LOCUS       XM_006239200           16134 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus ubiquitin protein ligase E3 component
            n-recognin 4 (Ubr4), transcript variant X1, mRNA.
ACCESSION   XM_006239200
VERSION     XM_006239200.4
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051340.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jan 21, 2021 this sequence version replaced XM_006239200.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16134
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..16134
                     /gene="Ubr4"
                     /gene_synonym="Rbaf600"
                     /note="ubiquitin protein ligase E3 component n-recognin 4;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 60 ESTs, 2 long SRA reads, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 77 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:313658"
                     /db_xref="RGD:1563121"
     CDS             74..15775
                     /gene="Ubr4"
                     /gene_synonym="Rbaf600"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UBR4 isoform X1"
                     /protein_id="XP_006239262.1"
                     /db_xref="GeneID:313658"
                     /db_xref="RGD:1563121"
                     /translation="MATSGGEEAAAAAPAPGAPATGQDTTPGWEVAVRPLLSASYSAF
                     EMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAA
                     ACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKL
                     PQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVPSPPISPQALVE
                     GENDEQSSTEQASAVKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDA
                     VVANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSL
                     SCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEEDYESDAATIVQKCLEIYDMIGQAI
                     SSSRRAGGEHFQNFQLLGAWCLLNSLFLILHLSPTALADKGKEKDPLAALRVRDILSR
                     TKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAV
                     LSIMAQSTSTQRVQRLIDSVPLTNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDS
                     NTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVK
                     SPSKQASGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEQH
                     MATLASIIKEVDKDGLKGSSDEDFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPL
                     SSGPWPLYIHPQGLSVLSRLLLIWQHKAGAQGDPDVPECLKVWDRFLTTMKQSALQGV
                     VPSETEDLNIEHLQLLLLIFHSFSEKGRRAILTTLVQSIQELSVNMEVQMRSAPLILA
                     RLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSSSSSRRANIPLYHGFK
                     EVEENWSKHFSSDAAPQPRFYCVLSTEASEEDLNRLDSEACEVLFSKLVKYDELYSSL
                     TALLAAGSQLDTVKRKENKNMTALEACALQYYFLILWRILGILPPSKTYMNQLAMNSP
                     EMSECDILHTLRWSSRLRISSYVSWIKDHLIRQGMRPEHAGSLVELAASKCSSVKYDV
                     EIVEEYFARQISSFCSIDCTTVLQLHEIPSLQSIYTLDAAVSKVQVSLDEHFSKMAAE
                     TDPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNLNEEGSTEKPSQEKLHGFAAVLA
                     IGSSRCKANTLGPTLVQNLPSSVQSVCESWNNINTNEFPNIGSWRNAFANDTIPSESY
                     ISAVQAAHLGTLCGQSLPLAASLKHALLSLVRLTGDLIVWSDEMNPAQVIRALLPLLL
                     ESSTESAAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPSSGLDESVL
                     EECLQYLEKQLESSQARKAMEEFFSDGGELVQIMMATANEDLSAKFCNRVLKFFTKLF
                     QLTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLEVIQENRQLLQ
                     LLTTYIVRENSQVGEGVCAVLLGTLTPMATDMLANGDGTGFPELMVVMATLASAGQGA
                     GHLQLHNAAVDWLGRCKKYLSQKNVVEKLNANVMHGKHVMVLECTCHIMSYLADVTNA
                     LSQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTIT
                     QKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCL
                     ALVKRTPSSGMSSTMKESAFQSEPRVSESLVRHASTSPADKAKVTISDGKVADEEKPK
                     KSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQAL
                     SELHTVDKVVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMC
                     VLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLT
                     GNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELA
                     IVTADFVKIYDLSVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYMYTQL
                     MEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYSQGKSF
                     AATVSRSTLEVLQLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVV
                     MVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVEN
                     TSYWLQPSLQPSSVISIMKPVRKRKTATITARTSSQVTFPIDFFEHNQQLTDVEFGGN
                     DLLQVYNAQQIKHRLNSTGMYVANTKPGGFTMEISNNSSTMVMTGMRIQIGTQAIERA
                     PSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADRKLNLFIGASVDPAGVTMIDAVKI
                     YGKTKEQFGWPDEPPEDFPSASVSSVCPPNLNQSNSTGDSDSAAPATTSGTVLESSET
                     ESLTKLDRLVVSSLEALESCFAVGPIIEKERNKHAAQELATLLLSLPAPASVQQQSKS
                     LLASLHSSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAVTRP
                     NNLVHFTESKLPQMETDCFSPRCACWNLGIVGILIGAPLETPSAEGAEEGKEPQKQVE
                     GDGCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELD
                     CINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDD
                     DDDDDADEKMQSSGIPDGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSP
                     LEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQA
                     PSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSV
                     AGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGDGSEGEGEGEAEGD
                     VHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGAL
                     DNLLAQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICESSS
                     LISSATAAALLSSGAVDYCLHVLKSLLEYWKGQQSEEEPVTTSQLLKPHTTSSPPDMS
                     PFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKIADTSSRIPPPVFDHSWFYFLS
                     EYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRA
                     SVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLV
                     DEGVSPVLLQLLSCALCGSKVLAALAASTGSSSVASSAPPAASSGQTTTQSKSSTKKS
                     KKEEKEKEKEGESSGSQEDQLCTALVNQLNRFADKETLIQFLRCFLLESNSSSVRWQA
                     HCLTLHIYRNSNKAQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTAQTEKKL
                     KEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCY
                     IKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAI
                     VELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQC
                     PRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAK
                     PCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQ
                     EDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQ
                     QREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALAT
                     NPALRHILVSQGLIRELFDYNLRRGAAAIREEVRQLMCLLTRDNPEATQQMNDLIIGK
                     VSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVV
                     VENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKA
                     SYEAWKKCLPIRGVDGNGKSPSKSELHRLYLTEKYVWRWKQFLSRRGKRTTPLDLKLG
                     HNNWLRQVLFTPATQAARQAACTIVEALATVPSRKQQVLDLLTSYLDELSVAGECAAE
                     YLALYQKLIASCHWKVYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKS
                     LTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVLQRTKLIDETQDMLLEMLEDM
                     TTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKD
                     PQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKI
                     ISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEV
                     YRMAGVMAQCGGLQCMLNRLAGVKDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLEM
                     NTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLT
                     GDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCSFDK
                     YDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQSALDYMKKHIPSAKN
                     LDADIWKKFLSRPALPFILRLLRGLAMQHPATQVLIGTDSITSLHKLEQVSSDEGIGT
                     LAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTK
                     TALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYS
                     TVSHFNIVHYDCHLAAVSCLSLLSSLSPSRLARGREEWESAALQNANTKCNGLLPVWG
                     PHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGG
                     RESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPREKWTESAFDVDGPHYFTI
                     LALHVLPPEQWKATRVEILRRLLVASHARAVAPGGATRLTDKAVKDYSAYRSSLLFWA
                     LVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFS
                     EFLDAAGLLSEITDPESFLKDLLNSVP"
ORIGIN      
        1 tccgctccct cccgggaggc ggcgctgggc cggtggcaag cccccggagg gagccgcagt
       61 agtacgacga aagatggcga cgagcggcgg cgaagaggcg gcggcagcag ctccagcgcc
      121 cggagccccg gcaaccgggc aggacacgac cccgggctgg gaggtggcgg tgcggcccct
      181 actgtccgcg tcctactccg ccttcgagat gaaggagttg ccgcagctgg tggcctcagt
      241 catcgagagt gagtcagaga tcctgcacca cgagaagcag tacgagccat tctattcatc
      301 ctttgtcgca ctgtccacgc actacatcac cacggtctgc agcctcattc cccggaacca
      361 gcttcagtcg gtggcggctg cctgtaaagt cctcattgag ttttccctcc tgcggctgga
      421 gaacccggac gaggcctgtg ctgtgtccca gaaacacttg attctgctga taaaaggcct
      481 gtgcactggc tgtagccgac tagacagaac agagattatc acctttacag caatgatgaa
      541 atccgccaag cttccacaga cagtgaagac gctttcagat gtggaagacc agaaagagct
      601 ggcctcacca gtgagccccg agctgaggca gaaggaggta cagatgaact ttttgaacca
      661 gctgacctca gtttttaacc ctagaaccgt accgtctcct cccattagtc cacaggctct
      721 ggtggaagga gaaaatgatg agcagtcctc cacagagcag gcctctgctg tcaagaccaa
      781 gaatgtgttc atagctcaga atgtggctag ccttcaagag cttgggggct ctgagaagtt
      841 actccgagta tgcctgaacc tgccctactt cctgcgctac atcaatcggt ttcaggatgc
      901 tgtggtggcc aattccttct tcatcatgcc tgcaacagta gctgatgcca ccgctgttcg
      961 aaatggtttt cactcactgg tgattgatgt aaccatggcc ttggataccc tttccctacc
     1021 tgtgctggaa cccctcaatc cttctcgttt gcaagatgtg acagtgctca gcctcagctg
     1081 tctttatgca ggtgtgagtg tggccacctg catggccatt cttcatgtgg ggagtgccca
     1141 gcaagtgcgg acagggtcca ccagctccaa agaagaagac tacgaaagtg atgcagccac
     1201 cattgttcag aaatgtcttg agatctatga catgattgga caggccatca gcagttcccg
     1261 ccgcgccggt ggtgagcact tccagaactt ccagctgctg ggtgcctggt gtctgctcaa
     1321 tagcctcttc ctcatactgc atctcagtcc cacagccctg gctgacaaag ggaaagagaa
     1381 ggacccgttg gctgccctcc gagtcagaga catcctttct cgtacaaagg agggagtagg
     1441 ctctcccaaa ctggggcctg gcaaagggca tcagggattt ggggtactct cagtgatact
     1501 ggcaaaccat gccatcaagc tgctgacatc tctctttcaa gacctgcagg tggaggcgct
     1561 ccacaagggc tgggagacag atggtccccc tgcagtcctg agtattatgg cccagagtac
     1621 ctccacacaa agggttcagc ggctgattga ctctgtccct ctgacaaacc tgctcttgac
     1681 gctgctttcc acttcataca gaaaggcatg tgtcctgcag cggcagagga agggctccat
     1741 gagcagtgac gccagtgcct ccactgactc caacacctac tatgaagacg acttcagtag
     1801 cactgaggag gatagcagcc aagatgatga cagtgagcca attttggggc agtggtttga
     1861 ggagaccatc tctcccagta aggaaaaagc tgcgcctcca ccccctcccc cgccccctcc
     1921 cctggagagc tctcctcggg ttaaaagccc cagtaaacag gcgtctggtg agaagggcaa
     1981 catcttggcc agtcgcaaag atcctgagtt gttcttaggt ctggcttcca acatcctgaa
     2041 ctttatcacc tcttccatgc tgaactctcg gaacaatttc atccggaact atctgagcgt
     2101 gtctctttcc gagcagcaca tggccacctt ggccagcatc attaaggagg tggacaaaga
     2161 tggactcaag gggtcatcgg atgaggactt tgctgctgct ctctaccact tcaaccactc
     2221 cctggtgacc tccgacctac agtccccgaa cctgcagaat acactgctac agcagctggg
     2281 agttgctcct ctctcctcag gcccttggcc cctctacatt cacccccaag gcctctctgt
     2341 gctttcccgc ctcctgctta tctggcagca taaagctgga gcacaaggtg accctgacgt
     2401 ccctgaatgc ctgaaagtgt gggacaggtt cttgaccaca atgaagcaga gtgcactgca
     2461 gggggtggtg cccagtgaga ccgaagacct gaacatcgag cacctgcagc tgctgctgct
     2521 catcttccac agcttctctg agaagggccg ccgggccatc ttgaccacac tggtgcagag
     2581 catccaggag ctgagtgtta acatggaggt gcagatgcgc tctgccccgc tgattctggc
     2641 ccgcctcctc ttgatcttcg actacctact tcatcagtac tccaaagccc ctgtgtatct
     2701 gtttgagcag gtgcaacaca acctgctaag cccccctttt gggtgggcaa gtggatccca
     2761 agacagcagc agcagcagcc gccgagccaa cattcctctg tatcatgggt tcaaggaagt
     2821 cgaagaaaat tggtccaaac atttttcatc agatgcagcc ccacaaccca ggttctactg
     2881 tgtcctgtcc actgaggcct ccgaggaaga tttgaaccgg ctggattctg aggcatgtga
     2941 agttcttttc tccaagcttg tcaagtacga tgaactatat tcttcactga ctgccctgct
     3001 tgcggctggg tctcagcttg atacagtcaa gaggaaggaa aataagaaca tgacagccct
     3061 ggaggcctgc gccctgcagt attacttctt gattctctgg aggatcttgg gaattttacc
     3121 gccttcaaag acttacatga accaactggc catgaactca cctgagatga gcgaatgcga
     3181 catcttacac actctgcggt ggtcgtcccg cctccggatc agttcctatg tcagctggat
     3241 aaaggatcac cttatcagac aaggcatgag gcccgagcat gcgggctcgc ttgttgagct
     3301 ggccgccagc aagtgcagtt cagtgaagta cgatgtcgag atcgtagagg agtactttgc
     3361 ccgacagatc tcgtcattct gctccattga ctgcaccact gttctccagc tgcatgagat
     3421 ccctagtctg cagtccatct acaccctgga cgcagctgtc tcaaaggtgc aggtctctct
     3481 ggatgagcac ttttctaaga tggctgcaga gaccgaccct cataagtcat ctgagatcac
     3541 caagaacctc cttccagcca cgctgcagct cattgacacc tacgcctcat tcacaagagc
     3601 ctatctgctt cagaacctta atgaagaggg atccactgag aagccctccc aggagaagct
     3661 gcatggcttt gcagcagtct tggctatcgg ctcgagtagg tgcaaggcaa acacactggg
     3721 tccaactctg gtgcagaatt taccgtcatc agtgcaatcg gtctgtgagt cctggaataa
     3781 catcaatacc aacgagtttc ccaacattgg atcctggcgc aatgcatttg ccaacgacac
     3841 catcccatcg gagagttata tcagtgcagt gcaggctgct cacctgggga ctctgtgtgg
     3901 ccagagtctg cccctggcgg cttccctgaa acatgccctc ctctccctgg tcaggttgac
     3961 tggggatctg attgtgtggt cggatgagat gaacccagcg caggtcatcc gggctctgct
     4021 accgctcctt ttggagtcaa gcacagagag cgctgctgag atcagcagta actccctgga
     4081 gcgcatcttg ggacctgcgg agtctgatga gttcctggct cgcgtgtatg agaagctgat
     4141 cacagggtgt tacaacattc tggccaacca cgcagacccc agcagtgggc tggatgagtc
     4201 cgtcctggag gagtgtttac agtatctgga gaagcagctg gagagcagcc aggcccggaa
     4261 ggccatggag gagtttttct ctgatggtgg ggaacttgtg cagatcatga tggccacggc
     4321 caatgaggac ctctctgcta aattctgtaa ccgagtcttg aaattcttca ccaaactctt
     4381 ccaactgact gagaagagcc ctaacccaag cctccttcac ctctgtggct ctctcgccca
     4441 gcttgcctgt gtggagccag tacgcctgca ggcctggctc acccgcatga caacatcgcc
     4501 cccaaaggat tctgaccagc tggaggtcat tcaggagaac cggcagctgc tacagttact
     4561 gaccacgtac attgttcggg aaaacagcca agttggagaa ggtgtgtgcg ctgtacttct
     4621 gggcactctg acccccatgg ccacagacat gctggcgaat ggtgatggga ccggcttccc
     4681 cgagctcatg gttgtgatgg ccactttagc cagtgccgga caaggagcgg gccaccttca
     4741 acttcacaat gctgctgtgg actggctggg cagatgcaag aaatacctgt cacagaagaa
     4801 tgtggttgag aaactgaatg ccaatgtaat gcatggaaag catgtgatgg tcttggaatg
     4861 cacatgtcac attatgtctt acctggctga cgtcacgaat gccctgagcc agagtaatgg
     4921 tcaaggaccg agccatctgt cggtagatgg ggaggagcgt gccattgagg tggattcaga
     4981 ctgggtggaa gagttagcgg tggaagagga agactcccag gctgaggact ccgatgaaga
     5041 ttctctttgc aataagctgt gcactttcac catcacacag aaggaattta tgaaccagca
     5101 ttggtaccac tgtcatacat gtaagatggt ggatggggtg ggtgtgtgca cagtgtgtgc
     5161 gaaggtgtgc cacaaggatc atgagatctc ctatgccaag tatggctcct ttttctgtga
     5221 ctgtggagcc aaggaagatg gcagctgctt ggcactggtg aaacgaactc ctagcagtgg
     5281 catgagctct accatgaagg agtcagcatt tcagagcgag cctagggttt cagagagtct
     5341 ggtgcgccat gccagcacct cacctgctga caaggccaag gtcaccatca gtgatggaaa
     5401 ggttgctgat gaagagaagc ccaagaagag cagcctgtgc cgcacagttg aggggtgccg
     5461 tgaggagctg cagaatcagg ccaatttctc cttcgctcct ctcgtgttag acatgctcaa
     5521 tttcctcatg gatgccattc agaccaactt tcagcaggct tccgccgtgg ggagcagcag
     5581 ccgggcacag caggccctca gtgaactgca cacagtggac aaggttgtgg agatgacaga
     5641 ccagctgatg gttcccacct taggctcaca ggaaggtgcc tttgagaatg ttcggatgaa
     5701 ttacagcgga gaccagggcc agactatacg gcagctgatc agtgcccacg tgctcaggcg
     5761 ggtggctatg tgtgtgcttt cttcccccca tgggcgccgc caacatttgg ctgtcagcca
     5821 cgagaagggc aagatcacgg tgctgcagct ctcggcgctc ctgaagcaag cagattccag
     5881 taagaggaag ttgactctaa cccgcttggc ttctgctcca gttcccttca ccgtgctgag
     5941 tcttactgga aacccctgca aggaggacta cctggcagtg tgtgggctga aggactgcca
     6001 tgtgctcacc ttcagtagct cgggctctgt ctccgatcac ttagtgttac atccccagtt
     6061 ggcaacaggg aacttcatca tcaaagctgt gtggctccct ggctctcaga ccgagctagc
     6121 cattgttact gcagacttcg tcaagattta cgacctgtct gttgatgcct tgagccccac
     6181 cttctacttc ctcctgccaa gctcaaagat aagggatgtc accttccttt tcaacgagga
     6241 aggcaagaac atcattgtca tcatgtcctc tgctgggtac atgtacacac agctcatgga
     6301 ggaggccagc agtgcccagc aggggccctt ctatgtcact aatgtgctgg aaataaatca
     6361 cgaggatctg aaggacagta acagccaggt ggcaggtggt ggcgtgtctg tgtactattc
     6421 acacgtgttg cagatgcttt tcttcagcta cagtcagggc aagtcctttg cagccaccgt
     6481 cagcaggagc actctggagg tgctgcagct cttccccatc aacatcaaaa gctccaatgg
     6541 tggcagtaag acttctcccg ccctttgcca gtggtctgag gtgatgaacc accctggctt
     6601 ggtgtgttgt gttcagcaaa ctactggtgt gcctctggta gtcatggtga aaccagacac
     6661 tttcctcatc caggagatta agactcttcc cgccaaagca aagatccagg acatggttgc
     6721 tattagacac actgcctgta atgagcagca gcgcaccacc atgatcctgc tgtgtgagga
     6781 tggcagcctg cgaatttata tggccaacgt ggagaacacc tcttactggc tccagccgtc
     6841 tctgcagccc agcagcgtca tcagcatcat gaagcctgtg cgaaagcgca aaacagctac
     6901 aatcacagcc cgcacatcca gccaggtgac cttccccatt gacttctttg aacacaacca
     6961 gcagctaacg gatgtggagt ttggtggtaa tgacctcctg caagtctaca atgcgcaaca
     7021 gataaagcac aggctcaact ccactggcat gtatgtggcg aacaccaagc ctggaggctt
     7081 caccatggag atcagtaaca acagtagcac catggtgatg acgggcatgc ggatccagat
     7141 tggcacacag gcaatcgagc gagcaccgtc ctacatcgag atctttggca gaaccatgca
     7201 gcttaacctg agccgctccc gctggtttga cttccccttc accagagagg aagccctgca
     7261 ggctgaccgg aagctgaacc tcttcatcgg tgcctctgtg gatccagctg gcgtcaccat
     7321 gatagatgct gtaaaaattt atggcaagac taaagagcag tttggctggc ctgatgagcc
     7381 cccagaagac ttcccttctg cctctgttag cagcgtctgc cctcctaacc tgaaccagag
     7441 caacagcact ggagacagtg actcagctgc tccagctaca accagtggca ctgtcctgga
     7501 gagttctgaa actgagtccc taaccaagct ggatcggctg gttgtgagtt ctttggaagc
     7561 cctggaaagc tgctttgctg tcggcccaat cattgagaag gagagaaaca agcacgcagc
     7621 ccaggagctg gccactttgt tgctctccct gccagcgcct gccagcgtcc aacagcaatc
     7681 aaagagcctc ctggccagcc tgcacagcag tcgctcggcc taccacagcc acaaggacca
     7741 ggccttgttg agcaaagctg tgcagtgtct caacacttcc agcaaagaag gcaaggactt
     7801 ggaccccgag gtgttccagc gtctagtaat cacagctcgc tctattgccg tcacacgtcc
     7861 caacaacctt gtgcacttta cggagtccaa gctgccccag atggaaacag actgtttttc
     7921 tcccagatgt gcctgctgga atctagggat agttggcata ttgattgggg ccccacttga
     7981 aactccctcc gcagaaggag cggaggaggg gaaagagccg cagaagcagg tggaaggaga
     8041 cggctgtagt ttcatcactc agcttgtaaa ccacttctgg aaactccatg catctaagcc
     8101 caagaatgcc ttcctggcac ctgcctgcct gccaggcctt actcatattg aagctacggt
     8161 taatgcgctg gtagacatta tccatggcta ttgtacctgc gagctggact gtatcaacac
     8221 agcatccaag atctacatgc agatgctgct gtgtcctgac cctgctgtga gcttctcctg
     8281 taaacaagct ctaattcgag tcctaaggcc caggaacaag cggagacacg tgacattgcc
     8341 ctcctccccc cgaagcaaca ctccaatggg agacaaggat gacgatgatg atgatgatgc
     8401 ggatgagaaa atgcagtcat cgggcatccc tgatggtggt cacatccgtc aggaaagcca
     8461 ggaacagagt gaggtggacc atggagattt tgagatggtg tctgagtcga tggtcctgga
     8521 aacagctgaa aatgtcaaca atggcaaccc ctctcccctg gaagccctgc tggccggtgc
     8581 tgagggcttt cctcccatgc tggacatccc acctgatgca gacgacgaga ccatggttga
     8641 actagccatt gccctcagcc tgcagcagga ccagcaaggc agcagcagca gtgccctggg
     8701 ccttcagagc ctgggactgt cgggccaggc acccagctct tcctctctgg acgcaggaac
     8761 cctctctgac accacagcat cagctccagc ctcagatgac gagggcagca ctgcagcaac
     8821 tgatggctcc accctgcgga cctcgccagc cgaccatggc ggtagtgtgg gctcagagag
     8881 cgggggaagt gcagtggact cggtggctgg cgagcacagt gtgtctggcc ggagcagtgc
     8941 atatggtgac gccacagctg aggggcaccc ggctggacca gggagcgtca gctctagcac
     9001 aggcgccatc agcaccacta ctgggcacca ggagggagat ggatctgagg gagaaggaga
     9061 aggggaagct gaaggagatg tgcacactag caacaggcta cacatggttc gtctaatgct
     9121 gttggaaaga ttactgcaga cactgcccca gttacggaat gtcggaggtg tccgggccat
     9181 cccatacatg caggtcattc tcatgctcac tacagatctg gatggagaag atgagaaaga
     9241 caagggagcc ctggacaacc tgcttgcaca gctcattgct gagctgggaa tggacaaaaa
     9301 ggatgtctcc aagaagaatg aacgcagtgc cttgaacgaa gtccatttgg tcgtgatgag
     9361 actcctgagt gtcttcatgt cccgcaccaa gtctggatcc aaatcttcca tctgtgagtc
     9421 gtcttccctc atctccagtg ccacggcagc agccctgctg agctccgggg ccgtggacta
     9481 ttgcctccat gtgctcaagt ctctgctgga atactggaag ggccagcaga gtgaggagga
     9541 gcctgtgacc accagccaat tgctgaaacc acacacgacc tcatctccac cagatatgag
     9601 cccgttcttt ctccgacaat atgtgaaggg tcatgctgct gatgtgttcg aagcctatac
     9661 ccagctgctc acagaaatgg tactgaggct tccctaccag atcaagaaga tcgcagatac
     9721 cagctctcga atccctcctc ctgtctttga tcactcctgg ttctactttc tctctgagta
     9781 cctaatgatc cagcagaccc cttttgtccg ccgccaagtc cggaaacttc tgctcttcat
     9841 ctgtggatca aaggagaaat accgtcagct ccgagacctg cacaccctgg actcccatgt
     9901 gcgtgggatc aagaagctgc tggaggaaca gggcatcttc ctcagggcca gcgtggttac
     9961 agccagttcc ggctccgctt tgcagtatga cacgctcatc agcctgatgg agcacctgaa
    10021 ggcctgtgca gagattgccg cccagcgcac catcaactgg cagaagttct gcatcaaaga
    10081 tgactctgtc ctgtacttcc tcctgcaagt gagtttcctg gtagatgagg gggtgtcccc
    10141 tgtgctactg cagctgcttt cctgtgctct ttgcggcagc aaagtgctcg cagccctggc
    10201 ggcctccacg ggctcctcca gtgtggcttc ctcagcccct cctgcagcca gttctggaca
    10261 aaccacaact cagtccaaat cctccactaa aaagagcaag aaagaagaaa aggagaaaga
    10321 gaaagagggt gagagctcgg gtagccagga agaccagctg tgtacagctc tcgtgaacca
    10381 gctgaacaga tttgcagaca aggagactct gatccagttt ctgcgctgct tcctattgga
    10441 gtccaactct tcgtcagtac gctggcaggc ccactgcctg acactgcaca tctacagaaa
    10501 ctccaacaag gctcagcagg agctcttgct agatctcatg tggtcaatct ggccagaact
    10561 cccagcttat ggtcggaagg ctgcccagtt tgtggatctc ctgggctatt tctccctgaa
    10621 aactgcacag acagagaaga agttgaagga gtactcacag aaggccgtgg agattctgag
    10681 gactcagaac cacattctca ccaatcatcc caactccaac atttacaata ccttgtctgg
    10741 cttagtggag tttgatggct actacctaga gagtgatccc tgcctggtgt gtaataaccc
    10801 tgaagtgccg ttttgttata tcaagctgtc ttccattaaa gtggacacac ggtacaccac
    10861 cacccagcag gtggtaaagc tcattggtag tcacaccatc agcaaggtga cagtgaaaat
    10921 tggggacctg aagcggacca agatggtgcg gacaatcaac ctgtattaca acaaccgaac
    10981 tgtgcaggcc attgtggagt tgaaaaataa gccagctcgc tggcacaaag ccaagaaagt
    11041 tcagctgacg cctggacaga cagaagtcaa gattgacctg cctctgccca ttgtggcctc
    11101 taacctgatg atcgagtttg cagacttcta tgagaactac caggcttcca cagagaccct
    11161 tcagtgtcct cgctgcagtg cctctgtccc cgccaatccc ggcgtctgtg gcaactgtgg
    11221 cgagaatgta taccagtgtc acaagtgcag gtccatcaac tatgatgaga aggatccctt
    11281 cctctgcaat gcttgtggct tttgtaaata tgcccgcttt gacttcatgc tttatgccaa
    11341 accttgctgc gcagtggatc ccatcgagaa cgaggaagat cggaagaagg ccgtttccaa
    11401 catcaacaca cttctggaca aagctgaccg cgtgtaccat cagctcatgg gacaccggcc
    11461 ccagctggag aacctgctct gcaaagtgaa tgaagcagct ccagaaaagc cacaggaaga
    11521 ctcgggaaca gcgggaggca tcagctccac ttcagccagt gtgaatcgct acatcctaca
    11581 gctggcgcag gagtattgtg gagactgtaa gaactcattt gacgagctct ccaaaatcat
    11641 ccagaaagtc ttcgcttcgc gcaaagagct gttagagtat gacctgcagc agagagaagc
    11701 ggccaccaag tcatcccgga catccgtgca gcccacgttt actgccagcc agtaccgtgc
    11761 gttgtctgtc ttaggctgtg gccacacctc ctccaccaag tgctatggct gtgcctcagc
    11821 tgtcacagag cattgtatca cactgctaag ggccctggcc accaatccag ccctgagaca
    11881 catcctcgtc tcccagggcc tcatccgaga gctctttgat tacaacctcc gcagaggcgc
    11941 ggcagccatc cgcgaggagg tccgccagct catgtgcctc ctgactagag acaacccaga
    12001 ggccacccag caaatgaatg acctgatcat tggcaaagtc tccactgcac tgaagggcca
    12061 ctgggctaat cctgacctgg ctagcagcct tcagtatgag atgctgctgc tgacagactc
    12121 catctccaag gaggacagct gctgggaact ccgcttacgc tgtgcactca gccttttcct
    12181 catggctgtg aacatcaaaa cgccagtggt tgttgagaac atcaccctca tgtgtctgcg
    12241 gatcttacag aagctgatta aaccacctgc cccaaccagc aagaagaaca aggacgtccc
    12301 tgtggaggcc ctcaccacgg tgaagccgta ctgcaatgag atccacgcgc aggctcagct
    12361 gtggctcaag cgagatccta aggcatccta cgaagcctgg aagaagtgcc tgcctatccg
    12421 aggggtagat ggcaacggga aatcccccag caagtccgag ctccaccggc tctacttgac
    12481 tgagaagtat gtgtggaggt ggaaacagtt cctgagtcgg cgggggaaga ggaccacccc
    12541 acttgacctc aagctgggcc acaacaactg gctgcggcag gtactcttta ccccggcaac
    12601 acaggcagca cggcaggcag cctgtactat tgtggaagct cttgctactg tccccagccg
    12661 caagcagcag gtccttgacc tcctcaccag ttacctggac gagctgagtg tggctgggga
    12721 gtgtgctgca gagtacctgg ctctctacca gaagctcatc gcctcctgcc actggaaagt
    12781 ctacctggct gctcggggag tcctgcccta cgtgggcaac ctcatcacca aggaaatcgc
    12841 ccgcctgctg gccttggagg aggccacact gagcacagac ctgcagcagg gatatgccct
    12901 caagagtctc acaggcctcc tctcctcctt tgtagaggtg gagtccatca agcgtcattt
    12961 caagagccgc ttggtgggca ctgtgctgaa tgggtacctg tgcttgcgga aactagtgct
    13021 gcagaggacc aagctcatcg atgagaccca ggacatgctg ctggagatgc tggaggacat
    13081 gaccacaggt acagagtctg aaaccaaggc cttcatggct gtgtgcattg agacagccaa
    13141 gcgctacaat ctggatgact accggactcc tgtgttcatc tttgagaggc tgtgcagcat
    13201 catctaccct gaggaaaatg aagtcactga gttctttgtg accctggaga aggaccccca
    13261 gcaagaggac tttctacagg gcaggatgcc cggaaaccca tatagcagca atgaaccagg
    13321 cattgggcct cttatgaggg acataaagaa caagatctgc caggactgtg acctggtggc
    13381 tcttctggag gacgacagtg ggatggagct tctagtgaac aataaaatta tcagtctgga
    13441 tcttcctgtg gctgaggttt acaagaaggt ctggtgtacg accaatgagg gagagcccat
    13501 gaggattgtt tatcgaatgc gggggctact gggcgatgcc accgaggagt ttatcgagtc
    13561 cctggactcc accacagatg aagaagagga cgaagaggaa gtgtacagaa tggccggtgt
    13621 gatggcccag tgcgggggtc tgcagtgcat gctgaacaga ctggcaggag tcaaagattt
    13681 taagcagggg cgccaccttc taacagtgct cctgaagctg ttcagttact gtgtgaaggt
    13741 gaaagtcaat cggcaacagt tggtcaagct ggaaatgaac accttgaatg tcatgttggg
    13801 gactttaaac ttggctctgg tagctgagca agagagcaag gacagcggag gagcagcggt
    13861 ggctgagcag gtgctgagca tcatggagat cattctagat gagtccaatg cagagcccct
    13921 gagtgaggac aagggcaacc tcctcctcac aggtgacaag gatcaactgg tgatgctctt
    13981 ggaccagatc aacagcacct tcgttcgttc caatcccagc gtgctgcagg gtttgctgcg
    14041 tatcatccca tacctgtcct tcggagaggt ggagaagatg cagatcctgg tggagcggtt
    14101 caagccatac tgcagcttcg ataagtacga tgaagaccat agtggggatg acaaagtctt
    14161 cctggattgc ttctgcaaga ttgctgctgg tatcaagaac aacagcaatg gtcatcagct
    14221 gaaggacctc atcctgcaga agggaatcac ccagagtgcc ctggactaca tgaaaaagca
    14281 tatccccagt gccaagaatt tggatgctga catctggaaa aagtttttgt ctcggcctgc
    14341 tctgccattt attttgaggc ttcttcgggg tctggccatg caacaccctg ccacccaggt
    14401 tctgattgga acggactcca tcacaagcct gcataagcta gagcaggtgt ccagtgatga
    14461 gggcattggg accttggccg agaacctcct ggaggcccta agagaacacc cagatgtgaa
    14521 caagaagatt gacgcagccc gcagagagac ccgggcagag aagaagcgca tggccatggc
    14581 catgaggcag aaggctctgg gaactctggg catgacgaca aacgagaagg gtcaggtggt
    14641 gaccaagact gcgctcctga agcaaatgga agagctgatt gaggagcccg gactcacgtg
    14701 ctgcatctgc agggaggggt acaagttcca gcccacgaag gtcttaggca tttacacttt
    14761 caccaagcgg gtggccttgg aggagatgga gaacaagcct cggaaacagc agggctacag
    14821 cactgtgtcc catttcaaca tcgtgcacta tgactgtcac ctggctgctg tcagttgctt
    14881 gtccctgctc tcctccctgt ccccatccag gttggctaga ggccgggaag agtgggaaag
    14941 tgctgccctg cagaacgcca acacgaagtg caatggactc cttccggtct ggggccccca
    15001 tgtccctgag tcagcttttg ccacttgttt agctaggcac aacacttacc tccaggagtg
    15061 taccggccag cgggagccca cgtaccagct caacatccac gacatcaaac tgcttttcct
    15121 gcgcttcgcc atggagcagt cattcagtgc agacaccggt gggggcggtc gggagagcaa
    15181 catccacctg atcccgtaca tcattcacac tgtgctttac gtcctgaaca cgacccgagc
    15241 aacgtcccgg gaggagaaga acctccaagg cttcctggag cagcccagag agaagtggac
    15301 agagagtgcc tttgatgtag atgggcccca ctacttcacc atcttagccc tgcatgtcct
    15361 cccccctgag cagtggaaag ccactcgagt ggagatccta cgcaggctgc tggtggcctc
    15421 gcatgcccgg gcagtggctc caggaggagc caccaggttg acagataagg cggtgaaaga
    15481 ctattctgcc taccgttctt ccttgctgtt ctgggctctc gttgatctca tttataacat
    15541 gtttaagaag gtgcccacta gtaacactga gggcggctgg tcctgctctc tggctgagta
    15601 catccgccac aatgacatgc ccatctacga agctgccgac aaagccctga aaaccttcca
    15661 ggaggagttc atgccagtgg agaccttctc agagttcctc gacgcagcag gtcttctatc
    15721 agaaatcacc gacccagaga gcttcctaaa ggacctgttg aactcagtcc cctgaccatc
    15781 cccatggaaa tgagatcgcg gtgacgagat tgaagctagc ttgcattctc ccctcattca
    15841 tctctccgtg tgcactcatt tcccccacgg atgctgcatt agcaccccct cctccctcag
    15901 ttttcttgga gtggcttggg gtttgtaggc ttcctgttct atcacgcgcg cgtgtgtgtg
    15961 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgctgcgc tggctatgac
    16021 gttgtctgtc gcccaggcca ttgaaggacc tatgcgtacc taggagctgt gagctgtccc
    16081 ggccagagtg agtgtgtaca tcttgaaata aatgaatgac ttagtacaca ttgg
//
