LOCUS       NM_133596               5053 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus UDP-glucose glycoprotein glucosyltransferase 1
            (Uggt1), mRNA.
ACCESSION   NM_133596
VERSION     NM_133596.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5053)
  AUTHORS   Cloutier,P., Lavallee-Adam,M., Faubert,D., Blanchette,M. and
            Coulombe,B.
  TITLE     A newly uncovered group of distantly related lysine
            methyltransferases preferentially interact with molecular
            chaperones to regulate their activity
  JOURNAL   PLoS Genet 9 (1), e1003210 (2013)
   PUBMED   23349634
REFERENCE   2  (bases 1 to 5053)
  AUTHORS   Totani,K., Ihara,Y., Tsujimoto,T., Matsuo,I. and Ito,Y.
  TITLE     The recognition motif of the glycoprotein-folding sensor enzyme
            UDP-Glc:glycoprotein glucosyltransferase
  JOURNAL   Biochemistry 48 (13), 2933-2940 (2009)
   PUBMED   19222173
  REMARK    GeneRIF: UGGT recognizes the hydrophobic region of client
            glycoproteins.
REFERENCE   3  (bases 1 to 5053)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 5053)
  AUTHORS   Ritter,C., Quirin,K., Kowarik,M. and Helenius,A.
  TITLE     Minor folding defects trigger local modification of glycoproteins
            by the ER folding sensor GT
  JOURNAL   EMBO J 24 (9), 1730-1738 (2005)
   PUBMED   15861139
REFERENCE   5  (bases 1 to 5053)
  AUTHORS   Taylor,S.C., Ferguson,A.D., Bergeron,J.J. and Thomas,D.Y.
  TITLE     The ER protein folding sensor UDP-glucose
            glycoprotein-glucosyltransferase modifies substrates distant to
            local changes in glycoprotein conformation
  JOURNAL   Nat Struct Mol Biol 11 (2), 128-134 (2004)
   PUBMED   14730348
REFERENCE   6  (bases 1 to 5053)
  AUTHORS   Zuber,C., Fan,J.Y., Guhl,B., Parodi,A., Fessler,J.H., Parker,C. and
            Roth,J.
  TITLE     Immunolocalization of UDP-glucose:glycoprotein glucosyltransferase
            indicates involvement of pre-Golgi intermediates in protein quality
            control
  JOURNAL   Proc Natl Acad Sci U S A 98 (19), 10710-10715 (2001)
   PUBMED   11535823
REFERENCE   7  (bases 1 to 5053)
  AUTHORS   Korotkov,K.V., Kumaraswamy,E., Zhou,Y., Hatfield,D.L. and
            Gladyshev,V.N.
  TITLE     Association between the 15-kDa selenoprotein and
            UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic
            reticulum of mammalian cells
  JOURNAL   J Biol Chem 276 (18), 15330-15336 (2001)
   PUBMED   11278576
REFERENCE   8  (bases 1 to 5053)
  AUTHORS   Tessier,D.C., Dignard,D., Zapun,A., Radominska-Pandya,A.,
            Parodi,A.J., Bergeron,J.J. and Thomas,D.Y.
  TITLE     Cloning and characterization of mammalian UDP-glucose glycoprotein:
            glucosyltransferase and the development of a specific substrate for
            this enzyme
  JOURNAL   Glycobiology 10 (4), 403-412 (2000)
   PUBMED   10764828
REFERENCE   9  (bases 1 to 5053)
  AUTHORS   Arnold,S.M., Fessler,L.I., Fessler,J.H. and Kaufman,R.J.
  TITLE     Two homologues encoding human UDP-glucose:glycoprotein
            glucosyltransferase differ in mRNA expression and enzymatic
            activity
  JOURNAL   Biochemistry 39 (9), 2149-2163 (2000)
   PUBMED   10694380
REFERENCE   10 (bases 1 to 5053)
  AUTHORS   Trombetta,S.E. and Parodi,A.J.
  TITLE     Purification to apparent homogeneity and partial characterization
            of rat liver UDP-glucose:glycoprotein glucosyltransferase
  JOURNAL   J Biol Chem 267 (13), 9236-9240 (1992)
   PUBMED   1533626
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133596.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF200359.1, SRR26643429.33401.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                JAXUCZ010000009.1  45964118-45964140   c
            24-159              JAXUCZ010000009.1  45955510-45955645   c
            160-242             JAXUCZ010000009.1  45950554-45950636   c
            243-373             JAXUCZ010000009.1  45947622-45947752   c
            374-486             JAXUCZ010000009.1  45941851-45941963   c
            487-661             JAXUCZ010000009.1  45939083-45939257   c
            662-758             JAXUCZ010000009.1  45933337-45933433   c
            759-837             JAXUCZ010000009.1  45932080-45932158   c
            838-938             JAXUCZ010000009.1  45929337-45929437   c
            939-1038            JAXUCZ010000009.1  45924755-45924854   c
            1039-1099           JAXUCZ010000009.1  45923732-45923792   c
            1100-1191           JAXUCZ010000009.1  45919894-45919985   c
            1192-1342           JAXUCZ010000009.1  45918610-45918760   c
            1343-1462           JAXUCZ010000009.1  45915202-45915321   c
            1463-1548           JAXUCZ010000009.1  45911268-45911353   c
            1549-1684           JAXUCZ010000009.1  45901925-45902060   c
            1685-1816           JAXUCZ010000009.1  45899987-45900118   c
            1817-1981           JAXUCZ010000009.1  45898175-45898339   c
            1982-2102           JAXUCZ010000009.1  45894003-45894123   c
            2103-2201           JAXUCZ010000009.1  45892440-45892538   c
            2202-2225           JAXUCZ010000009.1  45891623-45891646   c
            2226-2320           JAXUCZ010000009.1  45891063-45891157   c
            2321-2527           JAXUCZ010000009.1  45889786-45889992   c
            2528-2659           JAXUCZ010000009.1  45888970-45889101   c
            2660-2790           JAXUCZ010000009.1  45888300-45888430   c
            2791-2886           JAXUCZ010000009.1  45885015-45885110   c
            2887-2989           JAXUCZ010000009.1  45881069-45881171   c
            2990-3069           JAXUCZ010000009.1  45880084-45880163   c
            3070-3259           JAXUCZ010000009.1  45879081-45879270   c
            3260-3418           JAXUCZ010000009.1  45878360-45878518   c
            3419-3504           JAXUCZ010000009.1  45877806-45877891   c
            3505-3589           JAXUCZ010000009.1  45876403-45876487   c
            3590-3678           JAXUCZ010000009.1  45874721-45874809   c
            3679-3780           JAXUCZ010000009.1  45874240-45874341   c
            3781-3865           JAXUCZ010000009.1  45872948-45873032   c
            3866-4048           JAXUCZ010000009.1  45871413-45871595   c
            4049-4209           JAXUCZ010000009.1  45865437-45865597   c
            4210-4324           JAXUCZ010000009.1  45864162-45864276   c
            4325-4441           JAXUCZ010000009.1  45858003-45858119   c
            4442-4595           JAXUCZ010000009.1  45857457-45857610   c
            4596-5053           JAXUCZ010000009.1  45854985-45855442   c
FEATURES             Location/Qualifiers
     source          1..5053
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q21"
     gene            1..5053
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /note="UDP-glucose glycoprotein glucosyltransferase 1"
                     /db_xref="GeneID:171129"
                     /db_xref="RGD:619710"
     exon            1..23
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            24..159
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..4621
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /note="RUGT; UDP--Glc:glycoprotein glucosyltransferase;
                     UDP-glucose ceramide glucosyltransferase-like 1;
                     UDP-glucose glycoprotein: glucosyltransferase UGGT"
                     /codon_start=1
                     /product="UDP-glucose:glycoprotein glucosyltransferase 1
                     precursor"
                     /protein_id="NP_598280.1"
                     /db_xref="GeneID:171129"
                     /db_xref="RGD:619710"
                     /translation="MGLLIALALLCLFSLAEANSKAITTSLTTKWFSAPLLLEASEFL
                     AEDSQEKFWSFVEASQNIGSSDQHDTDRSYYDAILEAAFRFLSPLQQNLLKFCLSLRS
                     YSASIQAFQQIAVDEPPPEGCKSFLSVHGKQTCDLGTLESLLLTAPDRPKPLLFKGDH
                     RYPSSNPESPVVIFYSEIGHEEFSNIHHQLISKSNEGKINYVFRHYISNPRKEPVHLS
                     GYGVELAIKSTEYKAKDDTQVKGTEVNTTVIGENDPIDEVQGFLFGKLRELYPSLEGQ
                     LKEFRKHLVESTNEMAPLKVWQLQDLSFQTAARILAAPVELALVVMKDISQNFPTKAR
                     AITKTAVSAQLRAEVEENQKYFKGTIGLQPGDSALFINGLHIDLDTQDIFSLFDTLRN
                     EARVMEGLHRLGIEGLSLHNILKLNIQPSETDYAVDIRSPAISWVNNLEVDSRYNSWP
                     SSLQELLRPTFPGVIRQIRKNLHNMVFIVDPVHETTAELVSIAEMFLSNHIPLRIGFI
                     FVVNDSEDVDGMQDAGVAVLRAYNYVGQEVDGYHAFQTLTQIYNKVRTGEKVKVEHVV
                     SVLEKKYPYVEVNSILGIDSAYDQNRKEARGYYEQTGVGPLPVVLFNGMPFEKEQLDP
                     DELETITMHKILETTTFFQRAVYLGELSHDQDVVEYIMNQPNVVPRINSRILTAKREY
                     LDLTASNNFYVDDFARFSALDSRGKTAAIANSMNYLTKKGMSSKEIYDDSFIRPVTFW
                     IVGDFDSPSGRQLLYDAIKHQKTSNNVRISMINNPSREISDSSTPVSRAIWAALQTQT
                     SNSAKNFITKMVKEETAEALAAGVDIGEFSVGGMDVSLFKEVFESSRMDFILSHALYC
                     RDVLKLKKGQRVVISNGRIIGPLEDSELFNQDDFHLLENIILKTSGQKIKSHIQQLRV
                     EEDVASDLVMKVDALLSAQPKGEARIEYQFFEDKHSAIKLKPKEGETYYDVVAVVDPV
                     TREAQRLAPLLLVLAQLINMSLRVFMNCQSKLSDMPLKSFYRYVLEPEISFTADNSFA
                     KGPIAKFLDMPQSPLFTLNLNTPESWMVESVRTPYDLDNIYLEEVDSIVAAEYELEYL
                     LLEGHCYDITTGQPPRGLQFTLGTSANPTTVDTIVMANLGYFQLKANPGAWILRLRKG
                     RSDDIYRIYSHDGTDSPPDANDVVVILNNFKSKIIKVKVQKKADMANEDLLSDGTNEN
                     ESGFWDSFKWGFSGQKTEEVKQDKDDIINIFSVASGHLYERFLRIMMLSVLKNTKTPV
                     KFWFLKNYLSPTFKEFIPYMAKKYNFQYELVQYKWPRWLHQQTEKQRIIWGYKILFLD
                     VLFPLVVDKFLFVDADQIVRTDLKELRDFNLDGAPYGYTPFCDSRREMDGYRFWKSGY
                     WASHLAGRKYHISALYVVDLKKFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMI
                     HQVPIKSLPQEWLWCETWCDDASKKRAKTIDLCNNPMTKEPKLEAAVRIVPEWQDYDQ
                     EIKQLQTLFQEEKELGTLHEEETQEGSQKHEEL"
     exon            160..242
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            243..373
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..486
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..661
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..758
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            759..837
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            838..938
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1038
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1099
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1191
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1342
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1462
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1548
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1684
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1816
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1981
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2102
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2201
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2225
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2320
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2527
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2659
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2790
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2886
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..2989
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3069
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3070..3259
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3260..3418
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3504
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3589
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3590..3678
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3780
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3781..3865
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            3866..4048
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4049..4209
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..4324
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4325..4441
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4442..4595
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            4596..5053
                     /gene="Uggt1"
                     /gene_synonym="rUGT1; Ugcgl1; Uggt; UGT1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggctgcg cggcgggtga cagggctctg ttacaacatg ggactcctga ttgcactggc
       61 cttactgtgc ctgttttcct tagcagaagc caattcaaaa gccattacca cctctctcac
      121 cactaagtgg ttttctgctc cactgctgct agaagccagt gagttcctag cagaagacag
      181 tcaagagaaa ttttggagtt ttgtagaagc cagtcaaaac attggatcat cagatcaaca
      241 tgataccgac cgttcctatt atgatgccat attggaagct gcgtttcggt tcctgtcacc
      301 tctgcagcag aatttgttga agttttgtct ctctctccgt tcctactcag cctcaattca
      361 agccttccag cagatagcag tcgacgagcc tccaccagaa ggatgcaagt catttctctc
      421 agtgcatgga aagcagactt gtgatctggg cactcttgag agccttctgc tgactgcacc
      481 tgacagacct aaacctttat tgttcaaagg agatcacaga tatccctcat caaatcctga
      541 aagtccagtg gtcatttttt attctgagat tggccatgaa gaattttcta atattcacca
      601 ccaacttata tcaaaaagca atgaaggaaa aattaattat gtgttcagac attatatatc
      661 taatcccagg aaggagccgg tccacctttc tggctatggt gtagaattgg ccattaagag
      721 cacggagtac aaggccaagg atgatactca ggtgaaaggg accgaggtaa acaccacagt
      781 cattggggag aacgatccta ttgatgaagt tcaggggttc ctctttggaa aattaagaga
      841 actgtacccc agcttggaag gacagttgaa agagttccgg aagcatctcg tggagagcac
      901 caatgaaatg gcccccttga aagtctggca gctgcaagac ctcagtttcc agactgctgc
      961 ccgcatcttg gctgctcctg tggagttagc tctggtggtg atgaaggaca ttagtcagaa
     1021 ctttcctacc aaagccagag caataacaaa aacagctgtg agcgcacagc ttagagcgga
     1081 agtggaagag aaccagaagt atttcaaggg aactatagga ttacagcctg gagactcagc
     1141 tctcttcatc aacggacttc atattgattt agacacccag gatatcttca gtctgtttga
     1201 tactctgaga aatgaagccc gggtaatgga gggtctacat agactaggaa tagaaggcct
     1261 ttctctacat aatattttga agctcaacat ccagccgtct gagactgact acgcagtaga
     1321 catcaggagt cctgctattt cctgggtcaa caacctagag gttgatagcc gatataactc
     1381 atggccttca agtttacaag agttacttcg ccccacgttt cctggcgtta tacggcagat
     1441 cagaaagaac ctacataaca tggttttcat tgttgatcct gttcatgaga ccacggcaga
     1501 gctggttagc atagccgaga tgttcctcag caatcatata ccactaagga ttggttttat
     1561 ctttgtggtc aatgattctg aagatgttga tgggatgcaa gatgctggag tcgctgttct
     1621 gagagcatat aattatgtgg gtcaggaagt ggatggctac catgccttcc agactctcac
     1681 ccagatctac aacaaagtga ggactggaga aaaggtgaaa gttgagcatg tggtcagtgt
     1741 cttggagaag aagtacccgt atgttgaagt gaatagcatt ctggggattg attctgctta
     1801 tgatcagaat cggaaggaag ccagaggcta ctatgagcag actggtgtag gccccttgcc
     1861 tgttgtcttg ttcaatggga tgccctttga aaaggagcag ttagaccccg acgagctgga
     1921 aaccatcaca atgcacaaga tcttggagac gaccaccttc ttccaaagag ccgtgtattt
     1981 gggtgaactg tcacatgatc aagacgtggt agagtacatc atgaatcagc cgaatgttgt
     2041 tccaagaatc aactctagga ttttgacagc taagcgagag tatctggatc taacagcaag
     2101 caataatttt tatgtggatg actttgccag attttctgcc ttggactctc ggggcaagac
     2161 tgctgctatt gccaacagta tgaactatct gacaaaaaaa ggaatgtcct ccaaggaaat
     2221 ctatgatgat tcctttatta ggccagtgac tttttggatt gttggagatt ttgatagccc
     2281 ttctgggcgg cagttattat atgacgccat taaacatcag aaaaccagta acaatgttag
     2341 gataagtatg atcaataacc ccagccgaga gataagtgac tcaagcaccc ccgtctccag
     2401 agccatctgg gcagctctcc agacacagac ctccaactct gctaagaact tcatcaccaa
     2461 gatggtcaaa gaggagacgg cagaggccct ggccgcagga gtggacattg gggaattctc
     2521 tgtcgggggc atggatgtca gtctttttaa agaggtcttt gagtcttcca gaatggattt
     2581 cattttgtct catgccctgt actgcaggga tgttctgaaa ctgaagaagg gacagagagt
     2641 ggtgatcagc aacggaagga tcattgggcc actggaggac agtgagctct tcaaccaaga
     2701 tgatttccac ctcctggaaa atatcattct gaaaacatcg ggacagaaaa tcaagtctca
     2761 tatccaacag cttcgcgtag aagaagatgt ggccagtgat ttggtaatga aggtggatgc
     2821 tctcctgtca gcgcaaccca aaggagaggc gaggatcgag taccagttct ttgaagataa
     2881 gcacagtgca attaaactga agcccaaaga aggggagaca tactatgatg tggtagctgt
     2941 tgtcgaccct gtcacaagag aagcacagag gctcgccccc ttgctcttgg ttttggctca
     3001 gctgataaac atgagtctga gagtattcat gaattgccaa tccaagcttt ccgacatgcc
     3061 tttaaaaagc ttttaccgtt atgtcttaga gccggagatt tctttcactg cagacaacag
     3121 ctttgccaag ggaccaatag caaagtttct ggatatgcct cagtctccgc tgtttacttt
     3181 gaatttgaac acacccgaga gttggatggt agaatctgtc agaacaccct atgatcttga
     3241 taatatttac ctagaagagg tggacagtat agtggctgct gagtatgagc tggagtatct
     3301 gttactggaa ggtcattgtt acgacatcac cacaggccag ccccctcgag gactgcagtt
     3361 cacgttagga acttcagcca acccaacaac tgtggacaca atcgtgatgg ccaatctggg
     3421 atattttcag ctcaaagcca acccaggagc ctggattctg agactgagga aggggcgctc
     3481 ggatgacatt tataggatct acagccatga cggaacagat tcccctcctg atgcaaatga
     3541 cgttgttgtc atcctcaata acttcaagag caagatcatc aaagtgaagg ttcagaagaa
     3601 ggccgacatg gctaatgaag acttgctgag cgacgggacg aatgagaatg agtctggatt
     3661 ctgggactca ttcaagtggg gcttctcagg acagaagact gaggaagtaa agcaagataa
     3721 ggacgacata atcaatattt tctctgttgc atctggtcat ctctacgaaa ggtttcttcg
     3781 catcatgatg ctatcagtcc tgaagaatac caaaactcct gtgaaattct ggttcttgaa
     3841 gaattatttg tcccccacat ttaaggagtt tataccttac atggccaaaa aatacaattt
     3901 ccagtatgag cttgttcagt acaaatggcc acggtggctt caccagcaga ccgagaagca
     3961 gcgaattatc tggggctaca agatcctctt cctggatgtg cttttcccgt tggttgttga
     4021 caaattcctc tttgtggatg ctgatcagat tgtgcggaca gatctgaagg agttaagaga
     4081 tttcaatttg gatggtgcac cttacggtta cacgcccttc tgcgacagca ggagagagat
     4141 ggatggctac cgcttctgga agtcaggcta ctgggccagt catttggctg gacgaaagta
     4201 tcacatcagt gcgctgtatg tcgtggatct gaagaagttt aggaaaatag ctgctggtga
     4261 cagactcaga ggacagtacc aaggtctgag tcaggatccc aacagtcttt caaatcttga
     4321 tcaagatttg cccaataaca tgatccatca ggtgccaatc aaatcgctcc ctcaggagtg
     4381 gctttggtgt gagacgtggt gtgatgatgc ctctaagaag cgggccaaga ccatcgacct
     4441 gtgtaataat cccatgacta aggagcccaa actggaggct gctgtgcgga tcgtccctga
     4501 gtggcaagac tacgaccagg agatcaagca gttgcagacc ctcttccaag aggagaaaga
     4561 gttggggacc ctgcatgaag aggagacaca ggaaggatct cagaagcatg aagaattatg
     4621 atctctggag gaagataggg gacccacgtc tgacagtttt gtactaaatg ctgttttttt
     4681 ctgatctgtt gaaacaactg ctgatgaact gactgattgg gcaggtgtat cacacctatt
     4741 gatctgagca tttgattaga ctactgcacc ctagtgggtg ctagatcctt ggggctaagg
     4801 ctctgttgga tttgtacctc agaggaagac aagtgaccga tcttctggga ctctcttctc
     4861 gccagaggga actgaaagaa gcccagtcct tcggtgccca catcccagag cacacattgt
     4921 tgtgctggtc caggagctgg ccagaaaggt caccatgctc ttccttacct cagtttacct
     4981 gcagccctcg ctgcagtgca gatgcccacc ctgtaccagg tcaggccggc agatgcttca
     5041 tccatgcctc gag
//
