LOCUS       NP_001019914             508 aa            linear   ROD 26-OCT-2024
DEFINITION  UTP--glucose-1-phosphate uridylyltransferase isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001019914 XP_214108
VERSION     NP_001019914.1
DBSOURCE    REFSEQ: accession NM_001024743.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 508)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 508)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (residues 1 to 508)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (residues 1 to 508)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (residues 1 to 508)
  AUTHORS   Aw,T.Y. and Jones,D.P.
  TITLE     Control of glucuronidation during hypoxia. Limitation by
            UDP-glucose pyrophosphorylase
  JOURNAL   Biochem J 219 (3), 707-712 (1984)
   PUBMED   6331395
REFERENCE   6  (residues 1 to 508)
  AUTHORS   Guynn,R.W., Veloso,D., Lawson,J.W. and Veech,R.L.
  TITLE     The concentration and control of cytoplasmic free inorganic
            pyrophosphate in rat liver in vivo
  JOURNAL   Biochem J 140 (3), 369-375 (1974)
   PUBMED   4374936
REFERENCE   7  (residues 1 to 508)
  AUTHORS   Knop,J.K. and Hansen,R.G.
  TITLE     Uridine diphosphate glucose pyrophosphorylase. IV. Crystallization
            and properties of the enzyme from human liver
  JOURNAL   J Biol Chem 245 (10), 2499-2504 (1970)
   PUBMED   5427280
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jun 10, 2005 this sequence version replaced XP_214108.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097369.1, SRR26643292.52937.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     Protein         1..508
                     /product="UTP--glucose-1-phosphate uridylyltransferase
                     isoform 1"
                     /EC_number="2.7.7.9"
                     /note="UTP--glucose-1-phosphate uridylyltransferase"
                     /calculated_mol_wt=56892
     Region          55..473
                     /region_name="UDPGP"
                     /note="UTP--glucose-1-phosphate uridylyltransferase;
                     pfam01704"
                     /db_xref="CDD:460300"
     CDS             1..508
                     /gene="Ugp2"
                     /coded_by="NM_001024743.2:277..1803"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:289827"
                     /db_xref="RGD:1310210"
ORIGIN      
        1 msrfvqdlsk amsqdgasqf qevilqelel svkkelekil ttatshefeh tkkdldgfrk
       61 lfhrflqekg psvdwgkiqr ppedsiqpye kikarglpdn issvlnklvv vklngglgts
      121 mgckgpksli gvrnentfld ltvqqiehln ktyntdvplv lmnsfntded tkkilqkynh
      181 crvkiytfnq sryprinkes llpiakdvsy sgenteawyp pghgdiyasf ynsglldtfi
      241 eegkeyifvs nidnlgatvd lyilnhlmnp pngkrcefvm evtnktradv kggtltqyeg
      301 klrlveiaqv pkahvdefks vskfkifntn nlwislaavk rlqeqnaidm eiivnpktld
      361 gglnviqlet avgaaiksfe nslginvprs rflpvkttsd lllvmsnlys lnagsltmse
      421 krefptvplv klgssftkvq dylrrfesip dmleldhltv sgdvtfgknv slkgtviiia
      481 nhgdridipp gavlenkivs gnlrildh
//
