LOCUS       NM_001107688            3258 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus ubiquilin 4 (Ubqln4), mRNA.
ACCESSION   NM_001107688 XM_001074121 XM_227405
VERSION     NM_001107688.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3258)
  AUTHORS   Jachimowicz RD, Beleggia F, Isensee J, Velpula BB, Goergens J,
            Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL,
            Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T,
            Schmitt A, Distelmaier F, Ludecke HJ, Albrecht B, Kruger M,
            Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T,
            Peifer M, Ziv Y, Reinhardt HC, Wieczorek D and Shiloh Y.
  TITLE     UBQLN4 Represses Homologous Recombination and Is Overexpressed in
            Aggressive Tumors
  JOURNAL   Cell 176 (3), 505-519 (2019)
   PUBMED   30612738
REFERENCE   2  (bases 1 to 3258)
  AUTHORS   Hirayama S, Sugihara M, Morito D, Iemura SI, Natsume T, Murata S
            and Nagata K.
  TITLE     Nuclear export of ubiquitinated proteins via the UBIN-POST system
  JOURNAL   Proc Natl Acad Sci U S A 115 (18), E4199-E4208 (2018)
   PUBMED   29666234
REFERENCE   3  (bases 1 to 3258)
  AUTHORS   Suzuki R and Kawahara H.
  TITLE     UBQLN4 recognizes mislocalized transmembrane domain proteins and
            targets these to proteasomal degradation
  JOURNAL   EMBO Rep 17 (6), 842-857 (2016)
   PUBMED   27113755
REFERENCE   4  (bases 1 to 3258)
  AUTHORS   Lee DY, Arnott D and Brown EJ.
  TITLE     Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the
            autophagy machinery
  JOURNAL   EMBO Rep 14 (4), 373-381 (2013)
   PUBMED   23459205
REFERENCE   5  (bases 1 to 3258)
  AUTHORS   Li X, Su V, Kurata WE, Jin C and Lau AF.
  TITLE     A novel connexin43-interacting protein, CIP75, which belongs to the
            UbL-UBA protein family, regulates the turnover of connexin43
  JOURNAL   J Biol Chem 283 (9), 5748-5759 (2008)
   PUBMED   18079109
  REMARK    GeneRIF: A novel connexin43-interacting protein, CIP75, which
            belongs to the UbL-UBA protein family, regulates the turnover of
            connexin43
REFERENCE   6  (bases 1 to 3258)
  AUTHORS   Lim J, Hao T, Shaw C, Patel AJ, Szabo G, Rual JF, Fisk CJ, Li N,
            Smolyar A, Hill DE, Barabasi AL, Vidal M and Zoghbi HY.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   7  (bases 1 to 3258)
  AUTHORS   Riley BE, Xu Y, Zoghbi HY and Orr HT.
  TITLE     The effects of the polyglutamine repeat protein ataxin-1 on the
            UbL-UBA protein A1Up
  JOURNAL   J Biol Chem 279 (40), 42290-42301 (2004)
   PUBMED   15280365
REFERENCE   8  (bases 1 to 3258)
  AUTHORS   Matsuda M, Koide T, Yorihuzi T, Hosokawa N and Nagata K.
  TITLE     Molecular cloning of a novel ubiquitin-like protein, UBIN, that
            binds to ER targeting signal sequences
  JOURNAL   Biochem Biophys Res Commun 280 (2), 535-540 (2001)
   PUBMED   11162551
REFERENCE   9  (bases 1 to 3258)
  AUTHORS   Davidson JD, Riley B, Burright EN, Duvick LA, Zoghbi HY and Orr HT.
  TITLE     Identification and characterization of an ataxin-1-interacting
            protein: A1Up, a ubiquitin-like nuclear protein
  JOURNAL   Hum Mol Genet 9 (15), 2305-2312 (2000)
   PUBMED   11001934
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473976.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001074121.1, XM_227405.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3258
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3258
                     /gene="Ubqln4"
                     /gene_synonym="RGD1308273"
                     /note="ubiquilin 4"
                     /db_xref="GeneID:310633"
                     /db_xref="RGD:1308273"
     exon            1..200
                     /gene="Ubqln4"
                     /gene_synonym="RGD1308273"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1880
                     /gene="Ubqln4"
                     /gene_synonym="RGD1308273"
                     /codon_start=1
                     /product="ubiquilin-4"
                     /protein_id="NP_001101158.1"
                     /db_xref="GeneID:310633"
                     /db_xref="RGD:1308273"
                     /translation="MAEPSGAETRPQIRVTVKTPKDKEEILICDQASVKEFKEEISRR
                     FKAQQDQLVLIFAGKILKDGDTLNQHGIKDGLTVHLVIKTPQKAQDPVTTTASSPSTP
                     DSASAPSTTPASPAAPVQPCSSGNTTSDASSGGGPSPVAAEGPSNATASILSGFGGIL
                     GLGSLGLGSANFMELQQQMQRQLMSNPEMLSQIMENPLVQDMMSNPDLMRHMIMANPQ
                     MQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALSNLESVPGGYNAL
                     RRMYTDIQEPMFTAAREQFGNNPFSSLAGNSDNSSSQPLRTENREPLPNPWSPSPPTS
                     QAPGSGGEGTGGSGTSQVHPTVSNPFGINAASLGSGMFNSPEMQALLQQISENPQLMQ
                     NVISAPYMRTMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQNPES
                     LSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGTPRTSVPLAGSNSGSAAEAP
                     TASPGTPATTPPSAGSNTQQQLMQQMIQLLSGSGNSQVPVPEVRFQQQLEQLNSMGFV
                     NREANLQALIATGGDINAAIERLLGSQLS"
     exon            201..352
                     /gene="Ubqln4"
                     /gene_synonym="RGD1308273"
                     /inference="alignment:Splign:2.1.0"
     exon            353..552
                     /gene="Ubqln4"
                     /gene_synonym="RGD1308273"
                     /inference="alignment:Splign:2.1.0"
     exon            553..815
                     /gene="Ubqln4"
                     /gene_synonym="RGD1308273"
                     /inference="alignment:Splign:2.1.0"
     exon            816..974
                     /gene="Ubqln4"
                     /gene_synonym="RGD1308273"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1200
                     /gene="Ubqln4"
                     /gene_synonym="RGD1308273"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1340
                     /gene="Ubqln4"
                     /gene_synonym="RGD1308273"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1424
                     /gene="Ubqln4"
                     /gene_synonym="RGD1308273"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1540
                     /gene="Ubqln4"
                     /gene_synonym="RGD1308273"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1727
                     /gene="Ubqln4"
                     /gene_synonym="RGD1308273"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..3258
                     /gene="Ubqln4"
                     /gene_synonym="RGD1308273"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttggaggct ccggagccga gccgggccgg gcgggccagg aggaggagga ggaggaggag
       61 ctgggcgggc tggcgggcgg ccgggcggcg gcatggcgga gccgagtggg gctgagacga
      121 ggccccagat tcgggtcacc gtcaagaccc ccaaggacaa ggaggagatc ctgatctgcg
      181 atcaagcctc ggtcaaggag ttcaaggagg aaatctcccg gaggtttaag gctcagcagg
      241 atcagctggt cctgatcttc gcaggcaaga tcctcaagga tggagacaca ctgaaccagc
      301 atgggatcaa ggacgggctc acggttcatc tagtcatcaa aacccctcag aaggctcaag
      361 atccagtgac tactactgct tcctccccat ccactcctga ctctgcctca gcaccctcca
      421 ccacgcctgc ctcacctgcg gcccctgtcc agccctgcag ctctggcaat actacttcag
      481 atgctagcag tggagggggg ccttctccag tggcggcaga gggaccctca aatgccactg
      541 catcaattct ttctggcttt gggggcatcc tgggcctggg cagcctgggc ctgggctccg
      601 ccaactttat ggagctacag caacagatgc agcggcagct catgtccaat cctgagatgc
      661 tgtcgcagat catggagaac cccctggtcc aggatatgat gtcaaaccct gacctgatgc
      721 gccacatgat catggctaac ccccagatgc aacagctgat ggagaggaac cctgagatca
      781 gtcacatgct caacaacccg gagctcatga ggcagacaat ggagcttgct cgtaacccag
      841 ccatgatgca agaaatgatg cggaaccagg accgggccct cagcaacctg gaaagtgtcc
      901 cgggagggta taatgccctc cgccgcatgt acacggacat ccaggaaccc atgttcactg
      961 ctgcccggga acagtttggc aacaatccct tctcttccct ggccgggaac tccgacaact
     1021 catcctccca acctcttcgg actgagaatc gagagcccct ccctaacccc tggagcccct
     1081 cgccccccac ctcccaggcc cccgggtccg gtggggaggg caccggagga tcggggacca
     1141 gccaggtgca cccgacagtc tcgaacccct ttgggatcaa tgcggctagc ctggggtcag
     1201 ggatgttcaa cagcccagaa atgcaggcgc tgctccagca gatttctgaa aacccccagc
     1261 tgatgcagaa tgtcatctcg gccccttaca tgcgcaccat gatgcagacg cttgcccaga
     1321 accctgactt tgctgctcag atgatggtga atgtaccgct gtttgcaggg aatccacaac
     1381 tccaggagca gctgcgcctg cagctccctg tatttctgca gcagatgcag aacccagagt
     1441 ctctctccat cctcaccaac ccacgggcca tgcaagcctt gctgcagatc cagcaggggc
     1501 tgcagaccct ccagactgaa gcccctgggc tagtacccag ccttggctcc tttgggacac
     1561 cccggacctc ggtacctttg gcaggcagca actctggatc tgcagccgag gcccccactg
     1621 cttccccagg cacaccagcc acaactcctc ccagtgcggg ttccaatacc cagcagcaac
     1681 tcatgcagca gatgatccaa cttttgtctg gaagtgggaa ctcacaggtt ccagtgccag
     1741 aagtgagatt tcaacagcag ctggagcagc tcaactccat gggctttgtc aaccgtgagg
     1801 ccaacctaca agccctgatc gccacaggag gggacatcaa tgcggctatt gagagactcc
     1861 tgggatccca gctctcctga ccccttggct tgtgcctctt ttgttcccca cctctcagtg
     1921 ccagcctttg gctcctgtca agccctacct tctatagtct gtcttctttg atccctacga
     1981 aaagcagggt gactgccgag gcctgtgccc aacccatagc tctgtccaag gattttgatt
     2041 tgttgttgtc tcatgaaatc tctcctggtc ctcttggagc agagctatct agtgtgcaca
     2101 gtgtatcagt tggccacacc tccttgcccg aaagcacctt ggcagcggga ctgagaggag
     2161 gacccagtct ggctaatcgg aagtcttcca tcggtaccac tagagtttag cttgccttac
     2221 atgtactcct cttctcctgc cctcacctca gcccaaccgg tgtttgaatt tcactctttg
     2281 gccaggctct ggtgacactg tggttttctc tctctacacc tatactgatt cgaccagcac
     2341 tttttcatgg gctcctttgt gactctgagg cagggaaaaa gatacctatc cttctgtcca
     2401 aagggagcag tgagtcagca ctctgggcag gattatcaag atcaaacagg accagtgggg
     2461 cccggtgctg aagagcaaca cctgagagtc cttggaagca gggactcagg ggacagcctg
     2521 agcgggttca gaagtcagtc tagagacacc cacagatttc acggtggaga aggcaggctc
     2581 aggcctgacg gaagaagaga gactaatgaa ctgtgaactg aagagaggag ctcaacaaaa
     2641 ctgaccagga atcagactgg ctccgctgtt tccaaatatc atgccctcac acacactgca
     2701 tgagcccagc cttcaggctc cactccagac ccgatggggt tctcagctct gtaggacatc
     2761 tgtataagtg aatacatgca ggctggggag gttgttcctc gttgatttgt gtttcacaac
     2821 tttgtcaaca gagggagctg ggacccttgg tctccggatc tggggtaacc agaaagcata
     2881 ttgggtaatt cttctagtgg ttatggctcc aactggtacc cggccacctc ggtgaaagaa
     2941 tagtgaggtt tctctcccag agttcctgcc tttcagttcc tcgctggttc cctttaggcc
     3001 acaaagttct atttgaggag aagtagaaag gcagatgcct ttggtatgga attgggcttt
     3061 gctcaactag agtactgagg aagccctcac cacattctct ctgccctacg gtccaggtac
     3121 ttggaggacc cctggctgag aggcggaggt gagaaaaggc atcctgcttg gtcccaagca
     3181 gttcagacat gccttcctct tcccctccca acacccaccc tggcccttgt aaataaataa
     3241 tgtggttttt gtgagatt
//
