LOCUS       NM_001178072            5274 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ubiquitin protein ligase E3 component n-recognin
            1 (Ubr1), mRNA.
ACCESSION   NM_001178072 XR_085791 XR_086198
VERSION     NM_001178072.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5274)
  AUTHORS   Wang,C., Zhu,X., Chen,R., Zhang,X. and Lian,N.
  TITLE     Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy
            in Spinal Cord Injury
  JOURNAL   eNeuro 10 (6) (2023)
   PUBMED   37094938
  REMARK    GeneRIF: Upregulation of UBR1 m6A Methylation by METTL14 Inhibits
            Autophagy in Spinal Cord Injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5274)
  AUTHORS   Xue,Y., Guo,Y., Luo,S., Zhou,W., Xiang,J., Zhu,Y., Xiang,Z. and
            Shen,J.
  TITLE     Aberrantly Methylated-Differentially Expressed Genes Identify Novel
            Atherosclerosis Risk Subtypes
  JOURNAL   Front Genet 11, 569572 (2020)
   PUBMED   33381146
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5274)
  AUTHORS   Schoner,K., Fritz,B., Huelskamp,G., Louwen,F., Zenker,M., Moll,R.
            and Rehder,H.
  TITLE     Recurrent Johanson-Blizzard syndrome in a triplet pregnancy
            complicated by urethral obstruction sequence: a clinical,
            molecular, and immunohistochemical approach
  JOURNAL   Pediatr Dev Pathol 15 (1), 50-57 (2012)
   PUBMED   21711208
REFERENCE   4  (bases 1 to 5274)
  AUTHORS   Kume,K., Iizumi,Y., Shimada,M., Ito,Y., Kishi,T., Yamaguchi,Y. and
            Handa,H.
  TITLE     Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating
            the leucine-mTOR signaling pathway
  JOURNAL   Genes Cells 15 (4), 339-349 (2010)
   PUBMED   20298436
REFERENCE   5  (bases 1 to 5274)
  AUTHORS   Elting,M., Kariminejad,A., de Sonnaville,M.L., Ottenkamp,J.,
            Bauhuber,S., Bozorgmehr,B., Zenker,M. and Cobben,J.M.
  TITLE     Johanson-Blizzard syndrome caused by identical UBR1 mutations in
            two unrelated girls, one with a cardiomyopathy
  JOURNAL   Am J Med Genet A 146A (23), 3058-3061 (2008)
   PUBMED   19006206
REFERENCE   6  (bases 1 to 5274)
  AUTHORS   Kwon,Y.T., Xia,Z., An,J.Y., Tasaki,T., Davydov,I.V., Seo,J.W.,
            Sheng,J., Xie,Y. and Varshavsky,A.
  TITLE     Female lethality and apoptosis of spermatocytes in mice lacking the
            UBR2 ubiquitin ligase of the N-end rule pathway
  JOURNAL   Mol Cell Biol 23 (22), 8255-8271 (2003)
   PUBMED   14585983
REFERENCE   7  (bases 1 to 5274)
  AUTHORS   Kwon,Y.T., Xia,Z., Davydov,I.V., Lecker,S.H. and Varshavsky,A.
  TITLE     Construction and analysis of mouse strains lacking the ubiquitin
            ligase UBR1 (E3alpha) of the N-end rule pathway
  JOURNAL   Mol Cell Biol 21 (23), 8007-8021 (2001)
   PUBMED   11689692
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB549211.1.
            
            [WARNING] On Apr 9, 2024 this sequence was replaced by
            NM_001178072.2.
            
            On or before May 14, 2010 this sequence version replaced
            XR_085791.2, XR_086198.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB549211.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5274
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..5274
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /note="ubiquitin protein ligase E3 component n-recognin 1"
                     /db_xref="GeneID:499877"
                     /db_xref="RGD:1562326"
     CDS             1..5274
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase UBR1"
                     /protein_id="NP_001171543.1"
                     /db_xref="GeneID:499877"
                     /db_xref="RGD:1562326"
                     /translation="MADEEMDGAERMDVSPEPPLAPQPPASWWDQQGDFYTAFLHHLA
                     KLVPEIYFAEMDPDLEKQEENVQMSIFTPLEWYLFGEDPDVCLERLKHSAAFQLCGKV
                     FKSGETTYSCRDCAIDPTCVLCMDCFQSSVHKNHRYKMHTSTGGGFCDCGDTEAWKTG
                     PFCMDHEPGRAGTTKETLHCPLNEEVIAQARRIFPSVIKYIVEMTIWEEEKELPPELQ
                     RREKNERYYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGVY
                     SACQEAKEDIKSHSENVSQHPLHVEVLHSVVMAHQKFALRLGSWMNKIMSYSSDFRQI
                     FCQACLIEEPGSEHPCLISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKLFAMEF
                     VKYYKQLQKEYISDDHERSISITALSVQVFTVPTLARHLIEEQNVISVITETLLEVLP
                     EYLDRNNKFNFQGYSQDKLGRVYAVICDLKYILISKPLVWTERLRAQFLEGFRSFLKI
                     LTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEDLLLVAYKE
                     CHKAVMRCSTNFMSSTKTVVQLCGHSLETKSYKVSEDLVSIHLPLSRTLAGLHVRLSR
                     LGAVSRLHEFVPFDGFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYYQDVK
                     CREEMYDKDIIMLQIGASIMDPNKFLLLVLQRYELADAFNKTISTKDQDLIKQYNTLI
                     EEMLQVLIYIVGERYVPGVGNVTKEEVIMREITHLLCIEPMPHSAIARNLPENENNET
                     GLENVINKVATFKKPGVSGHGVYELKDESLKDFNMYFYHYSKTQHSKAEHMQKKRRKQ
                     ENKDEALPPPPPPEFCPAFSKVTDLLNCDIMMHILRTIFERAVDPESNLWTEGMLQMA
                     FHILALGLLEEKQQLQKAPEEEVAFDFYHKASRLGSSAMNAQNIQMLLEKLKGIPQLE
                     GQKDMITWILQMFDTVKRLREKSCLVVASTSGLESIKSEEITHDKEKAERKRKAEAAR
                     LHRQKIMAQMSALQKNFIETHKLMYDNTSEITGKEDSIMEEESPSAVSECSRIALGPK
                     RGPALTEKEVLTCILCQEEQEVKLENNAMVLSACVQKSTALTQHRGKPAGLLGESLDP
                     LFMDPDLAHGTYAGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLCK
                     SLCNTVIPIIPLQPQKINSENAEALSQLLTLARWIQTVLARISGYNMKHAKGEAPAVP
                     VLFNQGMGDSTFEFHSILSFGVQSSVKYSNSIKEMVILFATTIYRIGLKVPPDELDPR
                     VPMMTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQRTTCPQVLI
                     QKHLVRLLSVVLPNLQSENTPCLLSVDLFHVLVGAVLAFPSLYWDDTVDLQPSPLSSS
                     YSHLYLFHLVTMAHMLQILLTVDADQSPGLPLNEGGEDSEEARCASALFVEVSQHTDG
                     LIGCGAPGWYLWLSLRNGITPYLRCAALLFHYLLGVTPPEELFANSAEGEFSALCSYL
                     SLPTNLFLLFQEYWDTIRPLLQRWCGDPALLNSLKQKSALVRYPRKRNSLIELPDDYS
                     CLLNQASHFRCPRSSDDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACVFHALQC
                     GAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKL
                     HLVWQQHCIIEEIARSQETNQMLFGFNWQLL"
     exon            1..81
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            82..338
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            339..417
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            418..528
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            529..659
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            660..798
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            799..861
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            862..985
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1093
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1182
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1281
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1439
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1539
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1668
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1849
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1911
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2022
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2088
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2190
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2254
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2379
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2432
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2535
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2584
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2739
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2839
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2949
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3036
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3218
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3424
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..3518
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            3519..3668
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            3669..3766
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            3767..3860
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..4009
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            4010..4065
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            4066..4162
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            4163..4230
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            4231..4381
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            4382..4481
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            4482..4615
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            4616..4724
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            4725..4781
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            4782..4859
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            4860..5030
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            5031..5132
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
     exon            5133..5274
                     /gene="Ubr1"
                     /gene_synonym="RGD1562326"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggacg aagagatgga cggcgccgag aggatggacg tcagcccgga gcctcccctg
       61 gcccctcagc cgcccgcatc ctggtgggat cagcaaggtg atttttatac tgctttctta
      121 catcatttgg caaaattagt gccagaaatt tattttgctg agatggaccc agatttggaa
      181 aagcaagaag agaatgtaca aatgtcaata ttcactcctt tggaatggta cttatttgga
      241 gaggatccag acgtttgctt agagagatta aagcacagtg cagcatttca gttgtgcggg
      301 aaggttttca aaagtggaga aacaacatat tcctgtaggg attgtgcaat tgatccaacg
      361 tgtgtgctct gtatggactg cttccagagt agtgttcata aaaaccatcg ttacaagatg
      421 catacttcta ctggaggagg cttctgtgac tgtggagaca cagaagcgtg gaaaactggt
      481 cccttttgta tggatcacga acctggaaga gcaggtacta caaaagagac cttgcattgc
      541 ccactgaatg aagaggtaat tgctcaagcc aggagaatat tcccttcagt gataaagtac
      601 attgtagaaa tgactatatg ggaagaggaa aaggaactgc ctcctgaact gcagagaagg
      661 gagaaaaatg aaagatatta ctgtgtcctt ttcaacgatg agcaccattc atatgatcat
      721 gtgatataca gtctgcaaag agctcttgac tgtgagcttg cagaggcaca gttgcacaca
      781 actgccatag acaaagaggg tcgccgggct gtcaaagcag gtgtgtattc cgcttgccag
      841 gaagcaaagg aggatataaa gagtcactca gagaacgtct ctcagcaccc cctccatgtg
      901 gaagtgctgc attccgtggt tatggcccac cagaaatttg ctctgcgcct tggatcctgg
      961 atgaacaaaa ttatgagcta ttcaagtgac tttaggcaga tcttctgcca agcctgcctc
     1021 atagaggagc ctggctctga acatccctgt cttataagca gactaatgct ttgggatgca
     1081 aaactttata aaggtgcccg taagatcctt cacgaattga tctttagtag tttttttatg
     1141 gagatggaat acaaaaaact ctttgctatg gaatttgtga agtattataa acaactacag
     1201 aaagagtaca tcagtgacga ccacgagaga agcatctcta taaccgcact gtccgttcag
     1261 gtgttcactg tccccacctt ggcccgacat cttattgaag agcagaatgt tatttctgtc
     1321 attactgaaa ctctgctgga agttctacct gagtacttgg acaggaacaa taagttcaac
     1381 ttccagggct atagccagga caagctggga agagtgtacg cggtgatctg tgacctgaag
     1441 tacatcctga ttagcaagcc tctcgtatgg acagaaagac taagagcaca gttcctggaa
     1501 gggttccggt cttttctgaa gattctcacc tgtatgcagg gaatggaaga aatcagaaga
     1561 caagttggac agcacattga agtagaccct gactgggagg ctgccatcgc tatacagatg
     1621 caactaaaga atattttgct catgttccaa gagtggtgtg cttgtgatga agatctctta
     1681 ctagtggctt ataaagaatg tcacaaagct gtaatgaggt gcagcacaaa tttcatgtct
     1741 agtaccaaga cagtagtaca actgtgtggt catagtttgg aaactaaatc ctacaaagtg
     1801 tctgaggacc ttgtcagcat acatctacca ctctctagaa ctctcgctgg tcttcatgta
     1861 cgtttaagca gactaggtgc tgtttcaaga ctgcatgaat ttgtgccttt tgatggcttt
     1921 caagtagagg tcctagtaga gtaccctttg cgctgcctgg tgctggttgc tcaggttgtt
     1981 gccgagatgt ggcgaagaaa cgggctctcc ctcattagcc aggttttcta ttatcaagat
     2041 gttaaatgca gggaagaaat gtatgataaa gatatcatca tgcttcagat tggagcgtct
     2101 ataatggatc ccaacaagtt cttgttactg gtacttcaga ggtatgaact tgctgatgct
     2161 tttaacaaga ccatatccac aaaagaccag gatttgatta aacagtataa cacattaata
     2221 gaagaaatgc ttcaggtcct catctatatt gtgggagaac gttatgtacc cggagtggga
     2281 aacgtgacca aagaggaggt tataatgaga gagatcactc acttactttg cattgagccc
     2341 atgccacaca gtgccattgc cagaaaccta ccggagaatg aaaataacga aactggctta
     2401 gagaatgtca taaacaaagt ggccacattt aagaaaccgg gtgtgtcggg ccatggtgtt
     2461 tatgaattga aagacgaatc actgaaagac ttcaatatgt acttttacca ttattctaaa
     2521 acacagcata gcaaggctga acatatgcag aagaagagga gaaaacaaga aaataaagat
     2581 gaagccttgc caccgccacc tcctcctgag ttctgtcccg ctttcagcaa agtaactgac
     2641 cttctcaact gtgatattat gatgcacatt ctcaggacca tcttcgagcg ggcagtggac
     2701 cccgagtcta atctgtggac agaagggatg ctccaaatgg ccttccatat attggcgctg
     2761 ggcttgctgg aggagaagca gcagcttcag aaagctcctg aagaagaagt ggctttcgac
     2821 ttttaccata aggcttcaag attgggaagt tcagcaatga atgctcagaa tatacaaatg
     2881 cttttggaaa aactcaaagg aatcccccaa ttagaaggcc agaaggacat gataacatgg
     2941 attctccaga tgtttgacac agtgaagcga ttaagagaaa aatcttgttt agttgtggca
     3001 agcacttcag gattggagtc cattaaaagt gaggagatta ctcatgataa agaaaaagca
     3061 gaacggaaga gaaaagctga agctgctagg ctacatcgcc agaagatcat ggcccagatg
     3121 tctgccttac agaaaaactt cattgaaact cacaaactca tgtatgacaa tacatcagaa
     3181 ataacaggga aggaagactc cattatggaa gaagaaagcc cctcagcagt cagtgagtgc
     3241 tctcgaattg ctctgggccc taaacggggc ccagctctta cagaaaagga ggtgctgacg
     3301 tgcatcctct gccaagaaga acaagaggtg aaactagaaa acaacgccat ggtgttgtcc
     3361 gcctgtgtgc agaaatccac cgccctaacc cagcacaggg ggaagcctgc gggcctctta
     3421 ggggaatcac tggaccctct tttcatggat ccagacctgg cacatggcac ttacgcagga
     3481 agctgtggtc atgtaatgca tgcagtgtgc tggcagaagt attttgaagc agtgcagctg
     3541 agctctcagc agcgcattca cgtcgacctg tttgacttgg agagtggaga gtacctgtgc
     3601 cctctctgca agtctctctg caataccgtc atccccatca ttcctttgca gccacagaag
     3661 atcaacagtg agaatgcaga ggctctttct caacttttga ccttggcacg gtggatacag
     3721 actgtccttg caagaatatc aggttataat atgaaacacg ctaaaggaga agctccagca
     3781 gttcctgtcc tgtttaatca aggaatgggg gattctactt ttgagtttca ttccatcctg
     3841 agttttggag ttcagtcttc ggtgaaatac tcaaatagta tcaaggaaat ggtcattctc
     3901 tttgccacaa caatttacag aatcggcctg aaagtgcctc ctgatgaatt agacccacga
     3961 gtacccatga tgacctggag cacgtgtgct ttcaccatcc aggcaattga aaaccttttg
     4021 ggagatgaag gaaaacctct atttggagca cttcaaaata gacagcataa tggtctgaaa
     4081 gcgttaatgc aatttgcagt tgcacagagg actacctgtc ctcaggtcct gatacagaaa
     4141 catctggttc gactcctatc agttgttctt cctaacctac aatcagaaaa tacaccatgc
     4201 cttctatccg ttgatctatt tcatgttctg gtgggcgctg tcttagcgtt cccgtccttg
     4261 tactgggatg acacggtgga tctgcagcct tcaccgctca gctcttcata cagccacctt
     4321 tatctcttcc atctggtcac catggcccat atgcttcaga tactcctcac ggtagatgca
     4381 gatcagtctc cgggactccc acttaatgag ggtggagagg acagtgaaga ggctcgctgt
     4441 gcgtctgctc tcttcgtgga agtctcacag cacacagacg gcctcattgg gtgtggtgct
     4501 cctggctggt acctgtggct ctccctgagg aatggcatca ccccttacct ccgctgtgct
     4561 gcactgcttt tccactattt actcggagta actccgcctg aagaactgtt tgccaactct
     4621 gctgaaggag aattcagtgc actctgtagc tatctctctt tacccacaaa tttgttcctg
     4681 cttttccagg aatattggga taccataagg cccttacttc agaggtggtg tggagatcct
     4741 gccttactca actctttgaa gcagaaaagt gctctggtca ggtaccctag aaaaagaaat
     4801 agtttgatag agcttcctga tgactacagc tgtcttctaa atcaagcttc tcactttagg
     4861 tgtccacggt cttcagatga tgaacgaaag caccctgtcc tctgtctttt ctgtggggcc
     4921 atcctgtgtt ctcagaacat ctgttgccaa gaaatcgtga atggggagga ggttggagcg
     4981 tgcgtttttc atgcacttca gtgtggtgct ggagtctgca ttttcctaaa aatcagagaa
     5041 tgcagagtgg tcctggtaga aggaaaagcc agaggctgtg cctacccagc cccttacttg
     5101 gatgaatatg gagaaacaga cccagggcta aagaggggaa acccacttca tttatctcgg
     5161 gagcggtatc ggaagctgca tttggtctgg caacagcact gcattataga agagattgct
     5221 cggagccagg agactaatca gatgctgttt ggattcaact ggcagttact ctga
//
