LOCUS       NM_133385                911 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus urocortin 2 (Ucn2), mRNA.
ACCESSION   NM_133385
VERSION     NM_133385.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 911)
  AUTHORS   Kovacs,D.K., Eitmann,S., Berta,G., Kormos,V., Gaszner,B.,
            Petervari,E. and Balasko,M.
  TITLE     Aging Changes the Efficacy of Central Urocortin 2 to Induce Weight
            Loss in Rats
  JOURNAL   Int J Mol Sci 24 (10), 8992 (2023)
   PUBMED   37240340
  REMARK    GeneRIF: Aging Changes the Efficacy of Central Urocortin 2 to
            Induce Weight Loss in Rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 911)
  AUTHORS   Liu,C., Liu,X., Song,F., Li,J., Zhang,X. and Yang,J.
  TITLE     The effects of neuropeptide urocortin 2 on the spontaneous
            discharge and glutamatergic neurotransmission of striatum neurons
  JOURNAL   Neuropeptides 50, 17-21 (2015)
   PUBMED   25837973
  REMARK    GeneRIF: UCN2 could significantly inhibit the firing rate of 84% of
            the tested striatal neurons, and its inhibitory effect followed a
            concentration-dependent manner.
REFERENCE   3  (bases 1 to 911)
  AUTHORS   Liu,C., Liu,X., Yang,J., Duan,Y., Yao,H., Li,F. and Zhang,X.
  TITLE     The effects of vasoactive peptide urocortin 2 on hemodynamics in
            spontaneous hypertensive rat and the role of L-type calcium channel
            and CRFR2
  JOURNAL   Pharmacol Rep 67 (2), 394-398 (2015)
   PUBMED   25712670
  REMARK    GeneRIF: UCN2 can modulate electrical remodeling of the myocardium
            and hemodynamics.
REFERENCE   4  (bases 1 to 911)
  AUTHORS   Kolasa,M., Faron-Gorecka,A., Kusmider,M., Szafran-Pilch,K.,
            Solich,J., Zurawek,D., Gruca,P., Papp,M. and
            Dziedzicka-Wasylewska,M.
  TITLE     Differential stress response in rats subjected to chronic mild
            stress is accompanied by changes in CRH-family gene expression at
            the pituitary level
  JOURNAL   Peptides 61, 98-106 (2014)
   PUBMED   25236411
  REMARK    GeneRIF: The differentiated behavioral stress responses were
            reflected by gene expression changes in the pituitary. Alterations
            in the mRNA levels of Crh, Ucn2 and Ucn3 in the pituitary might
            confirm the paracrine and/or autocrine effects of these peptides
REFERENCE   5  (bases 1 to 911)
  AUTHORS   Watanabe,K., Nemoto,T., Akira,S., Takeshita,T. and Shibasaki,T.
  TITLE     Estrogens downregulate urocortin 2 expression in rat uterus
  JOURNAL   J Endocrinol 219 (3), 269-278 (2013)
   PUBMED   24109089
  REMARK    GeneRIF: Data suggest that estrogens down-regulate Ucn2 expression
            in uterus; at 9 weeks, mRNA expression levels and contents of Ucn2
            in uterus are lower in proestrus than in diestrus; plasma Ucn2
            levels do not differ between the two estrous cycle phases.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 911)
  AUTHORS   Tanaka,Y., Makino,S., Noguchi,T., Tamura,K., Kaneda,T. and
            Hashimoto,K.
  TITLE     Effect of stress and adrenalectomy on urocortin II mRNA expression
            in the hypothalamic paraventricular nucleus of the rat
  JOURNAL   Neuroendocrinology 78 (1), 1-11 (2003)
   PUBMED   12869794
REFERENCE   7  (bases 1 to 911)
  AUTHORS   Kageyama,K. and Suda,T.
  TITLE     Urocortin-related peptides increase interleukin-6 output via cyclic
            adenosine 5'-monophosphate-dependent pathways in A7r5 aortic smooth
            muscle cells
  JOURNAL   Endocrinology 144 (6), 2234-2241 (2003)
   PUBMED   12746280
  REMARK    GeneRIF: both Ucn and Ucn II induced accumulation of intracellular
            cAMP via corticotropin-releasing factor receptor type 2beta and
            also caused a significant increase in IL-6 output levels.
REFERENCE   8  (bases 1 to 911)
  AUTHORS   Ikeda,K., Tojo,K., Oki,Y. and Nakao,K.
  TITLE     Urocortin has cell-proliferative effects on cardiac non-myocytes
  JOURNAL   Life Sci 71 (16), 1929-1938 (2002)
   PUBMED   12175707
REFERENCE   9  (bases 1 to 911)
  AUTHORS   Douglas,S.A., Tayara,L., Ohlstein,E.H., Halawa,N. and Giaid,A.
  TITLE     Congestive heart failure and expression of myocardial urotensin II
  JOURNAL   Lancet 359 (9322), 1990-1997 (2002)
   PUBMED   12076554
REFERENCE   10 (bases 1 to 911)
  AUTHORS   Hsu,S.Y. and Hsueh,A.J.
  TITLE     Human stresscopin and stresscopin-related peptide are selective
            ligands for the type 2 corticotropin-releasing hormone receptor
  JOURNAL   Nat Med 7 (5), 605-611 (2001)
   PUBMED   11329063
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EF078966.1, JAXUCZ010000008.1 and AI454706.1.
            
            On Jul 24, 2009 this sequence version replaced NM_133385.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF078966.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345330, SAMN09345331
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-368               EF078966.1         1-368
            369-659             JAXUCZ010000008.1  118517134-118517424
            660-911             AI454706.1         1-252               c
FEATURES             Location/Qualifiers
     source          1..911
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..911
                     /gene="Ucn2"
                     /gene_synonym="Ucn3"
                     /note="urocortin 2"
                     /db_xref="GeneID:170896"
                     /db_xref="RGD:620765"
     exon            1..13
                     /gene="Ucn2"
                     /gene_synonym="Ucn3"
                     /inference="alignment:Splign:2.1.0"
     exon            14..895
                     /gene="Ucn2"
                     /gene_synonym="Ucn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..355
                     /gene="Ucn2"
                     /gene_synonym="Ucn3"
                     /note="ucn II; urocortin 3; urocortin II"
                     /codon_start=1
                     /product="urocortin-2 precursor"
                     /protein_id="NP_596876.2"
                     /db_xref="GeneID:170896"
                     /db_xref="RGD:620765"
                     /translation="MMTRWALVVFMVLMLDRVPGTPIPTFQLLPQNYPETTPSSVSSE
                     SPSDTTTGPSASWSNSKASPYLDTRVILSLDVPIGLLRILLEQARNKAARNQAATNAQ
                     ILARVGRR"
ORIGIN      
        1 cgttggcata acgcctcacc gcatgatgac caggtgggca ctggtggtgt ttatggtcct
       61 gatgttggat agggtcccag gaacccctat ccccaccttc cagctcctcc ctcagaacta
      121 tccggagaca actcccagct ctgtgtcctc agagagcccc tcagatacca ccactgggcc
      181 ctcagcttcc tggagcaact ctaaagccag cccttacctg gacacccgtg tcatactctc
      241 cctggatgtc cccattggcc tcctgcggat cttactggaa caggctcgga acaaggctgc
      301 caggaatcag gctgctacta atgcccaaat actagcccgt gttggccgcc gctgagactg
      361 gggaaggggt cataaagatg gggtgacctt ggatgagaag ttctggagga cagccaaaaa
      421 gccagacagt actacatcta ggccaagagc atacacagag atcgccgtag tggatcactg
      481 ccatagcttc caagtatcta cagtgtgttt agacagcttg gccatatagt gtcttgccat
      541 gtttctgaac ccctcacgcc cctcacactt aataatatgt ttgggcatct tggacactag
      601 catgtatgtt caatatgtag aatcttgtcg tgcctagctg tgtctggctt tcacagagca
      661 tctagatacc accacgtgag ctccatcatt aaaggtaaag gagaccccag tgttgcacct
      721 gagatccacc taaggcccat aggcctgggc ctcccacctg aggctgctac accagagact
      781 gctgcgggcg agggtcacgt gcttgttcta tggttttgtt tttgttttta aagacagtct
      841 tgcaatggaa tcctcgaatg tcctagaact tgctaatagc aatccttctg cctcaaaaaa
      901 aaaaaaaaaa a
//
