LOCUS       NM_001412818            7517 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus ubiquitin protein ligase E3 component n-recognin
            2 (Ubr2), transcript variant 1, mRNA.
ACCESSION   NM_001412818 XM_039083818
VERSION     NM_001412818.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7517)
  AUTHORS   MacLennan,M., Garcia-Canadas,M., Reichmann,J., Khazina,E.,
            Wagner,G., Playfoot,C.J., Salvador-Palomeque,C., Mann,A.R.,
            Peressini,P., Sanchez,L., Dobie,K., Read,D., Hung,C.C.,
            Eskeland,R., Meehan,R.R., Weichenrieder,O., Garcia-Perez,J.L. and
            Adams,I.R.
  TITLE     Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in
            mouse embryonic stem cells
  JOURNAL   Elife 6, e26152 (2017)
   PUBMED   28806172
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7517)
  AUTHORS   Crichton,J.H., Playfoot,C.J., MacLennan,M., Read,D., Cooke,H.J. and
            Adams,I.R.
  TITLE     Tex19.1 promotes Spo11-dependent meiotic recombination in mouse
            spermatocytes
  JOURNAL   PLoS Genet 13 (7), e1006904 (2017)
   PUBMED   28708824
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7517)
  AUTHORS   Kume,K., Iizumi,Y., Shimada,M., Ito,Y., Kishi,T., Yamaguchi,Y. and
            Handa,H.
  TITLE     Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating
            the leucine-mTOR signaling pathway
  JOURNAL   Genes Cells 15 (4), 339-349 (2010)
   PUBMED   20298436
REFERENCE   4  (bases 1 to 7517)
  AUTHORS   An,J.Y., Kim,E.A., Jiang,Y., Zakrzewska,A., Kim,D.E., Lee,M.J.,
            Mook-Jung,I., Zhang,Y. and Kwon,Y.T.
  TITLE     UBR2 mediates transcriptional silencing during spermatogenesis via
            histone ubiquitination
  JOURNAL   Proc Natl Acad Sci U S A 107 (5), 1912-1917 (2010)
   PUBMED   20080676
REFERENCE   5  (bases 1 to 7517)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   6  (bases 1 to 7517)
  AUTHORS   Kwon,Y.T., Xia,Z., An,J.Y., Tasaki,T., Davydov,I.V., Seo,J.W.,
            Sheng,J., Xie,Y. and Varshavsky,A.
  TITLE     Female lethality and apoptosis of spermatocytes in mice lacking the
            UBR2 ubiquitin ligase of the N-end rule pathway
  JOURNAL   Mol Cell Biol 23 (22), 8255-8271 (2003)
   PUBMED   14585983
REFERENCE   7  (bases 1 to 7517)
  AUTHORS   Kwon,Y.T., Xia,Z., Davydov,I.V., Lecker,S.H. and Varshavsky,A.
  TITLE     Construction and analysis of mouse strains lacking the ubiquitin
            ligase UBR1 (E3alpha) of the N-end rule pathway
  JOURNAL   Mol Cell Biol 21 (23), 8007-8021 (2001)
   PUBMED   11689692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Oct 19, 2022 this sequence version replaced XM_039083818.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.36716.1,
                                           SRR26643298.47787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               JAXUCZ010000009.1  21480117-21480496
            381-640             JAXUCZ010000009.1  21488691-21488950
            641-719             JAXUCZ010000009.1  21494906-21494984
            720-833             JAXUCZ010000009.1  21496671-21496784
            834-964             JAXUCZ010000009.1  21499933-21500063
            965-1103            JAXUCZ010000009.1  21501808-21501946
            1104-1166           JAXUCZ010000009.1  21502590-21502652
            1167-1287           JAXUCZ010000009.1  21505776-21505896
            1288-1395           JAXUCZ010000009.1  21506991-21507098
            1396-1484           JAXUCZ010000009.1  21507837-21507925
            1485-1583           JAXUCZ010000009.1  21508692-21508790
            1584-1747           JAXUCZ010000009.1  21513672-21513835
            1748-1847           JAXUCZ010000009.1  21513922-21514021
            1848-1976           JAXUCZ010000009.1  21515702-21515830
            1977-2160           JAXUCZ010000009.1  21516796-21516979
            2161-2222           JAXUCZ010000009.1  21519304-21519365
            2223-2333           JAXUCZ010000009.1  21520186-21520296
            2334-2399           JAXUCZ010000009.1  21521461-21521526
            2400-2522           JAXUCZ010000009.1  21522633-21522755
            2523-2586           JAXUCZ010000009.1  21522841-21522904
            2587-2711           JAXUCZ010000009.1  21523501-21523625
            2712-2764           JAXUCZ010000009.1  21524902-21524954
            2765-2867           JAXUCZ010000009.1  21525946-21526048
            2868-2916           JAXUCZ010000009.1  21526874-21526922
            2917-3071           JAXUCZ010000009.1  21528373-21528527
            3072-3174           JAXUCZ010000009.1  21530223-21530325
            3175-3284           JAXUCZ010000009.1  21532286-21532395
            3285-3365           JAXUCZ010000009.1  21532506-21532586
            3366-3544           JAXUCZ010000009.1  21533230-21533408
            3545-3744           JAXUCZ010000009.1  21533948-21534147
            3745-3838           JAXUCZ010000009.1  21534936-21535029
            3839-4000           JAXUCZ010000009.1  21535829-21535990
            4001-4104           JAXUCZ010000009.1  21537262-21537365
            4105-4183           JAXUCZ010000009.1  21538888-21538966
            4184-4332           JAXUCZ010000009.1  21541125-21541273
            4333-4388           JAXUCZ010000009.1  21542313-21542368
            4389-4485           JAXUCZ010000009.1  21542540-21542636
            4486-4553           JAXUCZ010000009.1  21542855-21542922
            4554-4689           JAXUCZ010000009.1  21544592-21544727
            4690-4780           JAXUCZ010000009.1  21545215-21545305
            4781-4911           JAXUCZ010000009.1  21546840-21546970
            4912-5020           JAXUCZ010000009.1  21548506-21548614
            5021-5077           JAXUCZ010000009.1  21549993-21550049
            5078-5155           JAXUCZ010000009.1  21553120-21553197
            5156-5326           JAXUCZ010000009.1  21554244-21554414
            5327-5428           JAXUCZ010000009.1  21556020-21556121
            5429-7517           JAXUCZ010000009.1  21557848-21559936
FEATURES             Location/Qualifiers
     source          1..7517
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..7517
                     /gene="Ubr2"
                     /note="ubiquitin protein ligase E3 component n-recognin 2"
                     /db_xref="GeneID:363188"
                     /db_xref="RGD:1593237"
     exon            1..380
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..5570
                     /gene="Ubr2"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase UBR2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UBR2 isoform 1"
                     /protein_id="NP_001399747.1"
                     /db_xref="GeneID:363188"
                     /db_xref="RGD:1593237"
                     /translation="MASEMEPEVQAIDRSLLECSAEEIAGKWLQATDLTREVYQHLAH
                     CVPKIYCRGPNPFPQKEDTLAQHILLGPMEWYICGEDPALGFPKLEQANKPSHLCGRV
                     FKVGEPTYSCRDCAVDPTCVLCMQCFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEG
                     PYCQRHELSSSEVVEEEDPLVHLSEDVIARTYNIFAIMFRYAVDMLTWEKESELPEDL
                     EVGEKTDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRYGD
                     FQYCDQAKTVIVRNTSRQTKPLKVQVMHSSVAAHQNFGLKALSWLGSVIGYSDGLRRI
                     LCQVGLQEGPDGENSSLVDRLMLNDSKLWKGARSVYHQLFMSSLLMDLKYKKLFAVRF
                     AKNYRQLQRDFMEDDHERAVSVTALSVQFFTAPTLARMLITEENLMTVIIKAFMDHLK
                     HRDAQGRFQFERYTALQAFKFRRVQSLILDLKYVLISKPTEWSDELRQKFLQGFDAFL
                     ELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHVISMVQDWCALDEKVLIEAY
                     KKCLAVLMQCHGGFTDGEQPITLSICGHSVETIRYCVSQEKVSIHLPISRLLAGLHVL
                     LSKSEVAYKFPELLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNGFSLVNQIYYYH
                     NVKCRREMFDKDIVMLQTGVSMMDPNHFLMIMLSRFELYQIFSTPDYGKRFSSEVTHK
                     DVVQQNNTLIEEMLYLIIMLVGERFSPGVGQVGATDEIKREIIHQLSIKPMAHSELVK
                     SLPEDENKETGMESVIETVAHFKKPGLTGRGMYELKPECAKEFNLYFYHFSRAEQSKA
                     EEAQRKLKRENKEDTALPPPALPPFCPLFGSLVNILQCDVMLSIMGTILQWAVERHGS
                     AWSESMLQRVLHLIGMALQEEKHHLENAVEGHVQTFTFTQKISKPGDAPNNSPSILAM
                     LETLQNAPSLEVHKDMIRWLLKMFNTIKKIRESSSSSPVAEAEGAIMEESSRDKDKAE
                     RKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQTIELDASASAALDNSPLVPDAA
                     LTALGPAQTQVPEPRQFVTCILCQEEQEVTVESRAMVLAAFVQRSTVLSKDRSKVIED
                     PEKYDPLFMHPDLSCGTHTGSCGHAMHAHCWQRYFDSVQAKEQRRQQRLRLHTSYDVE
                     NGEFLCPLCECLSNTVIPLLLPPRSILSRRLNFSDQPDLAQWTRTIAQQIKVIQMLRK
                     GDSAADKPSSEDTEDMNIIPIPEGFRPDFYPRNPYSDSIKEMLTTFGTATYKVGLKVH
                     PNEDDPRVPIMCWGTCAYTIQSIERILSEEEKPVFGPLPCRLDDCLRSLTRFAAAHWT
                     VALLPVVQGHFCKLFASLVPSDGSEDLPCILDIDMFHLLVGLVLSFPALQCQDFSGSS
                     LATGDLHIFHLVTLAHIVQILLTSCTEENGMDQENPTGEEELAILSLHKTLHRCTGSA
                     LDEAPSGWHLWRSVRAGILPFLKCSALFFHYLNGVPAPPDLQVSGASHFEHLCNYLSL
                     PTNLIRLFQENSDIMNSLIESWCQNSEVKRYLNGERGAISYPRGANKLIDLPEDYSSL
                     INQASNFSCPKSGGDKSRAPTLCLVCGSLLCSQSYCCQAELEGEDVGACTAHTYSCGS
                     GAGIFLRVRECQVLFLAGKTKGCFYSPPYLDDYGETDQGLRRGNPLHLCQERFRKIQK
                     LWQQHSITEEIGHAQEANQTLVGIDWQHL"
     exon            381..640
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..719
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            720..833
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            834..964
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1103
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1166
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1287
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1395
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1484
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1583
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1747
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1847
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1976
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2160
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2222
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2333
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2399
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2522
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2586
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2711
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2764
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2867
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..2916
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3071
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..3174
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3175..3284
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3365
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3366..3544
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..3744
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3745..3838
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            3839..4000
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4001..4104
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4105..4183
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4184..4332
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4333..4388
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4389..4485
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4486..4553
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4554..4689
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4690..4780
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4781..4911
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            4912..5020
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5021..5077
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5078..5155
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5156..5326
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5327..5428
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
     exon            5429..7517
                     /gene="Ubr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagtggcca tccggagtgc caggcctagg gttctcggtg tccttccccg ggtcacgggc
       61 gaggaggcga cttgacttct gggcgccgag cccgggcgcg cgcgcaagcg gctgccgtcc
      121 ccgctgcagg ttcgcgtccc gctttgctcc ttgcgcagct cggctcgcgg ccgccgggac
      181 ggcccgggac tgacggcccc gggacagggg tgaccgtcgc ggctgcggga gcagaggcga
      241 agctgaggcc cgggaagagg cgacagcggc gagagcaccc ggggagagga ggaggtgaga
      301 agatggcgtc ggagatggag cccgaggtgc aggccatcga ccgcagtttg ctggaatgtt
      361 ctgccgagga gatcgcaggg aaatggctgc aagcaaccga cctcaccaga gaagtatacc
      421 agcatttagc ccattgtgtg cccaaaatct actgccgggg ccccaaccct ttccctcaga
      481 aggaagacac actggcacag cacatcttgc tgggaccaat ggagtggtat atctgcggcg
      541 aagaccctgc gctggggttt ccaaagctgg agcaggcgaa caagccttct cacctctgtg
      601 gccgagtgtt taaagtaggg gaacctacct actcctgcag agactgtgca gtcgacccca
      661 cctgcgtttt atgcatgcag tgcttcttgg gaagtatcca cagagaccat cgatacagga
      721 tgaccacatc aggaggtggc ggcttctgtg actgtggtga cactgaagcg tggaaagagg
      781 gtccttactg ccaaagacac gagcttagca gttcagaagt tgtggaggag gaggatcctc
      841 ttgtgcatct gtcagaagac gtgatagcaa gaacgtacaa catttttgct attatgtttc
      901 gatacgcagt agatatgctg acctgggaaa aagaaagtga attgccggaa gacttagagg
      961 tgggagagaa gactgacacc tactactgca tgctgtttaa cgatgaggtt cacacctatg
     1021 agcaagtcat ttatactctt cagaaagctg tgaactgtac tcagaaagaa gccattggct
     1081 ttgcaactac agtcgatcga gatgggcgta ggtctgtccg gtatggagat ttccagtact
     1141 gtgatcaagc aaagacagtc attgtgagga acaccagcag gcagaccaag ccgctcaaag
     1201 ttcaggttat gcactcctcc gtggccgctc atcagaattt tggtttgaaa gctctgtctt
     1261 ggctgggaag tgttattgga tactcagatg gccttcgccg gattttgtgt caagttggat
     1321 tacaagaagg tccagatggt gaaaactctt ctctggtcga cagactgatg cttaatgatt
     1381 ccaaattatg gaaaggcgct cggagtgtgt accaccagct gttcatgagc agcctgctca
     1441 tggatctcaa gtataagaag ctgtttgctg ttcgctttgc aaaaaattac cggcagttgc
     1501 agagagattt tatggaggat gatcacgagc gggcagtgtc ggtgactgcc ctgtctgtcc
     1561 agttcttcac cgcacctacg ctggctcgaa tgctcatcac agaagagaac ctgatgactg
     1621 ttatcattaa ggccttcatg gatcatttga aacacagaga tgcccaaggc agattccaat
     1681 ttgaacgtta cactgccctc caagccttca agttcaggag agttcagagc cttatcttag
     1741 atctcaagta tgtgttgatc agcaaaccaa cggagtggtc agatgagctg aggcagaagt
     1801 tcttgcaagg cttcgatgcc ttcttggaat tactgaagtg catgcaggga atggatccaa
     1861 tcacacggca ggtaggacag cacattgaaa tggagccaga gtgggaggcg gccttcacgc
     1921 tgcaaatgaa actgacgcac gtgatttcca tggtgcagga ttggtgtgct ttggacgaaa
     1981 aagtgttaat tgaagcttac aagaaatgcc tggctgtgct gatgcagtgt catgggggat
     2041 ttactgatgg ggaacagcca ataacactca gtatttgtgg acactcggtg gaaacgatca
     2101 gatactgtgt ttcccaagaa aaagttagca ttcacctccc aatttctcgc ttacttgcag
     2161 gtttgcatgt gttattaagc aaaagtgaag tggcatataa attccccgag ctcctacctc
     2221 taagtgaact gagcccaccc atgttgatag agcatcctct tagatgtctt gtcttatgtg
     2281 cccaagtgca tgctgggatg tggagaagaa atggcttctc tctagtaaac cagatctatt
     2341 actaccataa tgtgaaatgc aggcgggaga tgttcgacaa ggacatagtg atgcttcaga
     2401 caggtgtctc catgatggat ccaaaccact tcctgatgat catgctcagc cgctttgagc
     2461 tctatcagat cttcagcacg cctgactacg gcaagagatt cagttccgag gttacccata
     2521 aggacgttgt tcagcagaac aacactctga tagaagagat gctctacctc atcatcatgc
     2581 tcgtcggaga aagattcagc cctggggttg gacaggtggg cgccacagat gaaatcaagc
     2641 gggagattat ccatcagctg agcatcaagc ccatggcgca cagcgagctg gtgaagtctc
     2701 tgcccgaaga cgagaacaag gagaccggca tggagagtgt catcgagacc gtagcacatt
     2761 tcaagaaacc tggtctgaca ggacgaggca tgtacgagct gaagccagag tgtgccaaag
     2821 agttcaacct gtatttttat catttctcca gggcagagca gtccaaggcg gaggaagctc
     2881 agcggaagtt gaaaagagaa aataaagaag atacagcact tcctcctccg gctttgccac
     2941 cgttctgccc tctgttcggg agcctggtta acatcttgca gtgtgatgtc atgctgtcca
     3001 tcatgggaac aatactgcag tgggctgtag agcgccatgg gtctgcctgg tcagagtcta
     3061 tgctgcaaag ggtgctgcat ttgattggga tggcgctcca ggaagagaag caccacttgg
     3121 agaatgctgt ggaagggcac gtgcagacgt tcaccttcac gcagaagatt tcaaaacctg
     3181 gcgatgcacc gaataactcc ccaagcatcc tcgctatgct agagaccttg cagaacgctc
     3241 cctccctgga ggtccacaag gacatgatta ggtggttgct aaagatgttt aatacaatta
     3301 agaagataag agagagttca tccagcagcc ctgtggcaga ggcagaagga gccataatgg
     3361 aagagagctc aagagacaaa gacaaagcag agagaaaaag gaaagcggag atcgccagac
     3421 tgcgccgaga gaagatcatg gctcagatgt ccgagatgca gaggcacttc attgacgaga
     3481 acaaagagct cttccagcag accatagagc tggacgcctc tgcctctgcc gctctcgaca
     3541 acagccctct ggttccagac gcggctctga cagcattggg tccggcacag acacaggtcc
     3601 ctgagcccag acagtttgtc acctgtatac tgtgtcagga ggagcaggag gtcactgtgg
     3661 aaagcagagc aatggtcttg gcagcgtttg ttcagaggtc aactgtgctg tcaaaagaca
     3721 gatcgaaagt cattgaggac ccagaaaaat atgacccact attcatgcac cctgatctgt
     3781 cctgtggaac acacactggc agctgtgggc acgccatgca cgcccattgt tggcaaaggt
     3841 attttgattc cgttcaagct aaggagcagc gaaggcagca gcgactgcgc ctgcacacta
     3901 gctacgatgt agagaacggc gagttcctct gcccgctctg tgagtgcctg agcaacaccg
     3961 tgatccccct gctgcttcct cccaggagca tcctcagcag gaggttaaat ttttcagacc
     4021 aaccagatct ggcacagtgg accagaacaa tagcccagca gataaaggtg atccagatgc
     4081 taaggaaagg agacagtgct gctgacaagc cctcttcaga ggacacagaa gacatgaata
     4141 taattcccat cccagaaggc ttcaggcctg atttttatcc tcggaaccca tattccgata
     4201 gcataaagga gatgctaaca acgtttggaa cagctactta caaggtggga ctaaaggttc
     4261 atcccaatga agatgacccc cgtgtaccca tcatgtgctg ggggacctgt gcatacacta
     4321 tccagagcat agaaagaatt ctgagtgagg aggaaaagcc cgtgttcgga cctctgccct
     4381 gcagactgga cgactgtctc aggtccttaa cacgctttgc agcagcacat tggacagtgg
     4441 cgttacttcc cgtggtacaa ggacacttct gtaaactctt tgcatccttg gtgcctagtg
     4501 acggctctga agacctcccg tgcatattag acatcgacat gtttcatttg ctggtgggcc
     4561 tggtgctctc cttcccggct ctgcagtgtc aggatttctc aggaagcagc ctggccacgg
     4621 gagacctgca catcttccac ctggttactc tggcacacat cgtacagatc ttacttacct
     4681 catgtacaga agagaatggc atggatcaag agaatcccac tggggaagaa gaactcgcca
     4741 ttctctcttt gcacaaaaca cttcaccggt gtactggaag tgccttggac gaagccccat
     4801 ccggctggca cctgtggagg agcgtgcggg ctggcatcct gcctttcctc aagtgctctg
     4861 ctctgttctt ccactattta aatggagtcc cggccccacc agacctgcaa gtttctggag
     4921 caagccattt tgaacattta tgtaactacc tttccctacc aaccaacctc atccgccttt
     4981 ttcaagaaaa cagtgacatc atgaactctc tgattgaaag ttggtgccag aacagcgaag
     5041 ttaaaaggta tctaaacggc gagagaggag cgataagcta cccgagagga gccaacaaac
     5101 tgatagacct tccggaggac tacagcagcc tcatcaacca agcttccaat ttctcgtgcc
     5161 ccaaatcagg tggtgacaag agcagagccc ctaccctgtg cctcgtatgt gggagtctcc
     5221 tctgctctca gagttactgc tgccaagccg agctggaggg cgaggatgtc ggggcctgca
     5281 cagcacacac ctactcctgc ggctctgggg ccggcatctt cctgagagta cgggaatgtc
     5341 aggtgctatt tttagctggc aaaaccaaag gctgttttta ttctcctcct taccttgatg
     5401 actacgggga gactgaccag ggactcagac gaggaaatcc tttacattta tgccaagagc
     5461 ggtttcgaaa gatccagaag ctctggcagc agcacagcat caccgaggag atcggacacg
     5521 cgcaggaggc caaccagacc ctggtgggca tcgactggca gcatttgtaa ctgctgctcc
     5581 accacaaacc tggacttgga gttttgtaac ccagctggct tttccagaaa gacaacagga
     5641 aataagttcg gctgaatcta ttttgaaata aattctttat ttaagctttt cttcccagtt
     5701 ttattttttt ttagtctggc tccagggact gatgaaaatc attttccgcc agattttatt
     5761 cccgtgtccc tcagatgttc cctggactga gaatcctttc tagactggag ccacgctcct
     5821 tccgatgccg cctgcttcaa ttgccagtaa ccaagccggt ccaacattgc ccacggattc
     5881 agcagaggcc aagaggagcc tggggcctgt caggacgatc cttccttcct tggtgccctg
     5941 aggctgagtg tagttcacct ctgggactgg acctcacctc cagagcaaag cagttgaatt
     6001 tgaagacagg attcccttct ccccatggcc taaagggctg gggactctaa caggaaaggc
     6061 tagggtggag atggccgcct ttcactgtct ttgtccagac gtttggcttt gagagcatta
     6121 ctcacttaaa gggctttatg agacataaag gaccccctag ttttccagac tctaaccttc
     6181 tgccccaagg ctaagcagag agcgtgcacc ctcaggcaga cagtggccga cagacagaca
     6241 ggcctcagcc aagtgcactg ctccaagcct gtaacccagc actcagactg cttaagctgc
     6301 acgaagagtt caaggctggc ttcaaccatg ttacaagctc aggccagcct gggtaacttg
     6361 aggagaccct ggatcagatg tgttgctact agtctgctgg ctggttcagg gccttcctca
     6421 gatgcacaca aacatctgtc ctttttaggt atttttctaa gaggtgcctt tctagaacta
     6481 gagccacttg gtgccgcaca cctatttcct catctgacgg atgtgtgcag agccgccaca
     6541 tagacacggt gacagcaggt tcagcagagg gacgaactcc agtctccagg aacagaaagg
     6601 gcctttcaga tttcctaacc atcaaagaac ctttcactca gcctctcaaa tcgcgtccac
     6661 accttctgtt ccacacagct gtctccatgc ctctgtatca gcagggtcag aaatccagac
     6721 cagaggctcg aagaagtgca gacagcacag tctcaaggat catgcgaggg gctgcctccc
     6781 ttcaaaggac ggacttcagt tagctcttca gcggggcaca ggctcaggaa ctgggagggt
     6841 ttgaacagga agcccaatct agactcctgt gcactccctt tctctagcct gccctcgcca
     6901 tggtctgaat gggctgtaac ggatgaggta actgatgctt ctcttgacct ttgagacgtg
     6961 cagtttcttt agattttaaa ttcagcctcc gttggctttt caccttccat ttaccaggct
     7021 taaatgtaaa gttgtgggaa catctcgagg cttgagcccc gggctagagc acttgcctag
     7081 catgagtgag gtcccgggtt cagcccagaa ggaagaaaaa aatcatgagc acagcttgct
     7141 tcttccaagc aggctttaaa catctgcact tccgccttca ggcctgactc cacaggagcc
     7201 tggcattagc agagggtggc ctgtgtttct ttcactcctg ggaatgtcgg tctgggcaat
     7261 gacttcccag agcgctgagc cgtcactcac actgtggcaa tgtcctgttt gctcctctcc
     7321 tacccacaca tcttcctttc atttgtgccg catgtttttg ttgtagaaat gtttatataa
     7381 catgctttcc atatcaggga aaaatcatat gtttaataaa ttggctataa ttttaatatc
     7441 tgtggacaat tgtaaaattt ggaatgtatc atatgtaaaa agtttaaaga tattcaaata
     7501 aatgctttag gtgttga
//
