LOCUS       NM_019354               1620 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus uncoupling protein 2 (Ucp2), mRNA.
ACCESSION   NM_019354 XM_006229784
VERSION     NM_019354.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1620)
  AUTHORS   Li,Q., Ma,H., Shang,Y., Xin,X., Liu,X., Wu,Z. and Yu,W.
  TITLE     The role of uncoupling protein 2 in experimental
            periodontitis-associated renal injury in rats
  JOURNAL   Hua Xi Kou Qiang Yi Xue Za Zhi 42 (4), 502-511 (2024)
   PUBMED   39049639
  REMARK    GeneRIF: The role of uncoupling protein 2 in experimental
            periodontitis-associated renal injury in rats.
REFERENCE   2  (bases 1 to 1620)
  AUTHORS   Geng,Z., Chen,W., Lu,Q., Fu,B. and Fu,X.
  TITLE     UCP2 overexpression activates SIRT3 to regulate oxidative stress
            and mitochondrial dynamics induced by myocardial injury
  JOURNAL   Arch Biochem Biophys 753, 109918 (2024)
   PUBMED   38301949
  REMARK    GeneRIF: UCP2 overexpression activates SIRT3 to regulate oxidative
            stress and mitochondrial dynamics induced by myocardial injury.
REFERENCE   3  (bases 1 to 1620)
  AUTHORS   Azizian,H., Farhadi,Z., Bader,M., Alizadeh Ghalenoei,J.,
            Ghafari,M.A. and Mahmoodzadeh,S.
  TITLE     GPER activation attenuates cardiac dysfunction by upregulating the
            SIRT1/3-AMPK-UCP2 pathway in postmenopausal diabetic rats
  JOURNAL   PLoS One 18 (12), e0293630 (2023)
   PUBMED   38134189
  REMARK    GeneRIF: GPER activation attenuates cardiac dysfunction by
            upregulating the SIRT1/3-AMPK-UCP2 pathway in postmenopausal
            diabetic rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1620)
  AUTHORS   Rigaud,V.O., Zarka,C., Kurian,J., Harlamova,D., Elia,A.,
            Kasatkin,N., Johnson,J., Behanan,M., Kraus,L., Pepper,H.,
            Snyder,N.W., Mohsin,S., Houser,S.R. and Khan,M.
  TITLE     UCP2 modulates cardiomyocyte cell cycle activity, acetyl-CoA, and
            histone acetylation in response to moderate hypoxia
  JOURNAL   JCI Insight 7 (15), e155475 (2022)
   PUBMED   35771638
  REMARK    GeneRIF: UCP2 modulates cardiomyocyte cell cycle activity,
            acetyl-CoA, and histone acetylation in response to moderate
            hypoxia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1620)
  AUTHORS   Forte,M., Bianchi,F., Cotugno,M., Marchitti,S., Stanzione,R.,
            Maglione,V., Sciarretta,S., Valenti,V., Carnevale,R., Versaci,F.,
            Frati,G., Volpe,M. and Rubattu,S.
  TITLE     An interplay between UCP2 and ROS protects cells from
            high-salt-induced injury through autophagy stimulation
  JOURNAL   Cell Death Dis 12 (10), 919 (2021)
   PUBMED   34625529
  REMARK    GeneRIF: An interplay between UCP2 and ROS protects cells from
            high-salt-induced injury through autophagy stimulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1620)
  AUTHORS   Hurtaud,C., Gelly,C., Bouillaud,F. and Levi-Meyrueis,C.
  TITLE     Translation control of UCP2 synthesis by the upstream open reading
            frame
  JOURNAL   Cell Mol Life Sci 63 (15), 1780-1789 (2006)
   PUBMED   16845607
REFERENCE   7  (bases 1 to 1620)
  AUTHORS   Strobel,A., Combettes-Souverain,M., Doare,L., Strosberg,A.D. and
            Issad,T.
  TITLE     Rat uncoupling protein 2 (UCP2): expression in obese ventromedial
            hypothalamus (VMH)-lesioned animals
  JOURNAL   Int J Obes Relat Metab Disord 22 (11), 1121-1126 (1998)
   PUBMED   9822952
REFERENCE   8  (bases 1 to 1620)
  AUTHORS   Yoshitomi,H., Yamazaki,K. and Tanaka,I.
  TITLE     Cloning of mouse uncoupling protein 3 cDNA and 5'-flanking region,
            and its genetic map
  JOURNAL   Gene 215 (1), 77-84 (1998)
   PUBMED   9666083
REFERENCE   9  (bases 1 to 1620)
  AUTHORS   Hidaka,S., Kakuma,T., Yoshimatsu,H., Yasunaga,S., Kurokawa,M. and
            Sakata,T.
  TITLE     Molecular cloning of rat uncoupling protein 2 cDNA and its
            expression in genetically obese Zucker fatty (fa/fa) rats
  JOURNAL   Biochim Biophys Acta 1389 (3), 178-186 (1998)
   PUBMED   9512646
REFERENCE   10 (bases 1 to 1620)
  AUTHORS   Matsuda,J., Hosoda,K., Itoh,H., Son,C., Doi,K., Tanaka,T.,
            Fukunaga,Y., Inoue,G., Nishimura,H., Yoshimasa,Y., Yamori,Y. and
            Nakao,K.
  TITLE     Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs:
            their gene expression in rats fed high-fat diet
  JOURNAL   FEBS Lett 418 (1-2), 200-204 (1997)
   PUBMED   9414126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ227097.1 and AB006613.1.
            
            On or before Aug 22, 2014 this sequence version replaced
            XM_006229784.2, NM_019354.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ227097.1, AB010743.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            regulatory uORF                    :: PMID: 16845607
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-787               FQ227097.1         1-787
            788-1303            AB006613.1         415-930
            1304-1620           FQ227097.1         1305-1621
FEATURES             Location/Qualifiers
     source          1..1620
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1620
                     /gene="Ucp2"
                     /note="uncoupling protein 2"
                     /db_xref="GeneID:54315"
                     /db_xref="RGD:3932"
     exon            1..115
                     /gene="Ucp2"
                     /inference="alignment:Splign:2.1.0"
     exon            116..277
                     /gene="Ucp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      127..237
                     /regulatory_class="uORF"
                     /gene="Ucp2"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:16845607]"
                     /note="this uORF is predicted to encode a 36 aa peptide
                     (PMID:16845607)"
     exon            278..499
                     /gene="Ucp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..1303
                     /gene="Ucp2"
                     /note="mitochondrial uncoupling protein 2; UCP 2; solute
                     carrier family 25 member 8; Uncoupling protein 2,
                     mitochondrial; uncoupling protein 2 (mitochondrial, proton
                     carrier); dicarboxylate carrier SLC25A8"
                     /codon_start=1
                     /product="dicarboxylate carrier UCP2"
                     /protein_id="NP_062227.2"
                     /db_xref="GeneID:54315"
                     /db_xref="RGD:3932"
                     /translation="MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQ
                     GESQGLARTAASAQYRGVLGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDS
                     VKQFYTKGSEHAGIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTV
                     EAYKTIAREEGIRGLWKGTSPNVARNAIVNCTELVTYDLIKDTLLKANLMTDDLPCHF
                     TSAFGAGFCTTVIASPVDVVKTRYMNSALGQYHSAGHCALTMLRKEGPRAFYKGFMPS
                     FLRLGSWNVVMFVTYEQLKRALMAAYESREAPF"
     exon            500..710
                     /gene="Ucp2"
                     /inference="alignment:Splign:2.1.0"
     exon            711..905
                     /gene="Ucp2"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1007
                     /gene="Ucp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1188
                     /gene="Ucp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1600
                     /gene="Ucp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1581..1586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ucp2"
     polyA_site      1600
                     /gene="Ucp2"
ORIGIN      
        1 actgtcagcc cctccctcgg tgccctggga tcgcttgctt cttgggcagc caccgccgcc
       61 gtcggaccta gccgtctgca ctcctgtgtt ctcctgtgta ttctcctgcg gtccggacac
      121 aatagtatga tctttaagtg tttcgtctcc cagacatttt ctatgggaaa tcaaggggat
      181 caggccatga tagccactgg cagctttgaa gaacgggaca cctttagaga agcttgatct
      241 tggaggcctc agcgtgagac ctcaaagcac cctcccgact ccggcagagt tcctctgtct
      301 cgtcttgacg attgaaggtc cccactgctt cagtttttct ccatcttctg ggaggtagca
      361 ggaagtcaga atcatggttg gtttcaaggc caccgatgtg ccccccacag ccaccgtgaa
      421 gttcctgggg gctgggacag cagcctgtat tgcagatctc atcactttcc ctctagacac
      481 cgccaaagtc cggctgcaga tccaaggaga gagtcaaggg ctagcgcgca ccgccgccag
      541 cgcccagtac cgcggcgtgc tgggcaccat cctaaccatg gtgcgcactg agggtccgcg
      601 cagcctctac aatgggctgg tcgccggcct acagcgccag atgagctttg cctccgtccg
      661 cattggcctc tacgactctg taaagcagtt ctacaccaag ggctcagagc atgcaggcat
      721 cgggagccgc ctcctggcag gtagcaccac aggtgccctg gctgtggctg tggcccaacc
      781 tacagatgtg gtaaaggtcc gcttccaggc ccaggcccgg gctggcggtg gtcggagata
      841 ccagagcact gtcgaagcct acaagaccat tgcacgagag gaagggatcc ggggcctctg
      901 gaaagggacc tctcccaatg ttgcccgaaa tgccattgtc aactgtactg agctggtgac
      961 ctatgacctc atcaaagata ctctcctgaa agccaacctc atgacagacg acctcccttg
     1021 ccacttcact tctgccttcg gggcgggctt ctgcaccacc gtcattgcct cccccgttga
     1081 tgtggtcaag acgagatata tgaactctgc cttgggccag taccacagcg ccggccactg
     1141 tgccctgacc atgctccgga aggaggggcc ccgagccttc tacaaggggt tcatgccttc
     1201 cttcctccgc ttgggatcct ggaacgtagt aatgtttgtc acctatgagc agctcaaaag
     1261 ggccctgatg gctgcctatg aatcccggga ggcacccttt tgagcctctc cagctgctga
     1321 cctggaccct gctccccatt cctgccctgt cttttccttc atcctctgcc cagccccaac
     1381 ctcttcccat ttcccacact ccaactccct tcccagctca tctccctata cctcctcagc
     1441 aaggaggcct taccctagca catctcacta tgcctcctca gcgaggaggc ctgaccccgg
     1501 accctgcacc ctcagtcctg ctaacagtta agcccaaatc ttttgtcctc attcccagcc
     1561 cagcttagcc agccttcgcc cataaagcaa gctcaatgtt aaaaaaaaaa aaaaaaaaaa
//
