LOCUS       NP_001380778             329 aa            linear   ROD 28-MAR-2024
DEFINITION  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001380778 XP_038946827
VERSION     NP_001380778.1
DBSOURCE    REFSEQ: accession NM_001393849.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 329)
  AUTHORS   Zhou,Z., Yao,X., Pang,S., Chen,P., Jiang,W., Shan,Z. and Zhang,Q.
  TITLE     The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog
            signaling by deubiquitinating Smoothened
  JOURNAL   J Mol Cell Biol 10 (3), 243-257 (2018)
   PUBMED   28992318
REFERENCE   2  (residues 1 to 329)
  AUTHORS   Ouh,I.O., Seo,M.G., Shah,F.A., Gim,S.A. and Koh,P.O.
  TITLE     Proteomic analysis of testicular ischemia-reperfusion injury in
            rats
  JOURNAL   J Vet Med Sci 76 (3), 313-321 (2014)
   PUBMED   24189580
REFERENCE   3  (residues 1 to 329)
  AUTHORS   Ko,Y.M., Chang,C.Y., Chiou,S.J., Hsu,F.J., Huang,J.S., Yang,Y.L.,
            Guh,J.Y. and Chuang,L.Y.
  TITLE     Ubiquitin C-terminal hydrolase-L5 is required for high
            glucose-induced transforming growth factor-beta receptor I
            expression and hypertrophy in mesangial cells
  JOURNAL   Arch Biochem Biophys 535 (2), 177-186 (2013)
   PUBMED   23500140
REFERENCE   4  (residues 1 to 329)
  AUTHORS   Matilainen,O., Arpalahti,L., Rantanen,V., Hautaniemi,S. and
            Holmberg,C.I.
  TITLE     Insulin/IGF-1 signaling regulates proteasome activity through the
            deubiquitinating enzyme UBH-4
  JOURNAL   Cell Rep 3 (6), 1980-1995 (2013)
   PUBMED   23770237
REFERENCE   5  (residues 1 to 329)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (residues 1 to 329)
  AUTHORS   Chen,L., Cai,Y., Jin,J., Florens,L., Swanson,S.K., Washburn,M.P.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     Subunit organization of the human INO80 chromatin remodeling
            complex: an evolutionarily conserved core complex catalyzes
            ATP-dependent nucleosome remodeling
  JOURNAL   J Biol Chem 286 (13), 11283-11289 (2011)
   PUBMED   21303910
REFERENCE   7  (residues 1 to 329)
  AUTHORS   Al-Shami,A., Jhaver,K.G., Vogel,P., Wilkins,C., Humphries,J.,
            Davis,J.J., Xu,N., Potter,D.G., Gerhardt,B., Mullinax,R.,
            Shirley,C.R., Anderson,S.J. and Oravecz,T.
  TITLE     Regulators of the proteasome pathway, Uch37 and Rpn13, play
            distinct roles in mouse development
  JOURNAL   PLoS One 5 (10), e13654 (2010)
   PUBMED   21048919
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 329)
  AUTHORS   Bousquet-Dubouch,M.P., Nguen,S., Bouyssie,D., Burlet-Schiltz,O.,
            French,S.W., Monsarrat,B. and Bardag-Gorce,F.
  TITLE     Chronic ethanol feeding affects proteasome-interacting proteins
  JOURNAL   Proteomics 9 (13), 3609-3622 (2009)
   PUBMED   19609968
REFERENCE   9  (residues 1 to 329)
  AUTHORS   Yao,T., Song,L., Jin,J., Cai,Y., Takahashi,H., Swanson,S.K.,
            Washburn,M.P., Florens,L., Conaway,R.C., Cohen,R.E. and
            Conaway,J.W.
  TITLE     Distinct modes of regulation of the Uch37 deubiquitinating enzyme
            in the proteasome and in the Ino80 chromatin-remodeling complex
  JOURNAL   Mol Cell 31 (6), 909-917 (2008)
   PUBMED   18922472
REFERENCE   10 (residues 1 to 329)
  AUTHORS   Koulich,E., Li,X. and DeMartino,G.N.
  TITLE     Relative structural and functional roles of multiple
            deubiquitylating proteins associated with mammalian 26S proteasome
  JOURNAL   Mol Biol Cell 19 (3), 1072-1082 (2008)
   PUBMED   18162577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Mar 18, 2021 this sequence version replaced XP_038946827.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220301.1, SRR26360186.1665018.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..329
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     Protein         1..329
                     /product="ubiquitin carboxyl-terminal hydrolase isozyme L5
                     isoform 1"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin carboxyl-terminal esterase L5; ubiquitin
                     carboxyl-terminal hydrolase isozyme L5; ubiquitin
                     carboxyl-terminal hydrolase L5"
                     /calculated_mol_wt=37503
     Region          8..223
                     /region_name="Peptidase_C12"
                     /note="Cysteine peptidase C12 contains ubiquitin
                     carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and
                     BAP1; cd02255"
                     /db_xref="CDD:187736"
     Site            order(82,88,164,179)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187736"
     Region          264..309
                     /region_name="UCH_C"
                     /note="Ubiquitin carboxyl-terminal hydrolases; pfam18031"
                     /db_xref="CDD:465622"
     CDS             1..329
                     /gene="Uchl5"
                     /coded_by="NM_001393849.1:100..1089"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:360853"
                     /db_xref="RGD:1305414"
ORIGIN      
        1 mssnagewcl mesdpgvfte likgfgcrga qveeiwslep enfeklkpvh gliflfkwqp
       61 geepagsvvq dsrletiffa kqvinnacat qaivsvllnc thqdvhlget lsefkefsqs
      121 fdaamkglal snsdvirqvh nsfarqqmfe fdtktsakee dafhfvsyvp vngrlyeldg
      181 lregpidlga cnqddwitav rpviekriqk ysegeirfnl maivsdrkmi yeqkiaelqr
      241 qlaeeepmdt dqgstvlsai qsevarnqml ieeevqklkr ykienirrkh nylpfimell
      301 ktlaehqqli plvekakekq nakkaqetk
//
