     1021 agaccatcga accttgcaaa gaacactatt cttgtcaaat ggctacccca aaacgatctg
     1081 cttggtcatc caaaggctcg ggcgttcatc acacactccg gttcccatgg tatttatgaa
     1141 ggaatatgca atggggttcc aatggtgatg atgcccttgt ttggtgatca gatggacaac
     1201 gccaagcgca tggaaactcg gggagctggg gtgaccctga atgtcctgga aatgactgcc
     1261 gatgatttgg aaaacgccct taaaactgtc atcaataaca agagttacaa ggagaacatc
     1321 atgcgcctct ccagccttca caaggaccgt cctatcgagc ctctggacct ggctgtgttc
     1381 tgggtggagt acgtgatgag gcacaagggg gcgccacacc tgcgccccgc cgcccacgac
     1441 ctcacctggt accagtacca ctccttggac gtgattggct ttctcctggc catcgtgttg
     1501 acggtggtct tcattgtcta taaaagttgt gcctatggct gccggaaatg ctttggggga
     1561 aagggtcgag tgaagaaatc acacaaatcc aagacccact gagaagtggc aggaagtgaa
     1621 ggagaagtat tagtccctta tccaatcagt tgaaacttgg aaacaagtgt taaatccatg
     1681 ttgcttttat tagggaaata attcaccata cactatacac ccagaacaat tttttttctt
     1741 tttctttttt tcggagctgg ggaccgaacc cagaacattt ttttttttaa ataaaaacaa
     1801 tctaattgct ggccacaccc atcagggaag atactggaat atgtgatctg tttctccagt
     1861 atcttcagtc tggacaatga ctgccatctg ttggtaactt acagaaagtt tagtgttctg
     1921 ccttcagtga cagcaccaca gtttccctta ctcctgtcag ctaatggctt cctcccctgg
     1981 attctcagac cagtgtggcc ttcccagtgt tagtcattcc tcactgtgct catgttttgt
     2041 gggtggcacg gcctttgagc tttgggagaa aagaagatga ggctgtgaca ctggtggccc
     2101 tgtgtttgag ataataatta ttgcttgtct ctgaatttga tgaaaactga agtacattct
     2161 aaagaaagta tgtcttctat tgtgttccca aaccaagaac ttgtcaataa attcatataa
     2221 attgtattat tactttt
//
