LOCUS       NM_001126279            2766 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus Ufm1-specific ligase 1 (Ufl1), mRNA.
ACCESSION   NM_001126279 XM_001061009 XM_232850
VERSION     NM_001126279.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2766)
  AUTHORS   Qin,B., Yu,J., Nowsheen,S., Wang,M., Tu,X., Liu,T., Li,H., Wang,L.
            and Lou,Z.
  TITLE     UFL1 promotes histone H4 ufmylation and ATM activation
  JOURNAL   Nat Commun 10 (1), 1242 (2019)
   PUBMED   30886146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2766)
  AUTHORS   Yoo,H.M., Kang,S.H., Kim,J.Y., Lee,J.E., Seong,M.W., Lee,S.W.,
            Ka,S.H., Sou,Y.S., Komatsu,M., Tanaka,K., Lee,S.T., Noh,D.Y.,
            Baek,S.H., Jeon,Y.J. and Chung,C.H.
  TITLE     Modification of ASC1 by UFM1 is crucial for ERalpha transactivation
            and breast cancer development
  JOURNAL   Mol Cell 56 (2), 261-274 (2014)
   PUBMED   25219498
REFERENCE   3  (bases 1 to 2766)
  AUTHORS   Zhang,Y., Zhang,M., Wu,J., Lei,G. and Li,H.
  TITLE     Transcriptional regulation of the Ufm1 conjugation system in
            response to disturbance of the endoplasmic reticulum homeostasis
            and inhibition of vesicle trafficking
  JOURNAL   PLoS One 7 (11), e48587 (2012)
   PUBMED   23152784
REFERENCE   4  (bases 1 to 2766)
  AUTHORS   Lemaire,K., Moura,R.F., Granvik,M., Igoillo-Esteve,M.,
            Hohmeier,H.E., Hendrickx,N., Newgard,C.B., Waelkens,E., Cnop,M. and
            Schuit,F.
  TITLE     Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect
            pancreatic beta cells from ER stress-induced apoptosis
  JOURNAL   PLoS One 6 (4), e18517 (2011)
   PUBMED   21494687
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2766)
  AUTHORS   Shiwaku,H., Yoshimura,N., Tamura,T., Sone,M., Ogishima,S.,
            Watase,K., Tagawa,K. and Okazawa,H.
  TITLE     Suppression of the novel ER protein Maxer by mutant ataxin-1 in
            Bergman glia contributes to non-cell-autonomous toxicity
  JOURNAL   EMBO J 29 (14), 2446-2460 (2010)
   PUBMED   20531390
REFERENCE   6  (bases 1 to 2766)
  AUTHORS   Wu,J., Lei,G., Mei,M., Tang,Y. and Li,H.
  TITLE     A novel C53/LZAP-interacting protein regulates stability of
            C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and
            modulates NF-kappaB signaling
  JOURNAL   J Biol Chem 285 (20), 15126-15136 (2010)
   PUBMED   20228063
REFERENCE   7  (bases 1 to 2766)
  AUTHORS   Kwon,J., Cho,H.J., Han,S.H., No,J.G., Kwon,J.Y. and Kim,H.
  TITLE     A novel LZAP-binding protein, NLBP, inhibits cell invasion
  JOURNAL   J Biol Chem 285 (16), 12232-12240 (2010)
   PUBMED   20164180
REFERENCE   8  (bases 1 to 2766)
  AUTHORS   Tatsumi,K., Sou,Y.S., Tada,N., Nakamura,E., Iemura,S., Natsume,T.,
            Kang,S.H., Chung,C.H., Kasahara,M., Kominami,E., Yamamoto,M.,
            Tanaka,K. and Komatsu,M.
  TITLE     A novel type of E3 ligase for the Ufm1 conjugation system
  JOURNAL   J Biol Chem 285 (8), 5417-5427 (2010)
   PUBMED   20018847
REFERENCE   9  (bases 1 to 2766)
  AUTHORS   Foster,L.J., Zeemann,P.A., Li,C., Mann,M., Jensen,O.N. and
            Kassem,M.
  TITLE     Differential expression profiling of membrane proteins by
            quantitative proteomics in a human mesenchymal stem cell line
            undergoing osteoblast differentiation
  JOURNAL   Stem Cells 23 (9), 1367-1377 (2005)
   PUBMED   16210410
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166498.1.
            
            On or before May 7, 2008 this sequence version replaced
            XM_232850.4, XM_001061009.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166498.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2766
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..2766
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /note="Ufm1-specific ligase 1"
                     /db_xref="GeneID:313115"
                     /db_xref="RGD:1309308"
     exon            1..124
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..2429
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /note="E3 UFM1-protein transferase 1; regulator of
                     C53/LZAP and DDRGK1; multiple alpha-helix protein located
                     at ER"
                     /codon_start=1
                     /product="E3 UFM1-protein ligase 1"
                     /protein_id="NP_001119751.1"
                     /db_xref="GeneID:313115"
                     /db_xref="RGD:1309308"
                     /translation="MADAWEEIRRLAADFQRAQFAESTQRLSERNCIEIVNKLISQKQ
                     LEVVHTLDGKEYITPAQISKEMRDELHVRGGRVNIVDLQQVINVDLTHIENRVGDIIK
                     SEKHVQMVLGQLVDENYLDRLSEEVNDKLQESGQVTVSELCKTYDLPGDFLTQALTQR
                     LGRIINGHLDLDNRGVIFTEAFVARHKARIRGLFSAITRPTAVNSLVSKYGFQEQLLY
                     SVLEELVSTGRLRGTVVGGRQDKAVFVPDIYSRTQSTWVDSFFRQNGYLEFDALSRLG
                     IPDAVNYIKKRYKNTPLLFLKATCVGQGLVDQVEASVEEAISSGTWVDVSPLLPSSLS
                     VEDAAMLLQQVMRPFGKHASATVFSDTVVVSEKFINDCTKLFSERMHQKAEKEMKNNP
                     VHLITEEDLKQISILESVNTNKKDKKDERRKKATEGSGSVRGGGGGNAREYKIKKVKK
                     KGRKDEDSDDESQSSHAGKKKPDITFMFQDEIEGCLRKHIPDAPEEFISELAEHLIKP
                     LNKMYLEVVRSVFMSSTSASGTGRKRTIKDLQEEVSNLYNNIRLFEKGMKYFADDTQT
                     ALTKHLLKTVCTDITNLMFNFLASDLMMAVEDPATITSDMRKKILSKLTEETKVALTK
                     LHNSLNEKSIEDFLSCLDSATEACDIMVKKGDKKRERQILFQHRQALADQLKVTEDPA
                     LILHLTSVLLFQFSTHSMLHAPGRCVPQIIAFLHNKIPEDQHTLLVKYQGLVVKQLVS
                     QNKKSGQGEDPSSDDLDKEQHDVTNTTRKELQELSLSIKDLVLKPRKSSVTEE"
     exon            125..270
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            271..299
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            300..397
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            398..512
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            513..643
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            644..702
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            703..849
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1025
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1205
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1326
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1449
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1567
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1731
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1862
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1943
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2029
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2210
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2740
                     /gene="Ufl1"
                     /gene_synonym="Maxer; RGD1309308"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgacgtg tctgccgttt cccggtgtcg cggagagcgg agcagtgatg gcggacgcct
       61 gggaggagat ccggcgtctg gcggctgact tccagcgggc gcagtttgct gagtccacgc
      121 aaaggctgtc agagcggaac tgcattgaga ttgtgaataa attgatctct cagaaacagc
      181 tggaagtagt tcatacgctt gatgggaagg aatatatcac tccagcccag atcagtaaag
      241 aaatgagaga tgagctacat gtccgaggtg gtcgagtaaa cattgtcgac ttacaacagg
      301 ttattaacgt ggacctgact catattgaaa atagagtcgg cgacattatt aagtcggaga
      361 agcatgtgca gatggtactg ggacagctgg tcgatgagaa ctatctggat cggttatcag
      421 aagaggtgaa tgataaattg caagaaagtg gtcaagtaac cgtctcagag ctgtgtaaaa
      481 cctatgacct tcctggggat tttctgacac aggcattaac tcagcgactt ggccggatta
      541 tcaatggcca tcttgacctt gataacagag gagtgatttt cactgaggcc tttgtggctc
      601 gccataaagc acgcatccgt ggactcttca gtgctattac ccggcctaca gcagtgaact
      661 ctttggtttc aaaatatgga tttcaggaac agctccttta ctctgtgctt gaggaacttg
      721 ttagcactgg ccgcctacga ggcacggtgg ttggcgggcg acaggacaaa gcagtgtttg
      781 tccctgacat ctattccagg acacagagta cttgggtgga ttccttcttc aggcagaacg
      841 gctatctaga atttgacgct ttatccagac ttggaatccc agatgctgtg aactatataa
      901 agaaaaggta taagaatacc ccactcttgt ttttgaaggc aacttgtgtt ggccaagggc
      961 tcgtggacca ggtggaagca tcggtagagg aggccatcag ctcaggaaca tgggttgacg
     1021 tttcgcctct gctgcccagt tctttgtcag ttgaagatgc tgctatgctg cttcagcagg
     1081 tgatgagacc atttggcaag catgcgtcag ccacagtctt tagtgacact gttgtggtca
     1141 gcgagaaatt catcaatgac tgtacaaaac tgttcagcga acgaatgcac caaaaagctg
     1201 aaaaggaaat gaaaaataat cctgtgcatt taatcacaga agaagatctg aaacaaatat
     1261 ccattttaga aagtgttaat acaaataaaa aggataaaaa agatgaacgc aggaagaaag
     1321 caacagaggg ttctggaagt gtaagaggcg gaggaggggg caatgccaga gaatacaaga
     1381 ttaagaaagt caagaagaag ggaagaaaag acgaggacag tgatgatgag tctcagtcat
     1441 cgcatgctgg aaagaagaag ccagacatca ccttcatgtt ccaggatgaa attgaaggtt
     1501 gcttaaggaa acacattcca gatgcccctg aggagtttat ttcagaactt gcagaacact
     1561 taataaagcc tctgaataaa atgtatcttg aggtggtacg ttcagtcttc atgtcgtcaa
     1621 catctgcttc tggaactggc agaaaacgca cgatcaagga cttacaagaa gaggtttcaa
     1681 atctatacaa taatatcaga ttatttgaaa aggggatgaa atattttgca gatgacacac
     1741 agactgctct gaccaagcac ttgctgaaga cagtgtgtac cgatatcact aacctcatgt
     1801 tcaacttcct agcctcagac ttgatgatgg cggtggagga ccctgcaacc attacaagtg
     1861 atatgagaaa aaaaatttta agcaaattga cagaagaaac taaagtagct ctcacaaaac
     1921 tccacaactc cctgaatgaa aaaagcatag aagacttcct ttcttgtctg gattctgcaa
     1981 cagaagcttg tgacattatg gtgaaaaagg gagacaaaaa aagggaaagg caaatccttt
     2041 tccagcatcg gcaggctctg gctgaccagc tgaaggtcac agaagaccct gctctgattt
     2101 tacatctcac atcagtcctg ttatttcagt tctcaaccca cagcatgctc catgcacctg
     2161 gaagatgtgt cccacagatc atcgcctttc ttcacaacaa aatcccagag gatcaacata
     2221 ctctcttggt aaaatatcaa ggattggttg tgaaacagtt agtcagtcaa aataagaaga
     2281 gtggacaggg agaggatccg tcaagcgatg acttagacaa ggaacaacat gacgtcacca
     2341 atactactcg gaaggagctt caggaactgt ctttatccat taaggacctt gttctgaagc
     2401 ccaggaaatc atctgtgaca gaggagtagt gcccctaatt tacttttgtt acatagtatt
     2461 ttctccagta gatgagtgat cacagtcact cagtacatcc tactccccca tcagccctcc
     2521 cacgcaatca aataaagtgg tggtgttgta atagatgaac attttatggg aagctttact
     2581 gttgagttct ccatgaaaca ttttcttttc ccataatcct atgtgtaact tttcatgtaa
     2641 taaaagttct tcaaagagtt cgaatctaga atatatgctt taatgttctt ccagatgtta
     2701 aaatgaaaaa taaaatagaa tactttttat ctctaggaaa aaaaaaaaaa aaaaaaaaaa
     2761 aaaaaa
//
