LOCUS       NP_001399747            1755 aa            linear   ROD 01-APR-2024
DEFINITION  E3 ubiquitin-protein ligase UBR2 isoform 1 [Rattus norvegicus].
ACCESSION   NP_001399747 XP_038939746
VERSION     NP_001399747.1
DBSOURCE    REFSEQ: accession NM_001412818.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1755)
  AUTHORS   MacLennan,M., Garcia-Canadas,M., Reichmann,J., Khazina,E.,
            Wagner,G., Playfoot,C.J., Salvador-Palomeque,C., Mann,A.R.,
            Peressini,P., Sanchez,L., Dobie,K., Read,D., Hung,C.C.,
            Eskeland,R., Meehan,R.R., Weichenrieder,O., Garcia-Perez,J.L. and
            Adams,I.R.
  TITLE     Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in
            mouse embryonic stem cells
  JOURNAL   Elife 6, e26152 (2017)
   PUBMED   28806172
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1755)
  AUTHORS   Crichton,J.H., Playfoot,C.J., MacLennan,M., Read,D., Cooke,H.J. and
            Adams,I.R.
  TITLE     Tex19.1 promotes Spo11-dependent meiotic recombination in mouse
            spermatocytes
  JOURNAL   PLoS Genet 13 (7), e1006904 (2017)
   PUBMED   28708824
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1755)
  AUTHORS   Kume,K., Iizumi,Y., Shimada,M., Ito,Y., Kishi,T., Yamaguchi,Y. and
            Handa,H.
  TITLE     Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating
            the leucine-mTOR signaling pathway
  JOURNAL   Genes Cells 15 (4), 339-349 (2010)
   PUBMED   20298436
REFERENCE   4  (residues 1 to 1755)
  AUTHORS   An,J.Y., Kim,E.A., Jiang,Y., Zakrzewska,A., Kim,D.E., Lee,M.J.,
            Mook-Jung,I., Zhang,Y. and Kwon,Y.T.
  TITLE     UBR2 mediates transcriptional silencing during spermatogenesis via
            histone ubiquitination
  JOURNAL   Proc Natl Acad Sci U S A 107 (5), 1912-1917 (2010)
   PUBMED   20080676
REFERENCE   5  (residues 1 to 1755)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   6  (residues 1 to 1755)
  AUTHORS   Kwon,Y.T., Xia,Z., An,J.Y., Tasaki,T., Davydov,I.V., Seo,J.W.,
            Sheng,J., Xie,Y. and Varshavsky,A.
  TITLE     Female lethality and apoptosis of spermatocytes in mice lacking the
            UBR2 ubiquitin ligase of the N-end rule pathway
  JOURNAL   Mol Cell Biol 23 (22), 8255-8271 (2003)
   PUBMED   14585983
REFERENCE   7  (residues 1 to 1755)
  AUTHORS   Kwon,Y.T., Xia,Z., Davydov,I.V., Lecker,S.H. and Varshavsky,A.
  TITLE     Construction and analysis of mouse strains lacking the ubiquitin
            ligase UBR1 (E3alpha) of the N-end rule pathway
  JOURNAL   Mol Cell Biol 21 (23), 8007-8021 (2001)
   PUBMED   11689692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Oct 19, 2022 this sequence version replaced XP_038939746.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.36716.1,
                                           SRR26643298.47787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1755
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     Protein         1..1755
                     /product="E3 ubiquitin-protein ligase UBR2 isoform 1"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase UBR2"
                     /calculated_mol_wt=198887
     Region          98..167
                     /region_name="UBR-box_UBR2"
                     /note="UBR-box found in ubiquitin-protein ligase
                     E3-alpha-2 (UBR2) and similar proteins; cd19679"
                     /db_xref="CDD:439077"
     Site            order(99,112,115,124,127,133,136,149,151,163,166)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:439077"
     Region          222..300
                     /region_name="ClpS"
                     /note="ATP-dependent Clp protease adaptor protein ClpS;
                     pfam02617"
                     /db_xref="CDD:460621"
     Region          1107..1222
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Site            order(1108,1111,1168,1170,1173,1176,1210,1213)
                     /site_type="other"
                     /note="cross-brace motif"
                     /db_xref="CDD:438347"
     Region          1310..1730
                     /region_name="PRT6_C"
                     /note="Proteolysis_6 C-terminal; pfam18995"
                     /db_xref="CDD:465944"
     CDS             1..1755
                     /gene="Ubr2"
                     /coded_by="NM_001412818.1:303..5570"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:363188"
                     /db_xref="RGD:1593237"
ORIGIN      
        1 masemepevq aidrsllecs aeeiagkwlq atdltrevyq hlahcvpkiy crgpnpfpqk
       61 edtlaqhill gpmewyicge dpalgfpkle qankpshlcg rvfkvgepty scrdcavdpt
      121 cvlcmqcflg sihrdhryrm ttsggggfcd cgdteawkeg pycqrhelss sevveeedpl
      181 vhlsedviar tynifaimfr yavdmltwek eselpedlev gektdtyycm lfndevhtye
      241 qviytlqkav nctqkeaigf attvdrdgrr svrygdfqyc dqaktvivrn tsrqtkplkv
      301 qvmhssvaah qnfglkalsw lgsvigysdg lrrilcqvgl qegpdgenss lvdrlmlnds
      361 klwkgarsvy hqlfmssllm dlkykklfav rfaknyrqlq rdfmeddher avsvtalsvq
      421 fftaptlarm liteenlmtv iikafmdhlk hrdaqgrfqf erytalqafk frrvqslild
      481 lkyvliskpt ewsdelrqkf lqgfdaflel lkcmqgmdpi trqvgqhiem epeweaaftl
      541 qmklthvism vqdwcaldek vlieaykkcl avlmqchggf tdgeqpitls icghsvetir
      601 ycvsqekvsi hlpisrllag lhvllsksev aykfpellpl selsppmlie hplrclvlca
      661 qvhagmwrrn gfslvnqiyy yhnvkcrrem fdkdivmlqt gvsmmdpnhf lmimlsrfel
      721 yqifstpdyg krfssevthk dvvqqnntli eemlyliiml vgerfspgvg qvgatdeikr
      781 eiihqlsikp mahselvksl pedenketgm esvietvahf kkpgltgrgm yelkpecake
      841 fnlyfyhfsr aeqskaeeaq rklkrenked talpppalpp fcplfgslvn ilqcdvmlsi
      901 mgtilqwave rhgsawsesm lqrvlhligm alqeekhhle naveghvqtf tftqkiskpg
      961 dapnnspsil amletlqnap slevhkdmir wllkmfntik kiresssssp vaeaegaime
     1021 essrdkdkae rkrkaeiarl rrekimaqms emqrhfiden kelfqqtiel dasasaaldn
     1081 splvpdaalt algpaqtqvp eprqfvtcil cqeeqevtve sramvlaafv qrstvlskdr
     1141 skviedpeky dplfmhpdls cgthtgscgh amhahcwqry fdsvqakeqr rqqrlrlhts
     1201 ydvengeflc plceclsntv iplllpprsi lsrrlnfsdq pdlaqwtrti aqqikviqml
     1261 rkgdsaadkp ssedtedmni ipipegfrpd fyprnpysds ikemlttfgt atykvglkvh
     1321 pneddprvpi mcwgtcayti qsierilsee ekpvfgplpc rlddclrslt rfaaahwtva
     1381 llpvvqghfc klfaslvpsd gsedlpcild idmfhllvgl vlsfpalqcq dfsgsslatg
     1441 dlhifhlvtl ahivqillts cteengmdqe nptgeeelai lslhktlhrc tgsaldeaps
     1501 gwhlwrsvra gilpflkcsa lffhylngvp appdlqvsga shfehlcnyl slptnlirlf
     1561 qensdimnsl ieswcqnsev krylngerga isyprgankl idlpedyssl inqasnfscp
     1621 ksggdksrap tlclvcgsll csqsyccqae legedvgact ahtyscgsga giflrvrecq
     1681 vlflagktkg cfysppyldd ygetdqglrr gnplhlcqer frkiqklwqq hsiteeigha
     1741 qeanqtlvgi dwqhl
//
