LOCUS       NM_001108344             989 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus ubiquitin-conjugating enzyme E2T (Ube2t), mRNA.
ACCESSION   NM_001108344 XM_001062580 XM_341124
VERSION     NM_001108344.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 989)
  AUTHORS   David Y, Ziv T, Admon A and Navon A.
  TITLE     The E2 ubiquitin-conjugating enzymes direct polyubiquitination to
            preferred lysines
  JOURNAL   J Biol Chem 285 (12), 8595-8604 (2010)
   PUBMED   20061386
REFERENCE   2  (bases 1 to 989)
  AUTHORS   Longerich S, San Filippo J, Liu D and Sung P.
  TITLE     FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL
  JOURNAL   J Biol Chem 284 (35), 23182-23186 (2009)
   PUBMED   19589784
REFERENCE   3  (bases 1 to 989)
  AUTHORS   Alpi AF, Pace PE, Babu MM and Patel KJ.
  TITLE     Mechanistic insight into site-restricted monoubiquitination of
            FANCD2 by Ube2t, FANCL, and FANCI
  JOURNAL   Mol Cell 32 (6), 767-777 (2008)
   PUBMED   19111657
REFERENCE   4  (bases 1 to 989)
  AUTHORS   Alpi A, Langevin F, Mosedale G, Machida YJ, Dutta A and Patel KJ.
  TITLE     UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited
            independently to chromatin: a basis for the regulation of FANCD2
            monoubiquitination
  JOURNAL   Mol Cell Biol 27 (24), 8421-8430 (2007)
   PUBMED   17938197
REFERENCE   5  (bases 1 to 989)
  AUTHORS   Machida YJ, Machida Y, Chen Y, Gurtan AM, Kupfer GM, D'Andrea AD
            and Dutta A.
  TITLE     UBE2T is the E2 in the Fanconi anemia pathway and undergoes
            negative autoregulation
  JOURNAL   Mol Cell 23 (4), 589-596 (2006)
   PUBMED   16916645
REFERENCE   6  (bases 1 to 989)
  AUTHORS   Lau NC, Seto AG, Kim J, Kuramochi-Miyagawa S, Nakano T, Bartel DP
            and Kingston RE.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW141189.1 and BC167012.1.
            
            On Apr 15, 2009 this sequence version replaced NM_001108344.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ233263.1, EV778800.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AW141189.1         1-39
            40-989              BC167012.1         1-950
FEATURES             Location/Qualifiers
     source          1..989
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..989
                     /gene="Ube2t"
                     /gene_synonym="RGD1310816"
                     /note="ubiquitin-conjugating enzyme E2T"
                     /db_xref="GeneID:360847"
                     /db_xref="RGD:1310816"
     exon            1..96
                     /gene="Ube2t"
                     /gene_synonym="RGD1310816"
                     /inference="alignment:Splign:2.1.0"
     exon            97..267
                     /gene="Ube2t"
                     /gene_synonym="RGD1310816"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..773
                     /gene="Ube2t"
                     /gene_synonym="RGD1310816"
                     /EC_number="6.3.2.19"
                     /note="ubiquitin-conjugating enzyme E2T (putative)"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 T"
                     /protein_id="NP_001101814.2"
                     /db_xref="GeneID:360847"
                     /db_xref="RGD:1310816"
                     /translation="MQRASRLKKELHMLAIEPPPGVTCWQEKDKMDNLRAQILGGANT
                     PYEKGIFTLEVIVPERYPFEPPQIRFLTPIYHPNIDSSGRICLDILKLPPKGAWRPSL
                     NIATVLTSIQLLMAEPNPDDPLMADISSEFKYNKIAFVKKARQWTETHARQKQKAGEE
                     EVGISSEVGDSEESHSTQKRKARPLGGMQKRFSPDVQRVCPGPS"
     exon            268..337
                     /gene="Ube2t"
                     /gene_synonym="RGD1310816"
                     /inference="alignment:Splign:2.1.0"
     exon            338..443
                     /gene="Ube2t"
                     /gene_synonym="RGD1310816"
                     /inference="alignment:Splign:2.1.0"
     exon            444..542
                     /gene="Ube2t"
                     /gene_synonym="RGD1310816"
                     /inference="alignment:Splign:2.1.0"
     exon            543..626
                     /gene="Ube2t"
                     /gene_synonym="RGD1310816"
                     /inference="alignment:Splign:2.1.0"
     exon            627..989
                     /gene="Ube2t"
                     /gene_synonym="RGD1310816"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggttcag cctgggcact gcagacacac gagcggaaag ccgggttgct gaggagtgcc
       61 gtgggagcca cccgagggga cgtacccgag gtcacgtaca ccccaccagc ccttagtgtg
      121 gagcagggaa ctgtttatgg ttcctttcac ttgaaaccat gcagagagct tcacgcctga
      181 agaaagaact gcacatgcta gccatcgaac ctcccccagg cgtcacgtgc tggcaggaaa
      241 aggacaaaat ggataatttg cgagctcaaa tactaggtgg agccaataca ccttatgaga
      301 aaggtatttt cacactggaa gttatcgttc ctgaaaggta cccatttgag ccaccacaga
      361 tccgatttct gactccaatc tatcatccaa acattgattc tagtggaagg atttgtctag
      421 atattctcaa attgccacca aagggtgcat ggagaccgtc cctcaacatt gccactgtat
      481 tgacctctat tcagctgctc atggccgagc ccaatcctga tgacccacta atggctgaca
      541 tttcttcaga atttaaatat aacaagatcg cttttgtcaa gaaagcaaga cagtggacag
      601 agactcatgc aagacagaaa caaaaggctg gtgaagagga ggtaggcatc tcatcggagg
      661 ttggtgactc tgaggaaagc cactccacac agaaaaggaa ggccaggcca ctaggaggaa
      721 tgcaaaagag gttttctcct gatgttcaga gagtctgtcc tggtccctct tagttactgg
      781 cagtctgtgt caaggtggtc tccttgcttg cttcttttca atgtttttct ttgtgtttga
      841 tgacaaatgt ttgtatcctt acaaaagacc tcgtatgttt acgaattctg ccatgcagcg
      901 attctttaag aatagtttgt tttatttatc ttgtacatat gtatttagaa aacttttaaa
      961 cttgaaaaat aaataatact taatgttaa
//
