LOCUS       NM_001110165             914 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Rattus norvegicus ubiquitin C-terminal hydrolase L3 (Uchl3), mRNA.
ACCESSION   NM_001110165 NM_053636 XM_341367
VERSION     NM_001110165.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 914)
  AUTHORS   Kazmierczak,M., Harris,S.L., Kazmierczak,P., Shah,P.,
            Starovoytov,V., Ohlemiller,K.K. and Schwander,M.
  TITLE     Progressive Hearing Loss in Mice Carrying a Mutation in Usp53
  JOURNAL   J Neurosci 35 (47), 15582-15598 (2015)
   PUBMED   26609154
REFERENCE   2  (bases 1 to 914)
  AUTHORS   Dennissen,F.J., Kholod,N., Hermes,D.J., Kemmerling,N.,
            Steinbusch,H.W., Dantuma,N.P. and van Leeuwen,F.W.
  TITLE     Mutant ubiquitin (UBB+1) associated with neurodegenerative
            disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3
            (UCH-L3)
  JOURNAL   FEBS Lett 585 (16), 2568-2574 (2011)
   PUBMED   21762696
REFERENCE   3  (bases 1 to 914)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   4  (bases 1 to 914)
  AUTHORS   Suzuki,M., Setsuie,R. and Wada,K.
  TITLE     Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling
            and adipogenesis
  JOURNAL   Endocrinology 150 (12), 5230-5239 (2009)
   PUBMED   19837878
REFERENCE   5  (bases 1 to 914)
  AUTHORS   Setsuie,R., Sakurai,M., Sakaguchi,Y. and Wada,K.
  TITLE     Ubiquitin dimers control the hydrolase activity of UCH-L3
  JOURNAL   Neurochem Int 54 (5-6), 314-321 (2009)
   PUBMED   19154770
REFERENCE   6  (bases 1 to 914)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   7  (bases 1 to 914)
  AUTHORS   Kurihara,L.J., Kikuchi,T., Wada,K. and Tilghman,S.M.
  TITLE     Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior
            paralysis and dysphagia
  JOURNAL   Hum Mol Genet 10 (18), 1963-1970 (2001)
   PUBMED   11555633
REFERENCE   8  (bases 1 to 914)
  AUTHORS   Larsen,C.N., Krantz,B.A. and Wilkinson,K.D.
  TITLE     Substrate specificity of deubiquitinating enzymes: ubiquitin
            C-terminal hydrolases
  JOURNAL   Biochemistry 37 (10), 3358-3368 (1998)
   PUBMED   9521656
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473951.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by
            NM_001110165.2.
            
            On or before Oct 4, 2008 this sequence version replaced
            NM_053636.1, XM_341367.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB043959.1, EV780152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..914
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q21"
     gene            1..914
                     /gene="Uchl3"
                     /gene_synonym="RGD1561196"
                     /note="ubiquitin C-terminal hydrolase L3"
                     /db_xref="GeneID:498560"
                     /db_xref="RGD:1561196"
     exon            1..121
                     /gene="Uchl3"
                     /gene_synonym="RGD1561196"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..772
                     /gene="Uchl3"
                     /gene_synonym="RGD1561196"
                     /EC_number="3.4.19.12"
                     /note="UCH-L3; ubiquitin thioesterase L3; ubiquitin
                     carboxyl-terminal esterase L3 (ubiquitin thiolesterase)"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase isozyme
                     L3"
                     /protein_id="NP_001103635.1"
                     /db_xref="GeneID:498560"
                     /db_xref="RGD:1561196"
                     /translation="MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMEPELLSM
                     VPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIH
                     AIANNKDKMHFESGSALKKFLEESVAMSPEERARHLENYDAIRVTHETSAHEGQTEAP
                     SIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGKTSDETLLEDAIEVCKKFMERDPD
                     ELRFNAIALSAA"
     exon            122..133
                     /gene="Uchl3"
                     /gene_synonym="RGD1561196"
                     /inference="alignment:Splign:2.1.0"
     exon            134..262
                     /gene="Uchl3"
                     /gene_synonym="RGD1561196"
                     /inference="alignment:Splign:2.1.0"
     exon            263..419
                     /gene="Uchl3"
                     /gene_synonym="RGD1561196"
                     /inference="alignment:Splign:2.1.0"
     exon            420..505
                     /gene="Uchl3"
                     /gene_synonym="RGD1561196"
                     /inference="alignment:Splign:2.1.0"
     exon            506..553
                     /gene="Uchl3"
                     /gene_synonym="RGD1561196"
                     /inference="alignment:Splign:2.1.0"
     exon            554..629
                     /gene="Uchl3"
                     /gene_synonym="RGD1561196"
                     /inference="alignment:Splign:2.1.0"
     exon            630..688
                     /gene="Uchl3"
                     /gene_synonym="RGD1561196"
                     /inference="alignment:Splign:2.1.0"
     exon            689..914
                     /gene="Uchl3"
                     /gene_synonym="RGD1561196"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcagcggc ggtggtggtg gtggtggtgg tggcggcggc ggctgctgtc agagctggag
       61 cgcggccggc tgagcagtca tggagggtca gcgctggctg ccgctggagg ccaaccctga
      121 ggtcaccaac cagtttctca agcaactagg cctgcatcct aactggcagt ttgtggacgt
      181 gtacgggatg gagcctgaac ttctcagcat ggttccgaga ccagtgtgcg ccgtgttact
      241 cctcttccct atcacagaga agtatgaagt cttcagaaca gaagaggaag agaaaataaa
      301 atcccaagga caagatgtta cgtcatcagt gtattttatg aaacaaacca tcagcaacgc
      361 ctgtggaacc attggactaa tccacgccat cgcgaacaac aaagacaaga tgcactttga
      421 atcagggtca gcattgaaaa agttcctgga ggagtctgta gcaatgagcc ctgaagaaag
      481 agccagacac ctggagaact atgacgctat tcgagttact catgaaacca gtgcacatga
      541 aggtcagact gaggcaccaa gtatagatga aaaagtagat cttcatttta ttgcgttagt
      601 tcatgtagat gggcatctct atgaattaga tggacggaaa ccgtttccaa ttaaccatgg
      661 gaaaactagt gatgagacat tgttagagga tgccatagaa gtctgcaaga agttcatgga
      721 gcgcgaccct gatgagttaa gatttaatgc aattgctctc tcagcagcat agcatcttga
      781 cagaaacacc aaatactgta ttatttgcaa caaaagttaa atttctgatg ccataactaa
      841 ctcaaaattt ttaatatttt cattaacttg actaattaaa ctttatgtga ataaactttg
      901 actttacctg tatt
//
