LOCUS       NM_207610               6084 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ubiquitination factor E4A (Ube4a), mRNA.
ACCESSION   NM_207610 XM_039081428 XM_236195
VERSION     NM_207610.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6084)
  AUTHORS   Contino,G., Amati,F., Pucci,S., Pontieri,E., Pichiorri,F.,
            Novelli,A., Botta,A., Mango,R., Nardone,A.M., Sangiuolo,F.C.,
            Citro,G., Spagnoli,L.G. and Novelli,G.
  TITLE     Expression analysis of the gene encoding for the U-box-type
            ubiquitin ligase UBE4A in human tissues
  JOURNAL   Gene 328, 69-74 (2004)
   PUBMED   15019985
REFERENCE   2  (bases 1 to 6084)
  AUTHORS   Hatakeyama,S., Yada,M., Matsumoto,M., Ishida,N. and Nakayama,K.I.
  TITLE     U box proteins as a new family of ubiquitin-protein ligases
  JOURNAL   J Biol Chem 276 (35), 33111-33120 (2001)
   PUBMED   11435423
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000198.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_207610.3.
            
            On or before Mar 10, 2021 this sequence version replaced
            XM_039081428.1, NM_207610.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC061761.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMD00132261,
                                    SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                JACYVU010000198.1  7091288-7091373     c
            87-183              JACYVU010000198.1  7088926-7089022     c
            184-345             JACYVU010000198.1  7084438-7084599     c
            346-519             JACYVU010000198.1  7077667-7077840     c
            520-632             JACYVU010000198.1  7076696-7076808     c
            633-785             JACYVU010000198.1  7075537-7075689     c
            786-945             JACYVU010000198.1  7074593-7074752     c
            946-1148            JACYVU010000198.1  7073867-7074069     c
            1149-1340           JACYVU010000198.1  7073210-7073401     c
            1341-1674           JACYVU010000198.1  7071116-7071449     c
            1675-1795           JACYVU010000198.1  7069733-7069853     c
            1796-2100           JACYVU010000198.1  7067350-7067654     c
            2101-2233           JACYVU010000198.1  7065997-7066129     c
            2234-2421           JACYVU010000198.1  7064801-7064988     c
            2422-2522           JACYVU010000198.1  7062026-7062126     c
            2523-2636           JACYVU010000198.1  7061810-7061923     c
            2637-2811           JACYVU010000198.1  7059368-7059542     c
            2812-2992           JACYVU010000198.1  7058126-7058306     c
            2993-3140           JACYVU010000198.1  7057086-7057233     c
            3141-3298           JACYVU010000198.1  7055434-7055591     c
            3299-6084           JACYVU010000198.1  7049335-7052120     c
FEATURES             Location/Qualifiers
     source          1..6084
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..6084
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /note="ubiquitination factor E4A"
                     /db_xref="GeneID:315608"
                     /db_xref="RGD:1303173"
     exon            1..86
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            87..183
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            184..345
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..3425
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /EC_number="2.3.2.27"
                     /note="ubiquitination factor E4A, UFD2 homolog;
                     ubiquitination factor E4A (UFD2 homolog, yeast); RING-type
                     E3 ubiquitin transferase E4 A"
                     /codon_start=1
                     /product="ubiquitin conjugation factor E4 A"
                     /protein_id="NP_997493.2"
                     /db_xref="GeneID:315608"
                     /db_xref="RGD:1303173"
                     /translation="MTDQENNNNISSNPFAALFGSLADAKQFAAIHKEQLKQQSDELP
                     ASPDDSDNSVSESLDEFDYSVSEISRSFRTHQEMCEQLNINHMIQRIFLITLDNSDPN
                     LKSGNGIPSRCVYLEEMAVELEDQDWLDMSNVEQAIFARLLLQDPGNHLISMTSSATL
                     NLSADRDAGERHIFCYLYSCFQRAKEEITKVPENLLPFAVQCRNLTVSNTRTVLLTPE
                     IYVDQNIHEQLVDLMLEAIQGAHFEDVTEFLEEVIEALLLDEEVRTFPEVMIPVFDIL
                     LGRIKDLELCQILLYAYLDILLYFTRQKDMAKVFLEYIQPKDPSNGQMYQKTLLGVIL
                     NISCLLKTPGVVENHGFFLNPSRSSPQEIKVQEANIHQFMAQFHEKIYQMLKNLLQLS
                     PETKHGILFWLGNCLHANAGRTKIWANQMPEIFFQMYASDAFFLNLGAALLKLCQPFC
                     KPRSSRLLTFNPTYCVLKDLNDEERKIKSVHMRGLDKETCLIPAVQEPVFPQSYNLVT
                     ENLALTEYTLYLGFHRLHDQMVKINQNLHRLQVAWRDAQQSSSPAADNLREQFERLMT
                     IYLSTKTAMTEPQMLQNCLNLQVSMAVLLVQLAIGNEGSQPIELSFPLPDGYSSLAYV
                     PEFFADNLGDFLIFLRRFAEDILETSADSLEHVLHFITIFTGSIERMKNPHLRAKLAE
                     VLEAVMPHLDQTPSPLVSSVFHRKRVFCNFPYAPQLSEALIKVFVDIEFTGDPHQFEQ
                     KFNYRRPMYPILRYMWGTDSYRESIKDLADYASKNLEAMNPPLFLRFLNLLMNDAIFL
                     LDEAIQYLSKIKIQQIEKDRGEWESLTPEARREKEAGLQMFGQLARFHNIMSNETIGT
                     LSFLTSEIKSLFVHPFLAERIISMLNYFLQHLVGPKMGALKVKDFSEFDFKPQQLVSD
                     ICTIYLNLGDEENFCATVPKDGRSYSPTLFAQTVRVLKKINKPGNMIVAFSNLAERIK
                     SLADLQQQEEETYADACDEFLDPIMSTLMSDPVVLPSSRVTVDRSTIARHLLSDQTDP
                     FNRSPLTMDQIRPNTELKEKIQRWLAERKQQKEQLE"
     exon            346..519
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            520..632
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            633..785
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            786..945
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1148
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1340
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1674
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1795
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..2100
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2233
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2421
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2522
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2636
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2811
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2992
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3140
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3298
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..6084
                     /gene="Ube4a"
                     /gene_synonym="Ab2-232"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctccggt tgccttgttg agtcggaagt gagaaccttt tggtcgctgt agctctgagg
       61 tgtcgttcct gccctttcag gctctggtac ttttattttc atgtgtaagc tcaatgacta
      121 agtctaacct gggatctcca ccgaggttct caacaggtga ccgatcaacc ctcctttttt
      181 cctctgctcc ccctagggct ggatggagga caccttaaag tgaaatgaca gaccaggaga
      241 ataacaacaa catctcaagt aacccctttg ctgctctttt tggctccctg gctgatgcca
      301 agcagtttgc agcaatccac aaagagcagc tgaaacagca gtctgatgag ctcccagcaa
      361 gcccagatga ctcagataat agtgtgtcgg agagcctgga tgagtttgac tactcagtgt
      421 ctgagatcag ccgctctttc cggacacatc aagaaatgtg tgaacaactc aacatcaatc
      481 acatgatcca aaggatcttc ctcattactc tggacaacag tgatccaaac ttgaaaagtg
      541 ggaacggcat ccccagtcgg tgcgtgtact tggaagaaat ggcagtggag ctggaagatc
      601 aagactggct ggatatgagc aacgtggagc aggccatctt tgctcggtta ctgcttcaag
      661 atccaggaaa ccacttgatc agcatgactt cctctgcaac tttaaacctc tctgctgatc
      721 gcgatgcagg agagcggcac atcttctgtt acctttactc ctgcttccaa agagccaagg
      781 aagagattac caaagttcca gaaaacctac tcccctttgc agtgcagtgc agaaacctca
      841 ctgtgtccaa cacgcgaaca gttctcctca ccccagagat ctatgttgac caaaacatcc
      901 atgagcaact ggtagacttg atgttggaag ctattcaggg agcccatttt gaagatgtga
      961 ctgagttttt agaagaggtc attgaagcct tgctattgga tgaggaggtt cgaacatttc
     1021 ctgaagtcat gattccagtg tttgatattt tacttggccg aataaaagat ctggaactct
     1081 gccagatcct cctgtacgca tacctggaca tccttctcta tttcaccagg cagaaggata
     1141 tggccaaggt ttttttagag tacattcagc ccaaggaccc tagcaatggg cagatgtatc
     1201 agaagacctt gctgggagtc attctgaata tctcgtgctt gttaaagact ccgggtgtgg
     1261 tagagaatca tggcttcttc ctgaatccat cccgttccag tcctcaggag atcaaagtac
     1321 aggaggccaa catccatcag ttcatggctc agttccatga aaagatctac cagatgctga
     1381 agaatctgct ccagctctct ccagaaacca agcatggtat cttgttctgg cttggaaact
     1441 gtttgcatgc aaatgcaggc cgcaccaaga tctgggccaa tcagatgccc gaaatcttct
     1501 tccaaatgta tgcctcggat gccttctttc tgaatctggg tgctgctctc ctgaagctgt
     1561 gccagccatt ctgcaaaccc agatcctctc ggctcctcac ctttaacccc acatactgtg
     1621 tcctcaagga cttgaatgat gaagaacgaa aaattaaaag tgtacatatg agaggtttag
     1681 acaaggagac ctgtctgatc ccagctgtgc aggagccagt gttcccccag agctacaatc
     1741 tggtgaccga gaacctggcc ctgaccgagt ataccttgta cttaggattt cacaggttgc
     1801 atgatcagat ggtaaaaatc aaccaaaatc tgcatcggct gcaggttgcc tggcgagatg
     1861 ctcagcagag ttctagccct gctgctgaca atctccgtga gcagttcgag cgcctgatga
     1921 ccatctatct ctctaccaag actgcaatga ctgaacccca gatgctgcag aactgcctga
     1981 atttgcaggt gtccatggct gttctgctgg ttcaactggc cataggcaat gagggctctc
     2041 agccaataga gctaagtttt cccctgccag atggctacag ctctttggct tatgtgccag
     2101 aattttttgc agataaccta ggtgatttcc tcatttttct ccggcgcttt gctgaggaca
     2161 ttttggagac gtcagcagat tccctggagc atgtccttca ttttatcacc attttcactg
     2221 gaagcataga aagaatgaag aatccccacc tgagggccaa actagcagag gtgttagaag
     2281 cagtgatgcc tcacctggac cagaccccaa gccccttggt gtccagtgtg ttccaccgaa
     2341 aacgtgtgtt ctgcaacttt ccatacgctc cccaactttc tgaagccttg atcaaggttt
     2401 ttgtggacat cgaatttaca ggggaccccc accaatttga acagaagttt aattaccgcc
     2461 gccctatgta tcccatccta agatacatgt gggggacaga tagctatcgg gagagcatta
     2521 aggatttggc tgactatgcc tctaagaatt tagaagctat gaatccccca ctgttcctcc
     2581 gatttcttaa cctattaatg aatgatgcta tcttcctttt ggatgaagcc atacagtatt
     2641 tgagcaagat aaagattcag cagattgaga aagaccgagg agaatgggag agcctgacgc
     2701 cagaagcccg ccgagagaaa gaggcaggtc tgcagatgtt tgggcagctg gcacgtttcc
     2761 ataacatcat gtccaatgaa acaattggga ccctttcctt cctgacatca gagatcaagt
     2821 cactgttcgt gcacccgttc ctggccgagc gcatcatctc catgctcaac tacttcctgc
     2881 agcacctggt tggccccaag atgggtgctc tcaaagtcaa ggacttcagc gaatttgatt
     2941 tcaaacctca gcagcttgta tcagacatct gcactatcta cttaaatctt ggagatgagg
     3001 agaatttctg tgccactgtg cccaaggacg gacgttccta ttcccctact ctctttgcac
     3061 agacagtccg agtcctgaag aaaatcaata agcccgggaa tatgatcgtg gctttcagta
     3121 acttggcaga gagaatcaag tctcttgcag acctccaaca acaagaggag gagacatatg
     3181 cagatgcctg cgatgagttc ctggacccca tcatgagcac actgatgtct gaccctgtgg
     3241 tgcttccgtc ttccagagtc actgtggaca gatccaccat cgccaggcat ttactcagtg
     3301 accaaacaga tccttttaat cgtagtcccc ttaccatgga ccagatccgg ccaaacacag
     3361 aactgaaaga aaaaattcaa cggtggcttg cagagaggaa gcaacaaaag gagcagcttg
     3421 aataaatact gtgaactctg ccccgggagc gtggccgggc gtagaccgtt gcttgtgctt
     3481 tctctctttc tgcctctgat cctctccctt ttctttgttc ggttttgttg ggtttttttt
     3541 gggggggggg ggcggtattt cattctttgt tgtttaaatt agaaaattgt tcttgtgcaa
     3601 attatgataa ttacgatttt taagaccttg ttgtttccct ggctcacagg aaattctcct
     3661 cacagcatct ttataaatca tcactaattt tcagcctccg ttttcctaca cttcttactt
     3721 ccttttctac cctaaattat attaagtcca acagcaaaaa tgtcctgcca ttttattctt
     3781 tcccttccta aggacggttc agacattttt ttagtgagca ctgcttttaa gtctatgatg
     3841 tcagtccttc agtgccagct gatggcatcc aagcccctac tgtcctgggt atttactacc
     3901 catagggtct gggctcaagc acctggcctt actatagctc tgtaatactg cagagttgct
     3961 ttccagataa atgcaaatac cttagtgtgt gtatagattt tctggctgat ggatgaggta
     4021 atcttatacg tttgtattat cttgtcactt aatgatacca tcacagacat tcaagtagct
     4081 gtatgatctt tcagtgagtg acagtgatat gtggaacttc cagtaagagg ataaataagc
     4141 cgtggggccc ttttctcttt tgtgctccaa ggactaggcc tgggtaaaat aggcaataaa
     4201 tattgtatct atatgaaaat gtcattttag gacacttaat gcagtatatg tatgtgttaa
     4261 acacacagat actgtgtcct tttttttatt ggtctcattt aattgagtgc cacattatat
     4321 catgtcttcc cgagtaagat ttatatagtg tgtggcagtg ttttctcact tacttgttct
     4381 agtcaggtaa aacccgaaga ctatacgatg tatatagcta gtgtttgggc tgtgacctgg
     4441 cttctaagag ctgcttctca cctagcctta gtttatcaat taatagagat tgaagcaaaa
     4501 tcttgccccc aagccgtttt aaaaatctac ttatctctgg gtagttaaaa gtggttctgc
     4561 cccacttctc caactgtttt gctataaggg gctcagtcct ttgtgggatg tttttatatc
     4621 agtatcaatc tcagcccaga ggtgtaaagg acaagaaaat gtggctgtga cttcttttac
     4681 agaacattac tgttccaaaa gaacatacaa aagcagtgtt tcagttccaa cacagttgca
     4741 ataagcagtc ctttgtgtgt ttttttcttg ttatcaactg gaaaacttgt gattagagag
     4801 agcacctcac tctggctatt aaagaatgtt acctgttgta aacagggatg cctcaggcat
     4861 atctgtaaat gccaaaaggt taaggctgat tcagtgtgcc cctgggcctt taggtatata
     4921 ttgacaggat ttcttttctt caggtgaact tcatttcctg tctgtagtat tctcctttcc
     4981 ctctctggca atgaactgca tatgaaataa gcttctaccc gctgctctta acttttccaa
     5041 agctaatgtg ggaggatgct tttacactct tatttgaaaa tgagggaaag cccagtttta
     5101 caagtgaaaa ctggaggaaa ataggtacag accctccaga agacagctgt tcccagcagc
     5161 tttctggcgg atgagctctg agctgtctct tgtctctgtc tgtattctga actgaactga
     5221 accttcagac tgtaagcctc tttggcaagt ttgtgttttg ttttgttttt taagctcttc
     5281 tgatactttt ctatgaatgg ctgtgacacc actgaggctg ctgaatacct ttaatgacaa
     5341 aagcaagtgt gtagcttaag gccactgttg gtgaggaaac caagtgtcct ctgtgccttc
     5401 tttctgtgaa ctaatttaaa gaaatccaga aaaagaaact ctaaggactc ccaacctggt
     5461 acagtaagac acatatgtgc atttgcaaag gtcaaagggt gtcttgtctg gaactcggcc
     5521 gcagctgtaa atctgttaag acttcctgac atgccaagtt ttacgtgatg actttgctgg
     5581 aggacaaaag gaaagtgaag acttcagtca gctcataact caccaagagg ctaatactaa
     5641 acttggaaaa tcatttagag ttcaagcagt tgtttgttta atatagcttt ctgtgggtgt
     5701 gtgaaaatgg agggccgctt gagaagtagc ctaacagaac aggcgaaggt gccagttgct
     5761 gctcagcact ccactctaca aaagcttcat tactttattt ggttctggtt gctaagcagc
     5821 cattgggcaa agcccactgg gtaccatgac aagccagact gatgccacat cattggcatg
     5881 tgaggaaata gtgcacatgt tctaactgct aaatggggaa gaacctagag cagaaaagga
     5941 agaacaaaac agcaaaaagg ttggactgaa atcaactcga tcgacaactg tatttgaaac
     6001 attccaggaa ggttactttt tgtcagactt gcctgggggg agtttgctca aaacttgtat
     6061 ttaataaatg agcagctgac ttac
//
