LOCUS       NM_001037643            2874 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus ubiquitin-conjugating enzyme E2Z (Ube2z), mRNA.
ACCESSION   NM_001037643 XM_220902
VERSION     NM_001037643.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2874)
  AUTHORS   Dong,J., Gong,Z., Bi,H., Yang,J., Wang,B., Du,K., Zhang,C. and
            Chen,L.
  TITLE     BMSC-derived exosomal miR-219-5p alleviates ferroptosis in neuronal
            cells caused by spinal cord injury via the UBE2Z/NRF2 pathway
  JOURNAL   Neuroscience 556, 73-85 (2024)
   PUBMED   39084457
  REMARK    GeneRIF: BMSC-derived exosomal miR-219-5p alleviates ferroptosis in
            neuronal cells caused by spinal cord injury via the UBE2Z/NRF2
            pathway.
REFERENCE   2  (bases 1 to 2874)
  AUTHORS   Lee,P.C., Dodart,J.C., Aron,L., Finley,L.W., Bronson,R.T.,
            Haigis,M.C., Yankner,B.A. and Harper,J.W.
  TITLE     Altered social behavior and neuronal development in mice lacking
            the Uba6-Use1 ubiquitin transfer system
  JOURNAL   Mol Cell 50 (2), 172-184 (2013)
   PUBMED   23499007
REFERENCE   3  (bases 1 to 2874)
  AUTHORS   Park,K.M., Kang,E., Jeon,Y.J., Kim,N., Kim,N.S., Yoo,H.S.,
            Yeom,Y.I. and Kim,S.J.
  TITLE     Identification of novel regulators of apoptosis using a
            high-throughput cell-based screen
  JOURNAL   Mol Cells 23 (2), 170-174 (2007)
   PUBMED   17464193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC107663.1 and BQ203723.1.
            
            On Oct 13, 2007 this sequence version replaced NM_001037643.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107663.1, FQ113856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2546              BC107663.1         1-2546
            2547-2874           BQ203723.1         1-328               c
FEATURES             Location/Qualifiers
     source          1..2874
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..2874
                     /gene="Ube2z"
                     /gene_synonym="RGD1308347"
                     /note="ubiquitin-conjugating enzyme E2Z"
                     /db_xref="GeneID:303478"
                     /db_xref="RGD:1308347"
     exon            1..364
                     /gene="Ube2z"
                     /gene_synonym="RGD1308347"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1112
                     /gene="Ube2z"
                     /gene_synonym="RGD1308347"
                     /EC_number="2.3.2.23"
                     /note="use1; ubiquitin-protein ligase Z; ubiquitin carrier
                     protein Z; uba6-specific E2 conjugating enzyme 1; E2
                     ubiquitin-conjugating enzyme Z; ubiquitin-conjugating
                     enzyme E2Z (putative)"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 Z"
                     /protein_id="NP_001032732.2"
                     /db_xref="GeneID:303478"
                     /db_xref="RGD:1308347"
                     /translation="MAESPTEEAATATAGAGAAGPGASGVAGVVGVSGSGGGFGPPFL
                     PDVWAAAAAAGGAGGPGSGLAPLPGLPPSAAAHGAALLSHWDPTLSSDWDGERTAPQC
                     LLRIKRDIMSIYKEPPPGMFVVPDTVDMTKIHALITGPFDTPYEGGFFLFVFRCPPDY
                     PIHPPRVKLMTTGNNTVRFNPNFYRNGKVCLSILGTWTGPAWSPAQSISSVLISIQSL
                     MTENPYHNEPGFEQERHPGDSKNYNECIRHETIRVAVCDMMEGKCPCPEPLRGVMEKS
                     FLEYYDFYEVACKDRLHLQGQTMQDPFGEKRGHFDYQSLLMRLGLIRQKVLERLHNEN
                     AEMDSDSSSSGTETDLHGSLRV"
     exon            365..437
                     /gene="Ube2z"
                     /gene_synonym="RGD1308347"
                     /inference="alignment:Splign:2.1.0"
     exon            438..625
                     /gene="Ube2z"
                     /gene_synonym="RGD1308347"
                     /inference="alignment:Splign:2.1.0"
     exon            626..737
                     /gene="Ube2z"
                     /gene_synonym="RGD1308347"
                     /inference="alignment:Splign:2.1.0"
     exon            738..850
                     /gene="Ube2z"
                     /gene_synonym="RGD1308347"
                     /inference="alignment:Splign:2.1.0"
     exon            851..941
                     /gene="Ube2z"
                     /gene_synonym="RGD1308347"
                     /inference="alignment:Splign:2.1.0"
     exon            942..2857
                     /gene="Ube2z"
                     /gene_synonym="RGD1308347"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggacga gctgctgagc agtcccggaa gcgaagcagc gatggcggag agtccgactg
       61 aggaggcggc tacggcgacg gcgggcgccg gggcagcagg cccaggggcg agcggtgttg
      121 ccggtgtggt cggcgttagc gggagcggcg gcgggttcgg gccgcctttc ctgccggatg
      181 tgtgggcggc ggcggcggcg gcgggcgggg ccgggggacc cgggagcggc ctggctccgc
      241 tgccaggact cccgccctcg gccgctgccc acggggccgc gctgcttagc cattgggacc
      301 ccacgctcag ctcggactgg gacggcgagc gaaccgcgcc tcagtgtcta cttcggatta
      361 agcgggatat catgtccatt tataaggagc ctcctccagg aatgttcgtt gtacctgaca
      421 ccgttgacat gactaagatt catgcattga tcacaggccc atttgacact ccttatgaag
      481 ggggtttctt cctgttcgtc tttcggtgtc cacccgacta tcccatccac ccacctcggg
      541 tcaaactgat gacaacgggc aataacacag tgaggtttaa ccccaacttc taccgcaatg
      601 ggaaagtctg cttgagtatt ctaggtacgt ggactggccc cgcctggagc ccagcccaga
      661 gcatctcttc tgtgcttatc tccatccagt ccctgatgac tgagaatccc taccacaacg
      721 agccaggctt tgaacaggaa agacatccag gagacagcaa aaactataat gaatgtatcc
      781 ggcatgagac catcagagtt gcagtctgtg acatgatgga gggcaagtgc ccctgccctg
      841 aacccctacg gggagtaatg gagaagtcct tcctggagta ttatgacttc tatgaggtgg
      901 cctgcaaaga ccgcctgcat cttcaaggcc agactatgca ggaccctttt ggagaaaagc
      961 ggggccactt tgactaccag tccctcttga tgcgcctcgg actgattcga cagaaagtgc
     1021 tggaaaggct ccataatgag aatgctgaaa tggactctga tagcagctca tctgggacag
     1081 agacagacct gcatgggagc ctaagggtct agaccctgct cccctgcccc tcccccaact
     1141 cgagagtccc agcagagccc ctcccctcac cccagggacg gagaggcact gtgcatctcc
     1201 cttcaaaagt gttggcatcc cgcaagatgg caagaagcaa gcaaactcaa tcccagggtg
     1261 tgggagtggg gctgttccca atctgacctc cttggtgctg gagcacctag ggctgtagtc
     1321 aatcctggat cagggccggc cggggtactt ttggagagta cctggagtga tgacctctgg
     1381 caaagctaaa caaccaacac acctctctgc agggccagct aattagggat aggagaagac
     1441 aggaaacgag aacccaaggg ggagcatgcc caagtggttt atagggatag ctgggagttt
     1501 gggtgggggt gctgtccatg acacttaagc agtctggttg gttatctgtt tgtcttcagt
     1561 cttgaagcag ggcttcccaa caccctcttc ttcccctccc ctattatttc ccatgggcca
     1621 gcataacttt gtttttccta atttatatag tcactgttct agacagacca aagacaagga
     1681 acagtggtgg agtctgggct gctgatcagt aagctttacc tagcacctga gcaccttctc
     1741 cctcacacca tttcctccgc attctaggtt acaggtagaa ggtaagccag ctgggactga
     1801 gcccaggtct ctgtgaagcc tgcatgggtg tcaggaagct gctcactgtg tccccacaat
     1861 cactgatttg aaaggttccc agcacaggca gctgcagcgt gtatgggatt tgagccacta
     1921 cataaaatag tctcttacag atttcctgaa tagtagtcaa tgagggtgtt cttcttgggg
     1981 tggagcatgg gaagactgat gctagtccct attttgttta gcagttatgt ctgtagtccc
     2041 tgtcctccct tctgccctac ccccattccc tggggatttg tgagcatgga cagccaatgg
     2101 cttgagggga ttgtggctgg gactctggag actcctctct ttatcgttcc ctctttgtca
     2161 ctggcgctgt tctttctttg aatttagcta cagtgatctt cagctggttg agtaagaagt
     2221 gttttcagtg gctcggggtc agtttagtac agttcacact ttcaggtttg ctgttctgac
     2281 tcccagtggg tggttagtga tccacgggat gcaggccttc tggtcagtgt ccaaccctga
     2341 ggaatggaga actacctgcc ctgcccgctg ctataaaggt ctctgccttg tggatcatgg
     2401 gactcccttg gagagagagg gagaaaatag ggcacaaaga gggacctctt ggaagggcag
     2461 aaagcagaga actggacagg gacaggtcac ttggggagca gttttgtttt gcctacatgg
     2521 aggctgggtc atatgtggag atttcagaag ggaccctgct tccaatttcc ctcttccatt
     2581 cccagagcta gtccagggct gagaatgcct ttggtctgtg ggtccagtgt tgtctgtcat
     2641 ccattaagtg ttcccacttt caagtgacaa tcttctcctt ggccctgcca tggggcagag
     2701 catgtctggc acagcagcct gacttttatg ccctaatttt aagttgagga aatatatgca
     2761 caggagtcaa agagatgtct ttatatctga ctgtacataa atgaagtttt cttttttttt
     2821 cctttttggt gcaataaagt ttgttttggc agaaggaaaa aaaaaaaaaa aaaa
//
