LOCUS       NM_001134550            8843 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ubiquitin protein ligase E3 component n-recognin
            3 (Ubr3), mRNA.
ACCESSION   NM_001134550 XM_001059320 XM_006224476 XM_008761951 XM_230007
VERSION     NM_001134550.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8843)
  AUTHORS   Ma,X.E., Liu,B. and Zhao,C.X.
  TITLE     Modulation of Ca2+-induced Ca2+ release by ubiquitin protein ligase
            E3 component n-recognin UBR3 and 6 in cardiac myocytes
  JOURNAL   Channels (Austin) 14 (1), 326-335 (2020)
   PUBMED   32988261
  REMARK    GeneRIF: Modulation of Ca(2+)-induced Ca(2+) release by ubiquitin
            protein ligase E3 component n-recognin UBR3 and 6 in cardiac
            myocytes.
REFERENCE   2  (bases 1 to 8843)
  AUTHORS   Zhao,C., Wang,L., Ma,X., Zhu,W., Yao,L., Cui,Y., Liu,Y., Li,J.,
            Liang,X., Sun,Y., Li,L. and Chen,Y.H.
  TITLE     Cardiac Nav 1.5 is modulated by ubiquitin protein ligase E3
            component n-recognin UBR3 and 6
  JOURNAL   J Cell Mol Med 19 (9), 2143-2152 (2015)
   PUBMED   26059563
  REMARK    GeneRIF: UBR3/6 regulate cardiomyocyte Nav 1.5 channel protein
            levels via the ubiquitin-proteasome pathway.
REFERENCE   3  (bases 1 to 8843)
  AUTHORS   Tasaki,T., Sohr,R., Xia,Z., Hellweg,R., Hortnagl,H., Varshavsky,A.
            and Kwon,Y.T.
  TITLE     Biochemical and genetic studies of UBR3, a ubiquitin ligase with a
            function in olfactory and other sensory systems
  JOURNAL   J Biol Chem 282 (25), 18510-18520 (2007)
   PUBMED   17462990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jun 3, 2021 this sequence version replaced NM_001134550.2.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-856               JAXUCZ010000003.1  75057615-75058470
            857-996             JAXUCZ010000003.1  75080814-75080953
            997-1155            JAXUCZ010000003.1  75084556-75084714
            1156-1299           JAXUCZ010000003.1  75092457-75092600
            1300-1349           JAXUCZ010000003.1  75093125-75093174
            1350-1416           JAXUCZ010000003.1  75104549-75104615
            1417-1547           JAXUCZ010000003.1  75105708-75105838
            1548-1776           JAXUCZ010000003.1  75107279-75107507
            1777-1956           JAXUCZ010000003.1  75112677-75112856
            1957-2090           JAXUCZ010000003.1  75113388-75113521
            2091-2177           JAXUCZ010000003.1  75120942-75121028
            2178-2243           JAXUCZ010000003.1  75124352-75124417
            2244-2333           JAXUCZ010000003.1  75124511-75124600
            2334-2462           JAXUCZ010000003.1  75125285-75125413
            2463-2515           JAXUCZ010000003.1  75126012-75126064
            2516-2649           JAXUCZ010000003.1  75126163-75126296
            2650-2735           JAXUCZ010000003.1  75126631-75126716
            2736-2877           JAXUCZ010000003.1  75128424-75128565
            2878-2974           JAXUCZ010000003.1  75131794-75131890
            2975-3116           JAXUCZ010000003.1  75139949-75140090
            3117-3221           JAXUCZ010000003.1  75143256-75143360
            3222-3395           JAXUCZ010000003.1  75144261-75144434
            3396-3856           JAXUCZ010000003.1  75146387-75146847
            3857-3945           JAXUCZ010000003.1  75154456-75154544
            3946-4095           JAXUCZ010000003.1  75156238-75156387
            4096-4229           JAXUCZ010000003.1  75160386-75160519
            4230-4340           JAXUCZ010000003.1  75166079-75166189
            4341-4553           JAXUCZ010000003.1  75170765-75170977
            4554-4690           JAXUCZ010000003.1  75173125-75173261
            4691-4776           JAXUCZ010000003.1  75179748-75179833
            4777-4882           JAXUCZ010000003.1  75183038-75183143
            4883-4986           JAXUCZ010000003.1  75190588-75190691
            4987-5111           JAXUCZ010000003.1  75199559-75199683
            5112-5219           JAXUCZ010000003.1  75204377-75204484
            5220-5345           JAXUCZ010000003.1  75204585-75204710
            5346-5525           JAXUCZ010000003.1  75208558-75208737
            5526-5735           JAXUCZ010000003.1  75210587-75210796
            5736-5875           JAXUCZ010000003.1  75211196-75211335
            5876-8843           JAXUCZ010000003.1  75211614-75214581
FEATURES             Location/Qualifiers
     source          1..8843
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21-q22"
     gene            1..8843
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /note="ubiquitin protein ligase E3 component n-recognin 3"
                     /db_xref="GeneID:311115"
                     /db_xref="RGD:1565257"
     exon            1..856
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..5993
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UBR3"
                     /protein_id="NP_001128022.2"
                     /db_xref="GeneID:311115"
                     /db_xref="RGD:1565257"
                     /translation="MAAAAAAAVGGPQPPQPEVSAQGPTLDKAATAAHLKAALSRPDN
                     RAGAEELQALLERVLNAERPLARAAGGEEAAGGGSPGEAEEDALEWCKCLLAGGGGYD
                     EFCAAVRAYDPAALCGLVWTANFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFR
                     SQAGGACDCGDSNVMRESGFCRRHQIKSSSNIPCVPKDLLMMSEFVLPRFIFCLIQYL
                     REGYNEPAADTPSEKDLNKVLQLLEPQISFLEDLTKTGGAMRAVLTQVLTNQQSYKDL
                     TAGLGENTCAKKSHEKYLIALKSSGLTYPEDKLVYGIQEPSAGTSTLAAQGFAGATGT
                     LGQIDSSDEEDQDGSQGLGKRKRVKLSSGTKDQSIMDVLKHKSFLEELLFWTIKYEFP
                     QKMVTFLLNMLPDQEYKVAFTKTFVQHYAFIMKTLKKSHESDTMSNRIVHISVQLFSN
                     EELARQVTEECQLLDIMVTVLLYMMESCLIKSELQDEENSLHVVVNCGEALLKNNTYW
                     PLVSDFINILSHQSVAKRFLEDHGLLVTWMNFVSFFQGMNLNKRELNEHVEFESQTYY
                     AAFAAELEACAQPMWGLLSHCKVRETQEYTRNVVRYCLEALQDWFDAINFVDEPAPNQ
                     VTFHLPLHRYYAMFLSKAVKCQELDLDSLLPDQEMLMKLMIHPLQIQASLAEIHSNMW
                     VRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCASRLDPDYFISSVFERFKVVDLLT
                     MASQHHNMVLDVEHERSMLEGALTFLVILLSLRLHLGMSDDEILRAEMVAQLCMNDRT
                     HSSLLDLIPENPNPKSGIIPGSYSFESVLSAVADFKAPVFEPGGSMQQGMYTPKAEVW
                     DQEFDPVMVILRTVYRRDVQSAMDRYTAFLKQSGKFSGNPWPPYKKRTSLHPSYKGLM
                     RLLHCKTLHIVLFTLLYKILMDHQNLSEHVLCMVLYLIELGLEDSAEDDSEEEVSMGG
                     PERCHDSWFPGSNLVSNMRHFINYVRVRVPETAPELKRDSLASTSSDGLGSLQNSGTA
                     QVFSLVAERRKKFQEIINRNNSEANQVVRPKTPSKWSAPGSAPQLTTAILEIKESILS
                     LLIKLHHKLSGKQNSYYPPWLDDIEVLIQPEIPKYSHGDGITAVERILLKAAVQSRMN
                     KRIIEEICRKVTPPVPPKKITTAEKKTLDKEERRQKARERQQKLLAEFASRQKSFMET
                     AMDVDSPENDIPMEITTAEPQVSEAVYDCVICGQSGPSSEDRPTGLVVLLQASSVLGQ
                     CRDNVEPKKLPITEEEQIYPWDTCAAVHDVRLSLLQRYFKDSSCLLAVSIGWEGGVYV
                     QTCGHTLHIDCHKSYMESLRNDQVLQGFSVDKGEFTCPLCRQFANSVLPCYPGSNVEN
                     NLWQRPSNKSTQDLIKEVEELQGRPGAFPVSISSETNLSKEMESVMKDIKNTTQKKYR
                     DYSKTPGSPDNDFLFMYSVARTNLELELIHRGGSLCSGGASTAGKRSCLNQLFHVLAL
                     HMRLYTIDSEYNPWKKLTHLVEDMNSQVGSEDQQPEVPVLYHDVTSLLLIQILMMPQP
                     LQKEHFTCIVKVLFTLLYTQALAALSVKGTEEDRSAWKHLGALKKDTCDAEKSYEVLL
                     GFVISELSKGKLYCEEGAQECTMVSPIAWSPESMERYIQDFCLPFLRISSLLQHHLFG
                     EDLPSCQEEEEFSVLASCLGLLPTFYQTDHPFISASCLDWPVAAFDIITQWCFEIRSF
                     TERHAEQGKALLIQESRWKLPHLLQLPENYNTIFQYYHRKTCSVCTKVPKDPAVCLVC
                     GAFVCLKGLCCKQQSYCECVLHSQNCGAGTGIFLLINASVIIIIRGHRFCLWGSVYLD
                     AHGEEDRDLRRGKPLYICEERYRVLEQQWVSHTFDHINKRWGPHYNGL"
     exon            857..996
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1155
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1299
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1349
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1416
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1547
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1776
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1956
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2090
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2177
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2243
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2333
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2462
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2515
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2649
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2735
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2877
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..2974
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3116
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3221
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3395
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3856
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            3857..3945
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4095
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            4096..4229
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            4230..4340
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            4341..4553
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            4554..4690
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            4691..4776
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            4777..4882
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            4883..4986
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            4987..5111
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            5112..5219
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            5220..5345
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            5346..5525
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            5526..5735
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            5736..5875
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
     exon            5876..8843
                     /gene="Ubr3"
                     /gene_synonym="RGD1565257"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcagaaaag ccgcttttat taaaggttgc cttggcgctg agttcttgtg taaggagttg
       61 tcagttttga aagttgggag ccaacaggta gagagggatc acaggagcag tacccgggct
      121 cggtggaggc gatgaccggg gagcccgacg aggggcgggg ctcggccgga gggcgtgagc
      181 aggggcgggg accgcgcaga agtgctctgc ggcgcccggt atcgcgagag ttgggcgggc
      241 gagccatcgc agcagtcaat tcccccaccc tcccgggagg agccgggggc cctggactct
      301 ccaaattctg agctctcatc atggcggcgg cggccgcggc ggccgtcggg ggcccgcagc
      361 caccccagcc ggaggtgtcc gcgcaggggc cgaccttaga caaggcggct accgccgcgc
      421 acctgaaggc cgctctcagc cggccggata accgtgcggg cgccgaggag ctgcaggcgc
      481 tgctggagcg ggtgctgaac gcagagcggc cgctggcccg ggctgcgggc ggcgaggagg
      541 cggcgggcgg cggcagccca ggcgaggccg aggaggatgc cctggagtgg tgtaagtgcc
      601 ttctggccgg cggcggcggc tacgatgagt tctgcgcggc cgtgcgggcc tacgaccccg
      661 cggcgctctg cggcctggtc tggacggcca acttcgtggc ctaccgctgc cggacgtgcg
      721 gcatctcccc ctgcatgtcg ctgtgcgcgg agtgcttcca ccagggcgac cacactggac
      781 acgacttcaa catgttccgc agccaggccg gaggcgcctg cgactgcggg gacagcaacg
      841 taatgcggga gagtgggttt tgcagaagac atcagattaa atcaagttct aatattccct
      901 gtgtccccaa agacttactg atgatgtctg aatttgttct tccaagattc attttttgtc
      961 ttattcagta cttaagagaa ggctataatg aaccagcagc tgatacacca tcagaaaaag
     1021 atctgaacaa agtccttcag cttttggagc ctcagatttc ctttttagaa gacctgacta
     1081 aaacgggagg agcaatgagg gctgttctca ctcaggtgct gacaaaccag cagagctaca
     1141 aagacctgac tgctggtctt ggagaaaata cttgtgcaaa gaagagtcat gagaagtacc
     1201 ttatagcttt gaagagctcc ggactcacgt atcctgagga taagcttgtg tacgggatac
     1261 aggagccgtc tgctggcact agcactctgg cagctcaagg ctttgcaggt gctactggga
     1321 cactgggtca gatagactct tcagatgagg aggaccaaga cgggagtcaa ggcttgggca
     1381 agaggaagcg ggtaaagcta agcagtggca ccaaagatca atccataatg gatgttttga
     1441 aacataaaag ttttttagaa gaactattgt tttggacaat aaagtatgaa ttcccccaga
     1501 agatggtaac tttcttactc aatatgcttc cagatcaaga gtataaggtt gcttttacaa
     1561 aaacttttgt tcagcattat gcatttatta tgaaaacact gaagaaaagt cacgagtcag
     1621 acacgatgtc caacagaatt gtgcatatta gtgtccagtt gttcagcaat gaggagctag
     1681 ccagacaggt gacagaggag tgtcagctcc tggacatcat ggtcaccgtg ctgctgtaca
     1741 tgatggagag ctgcctcatc aaaagtgagc tgcaagatga agagaacagt ttacatgtgg
     1801 tggtgaactg tggagaagcc ttactgaaga ataacaccta ctggcctctt gttagtgact
     1861 ttattaatat tctttctcac caaagtgtgg cgaagaggtt tttggaggat catggcttgt
     1921 tagttacgtg gatgaacttt gtttctttct ttcaaggtat gaacttgaac aagcgagagc
     1981 tcaatgaaca cgtggagttt gagtctcaaa cttactatgc tgcctttgct gctgagcttg
     2041 aagcctgtgc acaacccatg tgggggcttt tatcacattg caaagtcagg gaaactcaag
     2101 agtatacccg aaatgttgta aggtactgcc ttgaagctct tcaagattgg tttgatgcta
     2161 ttaactttgt agatgagcca gctcctaacc aagtcacttt ccacctgcca ctgcaccgtt
     2221 actatgctat gtttttgagt aaggctgtga aatgtcaaga actagatttg gattcacttt
     2281 taccggatca ggaaatgtta atgaaactaa tgatccaccc actccaaatt caagctagtc
     2341 ttgctgaaat tcacagtaac atgtgggtaa gaaatggtct gcaaatcaaa ggacaagcta
     2401 tgacctatgt ccagtctcat ttctgtaact ccatgattga tccagatatt tacttattac
     2461 aggtctgtgc ttctagactt gacccagatt actttatatc atctgtcttt gaaaggttta
     2521 aggtggtgga cttactgacc atggcttccc agcaccacaa catggtgctc gatgtggagc
     2581 acgagcggtc aatgctagag ggcgcgctca ccttcctcgt gattcttttg agtcttcgtt
     2641 tacacctagg gatgtctgat gatgagattc tcagggcaga gatggtagcc cagctgtgta
     2701 tgaatgacag gacgcatagc tctttgcttg acctcatccc agaaaatccc aaccctaaaa
     2761 gtggcattat tcctggaagc tatagctttg aatcagtttt atctgctgta gctgacttta
     2821 aggctcccgt ttttgaacct ggaggctcca tgcaacaagg catgtatact cccaaagctg
     2881 aagtctggga tcaggagttt gatcctgtca tggtcattct tcgaacagtt tatcgccgag
     2941 atgtgcagtc tgccatggac agatacacag catttttaaa acagagtgga aaattttctg
     3001 gaaatccctg gcctccttat aagaaaagaa catcactcca tcccagttat aaaggtctca
     3061 tgagacttct gcattgtaaa accttacaca ttgtgctgtt cactctgctt tacaagattc
     3121 tgatggatca tcaaaatctg tctgaacacg tgctctgcat ggtgttgtat ctgattgaat
     3181 taggcctgga agactctgct gaggacgact ctgaggaaga ggtatcaatg ggtggaccag
     3241 aacgttgtca tgatagttgg ttccctggca gtaacttggt atcaaacatg cggcacttta
     3301 taaattatgt cagagtgcga gtcccagaga ctgctcctga gttgaaaagg gattccctcg
     3361 ccagcacgag ctctgatggc ttgggctctt tacaaaattc tggtacagct caagttttca
     3421 gcttagtagc agagcgtaga aagaaatttc aggagatcat caatcgaaac aacagtgaag
     3481 caaatcaggt ggttcggccc aagactccaa gtaaatggtc agctcctggc tcagctcccc
     3541 agttaaccac agccattttg gaaattaagg aaagcatatt gtctttgcta ataaaacttc
     3601 accacaaact ctcaggaaaa caaaactctt actatcctcc atggcttgat gacatagaag
     3661 ttttaataca accagaaatt ccaaaataca gtcatggaga cggtataact gctgtagaaa
     3721 ggattttgct aaaagctgca gtgcaaagca gaatgaacaa gcgcatcatt gaagagatat
     3781 gcagaaaagt gactcctccc gtgccaccca aaaagatcac cacagcagag aagaagactc
     3841 tggacaagga ggaaaggcgc caaaaggcta gagaaaggca gcagaaattg cttgcagagt
     3901 ttgcctcacg acagaaaagc tttatggaga ctgcaatgga tgtcgattct cctgaaaacg
     3961 atattcctat ggaaattacc acagcagaac ctcaagtttc tgaagctgtg tatgactgtg
     4021 ttatttgtgg acagagtggt ccttcttctg aagacagacc tacaggactg gttgtactgt
     4081 tacaagcatc atcagtttta ggtcagtgcc gggacaatgt tgagccaaaa aagttgccta
     4141 tcactgaaga ggaacagatt tacccttggg acacatgtgc agccgttcac gatgtgaggc
     4201 tttcattact gcaacgttat tttaaagata gttcttgcct tttggcagta tcaattggct
     4261 gggaaggagg tgtttatgta caaacttgtg gccacacgtt gcacatagat tgtcataagt
     4321 cctatatgga atcattacgg aatgaccagg ttcttcaggg cttctcagtg gacaaaggag
     4381 aattcacatg tccactctgc agacagtttg ctaacagcgt tcttccatgt tatcctggaa
     4441 gcaatgtgga aaataacctt tggcaacgtc ctagtaacaa aagcacacaa gatctcataa
     4501 aggaagtgga ggagctgcag ggacggccgg gagctttccc agtaagcatc agttcagaaa
     4561 ccaacctaag taaagaaatg gagtctgtaa tgaaagatat aaaaaacacc actcagaaga
     4621 aatacagaga ctatagcaag accccaggct cgccagacaa tgactttctc tttatgtact
     4681 ctgttgctag aaccaattta gagctggagc tgattcacag aggaggcagc ctgtgctcag
     4741 gcggtgcaag cacggctggg aagaggtctt gtttgaatca gctgttccat gtattagcct
     4801 tgcacatgcg gctttatacc attgactctg agtataatcc atggaaaaaa ctcacccact
     4861 tagtggaaga tatgaattca caggtgggga gtgaagacca gcagcctgaa gttccagtcc
     4921 tttatcatga tgtgacatcg ctcctgctca tccagatctt aatgatgcca cagcccttac
     4981 agaaagagca cttcacctgc attgtcaaag ttctcttcac cctgctctac acccaggccc
     5041 tggcagcgct ctcagtgaag ggcactgaag aggatcggtc agcctggaaa caccttggag
     5101 ctcttaaaaa ggatacatgt gatgcagaga agtcttacga agtattgttg ggctttgtca
     5161 taagtgagct gtctaaaggg aagttatatt gtgaagaagg cgctcaggag tgtaccatgg
     5221 tcagtcctat tgcttggtct cctgagtcca tggaaagata catacaggat ttctgcttac
     5281 ctttcctcag gatcagcagc cttcttcagc accacctctt tggggaagat ttacccagtt
     5341 gccaggaaga agaggaattt tcagtccttg ccagctgcct gggacttctg ccaacttttt
     5401 accaaacaga tcacccattc atcagtgcct cgtgtctgga ctggccagtt gcagcatttg
     5461 acattataac tcagtggtgt tttgagataa gatcatttac agagaggcat gcagaacaag
     5521 ggaaggcttt gctaatccaa gagtcaagat ggaaattacc acacctgtta cagctgcccg
     5581 agaattacaa cactattttt cagtactacc acagaaaaac ctgcagtgtc tgcaccaagg
     5641 ttcctaaaga cccagctgtt tgtcttgtgt gtggcgcctt cgtctgcctg aaaggcctgt
     5701 gctgcaagca gcagagctac tgtgaatgtg tgctgcattc tcagaattgt ggtgccggaa
     5761 cagggatttt ccttttaatc aatgcgtcag tgattatcat catccgaggc caccgcttct
     5821 gcctctgggg ctctgtctat ctggatgctc atggagaaga ggaccgggac ctcaggcggg
     5881 gcaagcctct ctacatctgc gaggagcggt accgagttct cgagcagcag tgggtttccc
     5941 acacttttga ccacatcaat aaaagatggg gtccacatta caatgggctg tgacacacac
     6001 ctcagcatcg cacatattat cattttcact gagattgact ttcatcaact ataagcttta
     6061 atttaatttg ggggattgat gtctttgctg agagataaaa agtaaacatc cattatgaag
     6121 ccttcccaaa gttaggtgct tggcaaccac atcaatggtc tgatattctt ctaaaggatc
     6181 tcagcaacag taacttagat catcctgcag tggtcacttt taagtgcaca attaataaaa
     6241 agcacaactt gtccacagaa atcattcaga aatgattttc cctgcaatgc ccttagcggt
     6301 tgttcactga cagagaggat gtgatttatt tgaggtttta ctgctctttt tgtgttttta
     6361 tttgcatctg ctaaacacaa tgcatcattt cctttgtcat ccttgtgttg atttgagatt
     6421 tttgctgtat gtaattagaa acaaatgtaa aacatgattt atgtgaaata ttgtatagta
     6481 aaacttggtc taatagtaga actttaaatt tttttcttat tgtgaggaat ctgttaaaag
     6541 tttaaggctt tgctgaaaac ttaattcatt ctcaggaatt tcataaatgc tttccccggg
     6601 taaataattt aactagctgt aaaatatagt gcagtgtagt gcagcgcaca aggcggggca
     6661 aggtgtatgt gtggtcgggg ggtccttaaa aataaacatt tgtgggctga gggtgtagct
     6721 cagtggcaga atgcttactt ggctaacatg tatagaaccc gagtttcatc ttaagcacca
     6781 cacacgcaca cacacaaaat caacttgcca tttcaactga atgaattatt agagttgtta
     6841 gtgacgagca gatgttacaa taaaatcaaa gggttaagaa catatacatg gcagagtttt
     6901 gattctgtgc atgcccacct tttattacca accaagcctt tatttatatg atcagatcga
     6961 aaagctcatt tgtcccaaca catgaacttt aagttctgga actcccctga ctgactgaag
     7021 aagctcatct gtgttacagt cctgcagggt cacagttcac ggctgcttct gtgtgctttc
     7081 ctccggcaga aaaggctcag aggtcttgac cctgacaaag agccatgctt ctgctttaga
     7141 catggctgtg aaggtcagct tgtgtgtggg ggtttaattc agaatgggaa tgagtgggct
     7201 caaatcctct gagtaagagg ggaagaagaa catattttat tggtaccagg atttttccag
     7261 gtgattattt cacccatagt acttactatc aagcaattcc tggtactttt gatttccaag
     7321 gcttattaca taaaattaca ttttttactt gtgaaagtaa gaaatattga ataagaaaat
     7381 atcaaagtaa catcagaccc atgttccaaa atgttttgaa ttgacacagc attacagaat
     7441 atgaaattaa cgtaaaacag tggctttgca ttaaaataca ggaaacagag aaggacacac
     7501 acagatgtct tcagaatgtc agaagactgc ctgaggcatt ttaagaaaat atgtgggaat
     7561 agcttgctat ttttatatac atttccaaat ggtgagataa ctttgttaag acaagaatga
     7621 cttgttcagg taaatccctg tccttcctac acctgctcct taaaacgctg tgctacgagc
     7681 tcagcctgct acctttttgc tttggtcatt ataaatagca gaccattcgt aagtgtggtt
     7741 gaagagcaaa tgctaactac atctctagta aatactgtta caggactcat gaacttgagc
     7801 aattttacag tttggaactc tgatgctata tatacatggt ataatgtatt cagactttga
     7861 tcactacata tttaaatgga atgtttatgg tgttgcatat ggatgtgaag tgaaaatatt
     7921 agccttaact ttaaaatttg gatatttgat agtgtttatt ttgatattgg tgaattagtc
     7981 accagtaaat tttaaaaaag cacttggttg aaattgtact tgaaaacgta catgcatgct
     8041 gctaaattag agcctccatt tcccctaact tttataagtc ccatttataa acccactttt
     8101 aaaataacag gtccaagtta gagtgatgtg tgtatattat tcaaaaacat gtactggtgt
     8161 gatcttgtat gaatgatcat ttaaatacag tacattactg tagaagtgaa atcaaccttt
     8221 ataattaagc agaaattaca aaactaggaa taattgacat tgtaagatat gttaataaaa
     8281 cctactgtca tttgctttgt gcaagatcct taaaatgttg aatgtttatg ttttcttttc
     8341 caatgatgtg acacaggaga gggatggcat aattaggacc tgcctttcac tgtgctctct
     8401 tgcttcctgc aggaccaggt cctgcttgtt ttctgtggtc tcttgatcgc acttttgcta
     8461 agagtaagtg tttgtgctga gagcagaagc atgatgctgg cctggtccct gcctgctatc
     8521 tgctgagagt tcccatctag gcctggaaac tgcttcctaa gggcatttgt cttgagtggt
     8581 ctgtggtctt acatgaactc accattctct tcagtgcacc tctgtcctgt agttcaccag
     8641 gtagttataa aagatgctga ccataagcac tgaaggggat gtaacccaag accttccata
     8701 ctgcctttgg gattgtaact gctcattctc aaattccttt tgtgtggttt tttttgtttg
     8761 ttttgtttta ttttgtttgt ttttttttgt ttttttgagt tcatgtttga aaacaacaaa
     8821 ataaagtatc aacaaaaaca aaa
//
