LOCUS       NM_001107993            2978 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus UbiA prenyltransferase domain containing 1
            (Ubiad1), mRNA.
ACCESSION   NM_001107993 XM_001074290 XM_233672
VERSION     NM_001107993.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2978)
  AUTHORS   Yan,B. and Wang,J.
  TITLE     UBIAD1 expression is associated with cardiac hypertrophy in
            spontaneously hypertensive rats
  JOURNAL   Mol Med Rep 19 (1), 651-659 (2019)
   PUBMED   30483777
  REMARK    GeneRIF: Low Ubiad1 expression is associated with cardiac
            hypertrophy in spontaneously hypertensive rats.
REFERENCE   2  (bases 1 to 2978)
  AUTHORS   McCabe,K.M., Booth,S.L., Fu,X., Ward,E., Adams,M.A. and Holden,R.M.
  TITLE     Vitamin K Metabolism in a Rat Model of Chronic Kidney Disease
  JOURNAL   Am J Nephrol 45 (1), 4-13 (2017)
   PUBMED   27846632
  REMARK    GeneRIF: In a rat model of chronic kidney disease, there was a
            decrease in the thoracic aorta expression of Vkor and Ggcx enzymes,
            and a decrease in the kidney level of vitamin K1 to MK-4
            bioconversion enzyme Ubiad1.
REFERENCE   3  (bases 1 to 2978)
  AUTHORS   Hirota,Y., Nakagawa,K., Sawada,N., Okuda,N., Suhara,Y., Uchino,Y.,
            Kimoto,T., Funahashi,N., Kamao,M., Tsugawa,N. and Okano,T.
  TITLE     Functional characterization of the vitamin K2 biosynthetic enzyme
            UBIAD1
  JOURNAL   PLoS One 10 (4), e0125737 (2015)
   PUBMED   25874989
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2978)
  AUTHORS   Nickerson,M.L., Bosley,A.D., Weiss,J.S., Kostiha,B.N., Hirota,Y.,
            Brandt,W., Esposito,D., Kinoshita,S., Wessjohann,L., Morham,S.G.,
            Andresson,T., Kruth,H.S., Okano,T. and Dean,M.
  TITLE     The UBIAD1 prenyltransferase links menaquinone-4 [corrected]
            synthesis to cholesterol metabolic enzymes
  JOURNAL   Hum Mutat 34 (2), 317-329 (2013)
   PUBMED   23169578
  REMARK    Erratum:[Hum Mutat. 2013 Jul;34(7):1046]
REFERENCE   5  (bases 1 to 2978)
  AUTHORS   Mugoni,V., Postel,R., Catanzaro,V., De Luca,E., Turco,E.,
            Digilio,G., Silengo,L., Murphy,M.P., Medana,C., Stainier,D.Y.,
            Bakkers,J. and Santoro,M.M.
  TITLE     Ubiad1 is an antioxidant enzyme that regulates eNOS activity by
            CoQ10 synthesis
  JOURNAL   Cell 152 (3), 504-518 (2013)
   PUBMED   23374346
REFERENCE   6  (bases 1 to 2978)
  AUTHORS   Nakagawa,K., Hirota,Y., Sawada,N., Yuge,N., Watanabe,M., Uchino,Y.,
            Okuda,N., Shimomura,Y., Suhara,Y. and Okano,T.
  TITLE     Identification of UBIAD1 as a novel human menaquinone-4
            biosynthetic enzyme
  JOURNAL   Nature 468 (7320), 117-121 (2010)
   PUBMED   20953171
REFERENCE   7  (bases 1 to 2978)
  AUTHORS   McGarvey,T.W., Nguyen,T., Tomaszewski,J.E., Monson,F.C. and
            Malkowicz,S.B.
  TITLE     Isolation and characterization of the TERE1 gene, a gene
            down-regulated in transitional cell carcinoma of the bladder
  JOURNAL   Oncogene 20 (9), 1042-1051 (2001)
   PUBMED   11314041
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001074290.1, XM_233672.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2978
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2978
                     /gene="Ubiad1"
                     /gene_synonym="RGD1309588"
                     /note="UbiA prenyltransferase domain containing 1"
                     /db_xref="GeneID:313706"
                     /db_xref="RGD:1309588"
     exon            1..832
                     /gene="Ubiad1"
                     /gene_synonym="RGD1309588"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..1320
                     /gene="Ubiad1"
                     /gene_synonym="RGD1309588"
                     /EC_number="2.5.1.39"
                     /codon_start=1
                     /product="ubiA prenyltransferase domain-containing protein
                     1"
                     /protein_id="NP_001101463.1"
                     /db_xref="GeneID:313706"
                     /db_xref="RGD:1309588"
                     /translation="MAAVQAPGEKINIQAGETTQVGDTDQQRNDWPEEDRLPERSWRQ
                     KCASYVLALRPWSFSASLTPVALGSALAYRSQGVLDPRLLLGCAVAVLAVHGAGNLVN
                     TYYDFSKGIDHKKSDDRTLVDRILEPQDVVRFGVFLYTLGCVCAAYLYYLSTLKLEHL
                     ALIYFGGLSGSFLYTGGIGFKYVALGDLVILITFGPLAVMFAYAVQVGSLAIFPLVYA
                     IPLALSTEAILHSNNTRDMESDREAGIVTLAILIGPTLSYILYNTLLFLPYLIFTILA
                     THCSISLALPLLTSPMAFSLERQFRSQAFNKLPQRTAKLNLLLGLFYVFGIILAPAGS
                     LPRL"
     exon            833..2978
                     /gene="Ubiad1"
                     /gene_synonym="RGD1309588"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgcacaag atggcggcgc cgatggcccg ctggaagttg cgggccgagg ccggctattg
       61 agttgtggca cagggaaagg gaccccagac aggtctcgct caggtgacag gtgagcgggc
      121 agcgccgctg accccgtgac ggtgcatggc ctcctcgttg ctgtctccag tttttaccgc
      181 cccccaaacc ctgccccggg gcggaaccaa aggtcaggcc agtctgtccc gcctatcttc
      241 gtctcggggc ggttcccgtg agtggctcac ttttagaatt gagtttagcc acgtgtagct
      301 tccatggctg cggtacaggc cccgggggag aagattaata tccaggcagg agagacgacc
      361 caggtcgggg acacggacca gcagaggaac gactggcctg aggaggacag gcttccagaa
      421 cgatcctgga gacagaagtg cgcctcctat gtgttggccc tgagaccctg gagcttcagt
      481 gcctcactca ctcctgtggc cctgggcagt gccttggcct acagatccca gggtgtcctg
      541 gatcccaggc tgttgttggg ttgtgcagtg gccgtcctgg ctgtgcacgg ggctggcaat
      601 ttggtcaaca cttactatga cttttccaag ggcattgacc acaaaaagag tgatgacagg
      661 actctggtgg acagaatttt ggagccccag gatgttgttc gatttggagt cttcctctac
      721 accttgggct gtgtgtgtgc tgcttacctc tactacctat ccaccctgaa actggagcac
      781 ttggctctca tctactttgg aggcctgtct ggctcctttc tctacacagg aggaattgga
      841 ttcaagtacg tggcactggg agacctcgtc atcctcatca ctttcggccc gctggccgtg
      901 atgtttgcct atgctgtcca ggtggggtcc ttggccatat tccctctggt ctacgccatc
      961 cctctggccc tcagcacaga ggccattctc cattctaaca acaccaggga catggagtct
     1021 gaccgcgagg ctggcatcgt cacgctggcc atcctcatcg ggcccaccct ctcctacatc
     1081 ctctacaaca cgctgctctt cctgccctac ctgatcttca ccatcctggc cacgcactgc
     1141 agcatcagcc tggcactgcc cctcctcacc agccccatgg ccttctccct ggagaggcag
     1201 ttccgcagcc aggccttcaa caagctgccc cagaggacgg ccaagctcaa cctcctgctg
     1261 gggcttttct atgtctttgg catcatcctg gcaccagcag gcagcctgcc cagactctga
     1321 ggagaccagc agctcccacc acagcccagc ccctcctcag gaggtataga agccaaagac
     1381 tgagaagggg tgccagtggc cagggtgggt gcaggcacag actctgaact cttgcccttg
     1441 tgtgtcggga tgatcttcct agagataatc tgcttgtgat ttgtgtccca ggtcacgggg
     1501 aaccctgaaa ccactctagt gtctgaagag gaattggacg cactgtccct gtgttattta
     1561 tagtctccac tagagggtgc tgttaggcca ctttaggatg gaaggcccat ttcccctctt
     1621 gttctagaca gaatgcccta acaatttgtg aaggagctgt gtcccaagag agccgtagtg
     1681 actaggcatg gtactgccct gttaccttgg cacgtaggaa attgtagtaa ttggtgccag
     1741 gtcccattta cacagaacac ctgtcccctg aatgtgccac ctgctggaga agggccctca
     1801 tgaacagcat gtgctcctgg cttttgtgta gttggtggtt catatgcttc tgtccttcac
     1861 gtctcctttc agtcctcacc actgcggagg aaagggtcag atcaccctgc agcaagacag
     1921 ctaagcctgg ggtggtgaga aaagcactcc cctctcggta acacatggca tggggcggtg
     1981 agggaactgc ttccctctgt ggactccact agggtggcag taattttggg gacctgaagc
     2041 agtcatggga tgggcattta aagcccacag ggctggtctc ctacctggta ttcctcctgc
     2101 ccagcatctc tgcctccatt tgtccccagt atccagacag tgggcaacag taacatgagt
     2161 cagggacact tgcccacatc cacagagcca caggatgggc aaggcagggg cctcctgagt
     2221 gtacaagcca gtggatgaca gtcccggccc cactcagcca gaatgagagg ccatgccagt
     2281 gaaagaacta agaacatggt tcttcatctc tctgtgcttg gttgccttgt tcagatagtg
     2341 ggtggcttca gcgaggacca gaggtgtctc agtctctcct gtcacacccg tctgagtgta
     2401 acagcatctt gcatggagat gatcacacca tctccagtgt gcttccctct gaccagctgt
     2461 cctggagggt gcttcaggct ctcagcctgc agaaaaccac cttgacgtag cactgggtca
     2521 cttccttggg gaaacgttta aacattgccc agagttcctc tgtagtcagg gtggtttgtc
     2581 taccagagag ccggggtccc tgagctcgaa tcagggtcca gaaacctagg agaggaatat
     2641 tctttcctgt tctccccagc acgctgggtt tgtggcatct ggggctttgc agtgtcctgc
     2701 ctatgacccc tgcttggggc tgacaatttg tcacccagag cctggaggac caatgactct
     2761 cactgtccat atgccgggcc tgatatgtgg ctaccctcat gagaactgtg tcagctgcta
     2821 caccgagctc tggtgcagat tttaaatgcc tatttttata tacgatcccc agaggccata
     2881 tttgatgcca cattttgtat acagaccacc ataatttgta ttatgtctcc tgattcaatg
     2941 aaggtttcct gtaaatttat taaaataaga gaaaatac
//
