LOCUS       NM_019150                570 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus urocortin (Ucn), mRNA.
ACCESSION   NM_019150
VERSION     NM_019150.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 570)
  AUTHORS   Yamato,S., Kurematsu,A., Amano,T., Ariga,H., Ando,T., Komaki,G. and
            Wada,K.
  TITLE     Urocortin 1: A putative excitatory neurotransmitter in the enteric
            nervous system
  JOURNAL   Neurogastroenterol Motil 32 (10), e13842 (2020)
   PUBMED   32196844
  REMARK    GeneRIF: Urocortin 1: A putative excitatory neurotransmitter in the
            enteric nervous system.
REFERENCE   2  (bases 1 to 570)
  AUTHORS   Hanna,D.A., Khalaf,M.M. and Abo-Saif,A.A.
  TITLE     Polydatin protects against ovalbumin-induced bronchial asthma in
            rats; involvement of urocortin and surfactant-D expression
  JOURNAL   Immunopharmacol Immunotoxicol 41 (3), 403-412 (2019)
   PUBMED   30422021
  REMARK    GeneRIF: Polydatin significantly reduced the inflammatory mediators
            and restored the normal values of oxidative and nitrosative stress
            biomarkers. It also significantly reduced the expression of
            surfactant-D and UCN as compared to asthma control
REFERENCE   3  (bases 1 to 570)
  AUTHORS   Corsetti,G., Yuan,Z., Romano,C., Chen-Scarabelli,C., Fanzani,A.,
            Pasini,E., Dioguardi,F.S., Onorati,F., Linardi,D., Knight,R.,
            Patel,H., Faggian,G., Saravolatz,L. and Scarabelli,T.M.
  TITLE     Urocortin Induces Phosphorylation of Distinct Residues of Signal
            Transducer and Activator of Transcription 3 (STAT3) via Different
            Signaling Pathways
  JOURNAL   Med Sci Monit Basic Res 25, 139-152 (2019)
   PUBMED   31073117
  REMARK    GeneRIF: Ucn induces activation of STAT3 through diverging
            signaling pathways.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 570)
  AUTHORS   van der Doelen,R.H.A., Robroch,B., Arnoldussen,I.A., Schulpen,M.,
            Homberg,J.R. and Kozicz,T.
  TITLE     Serotonin and urocortin 1 in the dorsal raphe and Edinger-Westphal
            nuclei after early life stress in serotonin transporter knockout
            rats
  JOURNAL   Neuroscience 340, 345-358 (2017)
   PUBMED   27826101
  REMARK    GeneRIF: Effects of early life stress and 5-HTT genotype at the
            molecular level could constitute early life stress x 5-HTT genotype
            interaction modulating the impact of stress on
            Edinger-Westphal-Ucn1 and dorsal raphe-5-HT neurons.
REFERENCE   5  (bases 1 to 570)
  AUTHORS   Sumii,K., Miyake,H., Enatsu,N., Chiba,K. and Fujisawa,M.
  TITLE     Characterization of urocortin as an anti-apoptotic protein in
            experimental ischemia-reperfusion model of the rat testis
  JOURNAL   Biochem Biophys Res Commun 479 (2), 387-392 (2016)
   PUBMED   27659706
  REMARK    GeneRIF: urocortin may play a cytoprotective role in the germ cells
            in response to ischemia-reperfusion injury through the activation
            of major anti-apoptotic proteins, as well as by the
            mitogen-activated protein kinase signaling pathway activation.
REFERENCE   6  (bases 1 to 570)
  AUTHORS   Bittencourt,J.C., Vaughan,J., Arias,C., Rissman,R.A., Vale,W.W. and
            Sawchenko,P.E.
  TITLE     Urocortin expression in rat brain: evidence against a pervasive
            relationship of urocortin-containing projections with targets
            bearing type 2 CRF receptors
  JOURNAL   J Comp Neurol 415 (3), 285-312 (1999)
   PUBMED   10553117
REFERENCE   7  (bases 1 to 570)
  AUTHORS   Radulovic,J., Ruhmann,A., Liepold,T. and Spiess,J.
  TITLE     Modulation of learning and anxiety by corticotropin-releasing
            factor (CRF) and stress: differential roles of CRF receptors 1 and
            2
  JOURNAL   J Neurosci 19 (12), 5016-5025 (1999)
   PUBMED   10366634
REFERENCE   8  (bases 1 to 570)
  AUTHORS   Gottowik,J., Goetschy,V., Henriot,S., Kitas,E., Fluhman,B.,
            Clerc,R.G., Moreau,J.L., Monsma,F.J. and Kilpatrick,G.J.
  TITLE     Labelling of CRF1 and CRF2 receptors using the novel radioligand,
            [3H]-urocortin
  JOURNAL   Neuropharmacology 36 (10), 1439-1446 (1997)
   PUBMED   9423932
REFERENCE   9  (bases 1 to 570)
  AUTHORS   Vaughan,J., Donaldson,C., Bittencourt,J., Perrin,M.H., Lewis,K.,
            Sutton,S., Chan,R., Turnbull,A.V., Lovejoy,D., Rivier,C. et al.
  TITLE     Urocortin, a mammalian neuropeptide related to fish urotensin I and
            to corticotropin-releasing factor
  JOURNAL   Nature 378 (6554), 287-292 (1995)
   PUBMED   7477349
REFERENCE   10 (bases 1 to 570)
  AUTHORS   McKenzie,I.F., Pang,T. and Blanden,R.V.
  TITLE     The use of H-2 mutants as models for the study of T cell activation
  JOURNAL   Immunol Rev 35, 179-230 (1977)
   PUBMED   70397
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019150.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U33935.1, SRR26360176.1566059.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                JAXUCZ010000006.1  30958086-30958120
            36-570              JAXUCZ010000006.1  30958382-30958916
FEATURES             Location/Qualifiers
     source          1..570
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..570
                     /gene="Ucn"
                     /note="urocortin"
                     /db_xref="GeneID:29151"
                     /db_xref="RGD:3929"
     exon            1..35
                     /gene="Ucn"
                     /inference="alignment:Splign:2.1.0"
     exon            36..570
                     /gene="Ucn"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..417
                     /gene="Ucn"
                     /note="corticotensin"
                     /codon_start=1
                     /product="urocortin precursor"
                     /protein_id="NP_062023.1"
                     /db_xref="GeneID:29151"
                     /db_xref="RGD:3929"
                     /translation="MRQRGRATLLVALLLLVQLRPESSQWSPAAAAANVVQDPNLRWN
                     PGVRNQGGGVRALLLLLAERFPRRAGSEPAGERQRRDDPPLSIDLTFHLLRTLLELAR
                     TQSQRERAEQNRIIFDSVGK"
ORIGIN      
        1 ctccatcttg cactggatag acactccgat aacctggcag gcggcaccat gaggcagagg
       61 ggacgcgcta cgctcctggt agcgttgctg cttctggttc agctgcgccc ggagagcagc
      121 cagtggagcc cagcggctgc ggcggcgaat gtggtccagg atccgaatct gcgatggaac
      181 cccggagtgc ggaatcaggg cggaggtgtc cgcgcactcc tcttgctgtt agcggagcgc
      241 ttcccgcgcc gcgcgggatc tgagcctgca ggcgagcggc aacgacgaga cgacccgccg
      301 ttgtccatcg acctcacctt ccacctgctg cggaccctgc tagagctagc tcggacacag
      361 agccagcgcg agcgcgcaga gcagaaccgc atcatattcg attcggtggg caagtgatcg
      421 gccccgtatg gggtccagaa agccttgacc ctttccccca cctaccccgg ggctggagcg
      481 cgcacaaccg gagctggctc agtcccgcgt tgcagcgccg cccagagtta ccctgaacac
      541 tctgactgga tattttttaa taaaactgcc
//
