LOCUS       NM_001107831            1933 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus uridine-cytidine kinase 1 (Uck1), mRNA.
ACCESSION   NM_001107831 XM_001078114 XM_231143
VERSION     NM_001107831.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1933)
  AUTHORS   Van Rompay,A.R., Norda,A., Linden,K., Johansson,M. and Karlsson,A.
  TITLE     Phosphorylation of uridine and cytidine nucleoside analogs by two
            human uridine-cytidine kinases
  JOURNAL   Mol Pharmacol 59 (5), 1181-1186 (2001)
   PUBMED   11306702
REFERENCE   2  (bases 1 to 1933)
  AUTHORS   Yuh,I., Yaoi,T., Watanabe,S., Okajima,S., Hirasawa,Y. and
            Fushiki,S.
  TITLE     Up-regulated uridine kinase gene identified by RLCS in the ventral
            horn after crush injury to rat sciatic nerves
  JOURNAL   Biochem Biophys Res Commun 266 (1), 104-109 (1999)
   PUBMED   10581173
REFERENCE   3  (bases 1 to 1933)
  AUTHORS   Greenberg,N., Schumm,D.E. and Webb,T.E.
  TITLE     Uridine kinase activities and pyrimidine nucleoside phosphorylation
            in fluoropyrimidine-sensitive and -resistant cell lines of the
            Novikoff hepatoma
  JOURNAL   Biochem J 164 (2), 379-387 (1977)
   PUBMED   195585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001107831.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168897.1, SRR22582424.251906.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               JAXUCZ010000003.1  35942017-35942213   c
            198-357             JAXUCZ010000003.1  35941693-35941852   c
            358-454             JAXUCZ010000003.1  35940667-35940763   c
            455-597             JAXUCZ010000003.1  35940377-35940519   c
            598-692             JAXUCZ010000003.1  35940193-35940287   c
            693-741             JAXUCZ010000003.1  35937923-35937971   c
            742-1933            JAXUCZ010000003.1  35936328-35937519   c
FEATURES             Location/Qualifiers
     source          1..1933
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..1933
                     /gene="Uck1"
                     /note="uridine-cytidine kinase 1"
                     /db_xref="GeneID:311864"
                     /db_xref="RGD:1308313"
     exon            1..197
                     /gene="Uck1"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..923
                     /gene="Uck1"
                     /EC_number="2.7.1.48"
                     /codon_start=1
                     /product="uridine-cytidine kinase 1"
                     /protein_id="NP_001101301.2"
                     /db_xref="GeneID:311864"
                     /db_xref="RGD:1308313"
                     /translation="MSAAPEMASAGGGGSESAAPEADRPQPRPFLIGVSGGTASGKST
                     VCEKIMELLGQNEVDRRQRKLVILSQDCFYKVLTAEQKAKALKGQYNFDHPDAFDNDL
                     MHKTLKNIVEGKTVEVPTYDFVTHSRLPETTVVYPADVVLFEGILVFYTQEIRDMFHL
                     RLFVDTDSDVRLSRRVLRDVQRGRDLEQILTQYTAFVKPAFEEFCLPTKKYADVIIPR
                     GVDNMVAINLIVQHIQDILNGDLCKRHRGGPNGRNYKRTFPEPGDHPGVLATGKRSHL
                     ESSSRPH"
     exon            198..357
                     /gene="Uck1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..454
                     /gene="Uck1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..597
                     /gene="Uck1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..692
                     /gene="Uck1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..741
                     /gene="Uck1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..1933
                     /gene="Uck1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccccgg aagcgatgcg tacggcgtcc gcccctaggt cctggcggga gcaggcagag
       61 tcggtggatg tatgtcagcc gctccggaga tggcttcggc gggaggcggc ggctccgaga
      121 gcgccgcgcc ggaggccgat cgtccccagc cgcggccgtt tctcatcggc gtgagcggtg
      181 gcactgctag cggcaagtca acagtgtgtg agaagatcat ggagctgctg gggcagaacg
      241 aagtggaccg ccggcagcgc aagttggtca tcctgagcca ggactgcttc tataaggttc
      301 tgacagccga gcagaaggcc aaggccttga agggacagta caattttgac catccagatg
      361 cttttgataa tgatctgatg cacaagaccc tgaaaaacat tgtcgaaggc aaaactgtcg
      421 aggtccccac ctatgatttt gtgacccact caaggttacc agagaccact gtggtctacc
      481 cagctgatgt ggttctgttc gagggcatct tggtattcta cacccaggag atccgggaca
      541 tgttccacct gcgcctcttt gtggacacag actccgatgt taggctgtct cgaagagttc
      601 tccgggatgt gcagcgagga agggacctgg agcagatcct cacccagtac accgcctttg
      661 tgaaaccagc ctttgaggag ttctgcctgc cgaccaagaa atacgctgat gtgatcatcc
      721 ctcgaggggt tgataatatg gtggccatca acctgatcgt gcagcacatc caggacatcc
      781 tcaatggtga cctgtgcaag cggcaccgag gagggcccaa cgggcgcaac tacaagagga
      841 ccttcccgga gccaggagac caccctgggg tgttggccac tggcaaacgc tcacacctgg
      901 agtctagcag cagaccccat tgaggaccag catatgtagg ttccccatag acctgacaga
      961 taaagggtct gggcctgggg gacaactact ggctcctaaa agcacagtca gggatccctc
     1021 tagtgtgatc ttgggtggca tcaggaccaa agccttcctt gcataagagg gcagactcat
     1081 gctgaccgag cattctggtg tcctccgctt cctctcgctg gaggaggcca caggtctctg
     1141 ggtgggtcac tgtcccaaac agcatagtaa gcctatggcg ccagcttccc gagggatgca
     1201 ggacagacac atggggcaac agcggaaaca gcccaggcac tggctggcct ggtgttaaga
     1261 cagtgaaccc cagggaagta cttcccggtg tgatgtggtc cgtgtacgtg ttgcagaagt
     1321 ttgcagagat gttcgatatc ctttttgtgt gtgtgtgtgt gtaaggctgt ttgtgatctc
     1381 tgaacctagt tttacaacct aacactgggc tatggttcag tctgaggagc ctgaggcagg
     1441 agcctacatg actctatcta gggtcctgga tcagcgtctc cacaattctg caggaagcct
     1501 tgagcccaag gggctgtctg tgtacaagtc acttaggcat agttcatggc taacatgcag
     1561 gggcaggctc tcaccaggca ggggagccct ggagtgcaga ggcaggcaac cgtggctgcc
     1621 taaggccagt tagtctcctg cacaccaaac tcaagctcct ggcttcacac actccctcct
     1681 gtgctgtcaa gtttgtcttc cctcccatgg gatggcgtgt tttggaagta tccttggcta
     1741 ttgccacaag ctatggccca ggactctcat ttcttgttaa ctacaacttc atttcttgtt
     1801 caatacaact ggttctcacc acagcagctg agctgtgttg ctctcaggag gtggtttctg
     1861 ttagtgttgt gctgattttg ttgaaccgaa accccttttt ggagggagaa tcaataaata
     1921 acataaaaaa tta
//
