LOCUS       NM_013167               2395 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus uncoupling protein 3 (Ucp3), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_013167
VERSION     NM_013167.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2395)
  AUTHORS   Edwards,K.S., Ashraf,S., Lomax,T.M., Wiseman,J.M., Hall,M.E.,
            Gava,F.N., Hall,J.E., Hosler,J.P. and Harmancey,R.
  TITLE     Uncoupling protein 3 deficiency impairs myocardial fatty acid
            oxidation and contractile recovery following ischemia/reperfusion
  JOURNAL   Basic Res Cardiol 113 (6), 47 (2018)
   PUBMED   30374710
  REMARK    GeneRIF: we demonstrated that normal cardiac UCP3 levels are
            essential to recovery of long-chain fatty acid oxidation,
            mitochondrial respiratory capacity, and contractile function
            following cardiac ischemia/reperfusion
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2395)
  AUTHORS   Chu,X., He,X., Shi,Z., Li,C., Guo,F., Li,S., Li,Y., Na,L. and
            Sun,C.
  TITLE     Ursolic acid increases energy expenditure through enhancing free
            fatty acid uptake and beta-oxidation via an UCP3/AMPK-dependent
            pathway in skeletal muscle
  JOURNAL   Mol Nutr Food Res 59 (8), 1491-1503 (2015)
   PUBMED   25944715
  REMARK    GeneRIF: Data suggest that UCP3 expression, energy metabolism, and
            uptake/beta-oxidation of free fatty acids in skeletal muscle can be
            regulated by dietary components; here, ursolic acid, a dietary
            triterpenoid, has anti-obesity effects.
REFERENCE   3  (bases 1 to 2395)
  AUTHORS   Crescenzo,R., Bianco,F., Mazzoli,A., Giacco,A., Liverini,G. and
            Iossa,S.
  TITLE     Alterations in proton leak, oxidative status and uncoupling protein
            3 content in skeletal muscle subsarcolemmal and intermyofibrillar
            mitochondria in old rats
  JOURNAL   BMC Geriatr 14, 79 (2014)
   PUBMED   24950599
  REMARK    GeneRIF: Based on Ucp3 content, a decrease in oxidative capacity
            and proton leak in intermyofibrillar and subsarcolemmal
            mitochondria could induce a decline in energy expenditure and thus
            contribute to the reduced resting metabolic rate found in old rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2395)
  AUTHORS   de Queiroz,K.B., Rodovalho,G.V., Guimaraes,J.B., de Lima,D.C.,
            Coimbra,C.C., Evangelista,E.A. and Guerra-Sa,R.
  TITLE     Endurance training blocks uncoupling protein 1 up-regulation in
            brown adipose tissue while increasing uncoupling protein 3 in the
            muscle tissue of rats fed with a high-sugar diet
  JOURNAL   Nutr Res 32 (9), 709-717 (2012)
   PUBMED   23084644
  REMARK    GeneRIF: Endurance training blocked the high-sugar diet induced
            up-regulation of UCP1 expression in interscapular brown adipose
            tissue, whereas it up-regulated the expression of Ucp3 mRNA in
            muscle.
REFERENCE   5  (bases 1 to 2395)
  AUTHORS   Du,Z., Yang,Y., Hu,Y., Sun,Y., Zhang,S., Peng,W., Zhong,Y.,
            Huang,X. and Kong,W.
  TITLE     A long-term high-fat diet increases oxidative stress, mitochondrial
            damage and apoptosis in the inner ear of D-galactose-induced aging
            rats
  JOURNAL   Hear Res 287 (1-2), 15-24 (2012)
   PUBMED   22543089
REFERENCE   6  (bases 1 to 2395)
  AUTHORS   Walder,K., Norman,R.A., Hanson,R.L., Schrauwen,P., Neverova,M.,
            Jenkinson,C.P., Easlick,J., Warden,C.H., Pecqueur,C., Raimbault,S.,
            Ricquier,D., Silver,M.H., Shuldiner,A.R., Solanes,G., Lowell,B.B.,
            Chung,W.K., Leibel,R.L., Pratley,R. and Ravussin,E.
  TITLE     Association between uncoupling protein polymorphisms (UCP2-UCP3)
            and energy metabolism/obesity in Pima indians
  JOURNAL   Hum Mol Genet 7 (9), 1431-1435 (1998)
   PUBMED   9700198
REFERENCE   7  (bases 1 to 2395)
  AUTHORS   Boss,O., Samec,S., Desplanches,D., Mayet,M.H., Seydoux,J.,
            Muzzin,P. and Giacobino,J.P.
  TITLE     Effect of endurance training on mRNA expression of uncoupling
            proteins 1, 2, and 3 in the rat
  JOURNAL   FASEB J 12 (3), 335-339 (1998)
   PUBMED   9506477
REFERENCE   8  (bases 1 to 2395)
  AUTHORS   Matsuda,J., Hosoda,K., Itoh,H., Son,C., Doi,K., Tanaka,T.,
            Fukunaga,Y., Inoue,G., Nishimura,H., Yoshimasa,Y., Yamori,Y. and
            Nakao,K.
  TITLE     Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs:
            their gene expression in rats fed high-fat diet
  JOURNAL   FEBS Lett 418 (1-2), 200-204 (1997)
   PUBMED   9414126
REFERENCE   9  (bases 1 to 2395)
  AUTHORS   Larkin,S., Mull,E., Miao,W., Pittner,R., Albrandt,K., Moore,C.,
            Young,A., Denaro,M. and Beaumont,K.
  TITLE     Regulation of the third member of the uncoupling protein family,
            UCP3, by cold and thyroid hormone
  JOURNAL   Biochem Biophys Res Commun 240 (1), 222-227 (1997)
   PUBMED   9367914
REFERENCE   10 (bases 1 to 2395)
  AUTHORS   Boss,O., Samec,S., Paoloni-Giacobino,A., Rossier,C., Dulloo,A.,
            Seydoux,J., Muzzin,P. and Giacobino,J.P.
  TITLE     Uncoupling protein-3: a new member of the mitochondrial carrier
            family with tissue-specific expression
  JOURNAL   FEBS Lett 408 (1), 39-42 (1997)
   PUBMED   9180264
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072546.1.
            
            On Jun 13, 2004 this sequence version replaced NM_013167.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072546.1, U92069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2395
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2395
                     /gene="Ucp3"
                     /note="uncoupling protein 3"
                     /db_xref="GeneID:25708"
                     /db_xref="RGD:3933"
     exon            1..96
                     /gene="Ucp3"
                     /inference="alignment:Splign:2.1.0"
     exon            97..254
                     /gene="Ucp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1055
                     /gene="Ucp3"
                     /note="mitochondrial uncoupling protein 3; uncoupling
                     protein 3 (mitochondrial, proton carrier); UCP 3; solute
                     carrier family 25 member 9; Uncoupling protein 3,
                     mitochondrial"
                     /codon_start=1
                     /product="putative mitochondrial transporter UCP3"
                     /protein_id="NP_037299.1"
                     /db_xref="GeneID:25708"
                     /db_xref="RGD:3933"
                     /translation="MVGLQPSEVPPTTVVKFLGAGTAACFADLLTFPLDTAKVRLQIQ
                     GENPGVQSVQYRGVLGTILTMVRTEGPRSPYSGLVAGLHRQMSFASIRIGLYDSVKQF
                     YTPKGTDHSSVAIRILAGCTTGAMAVTCAQPTDVVKVRFQAMIRLGTGGERKYRGTMD
                     AYRTIAREEGVRGLWKGTWPNITRNAIVNCAEMVTYDIIKEKLLDSHLFTDNFPCHFV
                     SAFGAGFCATVVASPVDVVKTRYMNAPPGRYRSPLHCMLRMVAQEGPTAFYKGFMPSF
                     LRLGSWNVMMFVTYEQLKRALMKVQVLRESPF"
     exon            255..456
                     /gene="Ucp3"
                     /inference="alignment:Splign:2.1.0"
     exon            457..657
                     /gene="Ucp3"
                     /inference="alignment:Splign:2.1.0"
     exon            658..759
                     /gene="Ucp3"
                     /inference="alignment:Splign:2.1.0"
     exon            760..940
                     /gene="Ucp3"
                     /inference="alignment:Splign:2.1.0"
     exon            941..2375
                     /gene="Ucp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtgaatgg tgaggagggg ctgtcagatc ctgctgctgc taatggatgg agccttaggg
       61 tgcccctaca cctcctgacc ttggctagac tcacaggcag caaaggaacc aggccatcct
      121 ccggaaccat ggttggactt cagccatcag aagtgcctcc cacaacagtt gtaaagttcc
      181 tgggggccgg cactgcagcc tgttttgctg atctcctcac cttccccctg gacaccgcca
      241 aggtccgcct gcagatccaa ggggagaacc caggagtgca gagcgtgcag taccgcggcg
      301 tgctcggtac catcctgact atggtgcgca cagagggtcc ccgcagcccc tacagcgggc
      361 tggtcgctgg cctgcatcgc cagatgagtt ttgcctccat tcgaattggc ctctacgact
      421 ctgtcaagca gttctacacc cccaaaggaa cggaccactc cagcgtcgcc atcaggattc
      481 tggcaggctg caccacggga gccatggcag tgacctgtgc tcaacccacg gatgtggtga
      541 aggtccgatt tcaagccatg atacgcctgg gaactggagg cgagaggaaa tacagaggga
      601 ctatggatgc ctacagaacc atcgccaggg aagaaggagt caggggactg tggaaaggga
      661 cttggcccaa catcacaaga aacgccattg tcaattgtgc tgagatggtg acctatgaca
      721 tcatcaagga gaagctgctg gactctcacc tgttcactga caacttcccc tgtcactttg
      781 tctctgcctt tggagctggt ttctgtgcca cggtggtggc ctccccagtg gatgtggtaa
      841 agacccgata catgaacgct cccccaggca ggtaccgaag ccccctacac tgtatgctga
      901 ggatggtggc ccaggagggc cccacagcct tctacaaagg attcatgccc tcctttctgc
      961 gtctgggatc ctggaacgtg atgatgtttg taacctacga gcagctgaaa cgggccttga
     1021 tgaaagtcca ggtactgcgg gaatctccat tttgaacaag gcaagcaggc cgcttggtac
     1081 tttcctcatt aaaaaaggcc gcctggaaca gaacaaagct tctctgccca ggggtcgcag
     1141 gcccatgcac gcacacgacg gaaccctgca ctgttactga cttgagaaac tgaactaaaa
     1201 gagggggaga gttttggtct tcgatgtttc atcctaaaac acctttgttt tgcactgacc
     1261 agatgggaaa taaattatat taatttttaa aacctttccg gttggatgcc taacatttag
     1321 gcaagagaca acaaagaaaa ccagagtcga cgcctttgaa atgtaggatc aaatgatgca
     1381 taatgaacag gaaaggccaa aggctttggc aagatcggcc cactgtgttg tccttgaatc
     1441 aaacaaactg gccggaggga cccttcagcg tcagcacaaa gctgccattg cagccttcct
     1501 agtcaccaga tgactccgcc ctgtaatgtg tctgccaagt ggactccatc aggattctgg
     1561 gggaagtgag gaaggaaaaa gaacacattg aacctgtaca gacgagtccc gctgggccca
     1621 cggaggacac tggaggatag agcatgttca gtggataaca gtgctcccct gtctgcccca
     1681 tcagggtgtt gggaagatag aacatggaag cactttcgac aaggcctgtc gtccacaaat
     1741 gaggacgatg ttttaggaga gattctgtcc aaagaagttt gaggaaaatg caacctggac
     1801 cgcatgctaa ggaccatagg tgactgaagc catggggacc tgctgcctgg aaacgtcaaa
     1861 gggctgggct ggggagcact gcctgtccat cagtctagag cagcaggact cggaatcttt
     1921 agggaattgt taggactcag taaaggaatt tctaccttaa gggcgagggg gggaacatct
     1981 gctcttccgc cttctccctt ggagattttc tcacctcagg gtcctcctgg tcaggtccct
     2041 gaccagcttc acctgcatac actgcctcct gctctcaccc tgttttggtt gcaaagcctt
     2101 tgttctaccc gttaagcctt cagccttcca tctgcaaaag ggagggcgaa gttcaggacc
     2161 aacttctacg cttaagactg cacatctcga aaagaagtaa ctcagtgggg tcaattcagg
     2221 ggacccacat ggtggaagga caggatggac tctcgaaaat tgtcctctga cctccatacg
     2281 agcgccctag acaggtgcat atacgtgtat attgtacaaa cacaataaag accgcaataa
     2341 atgtaaaaaa aaaataaagg aaaagtttta ctgaaaaaaa aaaaaaaaaa aaaaa
//
