LOCUS       NM_053928               1575 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus ubiquitin-conjugating enzyme E2N (Ube2n), mRNA.
ACCESSION   NM_053928 XM_001077606
VERSION     NM_053928.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1575)
  AUTHORS   Cadena,C., Ahmad,S., Xavier,A., Willemsen,J., Park,S., Park,J.W.,
            Oh,S.W., Fujita,T., Hou,F., Binder,M. and Hur,S.
  TITLE     Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in
            Innate Immunity
  JOURNAL   Cell 177 (5), 1187-1200 (2019)
   PUBMED   31006531
REFERENCE   2  (bases 1 to 1575)
  AUTHORS   Valnegri,P., Huang,J., Yamada,T., Yang,Y., Mejia,L.A., Cho,H.Y.,
            Oldenborg,A. and Bonni,A.
  TITLE     RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the
            mammalian brain
  JOURNAL   Nat Commun 8 (1), 1271 (2017)
   PUBMED   29097665
  REMARK    GeneRIF: Knockdown or conditional knockout of RNF8 or UBC13 in
            rodent cerebellar granule neurons robustly increases the number of
            parallel fiber presynaptic boutons and functional parallel
            fiber/Purkinje cell synapses. In contrast to the role of nuclear
            RNF8 in proliferating cells, RNF8 operates in the cytoplasm in
            neurons to suppress synapse differentiation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1575)
  AUTHORS   Ma,Q., Ruan,H., Peng,L., Zhang,M., Gack,M.U. and Yao,W.D.
  TITLE     Proteasome-independent polyubiquitin linkage regulates synapse
            scaffolding, efficacy, and plasticity
  JOURNAL   Proc Natl Acad Sci U S A 114 (41), E8760-E8769 (2017)
   PUBMED   28973854
REFERENCE   4  (bases 1 to 1575)
  AUTHORS   Lentucci,C., Belkina,A.C., Cederquist,C.T., Chan,M., Johnson,H.E.,
            Prasad,S., Lopacinski,A., Nikolajczyk,B.S., Monti,S.,
            Snyder-Cappione,J., Tanasa,B., Cardamone,M.D. and Perissi,V.
  TITLE     Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates
            Multiple Stages of B Cell Development
  JOURNAL   J Biol Chem 292 (7), 2754-2772 (2017)
   PUBMED   28039360
REFERENCE   5  (bases 1 to 1575)
  AUTHORS   Deng,L., Jiang,C., Chen,L., Jin,J., Wei,J., Zhao,L., Chen,M.,
            Pan,W., Xu,Y., Chu,H., Wang,X., Ge,X., Li,D., Liao,L., Liu,M.,
            Li,L. and Wang,P.
  TITLE     The ubiquitination of rag A GTPase by RNF152 negatively regulates
            mTORC1 activation
  JOURNAL   Mol Cell 58 (5), 804-818 (2015)
   PUBMED   25936802
REFERENCE   6  (bases 1 to 1575)
  AUTHORS   Zhou,H., Wertz,I., O'Rourke,K., Ultsch,M., Seshagiri,S., Eby,M.,
            Xiao,W. and Dixit,V.M.
  TITLE     Bcl10 activates the NF-kappaB pathway through ubiquitination of
            NEMO
  JOURNAL   Nature 427 (6970), 167-171 (2004)
   PUBMED   14695475
REFERENCE   7  (bases 1 to 1575)
  AUTHORS   Rajapurohitam,V., Bedard,N. and Wing,S.S.
  TITLE     Control of ubiquitination of proteins in rat tissues by ubiquitin
            conjugating enzymes and isopeptidases
  JOURNAL   Am J Physiol Endocrinol Metab 282 (4), E739-E745 (2002)
   PUBMED   11882492
REFERENCE   8  (bases 1 to 1575)
  AUTHORS   Ashley,C., Pastushok,L., McKenna,S., Ellison,M.J. and Xiao,W.
  TITLE     Roles of mouse UBC13 in DNA postreplication repair and Lys63-linked
            ubiquitination
  JOURNAL   Gene 285 (1-2), 183-191 (2002)
   PUBMED   12039045
REFERENCE   9  (bases 1 to 1575)
  AUTHORS   Lopez Salon,M., Morelli,L., Castano,E.M., Soto,E.F. and
            Pasquini,J.M.
  TITLE     Defective ubiquitination of cerebral proteins in Alzheimer's
            disease
  JOURNAL   J Neurosci Res 62 (2), 302-310 (2000)
   PUBMED   11020223
REFERENCE   10 (bases 1 to 1575)
  AUTHORS   JACKSON,B.R. and DANIEL,W.H.
  TITLE     Recurrent carcinoma of the rectum, surgical treatment
  JOURNAL   Calif Med 91 (3), 149-150 (1959)
   PUBMED   14406273
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC090072.1.
            
            On or before Jun 25, 2006 this sequence version replaced
            XM_001077606.1, NM_053928.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090072.1, FQ195018.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1575
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1575
                     /gene="Ube2n"
                     /note="ubiquitin-conjugating enzyme E2N"
                     /db_xref="GeneID:116725"
                     /db_xref="RGD:621096"
     exon            1..369
                     /gene="Ube2n"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..798
                     /gene="Ube2n"
                     /EC_number="2.3.2.23"
                     /note="ubiquitin-protein ligase N; ubiquitin carrier
                     protein N; bendless-like ubiquitin-conjugating enzyme;
                     bendless protein; ubiquitin-conjugating enzyme E2N
                     (homologous to yeast UBC13); ubiquitin-conjugating enzyme
                     E2N (UBC13 homolog, yeast); E2 ubiquitin-conjugating
                     enzyme N"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 N"
                     /protein_id="NP_446380.1"
                     /db_xref="GeneID:116725"
                     /db_xref="RGD:621096"
                     /translation="MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQD
                     SPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIR
                     TVLLSIQALLSAPNPDDPLANDVAEQWKSNEAQAIETARAWTRLYAMNNI"
     exon            370..616
                     /gene="Ube2n"
                     /inference="alignment:Splign:2.1.0"
     exon            617..757
                     /gene="Ube2n"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1488
                     /gene="Ube2n"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctggacgc ccagttgcgc gaattctgcc gcgggcgaag aagctcggcg ccgcctcgcg
       61 ccgcctcccc caaagtccct gccccgccgc ggagcgtcac ttccgccacc ccgggctggg
      121 gttggggcgg ggagcgcggg ggagggggcc actaggtcgg agggaaggcc gcctgaagcc
      181 cgcgccctag cagggactac atttcccgag gggcctcggc ggaggtagcg acggcgggcg
      241 cggcgacgtc ccccggaagt ggagcccggg acttccactc gtgcgtgagg cgagcggagc
      301 cggagacaag agcagaggcc gaactcggga tctgacaaga tggccgggct gccccgcagg
      361 atcatcaagg aaacccagcg tttgctggca gaaccagttc ctggcattaa agcagaacca
      421 gatgagagca acgcccgtta ttttcatgtg gtcattgctg gtccccagga ttcccccttt
      481 gagggaggga cttttaaact tgaactattc cttccagaag aatacccaat ggcagcacct
      541 aaagtacgtt tcatgaccaa aatttatcat cctaatgtag acaagttggg aagaatatgt
      601 ttagatattt tgaaagataa gtggtcccca gcactgcaga tccgaacagt tctgctatca
      661 atccaggctt tgttaagtgc tcctaatcca gatgatccat tagcaaatga tgtagctgag
      721 cagtggaaga gcaacgaagc ccaagccata gaaacagcaa gagcatggac taggctatat
      781 gccatgaaca atatttaagt cgatcagatc atcaagtgta caccacttct cctgttctgc
      841 caagacttct tccttttttt gtttgcattt aatggacaca gtcttagaaa cattacagaa
      901 taaaagccca ggcatcttca tctttggtga tcacatgcac ttagcaaacc tgtcttgtcc
      961 tgattcactg ttgtaaagca tgagcagagg ctagaagcat cacccgggtt gctgagagat
     1021 gctgagaagc aggactctct gctttgactc ctttccccat catggtctaa gtacaaggca
     1081 ctgtgaatga aggtagttgt cagggttagc tgccaggggc atgggtgttt ttattttatt
     1141 ttttaggggg aaagtagttt tattttaatt ttatggcctc ccctctctta agggatctaa
     1201 ttgcagtggt taaatgcagc taaccggtgt tttagaatat gctctctagc caagtctaac
     1261 tttagacgct gtagatggac aagcttgact gtctgatcca aaatgggaac attaaataaa
     1321 catcacagcc ctcactaata acattgtgac tttgccgtca ggtgtagatt ctctgtcccc
     1381 cccccccccc ccccaaaaga cgaagaaaaa gcttgtgacc attttgtatg gcttgtctgg
     1441 aaacttctgt aaatcttatg ttttagtaaa atattttttg ttattctaaa aaaaaaaaaa
     1501 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1561 aaaaaaaaaa aaaaa
//
