LOCUS       NM_001399350             897 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus upper zone of growth plate and cartilage matrix
            associated (Ucma), mRNA.
ACCESSION   NM_001399350 XM_017600493
VERSION     NM_001399350.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 897)
  AUTHORS   Willems,B.A., Furmanik,M., Caron,M.M.J., Chatrou,M.L.L.,
            Kusters,D.H.M., Welting,T.J.M., Stock,M., Rafael,M.S.,
            Viegas,C.S.B., Simes,D.C., Vermeer,C., Reutelingsperger,C.P.M. and
            Schurgers,L.J.
  TITLE     Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell
            calcification via SMAD-dependent BMP signalling
  JOURNAL   Sci Rep 8 (1), 4961 (2018)
   PUBMED   29563538
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 897)
  AUTHORS   Le Jeune,M., Tomavo,N., Tian,T.V., Flourens,A., Marchand,N.,
            Camuzeaux,B., Mallein-Gerin,F. and Duterque-Coquillaud,M.
  TITLE     Identification of four alternatively spliced transcripts of the
            Ucma/GRP gene, encoding a new Gla-containing protein
  JOURNAL   Exp Cell Res 316 (2), 203-215 (2010)
   PUBMED   19819238
REFERENCE   3  (bases 1 to 897)
  AUTHORS   Viegas,C.S., Simes,D.C., Laize,V., Williamson,M.K., Price,P.A. and
            Cancela,M.L.
  TITLE     Gla-rich protein (GRP), a new vitamin K-dependent protein
            identified from sturgeon cartilage and highly conserved in
            vertebrates
  JOURNAL   J Biol Chem 283 (52), 36655-36664 (2008)
   PUBMED   18836183
REFERENCE   4  (bases 1 to 897)
  AUTHORS   Surmann-Schmitt,C., Dietz,U., Kireva,T., Adam,N., Park,J.,
            Tagariello,A., Onnerfjord,P., Heinegard,D.,
            Schlotzer-Schrehardt,U., Deutzmann,R., von der Mark,K. and Stock,M.
  TITLE     Ucma, a novel secreted cartilage-specific protein with implications
            in osteogenesis
  JOURNAL   J Biol Chem 283 (11), 7082-7093 (2008)
   PUBMED   18156182
REFERENCE   5  (bases 1 to 897)
  AUTHORS   Tagariello,A., Luther,J., Streiter,M., Didt-Koziel,L., Wuelling,M.,
            Surmann-Schmitt,C., Stock,M., Adam,N., Vortkamp,A. and
            Winterpacht,A.
  TITLE     Ucma--A novel secreted factor represents a highly specific marker
            for distal chondrocytes
  JOURNAL   Matrix Biol 27 (1), 3-11 (2008)
   PUBMED   17707622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jan 6, 2022 this sequence version replaced XM_017600493.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB322394.1, EU022754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               JAXUCZ010000017.1  78212808-78212996   c
            190-255             JAXUCZ010000017.1  78212355-78212420   c
            256-351             JAXUCZ010000017.1  78212169-78212264   c
            352-450             JAXUCZ010000017.1  78207677-78207775   c
            451-897             JAXUCZ010000017.1  78203268-78203714   c
FEATURES             Location/Qualifiers
     source          1..897
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..897
                     /gene="Ucma"
                     /gene_synonym="GRP; RGD1308977"
                     /note="upper zone of growth plate and cartilage matrix
                     associated"
                     /db_xref="GeneID:291312"
                     /db_xref="RGD:1308977"
     exon            1..189
                     /gene="Ucma"
                     /gene_synonym="GRP; RGD1308977"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..548
                     /gene="Ucma"
                     /gene_synonym="GRP; RGD1308977"
                     /note="Gla-rich protein; unique cartilage
                     matrix-associated protein"
                     /codon_start=1
                     /product="unique cartilage matrix-associated protein
                     precursor"
                     /protein_id="NP_001386279.1"
                     /db_xref="GeneID:291312"
                     /db_xref="RGD:1308977"
                     /translation="MSWRQVILLSSLSALVLLCMLQEGTSASVGSRQAAGEEVQEGMK
                     QKIFMQESDASNFLKRRGKRSPKSRDEVTAENRQKLRDDELRREYYEEQRNEFENFVE
                     EQRDEQEERTREAVEQWRQWHYDGLYPSYLYNRQNI"
     exon            190..255
                     /gene="Ucma"
                     /gene_synonym="GRP; RGD1308977"
                     /inference="alignment:Splign:2.1.0"
     exon            256..351
                     /gene="Ucma"
                     /gene_synonym="GRP; RGD1308977"
                     /inference="alignment:Splign:2.1.0"
     exon            352..450
                     /gene="Ucma"
                     /gene_synonym="GRP; RGD1308977"
                     /inference="alignment:Splign:2.1.0"
     exon            451..897
                     /gene="Ucma"
                     /gene_synonym="GRP; RGD1308977"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctctctct tgcctgtctg cctgactcag aagtgaggac ttactgggca gtcgcttcag
       61 ctgtactggg ggcttccaag atacctcacc ttattatctg ccctgtggtt tctgggaagt
      121 gcactgtaaa gatgtcctgg agacaagtca tcctcctgtc atctctctcg gccctggtgc
      181 tcctgtgtat gctacaagag gggaccagcg cttctgtggg cagcagacag gcggctggag
      241 aggaggtgca ggaaggtatg aaacagaaga ttttcatgca agaatccgat gcctcgaatt
      301 tcctcaagag gcgtggcaag cggtctccca agtcccgaga tgaagtcact gcggaaaaca
      361 gacagaagct tcgggacgat gagcttcgga gggagtatta tgaggagcaa aggaatgagt
      421 tcgagaactt cgtggaggaa cagagagatg agcaggaaga aaggaccagg gaggcggtgg
      481 agcaatggcg gcagtggcac tatgatggcc tgtatccttc ctacctctac aaccgccaaa
      541 acatatgacc tcaccctcaa gcaactgggg aagagaagca tagacacgcc tcccgcctct
      601 ctgcagacag acccataagg tgaagctccc tcgaggccct cgccaccagt tgcaggaaac
      661 acacctttgt tctgacgcct tttgaggcct ggttttccct tctttccgga tgtttgcttt
      721 gtcttgtttt tgagtgagcg accgcctgtg gttcttccca gcgtcagatc tacaccttgc
      781 ccgcttgctt agccaccaga aacagagtta gaatgcctgt ctgatgggac acttggagga
      841 tcgaagcata aagattttaa gcttgcttgt ggcctattaa taaaagtgct gactcga
//
