LOCUS       NM_053418               1802 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus ubiquitin recognition factor in ER associated
            degradation 1 (Ufd1), mRNA.
ACCESSION   NM_053418
VERSION     NM_053418.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1802)
  AUTHORS   Hao,Q., Jiao,S., Shi,Z., Li,C., Meng,X., Zhang,Z., Wang,Y.,
            Song,X., Wang,W., Zhang,R., Zhao,Y., Wong,C.C. and Zhou,Z.
  TITLE     A non-canonical role of the p97 complex in RIG-I antiviral
            signaling
  JOURNAL   EMBO J 34 (23), 2903-2920 (2015)
   PUBMED   26471729
REFERENCE   2  (bases 1 to 1802)
  AUTHORS   Zhong,Y., Shen,H., Wang,Y., Yang,Y., Yang,P. and Fang,S.
  TITLE     Identification of ERAD components essential for dislocation of the
            null Hong Kong variant of alpha-1-antitrypsin (NHK)
  JOURNAL   Biochem Biophys Res Commun 458 (2), 424-428 (2015)
   PUBMED   25660456
REFERENCE   3  (bases 1 to 1802)
  AUTHORS   Chen,S.F., Wu,C.H., Lee,Y.M., Tam,K., Tsai,Y.C., Liou,J.Y. and
            Shyue,S.K.
  TITLE     Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and
            degradation of cyclooxygenase-2 via collaboration with p97 complex
  JOURNAL   J Biol Chem 288 (46), 33462-33469 (2013)
   PUBMED   24089527
REFERENCE   4  (bases 1 to 1802)
  AUTHORS   Bebeacua,C., Forster,A., McKeown,C., Meyer,H.H., Zhang,X. and
            Freemont,P.S.
  TITLE     Distinct conformations of the protein complex p97-Ufd1-Npl4
            revealed by electron cryomicroscopy
  JOURNAL   Proc Natl Acad Sci U S A 109 (4), 1098-1103 (2012)
   PUBMED   22232657
REFERENCE   5  (bases 1 to 1802)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 1802)
  AUTHORS   Botta,A., Tandoi,C., Fini,G., Calabrese,G., Dallapiccola,B. and
            Novelli,G.
  TITLE     Cloning and characterization of the gene encoding human NPL4, a
            protein interacting with the ubiquitin fusion-degradation protein
            (UFD1L)
  JOURNAL   Gene 275 (1), 39-46 (2001)
   PUBMED   11574150
REFERENCE   7  (bases 1 to 1802)
  AUTHORS   De Luca,A., Pasini,A., Amati,F., Botta,A., Spalletta,G.,
            Alimenti,S., Caccamo,F., Conti,E., Trakalo,J., Macciardi,F.,
            Dallapiccola,B. and Novelli,G.
  TITLE     Association study of a promoter polymorphism of UFD1L gene with
            schizophrenia
  JOURNAL   Am J Med Genet 105 (6), 529-533 (2001)
   PUBMED   11496370
REFERENCE   8  (bases 1 to 1802)
  AUTHORS   Chung,M.Y., Lu,J.H., Weng,Y.Y. and Hwang,B.
  TITLE     Absence of mutations in human ubiquitin fusion-degradation protein
            gene in tetralogy of Fallot
  JOURNAL   J Mol Med (Berl) 79 (5-6), 338-342 (2001)
   PUBMED   11485030
REFERENCE   9  (bases 1 to 1802)
  AUTHORS   Meyer,H.H., Shorter,J.G., Seemann,J., Pappin,D. and Warren,G.
  TITLE     A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to
            ubiquitin and nuclear transport pathways
  JOURNAL   EMBO J 19 (10), 2181-2192 (2000)
   PUBMED   10811609
REFERENCE   10 (bases 1 to 1802)
  AUTHORS   Yamagishi,H., Garg,V., Matsuoka,R., Thomas,T. and Srivastava,D.
  TITLE     A molecular pathway revealing a genetic basis for human cardiac and
            craniofacial defects
  JOURNAL   Science 283 (5405), 1158-1161 (1999)
   PUBMED   10024240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK599711.1, AF234601.1 and BC061998.1.
            
            On Oct 18, 2005 this sequence version replaced NM_053418.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161818.1, CF110642.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                CK599711.1         1-25
            26-265              AF234601.1         1-240
            266-1802            BC061998.1         222-1758
FEATURES             Location/Qualifiers
     source          1..1802
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1802
                     /gene="Ufd1"
                     /note="ubiquitin recognition factor in ER associated
                     degradation 1"
                     /db_xref="GeneID:84478"
                     /db_xref="RGD:619822"
     exon            1..98
                     /gene="Ufd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1019
                     /gene="Ufd1"
                     /note="UB fusion protein 1; ubiquitin fusion degradation
                     protein 1 homolog; ubiquitin fusion degradation 1 like"
                     /codon_start=1
                     /product="ubiquitin recognition factor in ER-associated
                     degradation protein 1"
                     /protein_id="NP_445870.1"
                     /db_xref="GeneID:84478"
                     /db_xref="RGD:619822"
                     /translation="MFSFNMFDHPIPRVFQNRFSTQYRCFSVSMLAGPNDRSDVEKGG
                     KIIMPPSALDQLSRLNITYPMLFKLTNKNSDRMTHCGVLEFVADEGICYLPHWMMQNL
                     LLEEGGLVQVESVNLQVATYSKFQPQSPDFLDITNPKAVLENALRNFACLTTGDVIAI
                     NYNEKIYELRVMETKPDKAVSIIECDMNVDFDAPLGYKEPERPVQHEESIEGEADHSG
                     YAGEVGFRAFSGSGNRLDGKKKGVEPSPSPIKPGDIKRGIPNYEFKLGKITFIRNSRP
                     MVKKVEEDEAGGRFVAFSGEGQSLRKKGRKP"
     exon            99..231
                     /gene="Ufd1"
                     /inference="alignment:Splign:2.1.0"
     exon            232..264
                     /gene="Ufd1"
                     /inference="alignment:Splign:2.1.0"
     exon            265..386
                     /gene="Ufd1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..517
                     /gene="Ufd1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..590
                     /gene="Ufd1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..659
                     /gene="Ufd1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..725
                     /gene="Ufd1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..773
                     /gene="Ufd1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..862
                     /gene="Ufd1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..944
                     /gene="Ufd1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1783
                     /gene="Ufd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttcagag cggtggcctc ggctgcgaag agggagctct gggtttctat tgtaaggttc
       61 aggaaaagaa gcggcatcac caagcgctgt cagtcatgtt ttctttcaac atgtttgacc
      121 acccgattcc ccgggtcttc cagaaccgct tctccacgca gtaccgctgc ttctctgtat
      181 ccatgctagc agggcctaat gacaggtcag atgtggagaa aggagggaag ataattatgc
      241 caccctcagc cctcgatcaa ctcagccggc tcaacattac ctatcctatg ctgtttaaat
      301 tgaccaataa gaattcagac cgaatgacac actgtggtgt actggagttt gttgctgatg
      361 aaggcatctg ttacctcccc cactggatga tgcagaattt gctgttggaa gaagggggcc
      421 tggttcaggt ggaaagtgtc aaccttcagg tggctactta ctctaagttc cagcctcaga
      481 gcccagactt cctggatatc accaacccca aagcagtatt agaaaatgca ctgaggaact
      541 tcgcctgtct gacgactgga gatgtgatcg ctatcaacta caatgagaag atctatgaac
      601 tgcgggtgat ggagaccaaa ccggacaagg ccgtatccat tattgaatgt gacatgaatg
      661 tggattttga tgctcccttg ggctacaaag aaccagaaag accagtacag catgaggagt
      721 caatagaggg agaagctgac cacagtggct atgctggaga agtgggcttc cgtgccttct
      781 ctggttctgg gaatagactg gatggaaaga aaaagggggt tgaacccagt ccctccccaa
      841 tcaagcctgg agacattaaa agaggaattc ctaattacga atttaagctt ggtaagatca
      901 ctttcatcag aaattcacgt ccaatggtca aaaaggttga agaggatgaa gctggaggca
      961 gattcgttgc tttctctgga gaaggacagt cgctgcggaa gaagggaaga aagccctaag
     1021 tgcaaaactg tgggctgacg ggaaaataaa agatccgatt gcaactggct tacagttact
     1081 agctctgaca agttcagaga tgctctgtta tttatggttt gtttagagtt acctaagaac
     1141 tatcaagctt gtcctggatg caaaacagca gaacttggag gttgtgtgct tgatctcggg
     1201 ggagagagtg ctcccgggtc ctggaggtgg ctgcctgctc cacatcctgt gctctgctcc
     1261 agggccctcc cagggcctcc gcagagcaga tccctgtttc ctgatctgct cttctttccc
     1321 atgtctgtac ccgggcagtg tctttagtcc atcatggcta ctcaggccag agctggagta
     1381 cctgacaaag atggcgtctt tttatttgac agtgactcag aagggatctc atccagatga
     1441 atgcactctc attttgatct gctcactctc agcgaattcc atgatgaagc cagatgtgca
     1501 aggcagaatg aatacgtgct caagttctgt gccccgttac atttattacc catggttctg
     1561 atagtttgtt tttcaaggat agggttgaag tagaacccca tgaatatcaa gcatgccaca
     1621 cactctgcca ctaaggctca cccgtgcccc cttttcttac tgttttactg tcctcagagc
     1681 tgcactttgt atgatgtaag attttttgcc atgctgatcc agttatttaa aatttgttcc
     1741 ttgagaataa ttcttttgaa gaattaaact tgattaaaac tcaaaaaaaa aaaaaaaaaa
     1801 aa
//
