LOCUS       NM_001126080            2151 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ubiquitin-fold modifier 1 (Ufm1), mRNA.
ACCESSION   NM_001126080 XM_001057949 XM_001073765
VERSION     NM_001126080.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2151)
  AUTHORS   Nahorski,M.S., Maddirevula,S., Ishimura,R., Alsahli,S., Brady,A.F.,
            Begemann,A., Mizushima,T., Guzman-Vega,F.J., Obata,M., Ichimura,Y.,
            Alsaif,H.S., Anazi,S., Ibrahim,N., Abdulwahab,F., Hashem,M.,
            Monies,D., Abouelhoda,M., Meyer,B.F., Alfadhel,M., Eyaid,W.,
            Zweier,M., Steindl,K., Rauch,A., Arold,S.T., Woods,C.G., Komatsu,M.
            and Alkuraya,F.S.
  TITLE     Biallelic UFM1 and UFC1 mutations expand the essential role of
            ufmylation in brain development
  JOURNAL   Brain 141 (7), 1934-1945 (2018)
   PUBMED   29868776
REFERENCE   2  (bases 1 to 2151)
  AUTHORS   Li,Y.Y., Zhang,G.Y., He,J.P., Zhang,D.D., Kong,X.X., Yuan,H.M. and
            Chen,F.L.
  TITLE     Ufm1 inhibits LPS-induced endothelial cell inflammatory responses
            through the NF-kappaB signaling pathway
  JOURNAL   Int J Mol Med 39 (5), 1119-1126 (2017)
   PUBMED   28393202
REFERENCE   3  (bases 1 to 2151)
  AUTHORS   Yoo,H.M., Kang,S.H., Kim,J.Y., Lee,J.E., Seong,M.W., Lee,S.W.,
            Ka,S.H., Sou,Y.S., Komatsu,M., Tanaka,K., Lee,S.T., Noh,D.Y.,
            Baek,S.H., Jeon,Y.J. and Chung,C.H.
  TITLE     Modification of ASC1 by UFM1 is crucial for ERalpha transactivation
            and breast cancer development
  JOURNAL   Mol Cell 56 (2), 261-274 (2014)
   PUBMED   25219498
REFERENCE   4  (bases 1 to 2151)
  AUTHORS   Zhang,Y., Zhang,M., Wu,J., Lei,G. and Li,H.
  TITLE     Transcriptional regulation of the Ufm1 conjugation system in
            response to disturbance of the endoplasmic reticulum homeostasis
            and inhibition of vesicle trafficking
  JOURNAL   PLoS One 7 (11), e48587 (2012)
   PUBMED   23152784
REFERENCE   5  (bases 1 to 2151)
  AUTHORS   Lemaire,K., Moura,R.F., Granvik,M., Igoillo-Esteve,M.,
            Hohmeier,H.E., Hendrickx,N., Newgard,C.B., Waelkens,E., Cnop,M. and
            Schuit,F.
  TITLE     Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect
            pancreatic beta cells from ER stress-induced apoptosis
  JOURNAL   PLoS One 6 (4), e18517 (2011)
   PUBMED   21494687
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2151)
  AUTHORS   Tatsumi,K., Sou,Y.S., Tada,N., Nakamura,E., Iemura,S., Natsume,T.,
            Kang,S.H., Chung,C.H., Kasahara,M., Kominami,E., Yamamoto,M.,
            Tanaka,K. and Komatsu,M.
  TITLE     A novel type of E3 ligase for the Ufm1 conjugation system
  JOURNAL   J Biol Chem 285 (8), 5417-5427 (2010)
   PUBMED   20018847
REFERENCE   7  (bases 1 to 2151)
  AUTHORS   Komatsu,M., Chiba,T., Tatsumi,K., Iemura,S., Tanida,I., Okazaki,N.,
            Ueno,T., Kominami,E., Natsume,T. and Tanaka,K.
  TITLE     A novel protein-conjugating system for Ufm1, a ubiquitin-fold
            modifier
  JOURNAL   EMBO J 23 (9), 1977-1986 (2004)
   PUBMED   15071506
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB787557.1, CV112030.1, FM099369.1, FM094134.1, BP500691.1 and
            BQ780192.1.
            
            On Nov 25, 2010 this sequence version replaced NM_001126080.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB787557.1, FQ229705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN06680423
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-372               CB787557.1         39-410
            373-769             CV112030.1         263-659
            770-1031            FM099369.1         332-593
            1032-1186           FM094134.1         173-327
            1187-1791           BP500691.1         36-640
            1792-2151           BQ780192.1         1-360               c
FEATURES             Location/Qualifiers
     source          1..2151
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..2151
                     /gene="Ufm1"
                     /gene_synonym="RGD1304890"
                     /note="ubiquitin-fold modifier 1"
                     /db_xref="GeneID:365797"
                     /db_xref="RGD:1304890"
     exon            1..86
                     /gene="Ufm1"
                     /gene_synonym="RGD1304890"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..342
                     /gene="Ufm1"
                     /gene_synonym="RGD1304890"
                     /codon_start=1
                     /product="ubiquitin-fold modifier 1"
                     /protein_id="NP_001119552.1"
                     /db_xref="GeneID:365797"
                     /db_xref="RGD:1304890"
                     /translation="MSKVSFKITLTSDPRLPYKVLSVPESTPFTAVLKFAAEEFKVPA
                     ATSAIITNDGIGINPAQTAGNVFLKHGSELRLIPRDRVGSC"
     exon            87..143
                     /gene="Ufm1"
                     /gene_synonym="RGD1304890"
                     /inference="alignment:Splign:2.1.0"
     exon            144..201
                     /gene="Ufm1"
                     /gene_synonym="RGD1304890"
                     /inference="alignment:Splign:2.1.0"
     exon            202..241
                     /gene="Ufm1"
                     /gene_synonym="RGD1304890"
                     /inference="alignment:Splign:2.1.0"
     exon            242..274
                     /gene="Ufm1"
                     /gene_synonym="RGD1304890"
                     /inference="alignment:Splign:2.1.0"
     exon            275..2136
                     /gene="Ufm1"
                     /gene_synonym="RGD1304890"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggccgcg aaggacccca ctgcctgcca tcaaggaagc taggcgggcg gctgttcgcg
       61 gtttgagtac caggcggttc caccatgtcg aaggtgtcct ttaaaatcac gctgacgtcg
      121 gacccgcggc taccgtacaa agtcctcagc gttcctgaaa gcacaccttt cacagctgtg
      181 ctaaagtttg cagcagaaga gtttaaagtt cctgctgcta caagtgcgat tattactaat
      241 gatggaatag gaattaatcc tgcacagact gctggaaacg tttttctgaa gcacggctca
      301 gagctgcggc tcattcctcg agaccgagtt gggagctgct aatgtatgct tcttggaatg
      361 cacagcctct cagaatgaac actgggattt gttgttgctg tacaattgaa atcaggcatt
      421 cacagcacaa tggaagcacc gagaatcagc ggaacaggga accttgacgc ttgtcccttc
      481 ctgttcattt tttcatggga agagagaatg cctttgagtg gagggtacca caccacaggt
      541 cacaccgtgg tgactgctgc ctcaccagaa gagagtacct ctgtgacaaa tggactgtgc
      601 tttaaaacaa aaacagcaaa actggaggat aagtctgcta attcttttca ggagcatttg
      661 gaaaaattaa aattcacaga atcatatgta tcttctaatt ttgaaattta aaaggataat
      721 tgatcataga agcatttggc ttgacagcat ctcttagtta gacttttaaa ttatataatt
      781 tgtgatgaac ttaataggta tttgaatgaa cagttaaatt tatataaaac caaacattga
      841 attatggaat ctaaccattg taagttgctg ttgtgcatcg aatagcttca acaataatga
      901 ccctgtgaaa tcaagtgtca tggtgggagc tgacagtacc acaggagcac ccttagctat
      961 attatgaatt ccttgataaa gaataaagct ttaagacaga agtccttaaa ccattatttt
     1021 tgaagatttt atttttgagc agcatccaaa agtattgttg cagagatgat ctgaagtgtt
     1081 gatggggtgt cccttaatga agaggaaact ttaaagaagc tgttagcatt agtgacacgt
     1141 ggataaagaa ccagggaagc aaagccaggc ttttgccaga gagcagagga agtgaggggg
     1201 agcaggaggc tggcagtatc caaagtcagg atggagctgt ggcaggggtg gaaacgtgtg
     1261 aaagggagaa gactgggcac agggtcagaa ggcaattgca ttacacatca aaactcaggg
     1321 gagcaatcta caaggatggt gaaagggggc ttggtagggc tgacagcctg agttcaagtg
     1381 ccagagtgaa ggagattacc aactccccag agtcatcctc tgacctcatg cagacaccca
     1441 gatgtgagcc aatcccctcc cacgataact atttgccttt acacaggaag tccacagctg
     1501 gcacatgttt caagatggat caaatgctga ctgagggaga actaggcagc tctgctttag
     1561 taggggaact ctttggaggt gaggggtctc cctagaggta gaagtacaag ttctcaataa
     1621 atactaagtt cattgataat gtcttcagga ccagttttta tcttgtgtct catattcctt
     1681 atcatggggc tgtcttagta ggaaggaatt gtccttatct acaggtttgc aggttctggg
     1741 gttctgaatt atgtagcaat acgcagctca tgtttacttg ggtttttatg gttatgtcca
     1801 gtgcctggag accttattcc ttatattagg cctctgctaa ccggacattt aaaaatattt
     1861 gccacctaat tctgcttcta ttaaatttct tccattctgc ctttagcaca aaattctgct
     1921 tgtcagtact gtttatacag acttacagta tgaaatgatt tacctaacaa accagttctt
     1981 taatttgaaa atacatagtc ttgaaaatat tttactcaaa aactaggtaa tttgttatta
     2041 aatgtgatct gtaagttcag aacattttag gcattgtatt taattttaat gtctataatt
     2101 aatacctcag gaaaatacat tttgttatac cgtaaaaaaa aaaaaaaaaa a
//
