LOCUS       NM_017237               1029 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Rattus norvegicus ubiquitin C-terminal hydrolase L1 (Uchl1), mRNA.
ACCESSION   NM_017237
VERSION     NM_017237.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1029)
  AUTHORS   Kim,Y.J., Jeong,I.H., Ha,J.H., Kim,Y.S., Sung,S., Jang,J.H. and
            Choung,Y.H.
  TITLE     The Suppression of Ubiquitin C-Terminal Hydrolase L1 Promotes the
            Transdifferentiation of Auditory Supporting Cells into Hair Cells
            by Regulating the mTOR Pathway
  JOURNAL   Cells 13 (9), 737 (2024)
   PUBMED   38727276
  REMARK    GeneRIF: The Suppression of Ubiquitin C-Terminal Hydrolase L1
            Promotes the Transdifferentiation of Auditory Supporting Cells into
            Hair Cells by Regulating the mTOR Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1029)
  AUTHORS   Hu,Y., Qi,C., Shi,J., Tan,W., Adiljan,Abdurusul., Zhao,Z., Xu,Y.,
            Wu,H. and Zhang,Z.
  TITLE     Podocyte-specific deletion of ubiquitin carboxyl-terminal hydrolase
            L1 causes podocyte injury by inducing endoplasmic reticulum stress
  JOURNAL   Cell Mol Life Sci 80 (4), 106 (2023)
   PUBMED   36952018
  REMARK    GeneRIF: Podocyte-specific deletion of ubiquitin carboxyl-terminal
            hydrolase L1 causes podocyte injury by inducing endoplasmic
            reticulum stress.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1029)
  AUTHORS   Liu,S., Wang,C., Lu,J., Dai,G., Che,H. and He,W.
  TITLE     Long-term inhibition of UCHL1 decreases hypertension and
            retinopathy in spontaneously hypertensive rats
  JOURNAL   J Int Med Res 49 (6), 3000605211020641 (2021)
   PUBMED   34130526
  REMARK    GeneRIF: Long-term inhibition of UCHL1 decreases hypertension and
            retinopathy in spontaneously hypertensive rats.
REFERENCE   4  (bases 1 to 1029)
  AUTHORS   Kim,Y.J., Kim,K., Lee,Y.Y., Choo,O.S., Jang,J.H. and Choung,Y.H.
  TITLE     Downregulated UCHL1 Accelerates Gentamicin-Induced Auditory Cell
            Death via Autophagy
  JOURNAL   Mol Neurobiol 56 (11), 7433-7447 (2019)
   PUBMED   31041655
  REMARK    GeneRIF: UCHL1-dependent autophagic flux may have a potential as an
            otoprotective target for the treatment of gentamycin-induced
            auditory cell death.
REFERENCE   5  (bases 1 to 1029)
  AUTHORS   Camara,M.L., Almeida,T.B., de Santi,F., Rodrigues,B.M., Cerri,P.S.,
            Beltrame,F.L. and Sasso-Cerri,E.
  TITLE     Fluoxetine-induced androgenic failure impairs the seminiferous
            tubules integrity and increases ubiquitin carboxyl-terminal
            hydrolase L1 (UCHL1): Possible androgenic control of UCHL1 in germ
            cell death?
  JOURNAL   Biomed Pharmacother 109, 1126-1139 (2019)
   PUBMED   30551363
  REMARK    GeneRIF: The increase of UCHL1 in the damaged tubules associated
            with high incidence of cell death.
REFERENCE   6  (bases 1 to 1029)
  AUTHORS   Kajimoto,Y., Hashimoto,T., Shirai,Y., Nishino,N., Kuno,T. and
            Tanaka,C.
  TITLE     cDNA cloning and tissue distribution of a rat ubiquitin
            carboxyl-terminal hydrolase PGP9.5
  JOURNAL   J Biochem 112 (1), 28-32 (1992)
   PUBMED   1331034
REFERENCE   7  (bases 1 to 1029)
  AUTHORS   Oda,K., Yamazaki,K., Miura,H., Shibasaki,H. and Kikuchi,T.
  TITLE     Dying back type axonal degeneration of sensory nerve terminals in
            muscle spindles of the gracile axonal dystrophy (GAD) mutant mouse
  JOURNAL   Neuropathol Appl Neurobiol 18 (3), 265-281 (1992)
   PUBMED   1630580
REFERENCE   8  (bases 1 to 1029)
  AUTHORS   Mukoyama,M., Yamazaki,K., Kikuchi,T. and Tomita,T.
  TITLE     Neuropathology of gracile axonal dystrophy (GAD) mouse. An animal
            model of central distal axonopathy in primary sensory neurons
  JOURNAL   Acta Neuropathol 79 (3), 294-299 (1989)
   PUBMED   2558488
REFERENCE   9  (bases 1 to 1029)
  AUTHORS   Yamazaki,K., Wakasugi,N., Tomita,T., Kikuchi,T., Mukoyama,M. and
            Ando,K.
  TITLE     Gracile axonal dystrophy (GAD), a new neurological mutant in the
            mouse
  JOURNAL   Proc Soc Exp Biol Med 187 (2), 209-215 (1988)
   PUBMED   3340629
REFERENCE   10 (bases 1 to 1029)
  AUTHORS   Hoffman,L.E. Jr.
  TITLE     Patient education: how we designed our own program
  JOURNAL   Group Pract 25 (5), 21-24 (1976)
   PUBMED   70392
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 15, 2021 this sequence version replaced NM_017237.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ214229.1, BC060573.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                JAXUCZ010000014.1  41849336-41849417   c
            83-94               JAXUCZ010000014.1  41849212-41849223   c
            95-223              JAXUCZ010000014.1  41848582-41848710   c
            224-374             JAXUCZ010000014.1  41845833-41845983   c
            375-460             JAXUCZ010000014.1  41843282-41843367   c
            461-508             JAXUCZ010000014.1  41843158-41843205   c
            509-575             JAXUCZ010000014.1  41842159-41842225   c
            576-634             JAXUCZ010000014.1  41840980-41841038   c
            635-1029            JAXUCZ010000014.1  41838859-41839253   c
FEATURES             Location/Qualifiers
     source          1..1029
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..1029
                     /gene="Uchl1"
                     /note="ubiquitin C-terminal hydrolase L1"
                     /db_xref="GeneID:29545"
                     /db_xref="RGD:3928"
     exon            1..82
                     /gene="Uchl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..721
                     /gene="Uchl1"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin carboxy-terminal hydrolase L1; PGP9.5;
                     UCH-L1; PGP 9.5; ubiquitin thioesterase L1; neuron
                     cytoplasmic protein 9.5; ubiquitin carboxyl-terminal
                     esterase L1 (ubiquitin thiolesterase)"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase isozyme
                     L1"
                     /protein_id="NP_058933.2"
                     /db_xref="GeneID:29545"
                     /db_xref="RGD:3928"
                     /translation="MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPS
                     PACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANN
                     QDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNF
                     HFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVA
                     LCKAA"
     exon            83..94
                     /gene="Uchl1"
                     /inference="alignment:Splign:2.1.0"
     exon            95..223
                     /gene="Uchl1"
                     /inference="alignment:Splign:2.1.0"
     exon            224..374
                     /gene="Uchl1"
                     /inference="alignment:Splign:2.1.0"
     exon            375..460
                     /gene="Uchl1"
                     /inference="alignment:Splign:2.1.0"
     exon            461..508
                     /gene="Uchl1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..575
                     /gene="Uchl1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..634
                     /gene="Uchl1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..1029
                     /gene="Uchl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgttttt tggctcctgc gcttgttctt ccctgtgcac tccgcaaaga tgcagctgaa
       61 accgatggag attaaccccg agatgctgaa caaagtgttg gccaagctgg gggtcgccgg
      121 gcagtggcgc tttgccgacg tgctagggct ggaggaggag actctgggct cagtgccatc
      181 tcctgcctgc gccctgctgc tgctgtttcc cctcacggcc cagcatgaaa acttcaggaa
      241 aaaacaaatt gaggaactga agggacaaga agttagccct aaagtttact tcatgaagca
      301 gaccatcggg aactcctgtg gtaccattgg gctgatccac gcagtggcca ataaccaaga
      361 caagctggaa tttgaggatg gatcagtcct gaaacagttt ctgtctgaaa cggagaagtt
      421 gtcccctgaa gacagagcca agtgtttcga gaagaacgag gccattcagg cagcccatga
      481 ctccgtggcc caggagggcc agtgccgggt agacgacaaa gtgaatttcc attttatcct
      541 gttcaataat gtggacggcc acctctacga gctcgatggg cgaatgcctt tcccggtgaa
      601 ccatggcgcc agttcagagg actctctgct gcaggatgcc gccaaggtct gcagagaatt
      661 cactgagcgc gagcagggag aggtccgctt ctccgcagtg gctctctgca aagcagccta
      721 agtagggaga gagaaccagc cgctccccca tccctgggca ggcgcgcgct gccccgccct
      781 tggtttgcag ctttagcact taacaaccac agctgtcttc ttgcgttcta ctgccccgtc
      841 ccctccaccc cacccaggcc accagggagc tctgtgacag ccacaccagt gtgaacttca
      901 gaggctaagc tcttaccctc ctgtgtcttg taccttgctc tctatggtct ctttggtttc
      961 tgtaagttac ggccttggat gtggtttgtc tagtcctcaa gaggaagaat aaaacttttc
     1021 tgctggcaa
//
