LOCUS       NM_001329136            2864 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ubiquitin-conjugating enzyme E2L 3 (Ube2l3),
            mRNA.
ACCESSION   NM_001329136
VERSION     NM_001329136.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2864)
  AUTHORS   Durcan,T.M. and Fon,E.A.
  TITLE     The three 'P's of mitophagy: PARKIN, PINK1, and post-translational
            modifications
  JOURNAL   Genes Dev 29 (10), 989-999 (2015)
   PUBMED   25995186
  REMARK    Review article
REFERENCE   2  (bases 1 to 2864)
  AUTHORS   Lee,P.C., Dodart,J.C., Aron,L., Finley,L.W., Bronson,R.T.,
            Haigis,M.C., Yankner,B.A. and Harper,J.W.
  TITLE     Altered social behavior and neuronal development in mice lacking
            the Uba6-Use1 ubiquitin transfer system
  JOURNAL   Mol Cell 50 (2), 172-184 (2013)
   PUBMED   23499007
REFERENCE   3  (bases 1 to 2864)
  AUTHORS   Wenzel,D.M., Lissounov,A., Brzovic,P.S. and Klevit,R.E.
  TITLE     UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT
            hybrids
  JOURNAL   Nature 474 (7349), 105-108 (2011)
   PUBMED   21532592
REFERENCE   4  (bases 1 to 2864)
  AUTHORS   David,Y., Ziv,T., Admon,A. and Navon,A.
  TITLE     The E2 ubiquitin-conjugating enzymes direct polyubiquitination to
            preferred lysines
  JOURNAL   J Biol Chem 285 (12), 8595-8604 (2010)
   PUBMED   20061386
REFERENCE   5  (bases 1 to 2864)
  AUTHORS   Whitcomb,E.A., Dudek,E.J., Liu,Q. and Taylor,A.
  TITLE     Novel control of S phase of the cell cycle by ubiquitin-conjugating
            enzyme H7
  JOURNAL   Mol Biol Cell 20 (1), 1-9 (2009)
   PUBMED   18946090
REFERENCE   6  (bases 1 to 2864)
  AUTHORS   Ardley,H.C., Tan,N.G., Rose,S.A., Markham,A.F. and Robinson,P.A.
  TITLE     Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that
            regulate its interaction with the ubiquitin-conjugating enzyme,
            Ubch7
  JOURNAL   J Biol Chem 276 (22), 19640-19647 (2001)
   PUBMED   11278816
REFERENCE   7  (bases 1 to 2864)
  AUTHORS   Wang,M., Suzuki,T., Kitada,T., Asakawa,S., Minoshima,S.,
            Shimizu,N., Tanaka,K., Mizuno,Y. and Hattori,N.
  TITLE     Developmental changes in the expression of parkin and UbcR7, a
            parkin-interacting and ubiquitin-conjugating enzyme, in rat brain
  JOURNAL   J Neurochem 77 (6), 1561-1568 (2001)
   PUBMED   11413239
REFERENCE   8  (bases 1 to 2864)
  AUTHORS   Shimura,H., Hattori,N., Kubo,Si., Mizuno,Y., Asakawa,S.,
            Minoshima,S., Shimizu,N., Iwai,K., Chiba,T., Tanaka,K. and
            Suzuki,T.
  TITLE     Familial Parkinson disease gene product, parkin, is a
            ubiquitin-protein ligase
  JOURNAL   Nat Genet 25 (3), 302-305 (2000)
   PUBMED   10888878
REFERENCE   9  (bases 1 to 2864)
  AUTHORS   Moynihan,T.P., Nuber,U., Ardley,H.C., Rose,S.A., Markham,A.F.,
            Scheffner,M. and Robinson,P.A.
  TITLE     Characterization of the mouse ubiquitin-conjugating enzyme gene
            UbcM4
  JOURNAL   Mamm Genome 10 (10), 977-982 (1999)
   PUBMED   10501966
REFERENCE   10 (bases 1 to 2864)
  AUTHORS   Anan,T., Nagata,Y., Koga,H., Honda,Y., Yabuki,N., Miyamoto,C.,
            Kuwano,A., Matsuda,I., Endo,F., Saya,H. and Nakao,M.
  TITLE     Human ubiquitin-protein ligase Nedd4: expression, subcellular
            localization and selective interaction with ubiquitin-conjugating
            enzymes
  JOURNAL   Genes Cells 3 (11), 751-763 (1998)
   PUBMED   9990509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ074932.1, FQ095739.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMN12840109
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               JAXUCZ010000011.1  97301945-97302120
            177-290             JAXUCZ010000011.1  97302535-97302648
            291-386             JAXUCZ010000011.1  97321871-97321966
            387-573             JAXUCZ010000011.1  97337670-97337856
            574-2864            JAXUCZ010000011.1  97340794-97343084
FEATURES             Location/Qualifiers
     source          1..2864
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..2864
                     /gene="Ube2l3"
                     /gene_synonym="UbcH7; UbcR7"
                     /note="ubiquitin-conjugating enzyme E2L 3"
                     /db_xref="GeneID:363836"
                     /db_xref="RGD:1308361"
     exon            1..176
                     /gene="Ube2l3"
                     /gene_synonym="UbcH7; UbcR7"
                     /inference="alignment:Splign:2.1.0"
     exon            177..290
                     /gene="Ube2l3"
                     /gene_synonym="UbcH7; UbcR7"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..728
                     /gene="Ube2l3"
                     /gene_synonym="UbcH7; UbcR7"
                     /EC_number="6.3.2.19"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 L3"
                     /protein_id="NP_001316065.1"
                     /db_xref="GeneID:363836"
                     /db_xref="RGD:1308361"
                     /translation="MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNP
                     PYDKGAFRIEINFPAEYPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTD
                     QVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD"
     exon            291..386
                     /gene="Ube2l3"
                     /gene_synonym="UbcH7; UbcR7"
                     /inference="alignment:Splign:2.1.0"
     exon            387..573
                     /gene="Ube2l3"
                     /gene_synonym="UbcH7; UbcR7"
                     /inference="alignment:Splign:2.1.0"
     exon            574..2864
                     /gene="Ube2l3"
                     /gene_synonym="UbcH7; UbcR7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcccgaaag ttccttgtag tgggaggctg tatgtgaatg ttagtgggaa cgcacacaca
       61 tgcatttgga gacctgaggt ccacagaatt ctttccttgt ttgcacttta ctgttttttt
      121 gtttttgttt ttgttttttt cccttgaatc tgaggctcac caattcagtt aagcagcccc
      181 tccccctctc caggaagtga gggggttcaa gccgactggc ctaccgcgat gcattttggg
      241 aaagcagcag caccagatcc aagatggcgg ccagcaggag gctgatgaag gagcttgaag
      301 agatccgcaa atgtggaatg aaaaacttcc gtaacatcca ggttgatgaa gctaatttat
      361 tgacttggca agggcttatt gttcctgaca accctccata tgataaggga gccttcagaa
      421 ttgagatcaa cttcccagca gagtatccct tcaagccacc caagatcaca tttaaaacaa
      481 agatctacca ccctaacatc gacgagaagg ggcaggtctg tctgcccgta attagtgcgg
      541 aaaactggaa gccggccacc aagactgacc aagtaatcca gtccctcata gcactggtga
      601 acgaccctca gcctgagcac ccactccggg ctgacctagc tgaagaatac tctaaggacc
      661 gtaaaaaatt ctgtaagaat gctgaagagt ttacaaagaa atatggggaa aagcgacctg
      721 tggactaaaa tctgccacga gtgattccag caagtttgag cagagacccc gagcagtgca
      781 ttcagacacc ccgcaaagca ggactctgtg gaaattgaca cgtgccacca actggcgtcc
      841 gcttgtggca gttactaact ttctacagtt ttcttaatca aaagtggtct aggtaacctg
      901 taaagaagga ttaaaaaatt cagatgttct agttctgctt gctttgtttt aaaaatcact
      961 gctttagtct acttcaaaag aatggcattt cttttcttgc ccagatttac tcaaagttgc
     1021 agttagccca ggtttaaaga taaaggttgt ggtttcctct cccttccccg cttctccctt
     1081 ttcgatttcc acttccacag accaaggccc cagctcccca caggggcggc ggcagcattg
     1141 gcaactttgt cctgtgccac actgcccgtg gataatgaat agctcaagtc cccataccag
     1201 cttattgaca tctttaaaaa ctatagaaca gtatcagtgc cctgccccac gggacatccg
     1261 tgcaaaggga agccgttggt ttttgtttgt ttgtttgttt ttttacataa aatcttagca
     1321 aagggtttcc acagtagtaa tagactcaac agacagaccc catggtccac atcagtggtc
     1381 agactgtgct gggtctttgt ggggaaccct gttatatcag gtttgtggtg accttgaagg
     1441 gaggtctgcc attggagaat acagtgcact tgtgtgatga atttctctcc agaaaggctg
     1501 acagtcagca gtccttccta cagctgtggt agaagacctg gtcatcacat acaaagcaaa
     1561 accagaatat tcttttgaaa tttcaagctt ctctactacc aagctctgat aggatgtgct
     1621 aaggtgttcc cactcctcag cacagcaggc accacggcct tccctccttg gggtttactc
     1681 ttggtgggat cagccagggt tggtggcttc tgcctcttcc tcagagcagc tcctggggca
     1741 gcccaggaac aggatggctt ttccccctcc cctctggacc caaagccttt ccagtcaagc
     1801 tccacttgaa gctcaataat atcctttcaa tgtgttttat attgttttga ttgccttttt
     1861 ttgtagaaat aaaatttgag cttagaattt atcatcaaat gaactgtcaa gatttgaatg
     1921 ttaatgtctt ttcaagggaa gtgggactgt ccttgaagca gtagtgacac cctgaggaag
     1981 ctgatggcct gtccgtgcct atgctcacca cctcacttct gctactaggg tttgagatcc
     2041 tgtggagacg attgcctcaa gaaaccttgc tttctgcttt gaccttagtt ctataacttt
     2101 ggggctacct aggctcacag acttggaaaa cagctctgag ttttgcctat aaagaagtga
     2161 gacatgtcct ctcaggcagt gtaactttag ttttccaagt gtttggctcc tgtggtgcat
     2221 aaatgaacta tgctttagtt ctaggtatgc atggggcagg tttctggaga tttccatatg
     2281 cccaggatgg tcagagccct gggcctgtgt ttctatgtct gtctcttcat tggcagaaaa
     2341 gtgacaatgg attttatttc actcacattc agatttgtaa taaaatgcca aactctgtca
     2401 gaattgtcca aaccaaccac cattttgttg atgttgcttt tctgaatcta aagatagtcc
     2461 agctatctca ttgcttagct ctacctgcct gttaccctca ctgttctctg ctcatatggg
     2521 agtactctta tgccagcagc ccctctcagg gactctcagc cccactgttg acaaccatgg
     2581 cctgccctgg aagcagaggc ctggcttgga gtcagtggtg tccctctggg cttgcatgcc
     2641 ttgtcctttc caaccctgcc ctggagcagg ctttgaccaa gctggcaggg agacctgtgg
     2701 aacagccagc cacccacccc tgacccaagt tggctaagga attcacaccc ccctggttcc
     2761 ttgaagtgcc ctggtctcac cctgctcttt ccacagtggc agagaaggct ttctaagatg
     2821 ctgtgaccct actctgtcct taataaagat gttctcagac acta
//
