LOCUS       NM_001106224             991 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ubiquitin-conjugating enzyme E2S (Ube2s), mRNA.
ACCESSION   NM_001106224 XM_001071810 XM_214806
VERSION     NM_001106224.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 991)
  AUTHORS   Wang,W. and Kirschner,M.W.
  TITLE     Emi1 preferentially inhibits ubiquitin chain elongation by the
            anaphase-promoting complex
  JOURNAL   Nat Cell Biol 15 (7), 797-806 (2013)
   PUBMED   23708001
REFERENCE   2  (bases 1 to 991)
  AUTHORS   Wickliffe,K.E., Lorenz,S., Wemmer,D.E., Kuriyan,J. and Rape,M.
  TITLE     The mechanism of linkage-specific ubiquitin chain elongation by a
            single-subunit E2
  JOURNAL   Cell 144 (5), 769-781 (2011)
   PUBMED   21376237
REFERENCE   3  (bases 1 to 991)
  AUTHORS   Bremm,A., Freund,S.M. and Komander,D.
  TITLE     Lys11-linked ubiquitin chains adopt compact conformations and are
            preferentially hydrolyzed by the deubiquitinase Cezanne
  JOURNAL   Nat Struct Mol Biol 17 (8), 939-947 (2010)
   PUBMED   20622874
REFERENCE   4  (bases 1 to 991)
  AUTHORS   David,Y., Ziv,T., Admon,A. and Navon,A.
  TITLE     The E2 ubiquitin-conjugating enzymes direct polyubiquitination to
            preferred lysines
  JOURNAL   J Biol Chem 285 (12), 8595-8604 (2010)
   PUBMED   20061386
REFERENCE   5  (bases 1 to 991)
  AUTHORS   Garnett,M.J., Mansfeld,J., Godwin,C., Matsusaka,T., Wu,J.,
            Russell,P., Pines,J. and Venkitaraman,A.R.
  TITLE     UBE2S elongates ubiquitin chains on APC/C substrates to promote
            mitotic exit
  JOURNAL   Nat Cell Biol 11 (11), 1363-1369 (2009)
   PUBMED   19820702
REFERENCE   6  (bases 1 to 991)
  AUTHORS   Williamson,A., Wickliffe,K.E., Mellone,B.G., Song,L., Karpen,G.H.
            and Rape,M.
  TITLE     Identification of a physiological E2 module for the human
            anaphase-promoting complex
  JOURNAL   Proc Natl Acad Sci U S A 106 (43), 18213-18218 (2009)
   PUBMED   19822757
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC169077.1.
            
            On Sep 4, 2008 this sequence version replaced NM_001106224.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169077.1, EV772705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..991
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..991
                     /gene="Ube2s"
                     /gene_synonym="RGD1564746"
                     /note="ubiquitin-conjugating enzyme E2S"
                     /db_xref="GeneID:292588"
                     /db_xref="RGD:1564746"
     exon            1..135
                     /gene="Ube2s"
                     /gene_synonym="RGD1564746"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..804
                     /gene="Ube2s"
                     /gene_synonym="RGD1564746"
                     /EC_number="2.3.2.23"
                     /note="ubiquitin-protein ligase S; ubiquitin carrier
                     protein S; E2 ubiquitin-conjugating enzyme S"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 S"
                     /protein_id="NP_001099694.1"
                     /db_xref="GeneID:292588"
                     /db_xref="RGD:1564746"
                     /translation="MNSNVENLPPHIIRLVYKEVTTLTADPPDGIKVFPNEEDLTDLQ
                     VTIEGPEGTPYAGGLFRMKLLLGKDFPASPPKGYFLTKIFHPNVGPNGEICVNVLKRD
                     WTAELGIRHVLLTIKCLLIHPNPESALNEEAGRLLLENYEEYAARARLLTEIHGGACS
                     TSSGRAEASRDLASGASASSTDPMTPGVLGGAEGPMAKKHAGERDKKLAAKKKLDKKR
                     ALRRL"
     exon            136..283
                     /gene="Ube2s"
                     /gene_synonym="RGD1564746"
                     /inference="alignment:Splign:2.1.0"
     exon            284..474
                     /gene="Ube2s"
                     /gene_synonym="RGD1564746"
                     /inference="alignment:Splign:2.1.0"
     exon            475..948
                     /gene="Ube2s"
                     /gene_synonym="RGD1564746"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggggagcgg agcgggccct cgggggcctc gctagggcca cagcggccgg cagttgggcc
       61 ccccgccccg gccggcggtc cgaggagtgc aggaaggggg ccggggggac ccgcccccgg
      121 cctgttgaag tcatgaactc caatgtagag aatctccctc cccacatcat ccgcctagtg
      181 tacaaggagg tgacaacact gacagcagat ccacccgatg gcattaaagt cttccccaat
      241 gaggaggatc tcaccgacct gcaggttaca atcgagggcc ctgaagggac cccctatgct
      301 ggaggtctgt tccgtatgaa gctcctacta gggaaggact tccctgcctc cccacccaag
      361 ggctacttcc tgactaaaat cttccaccca aatgtgggcc ccaatggtga gatctgtgtc
      421 aacgtgctca agagggactg gactgctgag ttgggcatac gacatgtgct gctgaccatc
      481 aagtgcctgc tgatccatcc taacccagag tctgcactca atgaggaggc aggccgcctg
      541 cttttggaga actacgagga gtatgctgcc cgggcccgtc tgctcacaga gatccatggg
      601 ggtgcatgta gcaccagcag tgggagggct gaggcttccc gggacctggc cagtggggct
      661 tcagcctcct ccactgaccc tatgacccca ggggtcctag gaggagctga gggtcccatg
      721 gccaagaaac atgcaggtga gcgagataag aagctggcag ccaagaaaaa gttggacaag
      781 aagcgagcac tgaggcgact gtagtggggc tcttctctct ccttccctct cttctatccc
      841 ctcccactct gtctctaagt tatttaaatt atggctgggg tgggggaggg agatgggggg
      901 gcaccagaac ctggatttgg ttttctaaat aaaaagttgg aaaagcaaaa aaaaaaaaaa
      961 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
