LOCUS       NM_001191837           10041 bp    mRNA    linear   ROD 31-JUL-2023
DEFINITION  Rattus norvegicus ubiquitin protein ligase E3A (Ube3a), mRNA.
ACCESSION   NM_001191837 XM_039082246 XM_341867
VERSION     NM_001191837.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10041)
  AUTHORS   Ma N, Zhou J, Zhou Z, Wan B and Lu W.
  TITLE     Effects of UBE3A on the insulin resistance in polycystic ovary
            syndrome through the ubiquitination of AMPK
  JOURNAL   BMC Endocr Disord 23 (1), 152 (2023)
   PUBMED   37461021
  REMARK    GeneRIF: Effects of UBE3A on the insulin resistance in polycystic
            ovary syndrome through the ubiquitination of AMPK.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10041)
  AUTHORS   Berg EL, Jami SA, Petkova SP, Berz A, Fenton TA, Lerch JP, Segal
            DJ, Gray JA, Ellegood J, Wohr M and Silverman JL.
  TITLE     Excessive Laughter-like Vocalizations, Microcephaly, and
            Translational Outcomes in the Ube3a Deletion Rat Model of Angelman
            Syndrome
  JOURNAL   J Neurosci 41 (42), 8801-8814 (2021)
   PUBMED   34475199
  REMARK    GeneRIF: Excessive Laughter-like Vocalizations, Microcephaly, and
            Translational Outcomes in the Ube3a Deletion Rat Model of Angelman
            Syndrome.
REFERENCE   3  (bases 1 to 10041)
  AUTHORS   Dodge A, Peters MM, Greene HE, Dietrick C, Botelho R, Chung D,
            Willman J, Nenninger AW, Ciarlone S, Kamath SG, Houdek P, Sumova A,
            Anderson AE, Dindot SV, Berg EL, O'Geen H, Segal DJ, Silverman JL,
            Weeber EJ and Nash KR.
  TITLE     Generation of a Novel Rat Model of Angelman Syndrome with a
            Complete Ube3a Gene Deletion
  JOURNAL   Autism Res 13 (3), 397-409 (2020)
   PUBMED   31961493
  REMARK    GeneRIF: Generation of a Novel Rat Model of Angelman Syndrome with
            a Complete Ube3a Gene Deletion.
REFERENCE   4  (bases 1 to 10041)
  AUTHORS   Berg EL, Pride MC, Petkova SP, Lee RD, Copping NA, Shen Y, Adhikari
            A, Fenton TA, Pedersen LR, Noakes LS, Nieman BJ, Lerch JP, Harris
            S, Born HA, Peters MM, Deng P, Cameron DL, Fink KD, Beitnere U,
            O'Geen H, Anderson AE, Dindot SV, Nash KR, Weeber EJ, Wohr M,
            Ellegood J, Segal DJ and Silverman JL.
  TITLE     Translational outcomes in a full gene deletion of ubiquitin protein
            ligase E3A rat model of Angelman syndrome
  JOURNAL   Transl Psychiatry 10 (1), 39 (2020)
   PUBMED   32066685
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10041)
  AUTHORS   Lopez SJ, Laufer BI, Beitnere U, Berg EL, Silverman JL, O'Geen H,
            Segal DJ and LaSalle JM.
  TITLE     Imprinting effects of UBE3A loss on synaptic gene networks and Wnt
            signaling pathways
  JOURNAL   Hum Mol Genet 28 (22), 3842-3852 (2019)
   PUBMED   31625566
  REMARK    GeneRIF: Results provide a holistic examination of the molecular
            impacts of UBE3A loss in brain, supporting the existence of
            interactive epigenetic networks between maternal and paternal
            transcripts at the Ube3a locus.
REFERENCE   6  (bases 1 to 10041)
  AUTHORS   Smith CL, DeVera DG, Lamb DJ, Nawaz Z, Jiang YH, Beaudet AL and
            O'Malley BW.
  TITLE     Genetic ablation of the steroid receptor coactivator-ubiquitin
            ligase, E6-AP, results in tissue-selective steroid hormone
            resistance and defects in reproduction
  JOURNAL   Mol Cell Biol 22 (2), 525-535 (2002)
   PUBMED   11756548
REFERENCE   7  (bases 1 to 10041)
  AUTHORS   Huang L, Kinnucan E, Wang G, Beaudenon S, Howley PM, Huibregtse JM
            and Pavletich NP.
  TITLE     Structure of an E6AP-UbcH7 complex: insights into ubiquitination by
            the E2-E3 enzyme cascade
  JOURNAL   Science 286 (5443), 1321-1326 (1999)
   PUBMED   10558980
REFERENCE   8  (bases 1 to 10041)
  AUTHORS   Hatakeyama S, Jensen JP and Weissman AM.
  TITLE     Subcellular localization and ubiquitin-conjugating enzyme (E2)
            interactions of mammalian HECT family ubiquitin protein ligases
  JOURNAL   J Biol Chem 272 (24), 15085-15092 (1997)
   PUBMED   9182527
REFERENCE   9  (bases 1 to 10041)
  AUTHORS   Kishino T, Lalande M and Wagstaff J.
  TITLE     UBE3A/E6-AP mutations cause Angelman syndrome
  JOURNAL   Nat Genet 15 (1), 70-73 (1997)
   PUBMED   8988171
  REMARK    Erratum:[Nat Genet 1997 Apr;15(4):411]
REFERENCE   10 (bases 1 to 10041)
  AUTHORS   Huibregtse JM, Scheffner M, Beaudenon S and Howley PM.
  TITLE     A family of proteins structurally and functionally related to the
            E6-AP ubiquitin-protein ligase
  JOURNAL   Proc Natl Acad Sci U S A 92 (7), 2563-2567 (1995)
   PUBMED   7708685
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1995 May 23;92(11):5249. PMID:
            7761480]
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JACYVU010000033.1.
            
            [WARNING] On Mar 31, 2024 this sequence was replaced by
            NM_001191837.5.
            
            On or before Jun 1, 2021 this sequence version replaced
            XM_039082246.1, NM_001191837.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               JACYVU010000033.1  33947434-33947939
            507-570             JACYVU010000033.1  33960884-33960947
            571-690             JACYVU010000033.1  33963135-33963254
            691-735             JACYVU010000033.1  33966836-33966880
            736-1019            JACYVU010000033.1  34000084-34000367
            1020-2266           JACYVU010000033.1  34003997-34005243
            2267-2411           JACYVU010000033.1  34012723-34012867
            2412-2617           JACYVU010000033.1  34014310-34014515
            2618-2782           JACYVU010000033.1  34015124-34015288
            2783-2938           JACYVU010000033.1  34016517-34016672
            2939-3012           JACYVU010000033.1  34016772-34016845
            3013-3156           JACYVU010000033.1  34030350-34030493
            3157-10041          JACYVU010000033.1  34031504-34038388
FEATURES             Location/Qualifiers
     source          1..10041
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..10041
                     /gene="Ube3a"
                     /note="ubiquitin protein ligase E3A"
                     /db_xref="GeneID:361585"
                     /db_xref="RGD:1306361"
     exon            1..506
                     /gene="Ube3a"
                     /inference="alignment:Splign:2.1.0"
     exon            507..570
                     /gene="Ube3a"
                     /inference="alignment:Splign:2.1.0"
     exon            571..690
                     /gene="Ube3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             671..3277
                     /gene="Ube3a"
                     /EC_number="6.3.2.19"
                     /codon_start=1
                     /product="ubiquitin-protein ligase E3A"
                     /protein_id="NP_001178766.1"
                     /db_xref="GeneID:361585"
                     /db_xref="RGD:1306361"
                     /translation="MATACKRSSGESQSEDIEASRMKRAAAKHLIERYYHQLTEGCGN
                     EACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAS
                     NNSEIKMNKKEEFKEVDYLTEEKVYEIYEFCREREDYSPLIRVIGRIFSSAEALVQSF
                     RKVKQHTKEELKSLQEKDEDKDEDEKEKAACSAAAMEEDSEASSSRMGDSSQGDNNVQ
                     KLGPDDVTVDIDAIRRVYSSLLSDEKIETAFLNALVYLSPNVECDLTYHNVYTRDPNY
                     LNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYSADQIRRMME
                     TFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGDVDTNHNEEDDEE
                     PIPESSELTLQELLGEERRNKKGPRVDPLETEIGVKTLDCRKPLISFEEFINEPLNDV
                     LEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQ
                     GQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKE
                     FFQLVVEEIFNPDIGMFTYDEATRLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDV
                     HFPMVVYRKLMGKKGTFCDLGDSHPILYQSLKDLLEYEGNVEDDMMITFQISQTDLFG
                     NPMMYDLKENGDKIPITNENRKEFVSLYSDYILNKSVEKQFKAFRRGFHMVTNESPLK
                     YLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLF
                     LQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLL
                     KAITYAKGFGML"
     exon            691..735
                     /gene="Ube3a"
                     /inference="alignment:Splign:2.1.0"
     exon            736..1019
                     /gene="Ube3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..2266
                     /gene="Ube3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2411
                     /gene="Ube3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2617
                     /gene="Ube3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2782
                     /gene="Ube3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2938
                     /gene="Ube3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3012
                     /gene="Ube3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3156
                     /gene="Ube3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..10041
                     /gene="Ube3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgggatac tcggtccgcc cacctagtct tctcgtcctc gttcgcgaga tccgtgtttc
       61 tcccaagatg gtggcgctcc tctttgggtg actacaggag acgacagggc ctttcgtctt
      121 cgcaagtacc tcgccgcccc tcctgcgttc gctcgcgcac cgggccacgc agctgttcac
      181 cgcctcatca cgactctcct cgttcgacca gtcgcggacg gtggcgcctc cttctgcttc
      241 tcttcggagt tgctcgccac cctcgccccc caccgtggac agatcgcggc agcagccgtt
      301 cagcgccgac ttcaaggttg cccaggcgcc cggcctcccg gcctcagttt cctgaggaga
      361 agcgcgggtc ccgcatgaga cccggcggtg gcgccagcga aagggaacga ggcggtggcg
      421 ggcggcggcg gtggacgagg gcgacaagga ccagtgaggc ggccgcagct gcgagggccg
      481 cagcccacgc gcgggggcga ggacaggtta aaaatctgta agagcctgat tttagagttc
      541 accagctcct cagaagtttg gcgaaatatg aattattaag cctacgttca gatcaagtta
      601 gcagctagac tggtgtgaca acctgttttt aatcagtgac tcaaagctgt tatcaccctg
      661 atgtcaccga atggccacag cttgtaaaag atcatcagga gaatcccagt ctgaggacat
      721 tgaagctagc cgaatgaagc gagcagctgc aaagcatcta atagagcgct actaccatca
      781 gttaactgag ggctgtggaa atgaggcctg cacgaatgag ttctgtgctt cctgtccaac
      841 ttttcttcgt atggataaca atgcagcagc tattaaagct cttgagcttt ataaaattaa
      901 tgcaaaactc tgtgatcctc atccctccaa gaaaggagca agctcagctt accttgagaa
      961 ctcaaaaggt gcatctaaca actcagagat aaaaatgaac aagaaggaag agtttaaaga
     1021 ggtggactac ctaactgaag agaaagtata tgaaatttat gaattttgta gggagagaga
     1081 ggattactcc cctttaattc gtgtaattgg aagaatattt tctagtgctg aggcactggt
     1141 tcagagcttt cggaaagtca aacagcacac taaggaggaa ttgaaatctc ttcaagagaa
     1201 ggatgaagac aaggatgaag atgaaaagga aaaagctgcg tgttctgctg ctgctatgga
     1261 agaagactca gaagcatctt cttcaaggat gggtgatagc tcacagggag acaacaatgt
     1321 acaaaaatta ggtcctgatg atgtgactgt ggatattgat gctataagaa gggtctacag
     1381 cagtttgctc tctgatgaaa aaatagaaac tgccttcctg aatgcacttg tatatctgtc
     1441 acctaacgtg gaatgtgatt tgacatatca taatgtgtac actcgagacc ctaattatct
     1501 caatttgttc attattgtaa tggaaaatag gaatctccac agtcctgaat atctggaaat
     1561 ggcattgccg ttattttgca aagctatgag taagctaccc cttgcagctc aaggaaaact
     1621 gattaggctg tggtctaaat acagtgctga ccagattcgg agaatgatgg aaacatttca
     1681 gcaacttatt acctacaaag tcataagcaa tgaatttaat agccgaaatc tagtgaatga
     1741 tgatgatgcc attgttgctg cttcaaagtg tttgaaaatg gtttactatg caaatgtagt
     1801 gggaggggac gtggacacaa atcataatga ggaagatgat gaagagccta tacctgagtc
     1861 cagtgaattg acacttcagg agcttctggg agaggaaaga agaaataaga aaggtcctcg
     1921 agtggatcca ctagaaaccg aaattggcgt taaaactcta gattgtcgaa aaccacttat
     1981 ctcctttgaa gaattcatta atgaaccact gaatgatgtt ctagaaatgg acaaagatta
     2041 tacttttttc aaagttgaaa cagagaacaa attctctttt atgacatgtc cctttatatt
     2101 gaatgctgtc acaaagaatc tgggattgta ttatgacaat agaattcgca tgtacagtga
     2161 aagaagaatc actgttcttt acagcctagt tcaaggacag cagttgaatc catatttgag
     2221 acttaaagtc agacgtgacc atattataga tgatgcactt gtccggctag agatgatcgc
     2281 tatggaaaat cctgcagact tgaagaaaca gttgtatgtg gaatttgaag gagaacaagg
     2341 agtagatgag ggaggcgttt ccaaagagtt ttttcagttg gttgtggagg aaatctttaa
     2401 tccagatatt ggtatgttca catacgatga agctacaaga ttattttggt ttaatccatc
     2461 ttcttttgaa actgagggtc aatttactct gattggcata gtcctgggtc tggctattta
     2521 caataactgt atactggatg tccattttcc catggttgtg tacaggaagc taatggggaa
     2581 aaaaggaacg ttttgtgact tgggagactc tcacccaatc ttatatcaga gtttaaagga
     2641 tttattggaa tatgaaggga atgtggaaga tgatatgatg atcactttcc agatatcaca
     2701 gacagatctt tttggtaacc caatgatgta tgatctaaaa gaaaatggtg ataaaattcc
     2761 aattacaaat gaaaacagga aggaatttgt cagtctctat tcagactaca ttctcaataa
     2821 atctgtagaa aaacaattca aggcatttcg cagaggtttt catatggtga ctaatgaatc
     2881 acccttaaaa tacttattca gaccagaaga aattgaatta cttatatgtg gaagccggaa
     2941 tctcgatttc caggcactag aagaaactac agagtatgat ggtggctata cgagagaatc
     3001 tgttgtgatt agggagttct gggaaattgt tcattcgttt acagatgaac agaaaagact
     3061 tttcctgcag tttacaacag gcacagacag agcacctgtt ggaggactcg gaaaattgaa
     3121 gatgattata gccaaaaatg gcccagacac agaaaggtta cctacatctc atacttgctt
     3181 taatgtcctt ttacttccgg aatattcaag caaagaaaaa cttaaagaga gattgctgaa
     3241 ggccatcaca tatgccaaag gatttggcat gctgtaaaca aaacaaaaac aaaaagaaaa
     3301 aaagaaaaaa gtcaaaaaac ttaataaata taagagggat aatttgatgg taatagtgtc
     3361 ccagttcaaa aaggctgtaa gatagtgaac cacagtactc atctatgtct gtgcctccct
     3421 tcttcattgg ggacattgtg ggctggaaca gcagatttca gctgcatata tgaacaaatc
     3481 ctttattatt attataatta tttttttgcg tgaaagtgtt acatattctt tcacttgtat
     3541 gtacagagag gtttttctga atatttattt taagggttaa atcacttttg cttgtgttta
     3601 ttactgcttg aggttgagcc tttttgagta tttaaaatat atataccaac gaaactattc
     3661 tcgcaaggaa aacattgcca ccatttgtag accatgtaat cttcaagtat gtgggttttt
     3721 tttttgtttg tttgtttgtt tttttttttt tttttttttt tttttttttt tttttttttt
     3781 ttttgtccct gtatctaagt caaatcagga actttttttt aaccatttgc ttttgaaact
     3841 tgaagttaag gaaacagtgt ggtgcaagta ctgctgttct agcccccaag gagttttctg
     3901 tacaaaattt tgagaatcaa taaagatgga agggagaatt tggaatgttt gaaccacagc
     3961 cctcagaact ttagtaacag cacaacaaat taaaacaact catgccacag tacgttgtct
     4021 tcatgtgtct tgcaatgaac tgtttcagta gccaatcctt ttagtatatg aaaggacagg
     4081 gatctttttt attgttgttg ttgttgttgt tgttgttgtt gttgtttttg ttgtttaagt
     4141 ttactgggga aagtgcatct ggccaaatga taggatagtc aagcctattg caacaaaatt
     4201 agaaagtttg ttgtataaat aagcatgtaa aagtgcactt aaaatgaatc tttattattc
     4261 ccgagatttt aaatagacaa tccaaagtct ccccttctct tgccatcatc ttgtttaatc
     4321 aactattttt caaggcactc gatcagtgtt gcagcataat agaaagtcca gctactgtgc
     4381 cttgtgttat ttatttacac agtaaacagg cctggaaatg aatggaacta gtactcctga
     4441 gaattaaatt gtatatcctc caaattaaaa tttacttcaa aagtgttaaa gaattcatgt
     4501 cctatatata aaatacaaat aggcttagat tgctggacat ttaatgtagt ttcccatccc
     4561 tagtctttta tgtttgtgat gttaatttct tttgttgcat aacaaaataa aagaattatg
     4621 tatttttaac taaggagaga catactggta tatcatttta ctacaagcta cagatatcct
     4681 gttgagcttg tgccttgatt gttttcacaa ctagtacaaa tcaacctgat gttttaaatt
     4741 ggcagggaat aattaattgt agctttcaaa tcattggaag gggaaaagga tgtcttttag
     4801 gattattttc cttcttgtag tagttgaggc agagctatta tttactgtaa tgctaaatga
     4861 aacagtggct taaatacttt aatgggaaaa aagaacacag tgcgttccat attgtgataa
     4921 ggtaatgtga ggtttttcct tttttttctg agctagcctt tagaacactg ttgtggtatg
     4981 tatgctacct tgattatagg accccctaaa tgtgactata gtcatcataa tgggcatcta
     5041 gtccactgtg cttcttatgt attatgaaag tgataagaag acaaattaag tgggtatatt
     5101 ttataaaata aattcatgaa gagatttgtg ttcttcagtt ctcaagttta ttatcactac
     5161 agtattgaag tagttgtgat actatatctg tgtgaaagtt ttgaaatggt aatatagatt
     5221 atcaaacaga agtaacatca gtatatttaa aagaaagtga aaacaaataa acctaaaatg
     5281 ttttcagagg taaaaataca ttctcacttg cttcctagtc agtttttctt ggcatgttgc
     5341 cacattatta tggctgcctt ttcatcattg cttttctaga ttgtcatgga acaatatttc
     5401 cgagttaaaa aaatacctct tgctatagta gaacatttca aaattacagc ataaaagcac
     5461 agtctggagc aaaatttttc tggagacttg gcagctgcag caaacaaatt gagtgtctgt
     5521 acatattgtg gtctataagt taattgtgtg atcaaattca tttgtaataa ccttaccttt
     5581 atttggaagt acatccctgt gtaggaacgt atatatcaaa agaaacctat aaatgagggt
     5641 tcagagaacc ggttcatatt gacatgtggc acatgcatca ctgggcagca tcactccctg
     5701 tttccataag gtggctatgc tgaaatcaac ctcttaaaga attattttct caagaatcca
     5761 tataacctag aaaaagaagt gttttactga ggctactctt tctgatgttc atcctttaac
     5821 ttcttatccc aagacttatt tttatccttt ctacccttcc caggcccccc agaattaaat
     5881 aattgatgat gatgatgatg atgatgatga tgatgatgat agtaacttcc attttcttat
     5941 cttttcttct cttactcaat gtcagagtgt aaaacaatcc ctggtgtttg gtggggaaaa
     6001 tatttacaca atacagacaa aggccttttt ttttctcttc ccctttcaaa tcagaaaatt
     6061 gactttaata acagttacaa gaaggtttgg gtgtatgtat gtactgcatt tcactatgta
     6121 aaggctgcta atccagggat atttcactga aaatatactt ggaatgatac taatagtttc
     6181 catttgccag aataaagaac tcttgttttt aacccttgat aggttgaggt aaagcttcct
     6241 gaaaggctca cttttccatc ccaactcata gactccttgt gtggatattc tgctgattat
     6301 acttagaatt aattcctctg aactttctgt tcaacctcag taattcccaa agatttttct
     6361 ctcgtttcat atcttgtggg tctcatatct catatcaaat cagacccgca tttctagtac
     6421 atcatcctgg tacctcaaag taagtatagt acaaaacagt acctataaaa acaaaattct
     6481 taatcttgta tctcctagcc attttttgtt actaccttta aaactgtcaa ttttgaggcc
     6541 tggtgaggtg gcttagtggg taaaggtgat cactatacaa aacttgacct gaatactctg
     6601 ccaagaccct acataaacat agaaggaaag aactccacaa agttgtcctc tgacctttct
     6661 acatgtacca tgtcttttgc tgttccctac cctctcacag tttatgcata tataggttgt
     6721 cagttatttt ctctcaaacc tatttaattt tactttattt cagggccaaa tcctttgatt
     6781 tactcaggtt attttcctaa ctgaactact actactaatt cttttcattt ttgttttctg
     6841 gtatgtatgg gtacttttcc ttcaaataaa ttgtacagat ggatttcagc atactttcct
     6901 agtgcctcct gttcaccagc atccctttac atccctactc aaaattcctt tacttagatt
     6961 ttctttatac aacacacata ttctttcagt tggacttttg aaagtaccat gctcaaaaag
     7021 acttctctcc ttagtgtaat agcagcctgc atatccctag tgaatcacat ttatggaaca
     7081 gttgaggagg ccttcagaag tgtgtgtcct tccttttttt ctgtgtgttt tagctttgat
     7141 attgtcccat tattgttttg cttaaagcat cttcttttat ggaatctgag taaattcata
     7201 gtggaaatta ccttgtactg atccctgtgt ctcttaggta gtaggcagat actcattaat
     7261 caagaaatat acacatgttt cttgaataga ttttctggaa tcacggtatc agctcctgga
     7321 aaaaggagtc agtgagttgg aaaagatgag atcattgaaa gcaagacagt tttttaactc
     7381 tacatcttga cttctggtgt actctggcaa tctagaccac cttccttatg tcactcacac
     7441 tctcttttat cccagcagac acggcaactg ataccttaag tctttctgct gttgctaact
     7501 agcccctcaa attctcatgg aggaatcatc tagactctgt tctctgtaaa tatgtgagtc
     7561 atatttaaca ttttcttgaa cagtaaagta caaagtcctg taaattctga caagaacttt
     7621 cagtgactgc caaatgcttg tgctcatgat ccttcatttt cacaaaatag atgagtcact
     7681 gtgacttgag aggttataaa ccttaccaaa agtcatacag acaagaaaag ggatgacaaa
     7741 tgctaagagg gtgggtccac atgaccatct aaaatttgtc atctttcttt tgcaaaatca
     7801 aagaactaaa ttaaacaaca aattaagatg cttaagctga catgcatgga acctgggatc
     7861 attatcctga ttttcgatta cccaattaca catagaaaaa atgataggga aggtagctgg
     7921 aatacagtac acattggttg aggttgtagc cttcagtcaa atgactctga atcttagtat
     7981 tggccctgca attcccttga cttggattat tcccactcct accttatctc tggttatgtg
     8041 gcttcagtag aattaccttg caggtggtaa ctaacatctt ggaaaacatc ctgagagcag
     8101 ttctcccagc atttgcttgt taacttgaga gagagagaga gagagagaga gagagagaga
     8161 gagagagaga gagagagaga gagagagaga gagaaaatgc ctgtaataaa gacttatttt
     8221 ggaatagttg cccttatatc atccaagtcg aagaattgtg ttttcccaca tctttgagat
     8281 aaaatccaca tagtataaaa tttaccattt taaagtgtaa agtttgtggt tacagtatat
     8341 tcacagattt gtgaaattgt ctttatataa ttccagagca ttttcatcgc tgtaaaaagt
     8401 tttctgtatc catgaagagt gactgcctgt tcttaaccct caacccctgg caactactca
     8461 tcttcgtatg cttatgaatt tgcctatttt ggacatctca tgttaatgga gccatacaat
     8521 atgtggcctt tttgtctgtt ttgccacctt ccccaaagta atgagttcaa actacatctg
     8581 tgttgtagca tgtactggta ctgtttcttt tgtggctgaa tattgtcata ttgatatact
     8641 gtatcttttt ttgcttgttc ttttggttgt ggatacttgt gttctttctg ctttgcatac
     8701 tatgaatact acaactatga acactttgtg tacatgtttt catttctctt atgtcttaag
     8761 catcttatgg ttttagttcg taaatttctg tctttgatcc atttttgcat gtggtgcatt
     8821 gtaggggtcc agtttcattc tttaatatgt ggatatctag tagaacaata cctaattgtt
     8881 aaaaatacta ataataattt ctttataaat gggcttggta tccttgtcag aaacacatat
     8941 aaaagtgact aatataaata tggctagttt tggactcttc aactttattc cattgtcctg
     9001 tgtgtctctc ttcttgtgcc agtaccatac tgtcttaatt actgtagcta tatagtaagc
     9061 tttgaattta ggatatatta ggtctctagc tttgttctac atcaagatca ttttacctat
     9121 tctgagtccc ttgcagtcca cttggatttt aggatttatt taatttctac ataaaaagca
     9181 tctgtgattt tgatagtatt tgtgttgaat caatacatca gattgaagta tggtggtatt
     9241 ttaacagtat taaattttct aatccataaa catggagtgt ctttccattt atttaggttt
     9301 gtaatttcct ttaatgttgt tcttatagat ttcagtgtat acatcttggc ttttttgggt
     9361 taaatgtttt tcacttgatg ctattataaa acaacttttt tttaaaaaaa atatttgttt
     9421 ggattactca ttgtacatct agaaagaatt gatattcgtg tattaacctt acataccata
     9481 gctattctga actgattttg tttttaaaat tttttatata agattgtgca tctgtgaata
     9541 taaatacttt tgtttcctct ccaatctgaa ttatttttat ttgatttccc tgcctaagtg
     9601 ccctggctag cacatccagt atatagaagt aaatagaagt ggcaagagtg tacaactttt
     9661 tcttgtttct gattgtagtg ggaaagcttt aggcctttca ccattaaata tgttgttagc
     9721 tgtgggattt tcatagatac tgcaagttga gaaatattcc atctattcct accttactga
     9781 gtcttttttt ttttttaatc aaaaaagggt attgaatttt gtcaaatgct tctgtatcta
     9841 aaaaggttgt catgtagttt ttgtccttta ttgatatgtt gtattacatt gatggaattt
     9901 ttgtattgaa cgaaccttgc attcctggaa taaccccact tgtctatgct acataaacca
     9961 ttttctatgc tgctggattt ggtttgctag tattttgttt agcatctttg cacctatatt
    10021 cataaaagtt tctggcctgt a
//
