LOCUS       NM_001401288            1624 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ubiquitin-conjugating enzyme E2W (Ube2w), mRNA.
ACCESSION   NM_001401288 XM_039110904
VERSION     NM_001401288.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1624)
  AUTHORS   Scaglione,K.M., Zavodszky,E., Todi,S.V., Patury,S., Xu,P.,
            Rodriguez-Lebron,E., Fischer,S., Konen,J., Djarmati,A., Peng,J.,
            Gestwicki,J.E. and Paulson,H.L.
  TITLE     Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP
  JOURNAL   Mol Cell 43 (4), 599-612 (2011)
   PUBMED   21855799
REFERENCE   2  (bases 1 to 1624)
  AUTHORS   Zhang,Y., Zhou,X., Zhao,L., Li,C., Zhu,H., Xu,L., Shan,L., Liao,X.,
            Guo,Z. and Huang,P.
  TITLE     UBE2W interacts with FANCL and regulates the monoubiquitination of
            Fanconi anemia protein FANCD2
  JOURNAL   Mol Cells 31 (2), 113-122 (2011)
   PUBMED   21229326
REFERENCE   3  (bases 1 to 1624)
  AUTHORS   David,Y., Ziv,T., Admon,A. and Navon,A.
  TITLE     The E2 ubiquitin-conjugating enzymes direct polyubiquitination to
            preferred lysines
  JOURNAL   J Biol Chem 285 (12), 8595-8604 (2010)
   PUBMED   20061386
REFERENCE   4  (bases 1 to 1624)
  AUTHORS   Alpi,A.F., Pace,P.E., Babu,M.M. and Patel,K.J.
  TITLE     Mechanistic insight into site-restricted monoubiquitination of
            FANCD2 by Ube2t, FANCL, and FANCI
  JOURNAL   Mol Cell 32 (6), 767-777 (2008)
   PUBMED   19111657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Feb 7, 2022 this sequence version replaced XM_039110904.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.15590.1,
                                           SRR22582424.775074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                JAXUCZ010000005.1  7474135-7474189
            56-147              JAXUCZ010000005.1  7499642-7499733
            148-250             JAXUCZ010000005.1  7503722-7503824
            251-406             JAXUCZ010000005.1  7519834-7519989
            407-482             JAXUCZ010000005.1  7522992-7523067
            483-1624            JAXUCZ010000005.1  7530385-7531526
FEATURES             Location/Qualifiers
     source          1..1624
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..1624
                     /gene="Ube2w"
                     /note="ubiquitin-conjugating enzyme E2W"
                     /db_xref="GeneID:100909445"
                     /db_xref="RGD:6503620"
     exon            1..55
                     /gene="Ube2w"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..496
                     /gene="Ube2w"
                     /EC_number="2.3.2.23"
                     /EC_number="2.3.2.25"
                     /note="N-terminus-conjugating E2; ubiquitin-protein ligase
                     W; ubiquitin carrier protein W; E2 ubiquitin-conjugating
                     enzyme W; N-terminal E2 ubiquitin-conjugating enzyme;
                     ubiquitin-conjugating enzyme E2 W-like"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 W"
                     /protein_id="NP_001388217.1"
                     /db_xref="GeneID:100909445"
                     /db_xref="RGD:6503620"
                     /translation="MASMQKRLQKELLALQNDPPPGMTLNEKSVQNSITQWIVDMEGA
                     PGTLYEGEKFQLLFKFSSRYPFDSPQVMFTGENIPVHPHVYSNGHICLSILTEDWSPA
                     LSVQSVCLSIISMLSSCKEKRRPPDNSFYVRTCNKNPKKTKWWYHDDTC"
     exon            56..147
                     /gene="Ube2w"
                     /inference="alignment:Splign:2.1.0"
     exon            148..250
                     /gene="Ube2w"
                     /inference="alignment:Splign:2.1.0"
     exon            251..406
                     /gene="Ube2w"
                     /inference="alignment:Splign:2.1.0"
     exon            407..482
                     /gene="Ube2w"
                     /inference="alignment:Splign:2.1.0"
     exon            483..1624
                     /gene="Ube2w"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtctcagg cctcgctggc cttgggggga tggtttcatc atggcgtcaa tgcagaaacg
       61 actacaaaaa gaactgttgg ctttgcagaa tgacccacct cctggaatga ctttaaatga
      121 aaagagcgtt cagaattcaa tcacccagtg gatcgtagac atggaaggtg caccaggaac
      181 cttatatgaa ggggaaaaat ttcaacttct gtttaaattt agtagtcgat acccttttga
      241 ctctcctcag gtcatgttta ctggtgaaaa tattcctgtt catcctcatg tgtatagcaa
      301 tggtcatatc tgtttatcca tcctaacaga agactggtcc ccggcgctct cagtgcaatc
      361 ggtctgtctc agcattatca gcatgctttc cagctgcaaa gaaaagagac gaccaccaga
      421 taattccttt tatgtgcgaa catgtaacaa gaatccaaag aaaacaaaat ggtggtatca
      481 tgatgatact tgttgatgcc actgttctca tcctcgtagc agaagatagt cctactgaga
      541 aaatgagcac tttgatcatt cagtctttga actttaacct ttgactggaa gtgacctata
      601 ggcaatgaag actacttcct tttactgcat ttttactcgt gtgcattctg ggcgcatgtt
      661 gatcgctggt tcagtccagg caactgacat gcttttatta gtcatacagt attaatgcag
      721 gtgtcaggaa atgtcaaata taattccatt ttttttattt ttattttttt aagcttttgg
      781 aaaagttcca ggtcctcatg tgttgtgcaa taacagtgac ttcctcagtg gtttgggggc
      841 gttcattgcc ggcaatggac gttgtgaaag agtgagtttt cttaactcct gccactcggt
      901 gattaatgca tgatagggcc tctgaaatga atttaccggt tattgtggga ttataaggaa
      961 agtgagggat ccaacgttac attgaaagac accccagctg ttgatattgg attctatgca
     1021 ctgtgatcct aaggctaaca gcatgaaaac atgcatcttt aaaggaccgt gagaaagatc
     1081 attgcatatt tatttaattg tttatatctg ctgtcaaatt gttttgacat ggaaagtttt
     1141 cgaggaacat tggcagagag gtacaatatg ttatccctat ggtgaaaata aattcattta
     1201 ttgtatataa tcctcaatct ctgaagtaaa ggtgtgaata atagggtatg aatggtttaa
     1261 ctaaggcttt gttttggaag taaaaaaata gcagtgatga ttaaattact gccatccatc
     1321 atttgggcct gttattattt tccaagtata tgacactctt acttcctgct agccatcagc
     1381 atgagccctg ttacctaaac actattcatc tatttatgtt tggaaaaatc cataaacatt
     1441 tttgtttgta atcttgtttc ttttgttatg ttttcagttt gttttaatgt tacaatactt
     1501 taattgaaag aattttgtca agttttttct tgtaactttt ctttacttgt atcatcttgt
     1561 ccttcaatac tgtaccctga aatgagaaat acatttttga cagaggctta atgttttaac
     1621 aaaa
//
