LOCUS       NM_001110345            1768 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus ubiquitin conjugating enzyme E2 V1 (Ube2v1),
            mRNA.
ACCESSION   NM_001110345 XM_215948
VERSION     NM_001110345.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1768)
  AUTHORS   Cadena,C., Ahmad,S., Xavier,A., Willemsen,J., Park,S., Park,J.W.,
            Oh,S.W., Fujita,T., Hou,F., Binder,M. and Hur,S.
  TITLE     Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in
            Innate Immunity
  JOURNAL   Cell 177 (5), 1187-1200 (2019)
   PUBMED   31006531
REFERENCE   2  (bases 1 to 1768)
  AUTHORS   Ma,Q., Ruan,H., Peng,L., Zhang,M., Gack,M.U. and Yao,W.D.
  TITLE     Proteasome-independent polyubiquitin linkage regulates synapse
            scaffolding, efficacy, and plasticity
  JOURNAL   Proc Natl Acad Sci U S A 114 (41), E8760-E8769 (2017)
   PUBMED   28973854
REFERENCE   3  (bases 1 to 1768)
  AUTHORS   Dauphinee,S.M., Clayton,A., Hussainkhel,A., Yang,C., Park,Y.J.,
            Fuller,M.E., Blonder,J., Veenstra,T.D. and Karsan,A.
  TITLE     SASH1 is a scaffold molecule in endothelial TLR4 signaling
  JOURNAL   J Immunol 191 (2), 892-901 (2013)
   PUBMED   23776175
REFERENCE   4  (bases 1 to 1768)
  AUTHORS   Hoxhaj,G., Najafov,A., Toth,R., Campbell,D.G., Prescott,A.R. and
            MacKintosh,C.
  TITLE     ZNRF2 is released from membranes by growth factors and, together
            with ZNRF1, regulates the Na+/K+ATPase
  JOURNAL   J Cell Sci 125 (Pt 19), 4662-4675 (2012)
   PUBMED   22797923
  REMARK    Erratum:[J Cell Sci. 2022 Mar 15;135(6):. PMID: 35267011]
REFERENCE   5  (bases 1 to 1768)
  AUTHORS   Pertel,T., Hausmann,S., Morger,D., Zuger,S., Guerra,J., Lascano,J.,
            Reinhard,C., Santoni,F.A., Uchil,P.D., Chatel,L., Bisiaux,A.,
            Albert,M.L., Strambio-De-Castillia,C., Mothes,W., Pizzato,M.,
            Grutter,M.G. and Luban,J.
  TITLE     TRIM5 is an innate immune sensor for the retrovirus capsid lattice
  JOURNAL   Nature 472 (7343), 361-365 (2011)
   PUBMED   21512573
REFERENCE   6  (bases 1 to 1768)
  AUTHORS   Zhang,M., Windheim,M., Roe,S.M., Peggie,M., Cohen,P., Prodromou,C.
            and Pearl,L.H.
  TITLE     Chaperoned ubiquitylation--crystal structures of the CHIP U box E3
            ubiquitin ligase and a CHIP-Ubc13-Uev1a complex
  JOURNAL   Mol Cell 20 (4), 525-538 (2005)
   PUBMED   16307917
REFERENCE   7  (bases 1 to 1768)
  AUTHORS   Andersen,P.L., Zhou,H., Pastushok,L., Moraes,T., McKenna,S.,
            Ziola,B., Ellison,M.J., Dixit,V.M. and Xiao,W.
  TITLE     Distinct regulation of Ubc13 functions by the two
            ubiquitin-conjugating enzyme variants Mms2 and Uev1A
  JOURNAL   J Cell Biol 170 (5), 745-755 (2005)
   PUBMED   16129784
REFERENCE   8  (bases 1 to 1768)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   9  (bases 1 to 1768)
  AUTHORS   Franko,J., Ashley,C. and Xiao,W.
  TITLE     Molecular cloning and functional characterization of two murine
            cDNAs which encode Ubc variants involved in DNA repair and
            mutagenesis
  JOURNAL   Biochim Biophys Acta 1519 (1-2), 70-77 (2001)
   PUBMED   11406273
REFERENCE   10 (bases 1 to 1768)
  AUTHORS   JACKSON,B.R. and DANIEL,W.H.
  TITLE     Recurrent carcinoma of the rectum, surgical treatment
  JOURNAL   Calif Med 91 (3), 149-150 (1959)
   PUBMED   14406273
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB792545.1, CO405669.1, DY309090.1 and CA505592.1.
            
            On May 20, 2008 this sequence version replaced NM_001110345.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK597661.1, EV766782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680423
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               CB792545.1         52-159
            109-721             CO405669.1         84-696
            722-1129            DY309090.1         282-689
            1130-1768           CA505592.1         1-639               c
FEATURES             Location/Qualifiers
     source          1..1768
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1768
                     /gene="Ube2v1"
                     /note="ubiquitin conjugating enzyme E2 V1"
                     /db_xref="GeneID:296390"
                     /db_xref="RGD:1305503"
     exon            1..64
                     /gene="Ube2v1"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..486
                     /gene="Ube2v1"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 variant 1"
                     /protein_id="NP_001103815.2"
                     /db_xref="GeneID:296390"
                     /db_xref="RGD:1305503"
                     /translation="MAATTGSGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMT
                     LTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPSVRFVTRVNMSGVSSSNGVVDP
                     RATAVLAKWQNSHSIKVILQELRRLMMSKENMKLPQPPEGQCYSN"
     exon            65..213
                     /gene="Ube2v1"
                     /inference="alignment:Splign:2.1.0"
     exon            214..339
                     /gene="Ube2v1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..1750
                     /gene="Ube2v1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggtgaaga aggggccggc cttcgagcga cagcgacgca agatggcagc caccacaggc
       61 tcgggagtaa aagtccctcg aaatttccga ctgttggaag agctggaaga aggccagaaa
      121 ggagtaggcg acggcacagt tagctggggt ctggaggacg acgaggacat gacgctcaca
      181 agatggacag gcatgataat tgggcctcca cgaacaattt atgaaaaccg aatatacagc
      241 cttaagatag agtgtgggcc taagtatcca gaagcacccc cgtctgtgag atttgtaaca
      301 agagtcaata tgagtggcgt gagcagttcc aatggagtgg tggatccacg agccacagca
      361 gtgctggcaa agtggcagaa ttcccacagc atcaaagtca tcctgcagga actgaggcgc
      421 ttgatgatgt caaaagagaa catgaagctg ccacagccac cagaaggaca gtgttacagc
      481 aattagtcac caaggccccg gcctcccttc cccatccaac ccaagtcttc attttccaca
      541 gtagtgaatt tttctagatc catctgtaga cctcaaagta ctggagagga agccccactc
      601 agacttcatc ctgagacact gctctgatac taacttcttg tccatttgaa aatcctaagt
      661 tgtgctgtgt aacatcatct gtcgagtgta accgctgtct gcctggttga acttctggga
      721 tcaagaaggt gtgttgaaat cggtttcctt tgggagcggt gggcacagct aacgcaactg
      781 tgaacagaca cgtctcacac aatcacctgc tgctggcact cggcctgggt ctgcctttgc
      841 ccgccctgcc ctccgccata gctgtgtggt ggcccttaga atagatgggg aggcttcagg
      901 tagcagccgt gggactgacc accgctgggc ttggggcgct ttggctgcac ccctgctttc
      961 ttaagtctta agtgattgcc ccatccaagc catggtcccc actcctccac tcccaccctt
     1021 ggccaaagct tagattgtaa tctcccttcc ctctgaaatt ggccgtgggt gaggaattca
     1081 gggcttcccg tctccccacc tttatcaagg ggtgctgctt tcccctcctc aagtcccttg
     1141 ttgcccgtca ccacccaaca cttgctgtgg ccagaagcca ccagatgagg ttggaagagc
     1201 ctggcctccc tcacttagct ccggaccaca ctcgttcacc tgccaccagc ctgggaaggg
     1261 agcgccgggt cctcggccct gccaccacca tcagcccttg agctttgagc tcaggtctag
     1321 aggtgaacag agcagtcacc gggcgactca gacgggccag cgctcagggt ccttggatat
     1381 atgcctagag aaaggccatg cggagagtcc tcggtgcaca tggttctgag ttggttcctt
     1441 ttcccataat tgctttgctt ttacacattg aagaggtttg aacagggctc tcagtcaccc
     1501 tgaccaccca tcgggtctgg tgtggagcct gacagctgga gcaggaagcc ctgaccctgc
     1561 agactcgggt ttcagtgttg ttcctcagac cctcggcagg gacccagagg agctctgtgt
     1621 caccacgttc gcagattttt gcagatcggt gggcctggct cctggctcat tgccacgctc
     1681 cccactctgt tcaggaccac taaatgttga aatgtggatg catactgaaa taaaggcaat
     1741 tcgttgtgtt aaaaaaaaaa aaaaaaaa
//
