LOCUS       NM_001003709            1038 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Rattus norvegicus ubiquitin-fold modifier conjugating enzyme 1
            (Ufc1), transcript variant 1, mRNA.
ACCESSION   NM_001003709 XM_237905
VERSION     NM_001003709.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1038)
  AUTHORS   Nahorski,M.S., Maddirevula,S., Ishimura,R., Alsahli,S., Brady,A.F.,
            Begemann,A., Mizushima,T., Guzman-Vega,F.J., Obata,M., Ichimura,Y.,
            Alsaif,H.S., Anazi,S., Ibrahim,N., Abdulwahab,F., Hashem,M.,
            Monies,D., Abouelhoda,M., Meyer,B.F., Alfadhel,M., Eyaid,W.,
            Zweier,M., Steindl,K., Rauch,A., Arold,S.T., Woods,C.G., Komatsu,M.
            and Alkuraya,F.S.
  TITLE     Biallelic UFM1 and UFC1 mutations expand the essential role of
            ufmylation in brain development
  JOURNAL   Brain 141 (7), 1934-1945 (2018)
   PUBMED   29868776
REFERENCE   2  (bases 1 to 1038)
  AUTHORS   Yoo,H.M., Kang,S.H., Kim,J.Y., Lee,J.E., Seong,M.W., Lee,S.W.,
            Ka,S.H., Sou,Y.S., Komatsu,M., Tanaka,K., Lee,S.T., Noh,D.Y.,
            Baek,S.H., Jeon,Y.J. and Chung,C.H.
  TITLE     Modification of ASC1 by UFM1 is crucial for ERalpha transactivation
            and breast cancer development
  JOURNAL   Mol Cell 56 (2), 261-274 (2014)
   PUBMED   25219498
REFERENCE   3  (bases 1 to 1038)
  AUTHORS   Zhang,Y., Zhang,M., Wu,J., Lei,G. and Li,H.
  TITLE     Transcriptional regulation of the Ufm1 conjugation system in
            response to disturbance of the endoplasmic reticulum homeostasis
            and inhibition of vesicle trafficking
  JOURNAL   PLoS One 7 (11), e48587 (2012)
   PUBMED   23152784
REFERENCE   4  (bases 1 to 1038)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1038)
  AUTHORS   Komatsu,M., Chiba,T., Tatsumi,K., Iemura,S., Tanida,I., Okazaki,N.,
            Ueno,T., Kominami,E., Natsume,T. and Tanaka,K.
  TITLE     A novel protein-conjugating system for Ufm1, a ubiquitin-fold
            modifier
  JOURNAL   EMBO J 23 (9), 1977-1986 (2004)
   PUBMED   15071506
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Mar 19, 2021 this sequence version replaced NM_001003709.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087648.1, FQ222464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               JAXUCZ010000013.1  86248163-86248490   c
            329-396             JAXUCZ010000013.1  86243353-86243420   c
            397-460             JAXUCZ010000013.1  86243101-86243164   c
            461-537             JAXUCZ010000013.1  86242727-86242803   c
            538-628             JAXUCZ010000013.1  86242388-86242478   c
            629-1038            JAXUCZ010000013.1  86241779-86242188   c
FEATURES             Location/Qualifiers
     source          1..1038
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1038
                     /gene="Ufc1"
                     /gene_synonym="ufc1-s"
                     /note="ubiquitin-fold modifier conjugating enzyme 1"
                     /db_xref="GeneID:445268"
                     /db_xref="RGD:1303313"
     exon            1..328
                     /gene="Ufc1"
                     /gene_synonym="ufc1-s"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..709
                     /gene="Ufc1"
                     /gene_synonym="ufc1-s"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Ufm1-conjugating enzyme 1-; ufm1-conjugating enzyme 1"
                     /codon_start=1
                     /product="ubiquitin-fold modifier-conjugating enzyme 1
                     isoform 1"
                     /protein_id="NP_001003709.1"
                     /db_xref="GeneID:445268"
                     /db_xref="RGD:1303313"
                     /translation="MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVE
                     NNKNADNDWFRLESNKEGTRWFGKCWYIHDFLKYEFDIEFEIPITYPTTAPEIAVPEL
                     DGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEVPDLIQKGVIQ
                     HKEKCNQ"
     exon            329..396
                     /gene="Ufc1"
                     /gene_synonym="ufc1-s"
                     /inference="alignment:Splign:2.1.0"
     exon            397..460
                     /gene="Ufc1"
                     /gene_synonym="ufc1-s"
                     /inference="alignment:Splign:2.1.0"
     exon            461..537
                     /gene="Ufc1"
                     /gene_synonym="ufc1-s"
                     /inference="alignment:Splign:2.1.0"
     exon            538..628
                     /gene="Ufc1"
                     /gene_synonym="ufc1-s"
                     /inference="alignment:Splign:2.1.0"
     exon            629..1038
                     /gene="Ufc1"
                     /gene_synonym="ufc1-s"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgaacaga gtaacccacc tccattctgt tcttcggacg cttgcgccag tgggtcaatt
       61 ttattttctt tcaaaaataa aagtcgagtg cattcagaga cggccttaag gcaatacgcc
      121 tcatcttccc acagtaaaga tggcgacgcc gtgagtaagt tacaagtaac tccacttccg
      181 caattttctt gagccctggt ccaagatggc ggacgaggcc acccggcggg tcgtgtctga
      241 gatcccggtg ctgaagacta acgccggacc ccgagatcgg gaattgtggg tgcagcgact
      301 aaaggaggaa tatcagtccc ttatccggta tgtcgaaaac aacaagaatg cggacaatga
      361 ttggttccga ctggagtcca acaaggaagg gacccggtgg tttggaaaat gctggtacat
      421 ccacgacttc ctcaaatacg agtttgacat cgagtttgaa attcctatca catatcccac
      481 tactgctcca gaaattgcag tccctgagct ggatgggaaa acggcaaaga tgtacagggg
      541 tggcaaaata tgtctaactg atcatttcaa acctttgtgg gccaggaatg tgcccaagtt
      601 tggactagct cacctcatgg ccctggggct gggtccttgg ctggcagtgg aagtccctga
      661 tctgattcag aagggtgtga tccagcacaa agaaaaatgc aaccaatgaa ggatgaagct
      721 tctgaggcag gacagaggga ctgttgctag actctgattc tgtttcctcc tttctcatga
      781 ttccttcaag ggtcacctct ggccattaca aagtagctgg agggacaaat aacaaaaccc
      841 aacaaaaggg caaggtcaca aagttgctaa attaagctgt acagagaggt gaaagatttg
      901 ggccttgaaa gaggcggttt gtatcccttc tccaagcaga gccctggagg cattttggag
      961 acctggggtg taactgacag catatagctt tttgatttct ggagacaacc tgtcaataaa
     1021 agctgcttcc catggtgg
//
