LOCUS       NM_001393849            1661 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin C-terminal hydrolase L5 (Uchl5),
            transcript variant 1, mRNA.
ACCESSION   NM_001393849 XM_039090899
VERSION     NM_001393849.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1661)
  AUTHORS   Zhou,Z., Yao,X., Pang,S., Chen,P., Jiang,W., Shan,Z. and Zhang,Q.
  TITLE     The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog
            signaling by deubiquitinating Smoothened
  JOURNAL   J Mol Cell Biol 10 (3), 243-257 (2018)
   PUBMED   28992318
REFERENCE   2  (bases 1 to 1661)
  AUTHORS   Ouh,I.O., Seo,M.G., Shah,F.A., Gim,S.A. and Koh,P.O.
  TITLE     Proteomic analysis of testicular ischemia-reperfusion injury in
            rats
  JOURNAL   J Vet Med Sci 76 (3), 313-321 (2014)
   PUBMED   24189580
REFERENCE   3  (bases 1 to 1661)
  AUTHORS   Ko,Y.M., Chang,C.Y., Chiou,S.J., Hsu,F.J., Huang,J.S., Yang,Y.L.,
            Guh,J.Y. and Chuang,L.Y.
  TITLE     Ubiquitin C-terminal hydrolase-L5 is required for high
            glucose-induced transforming growth factor-beta receptor I
            expression and hypertrophy in mesangial cells
  JOURNAL   Arch Biochem Biophys 535 (2), 177-186 (2013)
   PUBMED   23500140
REFERENCE   4  (bases 1 to 1661)
  AUTHORS   Matilainen,O., Arpalahti,L., Rantanen,V., Hautaniemi,S. and
            Holmberg,C.I.
  TITLE     Insulin/IGF-1 signaling regulates proteasome activity through the
            deubiquitinating enzyme UBH-4
  JOURNAL   Cell Rep 3 (6), 1980-1995 (2013)
   PUBMED   23770237
REFERENCE   5  (bases 1 to 1661)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 1661)
  AUTHORS   Chen,L., Cai,Y., Jin,J., Florens,L., Swanson,S.K., Washburn,M.P.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     Subunit organization of the human INO80 chromatin remodeling
            complex: an evolutionarily conserved core complex catalyzes
            ATP-dependent nucleosome remodeling
  JOURNAL   J Biol Chem 286 (13), 11283-11289 (2011)
   PUBMED   21303910
REFERENCE   7  (bases 1 to 1661)
  AUTHORS   Al-Shami,A., Jhaver,K.G., Vogel,P., Wilkins,C., Humphries,J.,
            Davis,J.J., Xu,N., Potter,D.G., Gerhardt,B., Mullinax,R.,
            Shirley,C.R., Anderson,S.J. and Oravecz,T.
  TITLE     Regulators of the proteasome pathway, Uch37 and Rpn13, play
            distinct roles in mouse development
  JOURNAL   PLoS One 5 (10), e13654 (2010)
   PUBMED   21048919
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1661)
  AUTHORS   Bousquet-Dubouch,M.P., Nguen,S., Bouyssie,D., Burlet-Schiltz,O.,
            French,S.W., Monsarrat,B. and Bardag-Gorce,F.
  TITLE     Chronic ethanol feeding affects proteasome-interacting proteins
  JOURNAL   Proteomics 9 (13), 3609-3622 (2009)
   PUBMED   19609968
REFERENCE   9  (bases 1 to 1661)
  AUTHORS   Yao,T., Song,L., Jin,J., Cai,Y., Takahashi,H., Swanson,S.K.,
            Washburn,M.P., Florens,L., Conaway,R.C., Cohen,R.E. and
            Conaway,J.W.
  TITLE     Distinct modes of regulation of the Uch37 deubiquitinating enzyme
            in the proteasome and in the Ino80 chromatin-remodeling complex
  JOURNAL   Mol Cell 31 (6), 909-917 (2008)
   PUBMED   18922472
REFERENCE   10 (bases 1 to 1661)
  AUTHORS   Koulich,E., Li,X. and DeMartino,G.N.
  TITLE     Relative structural and functional roles of multiple
            deubiquitylating proteins associated with mammalian 26S proteasome
  JOURNAL   Mol Biol Cell 19 (3), 1072-1082 (2008)
   PUBMED   18162577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Mar 18, 2021 this sequence version replaced XM_039090899.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220301.1, SRR26360186.1665018.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000013.1  58071076-58071250
            176-239             JAXUCZ010000013.1  58077377-58077440
            240-345             JAXUCZ010000013.1  58078923-58079028
            346-471             JAXUCZ010000013.1  58094293-58094418
            472-533             JAXUCZ010000013.1  58094499-58094560
            534-664             JAXUCZ010000013.1  58094693-58094823
            665-728             JAXUCZ010000013.1  58096959-58097022
            729-831             JAXUCZ010000013.1  58098497-58098599
            832-945             JAXUCZ010000013.1  58099661-58099774
            946-1044            JAXUCZ010000013.1  58101819-58101917
            1045-1661           JAXUCZ010000013.1  58106209-58106825
FEATURES             Location/Qualifiers
     source          1..1661
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..1661
                     /gene="Uchl5"
                     /note="ubiquitin C-terminal hydrolase L5"
                     /db_xref="GeneID:360853"
                     /db_xref="RGD:1305414"
     exon            1..175
                     /gene="Uchl5"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1089
                     /gene="Uchl5"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin carboxyl-terminal esterase L5; ubiquitin
                     carboxyl-terminal hydrolase isozyme L5; ubiquitin
                     carboxyl-terminal hydrolase L5"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase isozyme L5
                     isoform 1"
                     /protein_id="NP_001380778.1"
                     /db_xref="GeneID:360853"
                     /db_xref="RGD:1305414"
                     /translation="MSSNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFE
                     KLKPVHGLIFLFKWQPGEEPAGSVVQDSRLETIFFAKQVINNACATQAIVSVLLNCTH
                     QDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAKEE
                     DAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWITAVRPVIEKRIQKYSEGEIRF
                     NLMAIVSDRKMIYEQKIAELQRQLAEEEPMDTDQGSTVLSAIQSEVARNQMLIEEEVQ
                     KLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAKEKQNAKKAQETK"
     exon            176..239
                     /gene="Uchl5"
                     /inference="alignment:Splign:2.1.0"
     exon            240..345
                     /gene="Uchl5"
                     /inference="alignment:Splign:2.1.0"
     exon            346..471
                     /gene="Uchl5"
                     /inference="alignment:Splign:2.1.0"
     exon            472..533
                     /gene="Uchl5"
                     /inference="alignment:Splign:2.1.0"
     exon            534..664
                     /gene="Uchl5"
                     /inference="alignment:Splign:2.1.0"
     exon            665..728
                     /gene="Uchl5"
                     /inference="alignment:Splign:2.1.0"
     exon            729..831
                     /gene="Uchl5"
                     /inference="alignment:Splign:2.1.0"
     exon            832..945
                     /gene="Uchl5"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1044
                     /gene="Uchl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1661
                     /gene="Uchl5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccgcggc gggttttgct gaggtctgcg gccggtggca gcttgagctg cgggcttcgg
       61 agagcgcgag gtggagcggg gcggtgtgtg gtcggggcca tgtcgagcaa tgccggggag
      121 tggtgtctca tggaaagcga ccccggggtc ttcaccgagc tcattaaagg attcggttgc
      181 cgaggagctc aagtagaaga aatatggagc ttagagcctg agaatttcga aaagctaaag
      241 ccggttcatg ggttaatttt tcttttcaag tggcagccag gagaagaacc agctggctct
      301 gtggttcagg actccagact tgaaacaata ttttttgcta agcaggtaat taataatgct
      361 tgtgccacgc aggctatcgt aagtgtacta ctgaactgta cccatcaaga tgtccattta
      421 ggagagacat tatcagaatt taaggaattt tcccaaagtt ttgatgcagc tatgaagggg
      481 ttggcattga gtaactcaga tgtgattcga caagtgcaca acagttttgc cagacagcag
      541 atgtttgaat ttgatacaaa gacatcagcc aaagaagaag atgcttttca ctttgtcagt
      601 tatgttccag ttaatggaag actgtatgaa ttagatggat taagagaagg cccaattgat
      661 ttaggtgcat gcaatcagga tgactggatt actgcagtga ggccagtaat agagaagagg
      721 attcaaaagt atagtgaagg agaaattcga tttaatttaa tggccattgt atctgacaga
      781 aaaatgatat atgaacagaa gatagcagag ttacagagac agcttgcaga ggaggaaccc
      841 atggatacag atcagggtag tactgtgtta agtgctattc agtcagaagt tgccagaaac
      901 cagatgctta ttgaagaaga ggtacaaaag ttaaaaagat ataagattga aaatatcaga
      961 aggaagcata actacctgcc tttcattatg gaattgttaa agaccttagc agaacaccag
     1021 cagttaattc cacttgtgga aaaggcaaaa gaaaaacaga atgcaaagaa agctcaggaa
     1081 actaagtgaa gaggatattt ggacatgtgt acactgctgc acttaatttc atggacacca
     1141 ttaaataaaa gaaactttga acaacatcct aattgactca gtgcacgttt ggcatagtac
     1201 cagtctgtct ttatgcatgg agttaaaact ctttccttac ctgcatcatg tgtatgtagt
     1261 gcatattaaa taaaagtgac ataaaaagtg ctggccaaat ttcattattc agttctggat
     1321 ctgagagttc ttggtatcta gaaatgcagc tagagtaatg aacctggaaa atacagataa
     1381 tatgtttcat ctgtagttgg tctgattaat acttttattt gtttgcttaa tatattcaat
     1441 ttatgaatgt cagatctttc ttaaggttgg tcatctgttt ccaattgtgg caaaaataat
     1501 tagcattttt tgtcactgtg tgttttacag atcttaaaac tgaattttat cttataccaa
     1561 cttgattttt taaggccagt catttggaaa gactgataca atttctgatg atttacattg
     1621 ctctctgtaa agatgacaat aaatatccca attatacttt a
//
