LOCUS       NM_012682               1222 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus uncoupling protein 1 (Ucp1), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_012682
VERSION     NM_012682.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1222)
  AUTHORS   Warfel,J.D., Elks,C.M., Bayless,D.S., Vandanmagsar,B., Stone,A.C.,
            Velasquez,S.E., Olivares-Nazar,P., Noland,R.C., Ghosh,S., Zhang,J.
            and Mynatt,R.L.
  TITLE     Rats lacking Ucp1 present a novel translational tool for the
            investigation of thermogenic adaptation during cold challenge
  JOURNAL   Acta Physiol (Oxf) 238 (1), e13935 (2023)
   PUBMED   36650072
  REMARK    GeneRIF: Rats lacking Ucp1 present a novel translational tool for
            the investigation of thermogenic adaptation during cold challenge.
REFERENCE   2  (bases 1 to 1222)
  AUTHORS   Piel,M.S., Masscheleyn,S., Bouillaud,F., Moncoq,K. and Miroux,B.
  TITLE     Structural models of mitochondrial uncoupling proteins obtained in
            DPC micelles are not functionally relevant
  JOURNAL   FEBS J 288 (9), 3024-3033 (2021)
   PUBMED   33202085
  REMARK    GeneRIF: Structural models of mitochondrial uncoupling proteins
            obtained in DPC micelles are not functionally relevant.
REFERENCE   3  (bases 1 to 1222)
  AUTHORS   Bove,M., Monto,F., Guillem-Llobat,P., Ivorra,M.D., Noguera,M.A.,
            Zambrano,A., Sirerol-Piquer,M.S., Requena,A.C., Garcia-Alonso,M.,
            Tejerina,T., Real,J.T., Farinas,I. and D'Ocon,P.
  TITLE     NT3/TrkC Pathway Modulates the Expression of UCP-1 and Adipocyte
            Size in Human and Rodent Adipose Tissue
  JOURNAL   Front Endocrinol (Lausanne) 12, 630097 (2021)
   PUBMED   33815288
  REMARK    GeneRIF: NT3/TrkC Pathway Modulates the Expression of UCP-1 and
            Adipocyte Size in Human and Rodent Adipose Tissue.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1222)
  AUTHORS   Ceglarek,V.M., Bertasso,I.M., Pietrobon,C.B., Scomazzon,S.P.,
            Leite,N.C., Bonfleur,M.L., Araujo,A.C.F., Balbo,S.L. and
            Grassiolli,S.
  TITLE     Maternal Roux-en-Y gastric bypass surgery reduces lipid deposition
            and increases UCP1 expression in the brown adipose tissue of male
            offspring
  JOURNAL   Sci Rep 11 (1), 1158 (2021)
   PUBMED   33441773
  REMARK    GeneRIF: Maternal Roux-en-Y gastric bypass surgery reduces lipid
            deposition and increases UCP1 expression in the brown adipose
            tissue of male offspring.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1222)
  AUTHORS   Sepa-Kishi,D.M., Jani,S., Da Eira,D. and Ceddia,R.B.
  TITLE     Cold acclimation enhances UCP1 content, lipolysis, and
            triacylglycerol resynthesis, but not mitochondrial uncoupling and
            fat oxidation, in rat white adipocytes
  JOURNAL   Am J Physiol Cell Physiol 316 (3), C365-C376 (2019)
   PUBMED   30624981
  REMARK    GeneRIF: Instead of UCP1-mediated mitochondrial uncoupling, cold
            acclimation increased the capacity of Sc Ing adipocytes to export
            fatty acids.
REFERENCE   6  (bases 1 to 1222)
  AUTHORS   Miroux,B., Frossard,V., Raimbault,S., Ricquier,D. and Bouillaud,F.
  TITLE     The topology of the brown adipose tissue mitochondrial uncoupling
            protein determined with antibodies against its antigenic sites
            revealed by a library of fusion proteins
  JOURNAL   EMBO J 12 (10), 3739-3745 (1993)
   PUBMED   7691596
REFERENCE   7  (bases 1 to 1222)
  AUTHORS   Bouillaud,F., Raimbault,S. and Ricquier,D.
  TITLE     The gene for rat uncoupling protein: complete sequence, structure
            of primary transcript and evolutionary relationship between exons
  JOURNAL   Biochem Biophys Res Commun 157 (2), 783-792 (1988)
   PUBMED   3202878
REFERENCE   8  (bases 1 to 1222)
  AUTHORS   Ridley,R.G., Patel,H.V., Gerber,G.E., Morton,R.C. and Freeman,K.B.
  TITLE     Complete nucleotide and derived amino acid sequence of cDNA
            encoding the mitochondrial uncoupling protein of rat brown adipose
            tissue: lack of a mitochondrial targeting presequence
  JOURNAL   Nucleic Acids Res 14 (10), 4025-4035 (1986)
   PUBMED   3012461
REFERENCE   9  (bases 1 to 1222)
  AUTHORS   Bouillaud,F., Weissenbach,J. and Ricquier,D.
  TITLE     Complete cDNA-derived amino acid sequence of rat brown fat
            uncoupling protein
  JOURNAL   J Biol Chem 261 (4), 1487-1490 (1986)
   PUBMED   3753702
REFERENCE   10 (bases 1 to 1222)
  AUTHORS   Ridley,R.G., Patel,H.V., Parfett,C.L., Olynyk,K.A., Reichling,S.
            and Freeman,K.B.
  TITLE     Immunological detection of cDNA clones encoding the uncoupling
            protein of brown adipose tissue: evidence for an antigenic
            determinant within the C-terminal eleven amino acids
  JOURNAL   Biosci Rep 6 (1), 87-94 (1986)
   PUBMED   2421800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM087156.1 and BC088156.1.
            
            On Aug 18, 2012 this sequence version replaced NM_012682.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088156.1, M11814.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760434,
                                           SAMN09345238 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                FM087156.1         1-22
            23-1222             BC088156.1         11-1210
FEATURES             Location/Qualifiers
     source          1..1222
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1222
                     /gene="Ucp1"
                     /gene_synonym="Ucp; Ucpa; Uncp"
                     /note="uncoupling protein 1"
                     /db_xref="GeneID:24860"
                     /db_xref="RGD:3931"
     exon            1..307
                     /gene="Ucp1"
                     /gene_synonym="Ucp; Ucpa; Uncp"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1105
                     /gene="Ucp1"
                     /gene_synonym="Ucp; Ucpa; Uncp"
                     /note="UCP 1; solute carrier family 25 member 7;
                     thermogenin; uncoupling protein 1 (mitochondrial, proton
                     carrier); mitochondrial brown fat uncoupling protein
                     1-like"
                     /codon_start=1
                     /product="mitochondrial brown fat uncoupling protein 1"
                     /protein_id="NP_036814.1"
                     /db_xref="GeneID:24860"
                     /db_xref="RGD:3931"
                     /translation="MVSSTTSEVQPTMGVKIFSAGVSACLADIITFPLDTAKVRLQIQ
                     GEGQASSTIRYKGVLGTITTLAKTEGLPKLYSGLPAGIQRQISFASLRIGLYDTVQEY
                     FSSGRETPASLGSKISAGLMTGGVAVFIGQPTEVVKVRMQAQSHLHGIKPRYTGTYNA
                     YRVIATTESLSTLWKGTTPNLMRNVIINCTELVTYDLMKGALVNHHILADDVPCHLLS
                     ALVAGFCTTLLASPVDVVKTRFINSLPGQYPSVPSCAMTMYTKEGPAAFFKGFAPSFL
                     RLGSWNVIMFVCFEQLKKELMKSRQTVDCTT"
     exon            308..506
                     /gene="Ucp1"
                     /gene_synonym="Ucp; Ucpa; Uncp"
                     /inference="alignment:Splign:2.1.0"
     exon            507..707
                     /gene="Ucp1"
                     /gene_synonym="Ucp; Ucpa; Uncp"
                     /inference="alignment:Splign:2.1.0"
     exon            708..809
                     /gene="Ucp1"
                     /gene_synonym="Ucp; Ucpa; Uncp"
                     /inference="alignment:Splign:2.1.0"
     exon            810..990
                     /gene="Ucp1"
                     /gene_synonym="Ucp; Ucpa; Uncp"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1199
                     /gene="Ucp1"
                     /gene_synonym="Ucp; Ucpa; Uncp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgccgggcg atccgggctt aaagagcgag aggaagggac gctcaccttt gagctcctcc
       61 acaaatagcc ctggtggctg ccacagaagt tcgaagttga gagttcggta cccacatcag
      121 gcaacagtgc cactgttgtc ttcagggctg attccttttg gtctctgccc tccgagccaa
      181 gatggtgagt tcgacaactt ccgaagtgca acccaccatg ggggtcaaga tcttctcagc
      241 cggcgtttct gcctgcctag cagacatcat caccttcccg ctggacaccg ccaaagtccg
      301 ccttcagatc caaggtgaag gccaggcttc cagtactatt aggtataaag gtgtcttagg
      361 gaccatcacc accctggcca agacagaagg attgccgaaa ctgtacagcg gtctgcctgc
      421 tggcatccag aggcaaatca gctttgcttc cctcaggatt ggcctctacg atacggtcca
      481 agagtacttc tcttcaggga gagaaacgcc tgcctctttg ggaagcaaga tctcggctgg
      541 cttgatgacg ggtggcgtgg cggtattcat tgggcagccc acagaggtgg tgaaggtcag
      601 aatgcaagca caaagccatc tgcacgggat caaaccccgc tacactggga cctacaatgc
      661 ttacagagtt atagccacca cagaaagctt gtcaacactg tggaaaggga cgactcctaa
      721 tctaatgaga aatgtcatca tcaactgtac agagctggtg acatatgacc tcatgaaggg
      781 ggcccttgtg aaccaccaca tactggcaga tgacgtcccc tgccatttac tgtcagctct
      841 tgtcgccggg ttttgcacca cactcctggc ctctccggtg gatgtggtaa aaacgagatt
      901 catcaactct ctaccaggac agtacccaag tgtacccagc tgtgcaatga ccatgtacac
      961 caaggaagga ccggcagcct ttttcaaagg gtttgcgcct tcttttctgc gactcggatc
     1021 ctggaacgtc atcatgtttg tgtgctttga acagctgaag aaagagctga tgaagtcccg
     1081 gcagacagtg gactgcacca cataggcgac ttggagaaag ggatgctaaa caccattggg
     1141 ctcctatgct gggctcctat gctgggagac cacgaataaa accaaccaaa gaaatcagaa
     1201 aaaaaaaaaa aaaaaaaaaa aa
//
