LOCUS       NM_001080208            1152 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus urocortin 3 (Ucn3), mRNA.
ACCESSION   NM_001080208 XM_001068553 XM_574076
VERSION     NM_001080208.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1152)
  AUTHORS   Grunddal,K.V., Trammell,S.A.J., Baech-Laursen,C., Andersen,D.B.,
            Xu,S.F.S., Andersen,H., Gillum,M.P., Ghiasi,S.M., Novak,I.,
            Tyrberg,B., Li,C., Rosenkilde,M.M., Hartmann,B., Holst,J.J. and
            Kuhre,R.E.
  TITLE     Opposing roles of the entero-pancreatic hormone urocortin-3 in
            glucose metabolism in rats
  JOURNAL   Diabetologia 65 (6), 1018-1031 (2022)
   PUBMED   35325259
  REMARK    GeneRIF: Opposing roles of the entero-pancreatic hormone
            urocortin-3 in glucose metabolism in rats.
REFERENCE   2  (bases 1 to 1152)
  AUTHORS   Zhang,X., Liu,Y., Qi,J., Tian,Z., Tang,N., Chen,D. and Li,Z.
  TITLE     Progress in understanding the roles of Urocortin3 (UCN3) in the
            control of appetite from studies using animal models
  JOURNAL   Peptides 121, 170124 (2019)
   PUBMED   31415798
  REMARK    GeneRIF: Urocortin 3, the newest member of corticotrophin releasing
            hormone family polypeptides, is an anorexic factor, which has a
            strong inhibitory effect on animal appetite regulation. (Review)
            Review article
REFERENCE   3  (bases 1 to 1152)
  AUTHORS   van-Hover,C. and Li,C.
  TITLE     Stress-activated afferent inputs into the anterior parvicellular
            part of the paraventricular nucleus of the hypothalamus: Insights
            into urocortin 3 neuron activation
  JOURNAL   Brain Res 1611, 29-43 (2015)
   PUBMED   25779038
  REMARK    GeneRIF: Study showed that acute stress rapidly stimulates
            Urocortin 3 expression in the paraventricular nucleus of the
            hypothalamus (PVHap) and identified specific stress-sensitive brain
            areas that project to the PVHap.
REFERENCE   4  (bases 1 to 1152)
  AUTHORS   Roustit,M.M., Vaughan,J.M., Jamieson,P.M. and Cleasby,M.E.
  TITLE     Urocortin 3 activates AMPK and AKT pathways and enhances glucose
            disposal in rat skeletal muscle
  JOURNAL   J Endocrinol 223 (2), 143-154 (2014)
   PUBMED   25122003
  REMARK    GeneRIF: UCN3 expression enhances glucose disposal and signalling
            in muscle by an autocrine/paracrine mechanism that is separate from
            its pro-hypertrophic effects.
REFERENCE   5  (bases 1 to 1152)
  AUTHORS   Mahajan,S., Liao,M., Barkan,P., Takahashi,K. and Bhargava,A.
  TITLE     Urocortin 3 expression at baseline and during inflammation in the
            colon: corticotropin releasing factor receptors cross-talk
  JOURNAL   Peptides 54, 58-66 (2014)
   PUBMED   24462512
  REMARK    GeneRIF: Ucn3 does not have an overt role in ameliorating
            histopathological inflammation in colon.
REFERENCE   6  (bases 1 to 1152)
  AUTHORS   Hillhouse,E.W. and Grammatopoulos,D.K.
  TITLE     The molecular mechanisms underlying the regulation of the
            biological activity of corticotropin-releasing hormone receptors:
            implications for physiology and pathophysiology
  JOURNAL   Endocr Rev 27 (3), 260-286 (2006)
   PUBMED   16484629
  REMARK    Review article
REFERENCE   7  (bases 1 to 1152)
  AUTHORS   Chanalaris,A., Lawrence,K.M., Stephanou,A., Knight,R.D., Hsu,S.Y.,
            Hsueh,A.J. and Latchman,D.S.
  TITLE     Protective effects of the urocortin homologues stresscopin (SCP)
            and stresscopin-related peptide (SRP) against hypoxia/reoxygenation
            injury in rat neonatal cardiomyocytes
  JOURNAL   J Mol Cell Cardiol 35 (10), 1295-1305 (2003)
   PUBMED   14519439
REFERENCE   8  (bases 1 to 1152)
  AUTHORS   Li,C., Vaughan,J., Sawchenko,P.E. and Vale,W.W.
  TITLE     Urocortin III-immunoreactive projections in rat brain: partial
            overlap with sites of type 2 corticotrophin-releasing factor
            receptor expression
  JOURNAL   J Neurosci 22 (3), 991-1001 (2002)
   PUBMED   11826127
REFERENCE   9  (bases 1 to 1152)
  AUTHORS   Lewis,K., Li,C., Perrin,M.H., Blount,A., Kunitake,K., Donaldson,C.,
            Vaughan,J., Reyes,T.M., Gulyas,J., Fischer,W., Bilezikjian,L.,
            Rivier,J., Sawchenko,P.E. and Vale,W.W.
  TITLE     Identification of urocortin III, an additional member of the
            corticotropin-releasing factor (CRF) family with high affinity for
            the CRF2 receptor
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7570-7575 (2001)
   PUBMED   11416224
REFERENCE   10 (bases 1 to 1152)
  AUTHORS   Hsu,S.Y. and Hsueh,A.J.
  TITLE     Human stresscopin and stresscopin-related peptide are selective
            ligands for the type 2 corticotropin-releasing hormone receptor
  JOURNAL   Nat Med 7 (5), 605-611 (2001)
   PUBMED   11329063
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jul 29, 2021 this sequence version replaced NM_001080208.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF078967.1, SRR26360176.1816297.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               JAXUCZ010000017.1  71219656-71219881
            227-1152            JAXUCZ010000017.1  71224979-71225904
FEATURES             Location/Qualifiers
     source          1..1152
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.2"
     gene            1..1152
                     /gene="Ucn3"
                     /gene_synonym="RGD1562213"
                     /note="urocortin 3"
                     /db_xref="GeneID:498791"
                     /db_xref="RGD:1562213"
     exon            1..226
                     /gene="Ucn3"
                     /gene_synonym="RGD1562213"
                     /inference="alignment:Splign:2.1.0"
     exon            227..1152
                     /gene="Ucn3"
                     /gene_synonym="RGD1562213"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..727
                     /gene="Ucn3"
                     /gene_synonym="RGD1562213"
                     /note="urocortin 3 (stresscopin)"
                     /codon_start=1
                     /product="urocortin-3 precursor"
                     /protein_id="NP_001073677.1"
                     /db_xref="GeneID:498791"
                     /db_xref="RGD:1562213"
                     /translation="MLMPTYFLLLLLLLLGGPRTSLSHKFYNAGPVFSCLNTALSEVK
                     KNKLEDVPVLSKKNFGYLPTQDPSGEEEDEQKHIKNKRTFSDAVGGNGGRSIRYRYQS
                     QAQPKGKLYPDKVKNDRGTKFTLSLDVPTNIMNILFNIDKAKNLRAKAAANAQLMAQI
                     GKKK"
ORIGIN      
        1 tacgatccac cctgtgatct gtcactttta catacatgca caggggagtg gagcggtttc
       61 catagagagg aactaccaca gctcactacg aacaatacca gagaagacga agctgcgacc
      121 ccgaacggcc aggagttcag aggacctgcg gggagcagcc ctccgggccc agaagctgtg
      181 cccctcgacc tgagcacttc caccctagag caaagtcctc ttacagggag cgatgctgat
      241 gcccacttac ttcctgctgc ttctgctgct gctcctaggg ggcccaagga caagcctctc
      301 ccacaagttc tacaacgcag gaccagtctt cagctgcctc aacacagccc tgtctgaggt
      361 caagaagaac aagctggagg atgtgccggt gctgagcaag aagaactttg gctacctgcc
      421 cacacaagac ccttcgggag aagaagagga tgaacaaaaa cacatcaaga acaaaagaac
      481 tttctcagac gctgtgggtg ggaatggagg tagaagcatc cggtacagat accaatccca
      541 agcacagccc aaaggaaagc tgtacccgga caaggtcaaa aacgaccggg gcaccaagtt
      601 cactctgtcc ctcgacgttc ccactaacat catgaacatc ctcttcaaca ttgacaaggc
      661 caagaatttg cgagccaagg cagcggccaa tgctcaactc atggcacaga ttgggaaaaa
      721 gaaataaagc aaaggccagg caggagggcg ccccatcgag acaagagccc cagaataaag
      781 gggagggaaa ctgaggacgt gccctcgaat tgcaaaggac ggatggtccg ttttcacagg
      841 ctactccact gctgtacccc tctgaccctc tcctgcttcc agcctgtgcc cacaatggag
      901 gttaacgtct ctccccatat cttgtgtttg ctttctagtt ccctgtggca acagacaagt
      961 tcacacagtg cccctccttt ccaagttcct ccctgatgtc ccatgtctga agagagagct
     1021 ctcgggctcc ctctttgttc tatgttggtc tgagcctcgg cagagacacg gagaagcaca
     1081 gctcaccctc ttgctaccaa gtacctcccc tacttcctca tccggattaa agtcagtggc
     1141 ttcttgaact tg
//
